Digital Commons Network^™

Bortezomib With Standard Chemotherapy For Children With Acute Myeloid Leukemia Does Not Improve Treatment Outcomes: A Report From The Children's Oncology Group., Richard Aplenc, Soheil Meshinchi, Lillian Sung, Todd Alonzo, John Choi, Brian Fisher, Robert Gerbing, Betsy Hirsch, Terzah Horton, Samir Kahwash, John Levine, Michael Loken, Lisa Brodersen, Jessica Pollard, Susana Raimondi, Edward Anders Kolb, A S. Gamis

Manuscripts, Articles, Book Chapters and Other Papers

New therapeutic strategies are needed for pediatric acute myeloid leukemia (AML) to reduce disease recurrence and treatment-related morbidity. The Children's Oncology Group Phase III AAML1031 trial tested whether the addition of bortezomib to standard chemotherapy improves survival in pediatric patients with newly diagnosed AML. AAML1031 randomized patients younger than 30 years of age with de novo AML to standard treatment with or without bortezomib. All patients received the identical chemotherapy backbone with either four intensive chemotherapy courses or three courses followed by allogeneic hematopoietic stem cell transplantation for high-risk patients. For those randomized to the intervention arm, bortezomib 1.3 mg/m2 …

1. Dft-Guided Discovery Of Hybrid Catalysts For C-C Bond Formation; 2. Synthesis Of A Reported Pdi Inhibitor, Eric Greve

Dissertations (1934 -)

1. Dual amine/pi Lewis acid catalyst systems have been reported for intramolecular direct additions of aldehydes/ketones to unactivated alkynes and occasionally alkenes, but related intermolecular reactions are rare. We reasoned that bulky metal ligands and bulky amine catalysts could minimize catalyst poisoning and could facilitate certain examples of direct intermolecular additions of unactivated aldehydes/ketones to alkenes/alkynes. Density Functional Theory (DFT) ground state calculations on putative catalytic intermediates for alkyne versus organocatalyst complexation to the -acid, and also the key carbon-carbon bond formation were used to prioritize ligand/organocatalyst combinations. Our calculations suggested that PyBOX-Pt(II) catalysts for alkene/alkyne activation could be combined …

Resources For Teaching And Assessing The Vision And Change Biology Core Concepts, Janet L. Branchaw, Pamela A. Pape-Lindstrom, Kimberly D. Tanner, Sarah A. Bissonnette, Tawnya L. Cary, Brian A. Couch, Alison J. Crowe, Jenny K. Knight, Katharine Semsar, Julia I. Smith, Michelle K. Smith, Mindi M. Summers, Caroline J. Wienhold, Christian D. Wright, Sara E. Brownell

School of Biological Sciences: Faculty Publications

The Vision and Change report called for the biology community to mobilize around teaching the core concepts of biology. This essay describes a collection of resources developed by several different groups that can be used to respond to the report’s call to transform undergraduate education at both the individual course and departmental levels. First, we present two frameworks that help articulate the Vision and Change core concepts, the BioCore Guide and the Conceptual Elements (CE) Framework, which can be used in mapping the core concepts onto existing curricula and designing new curricula that teach the biology core concepts. Second, we …

Perspectives On The Intracellular Bacterium Chlamydia Pneumoniae In Late-Onset Dementia, Brian J. Balin Phd

PCOM Scholarly Works

Purpose of Review

Chronic diseases remain a daunting challenge for clinicians and researchers alike. While difficult to completely understand, most chronic diseases, including late-onset dementias, are thought to arise as an interplay between host genetic factors and environmental insults. One of the most diverse and ubiquitous environmental insults centers on infectious agents. Associations of infectious agents with late-onset dementia have taken on heightened importance, including our investigations of infection by the intracellular respiratory bacterium, Chlamydia pneumoniae (Cpn), in late-onset dementia of the Alzheimer’s type.

Recent Findings

Over the last two decades, the relationship of this infection to pathogenesis …

Undergraduate Biology Education Research Gordon Research Conference: A Meeting Report, Erin L. Dolan, Michelle Borrero, Kristine Callis-Duehl, Miranda M. Chen Musgrove, Joelyn De Lima, Isi Ero-Tolliver, Laci M. Gerhart, Emma Goodwin, Lindsey R. Hamilton, Meredith A. Henry, Jose Herrera, Bethany Huot, Stacey Kiser, Melissa E. Ko, Marcy E. Kravec, Mark Lee, Lisa B. Limeri, Melanie E. Peffer, Debra Pires, Juan S. Ramirez Lugo, Starlette M. Sharp, Nicole A. Suarez

Biology Faculty Publications and Presentations

The 2019 Undergraduate Biology Education Research Gordon Research Conference (UBER GRC), titled “Achieving Widespread Improvement in Undergraduate Education,” brought together a diverse group of researchers and practitioners working to identify, promote, and understand widespread adoption of evidence-based teaching, learning, and success strategies in undergraduate biology. Graduate students and postdocs had the additional opportunity to present and discuss research during a Gordon Research Seminar (GRS) that preceded the GRC. This report provides a broad overview of the UBER GRC and GRS and highlights major themes that cut across invited talks, poster presentations, and informal discussions. Such themes include the importance of …

Phenotypic Plasticity Of Japanese Medaka Gill In Response To Changing Salinities, Laura V. Ellis

Graduate Theses and Dissertations

Japanese medaka (Oryzais latipes) are euryhaline fish, meaning they are capable of surviving in a variety of salinities from fresh water to seawater. The ability to maintain an internal osmotic concentration stems from the phenotypic plasticity of the osmoregulatory organs, the gill, kidney, intestine, and integument. The gill is the main site of osmotic and ionic regulation in fish due to the three-dimensional structure, the direct contact with the outside environment, and the composition of the gill cells. Fish gills are multifunctional as they regulate water movement, acid/base exchange, nitrogenous waste excretion, and ion fluctuations. In freshwater environments, fish are …

Gambaran Faktor Risiko Kontaminan Biologi Pada Uji Lingkungan Di Rsu “Y” Surabaya, Mochamad Rizal Maulana, Khuliyah Candraning Diyanah, Fransisca Susilastuti

Media Kesehatan Masyarakat Indonesia

Hospitals as a place of health care and workplace have a variety of potential hazards that can harm health. One of the efforts of the hospital environment can be done by conducting supervision and inspection. The purpose of this research, to describe the risk factors of biological contaminants in the environmental test results conducted in Surabaya General Hospital "Y". This research was descriptive research with a cross-sectional approach. This research uses secondary data of the laboratory test results of BBTKLPP Surabaya in 2015-August 2017, as well as literature from several sources to support the data available. Data were analyzed in …

Prevalence Of Genes Involved In Colistin Resistance In Acinetobacter Baumannii: First Report From Iraq, Israa M.S. Al-Kadmy, Susan A. Ibrahim, Nadal Al-Saryi, Sarah Naji Aziz, Alexandros Besinis, Helal F. Hetta

School of Engineering, Computing and Mathematics

No abstract provided.

Synthesis, Characterisation And Biological Evaluation Of Tyramine Derived Schiff Base Ligand And Its Transition Metal(Ii) Complexes, Abdul Khader Jailani, N.S.K. Gowthaman, Mookkandi Palsamy Kesavan

Karbala International Journal of Modern Science

In this study, a new tyramine derived Schiff base ligand (L) (L=1,3-phenylene-bis-4-aminoantipyrinyl-4-aminoethylphenol) and its derived transition metal(II) complexes [Cu(L)Cl₂](1), [Ni(L)Cl₂](2), [Co(L)Cl₂] (3) and [Zn(L)Cl₂] (4) have been synthesized and well characterized by the way of different spectroscopic and analytical techniques. Analytical and spectroscopic studies result suggests that metal(II) complexes more probably have octahedral geometry. DNA binding tendency of L and metal(II) complexes 1-4 have been assessed by probing their ability to bind with Calf Thymus DNA (CT-DNA) via electronic absorption and cyclic voltammetry titration methods. The results clearly reveal that the metal(II) …

Learning Transferable Deep Convolutional Neural Networks For The Classification Of Bacterial Virulence Factors, Dandan Zheng, Guansong Pang, Bo Liu, Lihong Chen, Jian Yang

Research Collection School Of Computing and Information Systems

Motivation: Identification of virulence factors (VFs) is critical to the elucidation of bacterial pathogenesis and prevention of related infectious diseases. Current computational methods for VF prediction focus on binary classification or involve only several class(es) of VFs with sufficient samples. However, thousands of VF classes are present in real-world scenarios, and many of them only have a very limited number of samples available.Results: We first construct a large VF dataset, covering 3446 VF classes with 160 495 sequences, and then propose deep convolutional neural network models for VF classification. We show that (i) for common VF classes with sufficient samples, …

The Weibull Topp-Leone Generated Family Of Distributions: Statistical Properties And Applications, Hamid Karamikabir, Mahmoud Afshari, Haitham M. Yousof, Morad Alizadeh, Gholamhossein G. Hamedani

Mathematical and Statistical Science Faculty Research and Publications

Statistical distributions are very useful in describing and predicting real world phenomena. Consequently, the choice of the most suitable statistical distribution for modeling given data is very important. In this paper, we propose a new class of lifetime distributions called the Weibull Topp-Leone Generated (WTLG) family. The proposed family is constructed via compounding the Weibull and the Topp-Leone distributions. It can provide better fits and is very flexible in comparison with the various known lifetime distributions. Several general statistical properties of the WTLG family are studied in details including density and hazard shapes, limit behavior, mixture representation, skewness and kurtosis, …

Genetic Counseling And Preventive Medicine In Bosnia And Herzegovina, Philip C. Aka

California Western International Law Journal

No abstract provided.

In-Service Biology Teachers’ Perceptions And Pedagogical Rating Of Two Mobile Learning Applications Recommended For Learning Biology In Nigerian Secondary Schools, Uchenna Udeani Prof, Jeremiah Nosakhare Akhigbe Mr

The African Journal of Information Systems

The study investigated in-service biology teachers’ perceptions of the instructional use of smartphones equipped with Biology Mobile Learning Applications (BMLAs) in the learning of biology concepts in Nigerian senior secondary schools and the pedagogical rating of two commercially available mobile learning applications recommended for learning biology. The study utilized a descriptive survey design. Data collected were analyzed using descriptive and inferential statistics. Findings gathered revealed that the in-service biology teachers had good perceptions of the instructional use of BMLAs and that these perceptions influence their pedagogical rating and selection of mobile applications. The study also revealed that demographic variables such …

Icdp Workshop On The Lake Tanganyika Scientific Drilling Project: A Late Miocene–Present Record Of Climate, Rifting, And Ecosystem Evolution From The World's Oldest Tropical Lake, James M. Russell, Philip Barker, Andrew Cohen, Sarah Ivory, Ishmael Kimirei, Christine Lane, Melanie Leng, Neema Maganza, Michael M. Mcglue, Emma Msaky, Anders Noren, Lisa Park Boush, Walter Salzburger, Christopher Scholz, Ralph Tiedemann, Shaidu Nuru, Lake Tanganyika Scientific Drilling Project Consortium

Earth and Environmental Sciences Faculty Publications

The Neogene and Quaternary are characterized by enormous changes in global climate and environments, including global cooling and the establishment of northern high-latitude glaciers. These changes reshaped global ecosystems, including the emergence of tropical dry forests and savannahs that are found in Africa today, which in turn may have influenced the evolution of humans and their ancestors. However, despite decades of research we lack long, continuous, well-resolved records of tropical climate, ecosystem changes, and surface processes necessary to understand their interactions and influences on evolutionary processes. Lake Tanganyika, Africa, contains the most continuous, long continental climate record from the mid-Miocene …

Icdp Workshop On The Lake Tanganyika Scientific Drilling Project: A Late Miocene-Present Record Of Climate, Rifting, And Ecosystem Evolution From The World's Oldest Tropical Lake, James M. Russell, Philip Barker, Andrew Cohen, Sarah Ivory, Ishmael Kimirei, Christine Lane, Melanie Leng, Neema Maganza, Michael Mcglue, Emma Msaky, Anders Noren, Lisa Park Boush, Walter Salzburger, Christopher Scholz, Ralph Tiedemann, Shaidu Nuru, Christian Albrecht, Rahma Ali, Ramon Arrowsmith, Danstan Asanga, Yemane Asmerom, Charles Bakundukize, Thorsten Bauersachs, Catherine Beck, Melissa Berke, Emily Beverley, Martin Blaauw, Lisa Boush, Erik Brown, Chris Campisano, Barbara Carrapa, Isla Castaûeda, Andy Cohen, Sylvia Dee, Alan Deino, Cindy Ebinger

Graduate School of Oceanography Faculty Publications

The Neogene and Quaternary are characterized by enormous changes in global climate and environments, including global cooling and the establishment of northern high-latitude glaciers. These changes reshaped global ecosystems, including the emergence of tropical dry forests and savannahs that are found in Africa today, which in turn may have influenced the evolution of humans and their ancestors. However, despite decades of research we lack long, continuous, well-resolved records of tropical climate, ecosystem changes, and surface processes necessary to understand their interactions and influences on evolutionary processes. Lake Tanganyika, Africa, contains the most continuous, long continental climate record from the mid-Miocene …

Adaptative Strategy Of Powerful Country Of Science And Technology For Modernization Of China's Space Governance, Fan Jie

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important field in the construction of ecological civilization, spatial governance is a relatively weak field in China's governance system. In the past 40 years of rapid economic development, unbalanced regional development, disharmony between nature and society, and disordered spatial structure have become prominent problems. In the support of space governance, science and technology have problems such as the division of natural sciences and social sciences, the imperfect data co-construction and sharing mechanism, and the disconnection of scientific research and decision-making management, which seriously hinders the need for the modernization of governance systems. The formation of an adapting strategy …

Synthesis, Characterization, And Investigation Of Metal Ion Quenching In Fluorescent Carbon Dot Surrogates For Particulate Matter Black Carbon And Evaluation Of Cellular Health Effects Due To The Surrogate Materials, Christopher Lee Sumner Jr

LSU Doctoral Dissertations

Black carbon (BC) is an environmental pollutant of particular concern to many international organizations for both its health effects and environmental effects. Probing health effects of BC as produced in the environment is difficult due to the complex nature of environmental pollutants found in their naturally occurring state. Fluorescent carbon dots (FCDs) were chosen to be used as a surrogate for BC. In the process of examining FCDs and their behavior as surrogates, information was gained on the health effects and behavior of FCDs as a class of nanomaterials for cell and tissue studies, which is outlined in this dissertation. …

Establishment Of High-Efficiency Agrobacterium-Mediated Transformation Of Callus Derived From Sehima Nervosum, An Important Range Grass Species, Krishna Kumar Dwivedi, Tanu Sonkar, R. Katiyar, Auji Radhakrishna, P. Kaushal

IGC Proceedings (1977-2023)

Sehima nervosum is one of the important rangeland grass in India, It is commonly known as Saen grass in India, white grass in Australia, and has also been reported from the Central East Africa and Sudan. It is a good forage grass and maybe utilized for grazing as well as for hay preparation. It is a perennial grass, prefers hot and dry climate and survive even in limited rainfalls. As this natural grass is found inherently rich in precursors for several industrially important biomolecules, fractionation of these precursors seems to be a promising endeavour. Production of nutraceuticals (prebiotic xylo-oligosaccharides) from …

Influence Of The Spatial Distribution Of Cationic Functional Groups At Nanoparticle Surfaces On Bacterial Viability And Membrane Interactions, Yongqian Zhang, Natalie V. Hudson-Smith, Seth D. Frand, Meghan S. Cahill, Larissa S. Davis, Vivian Feng, Christy L. Haynes, Robert J. Hamers

Faculty Authored Articles

While positively charged nanomaterials induce cytotoxicity in many organisms, much less is known about how the spatial distribution and presentation of molecular surface charge impact nanoparticle–biological interactions. We systematically functionalized diamond nanoparticle surfaces with five different cationic surface molecules having different molecular structures and conformations, including four small ligands and one polymer, and we then probed the molecular-level interaction between these nanoparticles and bacterial cells. Shewanella oneidensis MR-1 was used as a model bacterial cell system to investigate how the molecular length and conformation of cationic surface charges influence their interactions with the Gram-negative bacterial membranes. Nuclear magnetic resonance (NMR) …

Proteolysis-Targeting Chimera (Protac) For Targeted Protein Degradation And Cancer Therapy, Xin Li, Yongcheng Song

Faculty, Staff and Students Publications

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein of interest (POI) and a covalently linked ligand of an E3 ubiquitin ligase (E3). Upon binding to the POI, the PROTAC can recruit E3 for POI ubiquitination, which is subjected to proteasome-mediated degradation. PROTAC complements nucleic acid-based gene knockdown/out technologies for targeted protein reduction and could mimic pharmacological protein inhibition. To date, PROTACs targeting ~ 50 proteins, many of which are clinically validated drug targets, have been successfully developed with several …

Surplus Antioxidants Are Pathogenic For Hearts And Skeletal Muscle, Public Relations

Browse All News

No abstract provided.

Biomaterials For Bone Regeneration: Tunable Structural And Mechanical Characteristics, Anwer Mhanawee

Theses and Dissertations

Tissue engineering is a promising alternative treatment for damaged tissues. In bone regeneration, bone graft replacements can be made from different biomaterials (basically ceramic and polymer) and used for different treatment purposes. In the first section of this dissertation, the Compression test results showed that its modulus of elasticity depends on its porosity. Also, we developed a testing method to measure the swelling force of the material during expansion due to liquid absorption. The maximum swelling force was found to be proportional to the material modulus. In the second part, we successfully design, fabricate and characterize a novel expandable bone …

Getting The Gold, Jody Record

UNH Today Archive

No abstract provided.

Defining Insanity: How An Individual's View Can Impact A Trial, Jayme L. Ayres

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

The insanity plea has always been a controversial topic among anyone. No one sees eye to eye on the matter. This can present a problem within professional fields. When insanity cases are brought into courtrooms, legal and psychology professionals need to be able to agree to some extent. However, these professionals have no true control on how jurors define insanity. Jurors tend to determine guilty or not guilty in insanity cases, based on their own personal views. The current study is a replication of Doctor John Geiger’s 2003 and 2008 study of how legal professionals and undergraduate psychology students view …

Chemical Tools For Residue-Specific And Secondary Amine Selective Petasis (Sasp) Bioconjugation Of Peptides And Proteins, Yonnette Sim

Seton Hall University Dissertations and Theses (ETDs)

Chemical protein synthesis is an invaluable tool that enables the construction of novel protein design, incorporation of non-native functionalities, elucidation of structure-function relationships and enable a wide diversity of modifications (such as Post Translation Modification) to study protein functions. Native Chemical Ligation (NCL) in conjunction with Fmoc Solid Phase Peptide Synthesis (SPPS) is the most used method for synthesis of functional peptides and proteins. The synthesis relies on the reaction of a C-terminal peptide thioester and a N-terminal cysteine peptide. Fmoc SPPS of peptide thioester for chemical protein synthesis via NCL is a challenge. Methods that exist for the synthesis …

Latin American Biblical Hermeneutics & Popular And Community Reading Of The Bible: Some Inputs From Race And Ethnicity Criticism Within The Hellenistic And Jewish Culture Of The First Century, Diego Salazar Galvis

Jesuit School of Theology Dissertations

After the Second Vatican Council, scholars have used new lenses to approach the Bible as a way to respond to the cultural and socio-political realities of multiple and diverse contexts. Based on my background and Latino essence, I advocate for biblical reading and interpretation that comes from a Latin American setting, in which popular education and liberation theology come together in most of the communities. In this research, I will present a form of mutual collaboration between race-ethnicity biblical criticism and the Popular & Community Reading of the Bible (PCRB) perspective.

So far, biblical scholarship has not yet integrated elements …

Bionoinet: Ligand-Binding Site Classification With Off-The-Shelf Deep Neural Network, Wentao Shi, Jeffrey M. Lemoine, Abd El Monsif A. Shawky, Manali Singha, Limeng Pu, Shuangyan Yang, J. Ramanujam, Michal Brylinski

Faculty Publications

© The 2020 Author(s). Published by Oxford University Press. All rights reserved. Motivation: Fast and accurate classification of ligand-binding sites in proteins with respect to the class of binding molecules is invaluable not only to the automatic functional annotation of large datasets of protein structures but also to projects in protein evolution, protein engineering and drug development. Deep learning techniques, which have already been successfully applied to address challenging problems across various fields, are inherently suitable to classify ligand-binding pockets. Our goal is to demonstrate that off-the-shelf deep learning models can be employed with minimum development effort to recognize nucleotide-and …

A Pomc-Originated Circuit Regulates Stress-Induced Hypophagia, Depression, And Anhedonia, Na Qu, Yanlin He, Chunmei Wang, Pingwen Xu, Yongjie Yang, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Zheng Sun, Makoto Fukuda, Yi Li, Qing Tian, Yong Xu

Division of Basic Science Faculty Publications

Chronic stress causes dysregulations of mood and energy homeostasis, but the neurocircuitry underlying these alterations remain to be fully elucidated. Here we demonstrate that chronic restraint stress in mice results in hyperactivity of pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus (POMCARH neurons) associated with decreased neural activities of dopamine neurons in the ventral tegmental area (DAVTA neurons). We further revealed that POMCARH neurons project to the VTA and provide an inhibitory tone to DAVTA neurons via both direct and indirect neurotransmissions. Finally, we show that photoinhibition of the POMCARH→VTA circuit in mice increases body weight and food intake, …

The Influence Of Molecule Geometry On Epidermal Growth Factor Receptor Oligomer Signal Transduction, Kelvin Peterson

Undergraduate Papers

No abstract provided.

Recombinant Expression Of Preptin Analogs For Alanine Scanning Mutagenesis Of Residues 27-29, Tehgan N. Anguilm

Theses and Dissertations

The novel peptide preptin consists of 34 amino acid residues corresponding to Asp⁶⁹-Leu¹⁰² of proinsulin-like growth factor E-peptide. Preptin has been isolated from pancreatic beta cells, and it has been found to exhibit both metabolic and mitogenic activities. This makes preptin an attractive candidate to treat insulin-independent diabetes and osteoporosis. Alanine scanning mutagenesis was utilized to substitute an alanine for residues Trp²⁷, Arg²⁸, and Gln²⁹ of preptin in order to ultimately study the structure-activity relationship of these residues to preptin’s metabolic activity.