Digital Commons Network^™

Drip Water Chemistry Response To Human Activities At Diamond Caverns In Park City, Kentucky, Madison R. High

Honors Theses

This research aims to give insight into factors contributing to seasonal variation of karst cave drip water hydrochemistry relative to surface condition. The study area is a small show cave, Diamond Caverns, located just outside the boundary of Mammoth Cave National Park in Kentucky. Various water chemistry parameters, such as chloride, pH, and temperature were monitored. A YSI EXO2 was deployed to measure the aforementioned parameters at one-hour intervals in a drip water pool starting in November 2023. To discern significant changes in solute concentrations, daily averages were calculated based on the hourly data. Daily averages were then compared to …

Recurrent Lymphoid And Myeloid Relapses Due To Treatment Cessations Reveal Natural History Of Ph-Positive B-All And Pose A Diagnostic Challenge, Shimin Hu, Elias J Jabbour, Collin Y Hu, Guilin Tang, Wei Wang, L Jeffrey Medeiros, Carlos Bueso-Ramos

Faculty, Staff and Student Publications

No abstract provided.

Using Flipped Classroom Modules To Facilitate Higher Order Learning In Undergraduate Organic Chemistry, Lauren R. Holloway, Tabitha Miller, Bryce Da Camara, Paul M. Bogie, Briana L. Hickey, Jack Barbera, Angie L. Lopez, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

In an ongoing effort to incorporate active learning and promote higher order learning outcomes in undergraduate organic chemistry, a hybrid (“flipped”) classroom structure has been used to facilitate a series of collaborative activities in the first two courses of the lower division organic chemistry sequence. An observational study of seven classes over a five-year period reveals there is a strong correlation between performance on the in-class activities and performance on the final exam across all classes; however, a significant number of students in these courses continue to struggle on both the in-class activities and final exam. The Activity Engagement Survey …

Seabird Observations In The Southern Ocean South Of Africa, Summer 1975/1976, M. D. Flora

Marine Ornithology

No abstract provided.

Plasma Chemistry Reference Values In Free-Living Bonelli's Eagle (Hieraaetus Fasciatus) Nestlings, Javier Balbontin, Miguel Ferrer

Journal of Raptor Research

No abstract provided.

Serum Chemistry Values For Nestling Bald Eagles (Haliaeetus Leucocephalus&Rsqb; In Florida Bay, Everglades National Park, Brian Mealey, Greta M. Parks, Carlos M. Pages, Brian A. Millsap, Orin L. Bass, Gregory D. Bossart

Journal of Raptor Research

No abstract provided.

Blood Chemistry, Cytology, And Body Condition In Adult Northern Goshawks (Accipiter Gentilis), Lauri A. Hanauska-Brown, Alfred M. Dufty Jr., Gary J. Roloff

Journal of Raptor Research

No abstract provided.

Design Of Two New Sulfur Derivatives Of Perezone: In Silico Study Simulation Targeting Parp-1 And In Vitro Study Validation Using Cancer Cell Lines, Alejandro Rubiales-Martínez, Joel Martinez, Elvia Mera-Jiménez, Javier Perez-Flores, Guillermo Tellez-Isaias, Rene Miranda Ruvacalba, Maricarmen Hernandez-Rodriguez, Teresa Mancillo Percino, Martha Edith Macia Perez, Maria Ines Nicholas-Vazquez

Poultry Science Faculty Publications and Presentations

Poly-ADP-Ribose Polymerase (PARP-1) is an overexpressed enzyme in several carcinomas; consequently, the design of PARP-1 inhibitors has acquired special attention. Hence, in the present study, three compounds (8–10) were produced through a Michael addition protocol, using phenylmethanethiol, 5-fluoro-2-mercaptobenzyl alcohol, and 4-mercaptophenylacetic acid, respectively, as nucleophiles and perezone as the substrate, expecting them to be convenient candidates that inhibit PARP-1. It is convenient to note that in the first stage of the whole study, the molecular dynamics (MD) simulations and the quantum chemistry studies of four secondary metabolites, i.e., perezone (1), perezone angelate (2 …

Profile: Celebrating Sustainability, Communications And Marketing

Profile (1996-)

In this issue: Zavada is First Morton Gneiss Professor; Cougar Days of Giving Event is Resounding Success; Planned Giving is Way for Alum to Give Significant Support; New at UMN Morris: Degree in Three; Cofer Named Vice Chancellor for Academic Affairs and Dean; Pandemic Challenges Led to Improved Chemistry Lab; Kapemni Program Created with NSF Grant; UMN Morris Archives Receives National Endowment for the Humanities Grant; Morris Model Wins Competition to Energize Rural Communities; UMN Morris Included in Food Justice Initiative Funding; DuHamel Receives McKnight Musician Fellowship Grant; Peters Receives JEDI Award; Brugger Named Fellow of the Geological Society of …

Unusual Eluents, Small Systems, And Digital Signal Processing For Highly Efficient Greener Separations, Troy T. Handlovic

Chemistry & Biochemistry Dissertations - Archive

Separation science is a rapidly evolving field, where routine analyses are now done at speeds and efficiencies not thought to be possible several years ago. The tangential field of green analytical chemistry is evolving at an even faster rate and can be considered to be in its infancy stage. As green analytical chemistry is better understood, the greenness of a method will be considered during standard method development just as resolution, sensitivity, and efficiency are considered now. The first portion of this dissertation focuses on the development of mathematical and pragmatic methods to minimize the analytical method greenness score, and …

Chem 361-002: Environmental Chemistry Ii, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Combined In Silico And Experimental Approaches Of Pharmacognosy To Resolve Complex Natural Product Issues, William Michael Neal

Electronic Theses and Dissertations

Since the identification of useful bioactive natural products can often involve tedious dereplication measures to decipher complex mixtures, much emphasis is placed on methods that can effectively characterize natural products. Several in silico methods, such as quantitative structure-activity relationships (QSARs), molecular docking, and quantum calculations, provide researchers with valuable tools to overcome the challenge of complex natural product mixtures. To exemplify the abilities of computational methodologies to further the field of pharmacognosy, this dissertation elaborates on several research projects involving computational approaches in pharmacognosy, including: (1) global assessment of pregnane X receptor (PXR) agonism via multiple QSAR models, (2) differentiation …

A Phytochemical Analysis Of Secondary Metabolites In Eupatorium Serotinum, Elise Snow

Theses and Dissertations

Phytochemistry, a subset of Natural Products Chemistry, studies chemically derived products from natural substances. Advances in this field have important applications in medicinal research due to the distinctive and unique properties of natural compounds. All metabolites are produced from the metabolic cycle, which is a pathway that provides energy for the organism. These metabolic compounds vary greatly and are classified based on their function within the organism. Primary metabolites are abundant and contribute to organism growth, development, and maintenance of energy. Secondary metabolites are found in lesser quantity and correlate to natural defense mechanisms. For example, salicylic acid is a …

Efficacy Of Gonacon Fertility Control Against Prairie Dogs And Potential For Uses On Other Rodent Species, Aaron B. Shiels, Emily W. Ruell, Jason E. Bruemmer

United States Department of Agriculture Wildlife Services: Staff Publications

Use of a contraceptive (i.e., fertility control) is attractive for rodent management where lethal control is unwanted. Although population reduction is generally unachievable with small-scale, short-term contraceptive use, reduced juvenile recruitment is achievable. The injectable immunocontraceptive vaccine GonaCon (active ingredient: gonadotropin releasing hormone [GnRH]) was registered in 2022 by the United States Environmental Protection Agency (EPA) for controlling fertility of female prairie dogs (Cynomys, a type of ground squirrel) in urban/suburban settings. Here we: 1) describe past research, including a replicated field study in Colorado (GonaCon treatment vs. control sites) testing efficacy of GonaCon in prairie dogs, which …

Adsorption Behavior And Mechanism Of Brilliant Green Dye Onto Acid-Modified Mesoporous Volcanic Pumice, Suchada Sawasdee, Prachart Watcharabundit

Applied Environmental Research

Water pollution is a major problem in the environment. The important one is the dying effluent from the textile industry. Dye effluent has affected human health and aquatic life. Recently, natural adsorbents have been most commonly used for dye treatment wastewater. This study explores the adsorption mechanism of brilliant green onto HCl-modified pumice. It involves a comparative analysis of the raw and HCl-modified pumice's characterization and adsorption properties. The adsorption experiments were carried out by considering several parameters, such as pH, contact time, initial dye concentrations, and temperatures. The research indicated that the raw and acid-treated pumice possess Si-OH and …

Analysis Of Students' Perceptions On The Freedom Of Learning - Independent Campus (Mbkm) Program At Chemistry Study Program Of Ma Chung University, Yuyun Yuniati, Lilis Lestari Wilujeng

Jurnal Penelitian dan Evaluasi Pendidikan

Considering that Indonesian education has gone through such a long journey from 1922 to 2022 now, it is necessary to have an educational program that is able to meet the demands of workers' needs in this era of globalization. In the end, the Directorate General of Higher Education, Research, and Technology designed an education policy system in the realm of higher education, namely "Freedom of Learning - Independent Campus", as an accurate strategy for optimizing academics in today's Indonesia. In this study, a survey was aimed at 40 undergraduate students of the Chemistry Study Program at Ma Chung University. Data …

Comparison Of Metal-Carbenoid Reactions Of Β-2-Five-Membered Heteroaryl Substituted Α,Β-Unsaturated Ketones, Kumsal Eroğlu, Olcay Anaç, Füsun Şeyma Kişkan

Turkish Journal of Chemistry

In this study, β-2-heteroaryl substituted (N-methyl 2-pyrrolyl, 2-thiophenyl, 2-furyl) α,β-unsaturated ketones were reacted with two α-diazo carbonyl compounds that had different characteristics (dimethyl diazo malonate and 1-diazo-1-phenyl-propane-2-one) in the presence of both copper and rhodium catalysts. In the case of reactions with N-methyl 2-pyrrolyl α,β-unsaturated ketones, the major product was the insertion derivative. However, in the reactions of 2-thiophenyl and 2-furyl α,β-unsaturated ketones with dimethyl diazomalonate (acceptor-acceptor disubstituted), only dihydrofuran products were formed over carbonyl ylides. When 2-thiophenyl and 2-furyl α,β-unsaturated ketones were reacted with 1-diazo-1-phenyl-propane-2-one (donor-acceptor disubstituted), 1-phenylpropane-1,2-dione was obtained under our reaction conditions.

2023 Fall - Commencement Program, Office Of The Registrar, East Tennessee State University

ETSU Commencement Ceremonies and Programs

No abstract provided.

“Increasing Renewable Energy Potential Of Landfill Gas By Electrocatalytic Conversion Of Carbon Dioxide To Methane At Low Temperature.”, Asma Akter Rony

Civil Engineering Dissertations - Archive

The conversion of carbon dioxide into methane at a low temperature has great potential to reduce current international environmental issues like global warming and will create new sources of renewable energy. The overall goal of this research is to increase renewable energy production from landfill gas using an unconventional process – electrocatalytic methanation of carbon dioxide – which has not been implemented for landfill gas yet. The electrocatalytic methanation follows the Waseda process, which applies an electric field in the presence of a Ruthenium-supported cerium oxide (CeO2) catalyst. The specific objectives of this research were: 1. To explore the impact …

Computational Quantum Chemistry Studies Of The Stabilities Of Radical Adducts Formed During The Oxidation Of Melatonin Derivatives, James Horne

Electronic Theses and Dissertations

Melatonin is a natural antioxidant that has been investigated for properties as a potential spin trap to identify short-lived free radicals. Computational quantum chemistry studies have been performed for the oxidation of melatonin to N¹-acetyl-N²-formyl-5-methoxykynuramine. This research focused on modification of melatonin into derivatives and analyzing the change in total molecular energy from melatonin to its oxidation product, as well as the corresponding derivatives. Each of the molecular geometries were optimized at the DFT/B3LYP/6-31G(d), DFT/B3LYP/cc-pVXZ (X = D, T), HF/6-31G(d), HF/cc-PVXZ (X = D, T), MP2/6-31G(d), and MP2/cc-PVXZ (X = D, T) levels of theory. …

Cognitive Engagement During Group Learning Activities In Chemistry Courses: An Analysis Of Student Discourse, Safaa Youssef El-Mansy

Dissertations and Theses

As educators, our goal is to help our students be successful, but in order to accomplish this, we need to understand what factors contribute to student success. One factor, small-group active learning, has been correlated to improved academic outcomes; however, the magnitude of this improvement can vary across different courses, different types of group work, and even across courses that use the same group work structure. Therefore, it is important to understand what aspects of group work contribute to its effectiveness. The work presented in this dissertation investigated one specific aspect: students’ cognitive engagement. This was done by analyzing the …

Discovery, Structure-Activity Relationship And In Vitro Anticancer Activity Of Small-Molecule Inhibitors Of The Protein-Protein Interactions Between Af9/Enl And Af4 Or Dot1l, Xin Li, Xiaowei Wu, Shenyou Nie, Jidong Zhao, Yuan Yao, Fangrui Wu, Chandra Bhushan Mishra, Md Ashraf-Uz-Zaman, Bala Krishna Moku, Yongcheng Song

Faculty, Staff and Students Publications

Simple Summary

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene generate potent fusion oncogenes and cause acute myeloid leukemia or lymphocytic leukemia, which account for ~75% infant and 5–10% child/adult acute leukemia cases with a poor prognosis (5-year survival rates < 45%). Protein–protein interactions between the most frequent MLL fusion partner proteins AF9/ENL and AF4 or histone methyltransferase DOT1L are critical to malignant gene expression and are therefore a potential drug target for cancer. Compound screening followed by medicinal chemistry studies identified several novel small-molecule inhibitors showing strong inhibition of these protein–protein interactions, significant suppression of characteristic gene expression, and robust cellular anticancer activities with negligible cytotoxicity. These compounds are useful chemical probes for biological studies of these protein–protein interactions, as well as pharmacological leads for further drug development against MLL-rearranged and other leukemias.

Abstract

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause 5–10% acute leukemias with poor clinical outcomes. Protein–protein interactions (PPI) between the most frequent MLL fusion partner proteins AF9/ENL and AF4 or histone methyltransferase DOT1L are drug targets for MLL-rearranged (MLL-r) leukemia. Several benzothiophene-carboxamide compounds were identified as novel inhibitors of these PPIs with IC₅₀ values as …

A Computational Study On The Impact Of Anchoring Groups On The Optical And Electronic Properties Of Triphenylamine-Based Dyes For Dye-Sensitized Solar Cell Applications, Geradius Deogratias, Grace Kinunda

Tanzania Journal of Science

Anchoring groups are crucial for enhancing the performance of dye-sensitized solar cells (DSSCs). For instance, cyanoacrylic acid serves as the primary anchoring group in DSSC due to its crucial elements required for effective electron transport. However, it suffers from degradation. To address this limitation, this study proposes alternative cyano-based anchoring groups for sensitizers. Density functional theory (DFT) and time-dependent DFT were used to investigate the optical and electronic properties of the dyes. The studied dyes (excluding the dye containing OH group) displayed three absorption bands within the visible and NIR regions. Low-energy peaks ranged from 498 to 576 nm, corresponding …

Discovery Of Small-Molecule Inhibitors For The Β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction., Zilu Li

USF Tampa Graduate Theses and Dissertations

The Wnt/β-catenin signaling pathway is associated with activating genes that support cell proliferation, differentiation, and survival. Excessive activation of Wnt/β‐catenin signaling has been associated with development of several types of cancer and activation of stem-like cancer cells. Direct targeting of β‐catenin, the central hub in this signaling pathway, is a promising strategy to suppress the hyperactive β‐catenin signaling but has proven to be highlychallenging. Substantial efforts have been made to discover compounds that bind with β‐catenin, block β‐catenin mediated protein–protein interactions (PPIs) and suppress β‐catenin signaling. β‐catenin/BCL9 PPI has a smaller contacting area (1450 Å2) and a moderate binding affinity …

Standards Based Grading Learning Objective For The Chemistry, Life, The Universe, And Everything General Chemistry Curriculum, Dawn Del Carlo, Laura Strauss

Open Educational Resources

This document details the Learning Objectives (LOs) and accompanying rubrics used in CHEM 1110 and CHEM 1120 at the University of Northern Iowa (UNI) and are aligned with the Chemistry, Life, the Universe, and Everything (CLUE) Curriculum (Cooper & Klymkowsky, 2019). These rubrics were first developed and implemented in the Fall 2021, underwent substantial modification and then implemented again in Fall 2022. Minor modifications were made again and this document represents the rubrics to be implemented in the Fall 2023. As with all curriculum, these will also likely undergo minor changes.

Covid-19: Implications For Audiology Practice, Madison Jane Bacca

Doctoral Scholarly Projects & Capstones

Coronavirus Disease 2019, or COVID-19, emerged in Wuhan, China in December 2019 and quickly became an international public health emergency. COVID-19 was declared a worldwide pandemic in March 2020 and has spread throughout the globe (Balkhair, 2020). COVID-19 manifests in the body in a myriad of ways, ranging from no symptoms at all to critical illness or death. COVID-19 infection can have long-lasting, widespread effects on the human body, including the auditory and vestibular systems. Despite preventative efforts, COVID-19 patients have presented to audiologists with complaints of hearing loss, tinnitus, and vertigo. Audiologists need to be aware of the reported …

Chem 360-001: Environmental Chemistry, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Effective Standards-Based Grading Protocol In High School Chemistry, Matthew Jon Balcom

Student Theses and Dissertations

The American school system is funded, operated, and evaluated based on student academic achievement data that is generated by various assessment tools and grading practices. The most traditional grading practice, norm-referenced grading, assesses student academic achievement on a 100-point scale that is further broken into categorical levels (A-F) of proficiency. With the implementation of such a grading protocol, student performance is compared to their peers rather than to a student’s individualized academic growth. The purpose of this research case study was to evaluate the effectiveness of a norm-referenced grading protocol compared to a standards-based protocol. The specific variables compared between …

A Computational Kinetics Model To Quantify Radiation Induced Chemical Products Of Atmospheric Gas Mixtures, Patrick Ables

Dissertations

This research is focused on the development of a computational model which will calculate the effects of radiation on the chemical composition of the atmosphere. The approach utilizes the open-source chemical kinetics toolkit Cantera to model the creation of radiation-induced reactant species within irradiated air mixtures. Chemical solutions are iteratively stepped toward chemical equilibrium within a ‘constantly stirred’ (homogeneous) reactor of fixed volume. Three different radiation chemistry models are implemented in several different pulsed and continuous radiation schemes. The first model includes the mechanisms and rates of a pulse radiation model from the literature to test the validity of the …

Protein A And Multimodal Anion-Exchange Membrane Adsorbers For Downstream Purification Of Therapeutic Biomolecules, Joshua Osuofa

All Dissertations

This dissertation explores development and characterization of membrane chromatography tools for downstream purification of therapeutic biomolecules. Convective technologies, particularly membrane chromatography, are emerging in the field of bioseparations as an alternative to resin chromatography due to their improved throughput capability. On the forefront of emerging membrane technologies are multimodal and Protein A membrane adsorbers. The overarching theme of this dissertation research was to investigate advances in these membrane chromatography tools. The primary objective was to develop and characterize novel Protein A membrane adsorbers. A secondary objective was to characterize newly commercialized Protein A and multimodal anion exchange membrane adsorbers.

Two …