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Articles 9901 - 9930 of 732790
Full-Text Articles in Entire DC Network
The Current - Volume 36 Issue 6, Nova Southeastern University
The Current - Volume 36 Issue 6, Nova Southeastern University
Student Newspapers
No abstract provided.
Montana Kaimin, February 5, 2026, Students Of The University Of Montana, Missoula
Montana Kaimin, February 5, 2026, Students Of The University Of Montana, Missoula
Montana Kaimin, 1898-present
Student newspaper of the University of Montana, Missoula.
The Changing Fortunes Of The Fur Industry, Andrew Rowan Dphil
The Changing Fortunes Of The Fur Industry, Andrew Rowan Dphil
WellBeing News
This article traces the significant shift in the global fur industry, noting a steep decline in animals raised for fur and the dwindling market value for pelts as major fashion houses adopt fur-free policies and consumers increasingly reject animal cruelty; bolstered by regulatory bans in multiple countries and mounting public pressure, these combined forces suggest a long-term downturn that differs fundamentally from past cyclical fluctuations, even as advocates emphasize that meaningful progress still requires ongoing efforts to end suffering on fur farms.
Print, Pattern, Stick: Low–Cost Gecko–Inspired Adhesives Using Embedded Diffraction Structures, Motaz Hassan, Oluwafemi Fayomi, Ajay Mahajan, Joshua Faust
Print, Pattern, Stick: Low–Cost Gecko–Inspired Adhesives Using Embedded Diffraction Structures, Motaz Hassan, Oluwafemi Fayomi, Ajay Mahajan, Joshua Faust
University Research
Gecko-inspired adhesives offer strong, reversible, and directionally tunable adhesion, yet fabrication methods often depend on cleanroom lithography or proprietary molds, limiting scalability and accessibility. This study presents a low-cost, modular fabrication strategy combining high-resolution digital light processing 3D printing with 1000 lines/mm optical diffraction gratings to create hierarchical elastomeric adhesives. The resulting structures feature macroscale micropillars and embedded sub-micron surface topography, enabling effective contact splitting without advanced microfabrication. Mechanical testing reveals a nonlinear increase in shear performance with contact area, with maximum shear forces exceeding 80 N at 103.2 cm2. Peel testing across varied angles and surface areas demonstrates anisotropic …
The Setd2 L1609p Mutation Found In Leukemia Disrupts Methyltransferase Activity And Reduces Histone H3k36 Trimethylation, Christina Michail, Jérémy Berthelet, Ariel E Mechaly, Linh-Chi Bui, Haopeng Yang, Duo Cai, Amira Al Mahi, Aowei Xie, Valeria Bisio, Valentina Sirri, Jean-Marie Dupret, Fabien Guidez, Ximing Xu, Nicolas Joly, Leslie Regad, Mireille Viguier, Frédérique Deshayes, Nicolas Dulphy, Michael R Green, Ahmed Haouz, Fernando Rodrigues Lima
The Setd2 L1609p Mutation Found In Leukemia Disrupts Methyltransferase Activity And Reduces Histone H3k36 Trimethylation, Christina Michail, Jérémy Berthelet, Ariel E Mechaly, Linh-Chi Bui, Haopeng Yang, Duo Cai, Amira Al Mahi, Aowei Xie, Valeria Bisio, Valentina Sirri, Jean-Marie Dupret, Fabien Guidez, Ximing Xu, Nicolas Joly, Leslie Regad, Mireille Viguier, Frédérique Deshayes, Nicolas Dulphy, Michael R Green, Ahmed Haouz, Fernando Rodrigues Lima
Faculty, Staff and Student Publications
SETD2 is the primary methyltransferase responsible for generating H3K36me3, an epigenetic mark that is essential for transcriptional regulation and chromatin integrity. SETD2 mutations are frequently observed in various cancers and tend to cluster within its catalytic SET domain. Despite the clinical relevance of SETD2 missense mutations in cancer, their biochemical and structural consequences remain insufficiently characterized. Here, we present the enzymatic and structural characterization of the SETD2 L1609P mutant enzyme identified in leukemia. The L1609 residue is located in the SET domain within a conserved hydrophobic pocket that is involved in substrate H3K36 recognition. Interestingly, site-directed mutagenesis of residues within …
Endothelial Oncogenic Kras Mutation Drives The Dynamics Of Microglia And Macrophages In Brain Arteriovenous Malformation, Hyejin Park, Jung-Eun Park, Bridger H Freeman, Bosco Seong Kyu Yang, Shun-Ming Ting, Alexander K Suh, Jude Pj Savarraj, Shuning Huang, Jakob Körbelin, Huimahn Alex Choi, Sean P Marrelli, Jaroslaw Aronowski, Peng Roc Chen, Eunhee Kim, Eun S Park
Endothelial Oncogenic Kras Mutation Drives The Dynamics Of Microglia And Macrophages In Brain Arteriovenous Malformation, Hyejin Park, Jung-Eun Park, Bridger H Freeman, Bosco Seong Kyu Yang, Shun-Ming Ting, Alexander K Suh, Jude Pj Savarraj, Shuning Huang, Jakob Körbelin, Huimahn Alex Choi, Sean P Marrelli, Jaroslaw Aronowski, Peng Roc Chen, Eunhee Kim, Eun S Park
Faculty, Staff and Student Publications
Mutation of KRAS in endothelial cells (KRAS-EC) leads to intracerebral hemorrhage (ICH) in brain arteriovenous malformations (bAVM), resulting in severe disabilities or even death. However, it is unclear what causes this hemorrhagic conversion of bAVM. Here, using a locally established, clinically-relevant sporadic bAVM mouse model, created by overexpressing mutant KRAS (KRASG12V) in the brain EC, we demonstrate that KRAS-EC act as trigger for microglia (MG) activation and infiltration of macrophages (Mϕ). Using three-dimensional immunostaining approach with cleared human and mouse bAVM tissues, we demonstrate an abundance of MG/Mϕ around the bAVM nidus. The presence of MG/Mϕ are correlated to the …
Naturalness Of The Translation Of The Quranic Imperative Verses: A Comparative Study, Mohamad Zaka Al Farisi, Tatang Tatang, Mia Nurmala, Shofa Mushtofa Khalid
Naturalness Of The Translation Of The Quranic Imperative Verses: A Comparative Study, Mohamad Zaka Al Farisi, Tatang Tatang, Mia Nurmala, Shofa Mushtofa Khalid
Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya
The aspects of translation acceptability are not related only to the accuracy and clarity of the translation. They also cover the naturalness of translation. This study aims to reveal the degree of translation naturalness of the Quranic imperative verses. This evaluative study compares the translations of the verses by the Ministry of Religious Affairs of the Republic of Indonesia (MORA) and the one made by Muhammad Thalib (MT). The study used embedded case study research. The findings of the study show that in general, the translations of the verses in the two versions have an acceptable degree of naturalness. However, …
Bi-Allelic Variants In Neuronal Adhesion Molecule Astrotactin 1 Gene Astn1 Cause Diverse Neurodevelopmental Disorders, Jesse M Levine, Daniel G Calame, Riccardo Sangermano, Haowei Du, Ahmed Saad, Jasmin Lisfeld, Tatjana Bierhals, Jonas Denecke, Eyyup Uctepe, Merve Yoldas Celik, Ahmet Yesilyurt, Hilal Yildiz Er, Elif Yilmaz Gulec, Aziza Mushiba, Naif Almontashiri, Pawel Gawlinski, Wojciech Wiszniewski, Ender Karaca, Lama Alabdi, Davut Pehlivan, Dana Marafi, Maha S Zaki, Fowzan S Alkuraya, Joseph G Gleeson, Shalini N Jhangiani, Richard A Gibbs, Jennifer E Posey, Kinga M Bujakowska, James R Lupski
Bi-Allelic Variants In Neuronal Adhesion Molecule Astrotactin 1 Gene Astn1 Cause Diverse Neurodevelopmental Disorders, Jesse M Levine, Daniel G Calame, Riccardo Sangermano, Haowei Du, Ahmed Saad, Jasmin Lisfeld, Tatjana Bierhals, Jonas Denecke, Eyyup Uctepe, Merve Yoldas Celik, Ahmet Yesilyurt, Hilal Yildiz Er, Elif Yilmaz Gulec, Aziza Mushiba, Naif Almontashiri, Pawel Gawlinski, Wojciech Wiszniewski, Ender Karaca, Lama Alabdi, Davut Pehlivan, Dana Marafi, Maha S Zaki, Fowzan S Alkuraya, Joseph G Gleeson, Shalini N Jhangiani, Richard A Gibbs, Jennifer E Posey, Kinga M Bujakowska, James R Lupski
Faculty, Staff and Students Publications
ASTN1 encodes astrotactin 1, a neuronal-glial ligand in the developing brain that promotes neuronal migration along radial glia in brain structures with laminar organization, such as the cerebral cortex, hippocampus, and cerebellum. In mouse models, disruption of Astn1 results in neuronal migration deficits, a mild reduction in cerebellar volume, and balance and coordination deficits. In humans, bi-allelic ASTN1 variants have been identified in nine individuals with neurodevelopmental disorders (NDDs) with or without brain malformations. ASTN1 additionally interacts with astrotactin 2 (ASTN2) to implement neuronal migration; ASTN2 deletions associate with NDDs with reduced penetrance. Here, we describe eighteen individuals with NDDs …
The Indian Supreme Court Acts On The Stray Dog Issue: Is It A Crisis Or An Opportunity? Part 2, Andrew Rowan Dphil
The Indian Supreme Court Acts On The Stray Dog Issue: Is It A Crisis Or An Opportunity? Part 2, Andrew Rowan Dphil
WellBeing News
Part 2 of this article builds on the Supreme Court’s recent interventions in India’s stray dog issue by examining long-term data on dog bites and human rabies to assess whether reported crises align with scientific trends; it highlights a dramatic decline in both bite rates and rabies deaths over two decades, considers how effective implementation of Animal Birth Control and vaccination programs has contributed to this progress, and discusses how deeper engagement with evidence can inform more humane, structured approaches to stray dog management moving forward.
Sphingosine-1-Phosphate Regulation To Alleviate Sickle Cell Disease Severity: A Promising Therapeutic Approach, Shahanas Chathoth
Sphingosine-1-Phosphate Regulation To Alleviate Sickle Cell Disease Severity: A Promising Therapeutic Approach, Shahanas Chathoth
Saudi Medical Journal
Sickle cell disease (SCD) is a genetic disorder that affects millions of individuals worldwide. Chronic anemia, hemolysis and vasculopathy are the most common symptoms that arise from hemoglobin (Hb) polymerization, which is the primary event of SCD. The above process can lead to erythrocyte sickling. Therapeutic options for SCD remain limited, and novel therapies are still being evaluated for their effectiveness in particular populations. Sphingosine-1-phosphate (S1P), a significant bioactive sphingolipid, acts as a potent signal mediator, modulating several cellular functions. The potential role of erythrocyte-S1P in enhancing SCD severity has been previously reported by multiple studies. Therefore, the present review …
Ms-Based Workflow For Ptm Profiling Of Aav Capsid Proteins To Support Bioprocess Monitoring And Development, Patricia Alves, Mateus Tomás, Carvalho B. Sofia, Gomes-Alves Patrícia, Gomes A. Ricardo, Alexandre M. Bruno
Ms-Based Workflow For Ptm Profiling Of Aav Capsid Proteins To Support Bioprocess Monitoring And Development, Patricia Alves, Mateus Tomás, Carvalho B. Sofia, Gomes-Alves Patrícia, Gomes A. Ricardo, Alexandre M. Bruno
Advancing Manufacture of Cell and Gene Therapies IX [2026]
Please click Additional Files below to see the full abstract
Tuko Pamoja: Climate Perspectives From East Africa And Fulbright-Hays, Casey R. Schmitt
Tuko Pamoja: Climate Perspectives From East Africa And Fulbright-Hays, Casey R. Schmitt
Sustainability Research & Practice Seminar Presentations
Dr. Casey R. Schmitt, Interdisciplinary Studies, presents "Tuko Pamoja: Climate Perspectives from East Africa and Fulbright-Hays".
Challenges And Opportunities In Lentivirus Viral Vector Manufacturing For In Vivo Applications, Eduardo Barbieri, Caryn Heldt
Challenges And Opportunities In Lentivirus Viral Vector Manufacturing For In Vivo Applications, Eduardo Barbieri, Caryn Heldt
Michigan Tech Publications
The clinical success of chimeric antigen receptor (CAR) T-cell therapies has revolutionized oncology, yet the high costs and logistical complexities of ex vivo manufacturing remain significant barriers to global patient access. In vivo cell therapy, which involves the direct injection of lentiviral vectors (LVVs) to engineer cells within the patient’s body, offers a promising, cost-effective alternative. However, transitioning from ex vivo to in vivo applications necessitates a fundamental shift in LVV biomanufacturing to ensure safety and efficacy. This paper examines the critical bottlenecks in the current LVV production landscape. In upstream processing, we explore LVV particle assembly and maturation mechanisms, …
Mitigating Salmonella In Poultry Using Probiotics: Mechanisms, Challenges, And Opportunities, Oluwaseun D. Adeyemi, Samuel N. Nahashon
Mitigating Salmonella In Poultry Using Probiotics: Mechanisms, Challenges, And Opportunities, Oluwaseun D. Adeyemi, Samuel N. Nahashon
Food and Animal Sciences Faculty Research
The global poultry industry continues to face significant challenges due to Salmonella infections, which pose severe public health concerns and economic losses. Recently, the reemergence of antimicrobial resistance has led to the restriction of antibiotic use in poultry, especially as growth promoters, thus accelerating the search for sustainable alternatives. Among these, probiotics have gained attention as potential candidates for improving poultry health and mitigating Salmonella colonization in the gut. This review summarizes the key mechanisms through which probiotics exert anti-Salmonella effects, including competitive exclusion, production of antimicrobial substances, reinforcement of the intestinal barrier, and modulation of host immune responses. Commonly …
Development Of An Aav-Based Gene Therapy For The Ocular Phenotype Of Friedreich's Ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, Shannon E Boye
Development Of An Aav-Based Gene Therapy For The Ocular Phenotype Of Friedreich's Ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, Shannon E Boye
Faculty Research 2026
Friedreich's ataxia (FA) is a leading form of hereditary ataxia caused by autosomal recessive mutations in frataxin (FXN). GAA triplet repeat expansions lead to lower levels of FXN expression, abnormal influx of iron into mitochondria, and damage to the nervous system. Patients typically present before the second decade with loss of muscular function, speech impediments, and cardiomyopathy. At later stages, vision loss typically manifests. Work is under way to develop gene therapies that address the cardiac and CNS manifestations, but their routes of administration do not lead to efficient transduction of the retina. The purpose of this study was to …
Targeting Pediatric Glioblastomas By Combining Olig2 Inhibitor Ct-179 With Fractionated Radiation In A Panel Of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, Xiao-Nan Li
Targeting Pediatric Glioblastomas By Combining Olig2 Inhibitor Ct-179 With Fractionated Radiation In A Panel Of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, Xiao-Nan Li
Faculty Research 2026
The poor clinical outcomes of pediatric high-grade glioma (pHGG) highlight the urgent need for new therapies. Oligodendrocyte lineage transcription factor 2 (OLIG2) is a pro-mitotic transcription factor highly expressed in glioma stem cells and may represent a novel therapeutic target. To evaluate the therapeutic efficacy of an OLIG2 inhibitor CT-179 in pHGG, we determined the OLIG2 mRNA expression in 10 patient-derived orthotopic xenograft (PDOX) models. In vitro activities of CT-179 were analyzed in monolayer and neurosphere cells (0–10 µM) with and without radiation (XRT) (0–8 Gy), brain penetration was evaluated in tumor-bearing PDOX mice, and in vivo efficacy was determined …
Targeting Pediatric Glioblastomas By Combining Olig2 Inhibitor Ct-179 With Fractionated Radiation In A Panel Of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, Xiao-Nan Li
Targeting Pediatric Glioblastomas By Combining Olig2 Inhibitor Ct-179 With Fractionated Radiation In A Panel Of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, Xiao-Nan Li
Faculty Research 2026
The poor clinical outcomes of pediatric high-grade glioma (pHGG) highlight the urgent need for new therapies. Oligodendrocyte lineage transcription factor 2 (OLIG2) is a pro-mitotic transcription factor highly expressed in glioma stem cells and may represent a novel therapeutic target. To evaluate the therapeutic efficacy of an OLIG2 inhibitor CT-179 in pHGG, we determined the OLIG2 mRNA expression in 10 patient-derived orthotopic xenograft (PDOX) models. In vitro activities of CT-179 were analyzed in monolayer and neurosphere cells (0–10 µM) with and without radiation (XRT) (0–8 Gy), brain penetration was evaluated in tumor-bearing PDOX mice, and in vivo efficacy was determined …
Development Of An Aav-Based Gene Therapy For The Ocular Phenotype Of Friedreich's Ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, Shannon E Boye
Development Of An Aav-Based Gene Therapy For The Ocular Phenotype Of Friedreich's Ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, Shannon E Boye
Faculty Research 2026
Friedreich's ataxia (FA) is a leading form of hereditary ataxia caused by autosomal recessive mutations in frataxin (FXN). GAA triplet repeat expansions lead to lower levels of FXN expression, abnormal influx of iron into mitochondria, and damage to the nervous system. Patients typically present before the second decade with loss of muscular function, speech impediments, and cardiomyopathy. At later stages, vision loss typically manifests. Work is under way to develop gene therapies that address the cardiac and CNS manifestations, but their routes of administration do not lead to efficient transduction of the retina. The purpose of this study was to …
Seeing Beyond The Words: What Interdisciplinary Methodologies Reveal About International Law, Matthew S. Erie, Mark Pollack, Wolfgang Alschner, Beth Simmons, Katerina Linos
Seeing Beyond The Words: What Interdisciplinary Methodologies Reveal About International Law, Matthew S. Erie, Mark Pollack, Wolfgang Alschner, Beth Simmons, Katerina Linos
Scholarly Articles in Law Reviews & Journals
INTRODUCTION: On April 24, 2025, the International Law and Social Science Interest Group debuted at the ASIL Annual Meeting with a panel that posed a deceptively simple question: how can social science tools advance the work of international lawyers? Chaired by Chantal Thomas, the session brought together Matthew Erie, Wolfgang Alschner, Beth Simmons, and Katerina Linos— scholars who bridge doctrinal and empirical inquiry—to show how ethnography, computational text analysis, counterfactual inference, and mixed-method design can illuminate legal puzzles that doctrine alone cannot solve. The four short essays in this symposium provide parallel illustrations of this core theme: Erie’s ethnographic approach …
New Host And Distributional Records For Helminth Parasites (Monogenoidea, Trematoda, Cestoda, Nematoda) Of Arkansas Reptiles (Testudines, Ophidia), C. T. Mcallister, C. R. Bursey, T. J. Fayton, S. E. Trauth, H. W. Robison
New Host And Distributional Records For Helminth Parasites (Monogenoidea, Trematoda, Cestoda, Nematoda) Of Arkansas Reptiles (Testudines, Ophidia), C. T. Mcallister, C. R. Bursey, T. J. Fayton, S. E. Trauth, H. W. Robison
Journal of the Arkansas Academy of Science
Over the last decade or more, our collaborative research has provided noteworthy information on the helminth parasites of reptiles of Arkansas. Because several species still need to be surveyed from the state, some for the first time, there has been a general void of information on their parasites. We therefore examined 10 reptiles, including seven species/subspecies of turtles, as well as three species/subspecies of snakes for helminth parasites. Found were 24 taxa of parasites, including two monogeneans, 14 digeneans, one tapeworm, and seven nematodes. We document several new host and distributional records for these parasites from some reptiles of the …
The Bg News February 04, 2026, Bowling Green State University
The Bg News February 04, 2026, Bowling Green State University
BG News (Student Newspaper)
The BGSU campus student newspaper. February 04, 2026. Volume 105-Issue 16.
Ethical Constraint-Based Mpc With Adaptive Weight Scheduling For Autonomous Vehicles In Diverse Scenarios, Hend Mohammed Aafia`
Ethical Constraint-Based Mpc With Adaptive Weight Scheduling For Autonomous Vehicles In Diverse Scenarios, Hend Mohammed Aafia`
Theses and Dissertations
Autonomous vehicles (AVs) are increasingly deployed in complex and safety-critical environments, raising fundamental questions about how ethical principles should be operationalized within real-time control systems. While existing research has extensively addressed ethical decision-making at the planning and behavioral layers, ethical intent is commonly translated into predefined trajectories and delegated to low-level controllers under the assumption of safe execution. This separation introduces a critical gap between ethical reasoning and physical feasibility, particularly in scenarios involving nonlinear vehicle dynamics, actuation limits, constrained perception horizons, and time-critical interactions with vulnerable road users. This thesis proposes an Ethical Model Predictive Control (E-MPC) framework that …
Multiparent Recombinant Inbred Lines Crossed To A Tester Provide Novel Insights Into Sources Of Cis And Trans Regulation Of Gene Expression, Fabio Marroni, Alison M Morse, Adalena V Nanni, Nadja Nolte, Patricka Williams-Simon, Luis G León-Novelo, Rita M Graze, Paul Schmidt, Elizabeth King, Lauren M Mcintyre
Multiparent Recombinant Inbred Lines Crossed To A Tester Provide Novel Insights Into Sources Of Cis And Trans Regulation Of Gene Expression, Fabio Marroni, Alison M Morse, Adalena V Nanni, Nadja Nolte, Patricka Williams-Simon, Luis G León-Novelo, Rita M Graze, Paul Schmidt, Elizabeth King, Lauren M Mcintyre
Faculty, Staff and Student Publications
To understand the relative importance of cis and trans effects on regulation, we crossed multi-parent recombinant-inbred lines (RILs) to a common tester and measured allele-specific gene expression in the offspring. Testing the difference of allelic imbalance between two RIL × Tester crosses is a test of cis or trans, depending on the RIL alleles compared. The study design also enables to separation of two sources of trans variation, genetic and environmental, detected via interactions with cis effects. We demonstrate the effectiveness of this approach in a long-read RNA-seq experiment in female abdominal tissue at two time points in Drosophila melanogaster. …
Associations Between Big Five Personality Traits, Facets, And Sexual Fantasies, Emily Cannoot, Amy C. Moors, Wiliam J. Chopik
Associations Between Big Five Personality Traits, Facets, And Sexual Fantasies, Emily Cannoot, Amy C. Moors, Wiliam J. Chopik
Psychology Faculty Articles and Research
The present study investigated associations between Big Five personality traits, their facets, and the frequency and variety of sexual fantasies in a sample of 5,225 adults (M = 58.30 years old; 56.5% men). People high in conscientiousness and agreeableness report fewer sexual fantasies across exploratory, intimate, impersonal, and sadomasochistic domains; these effects were primarily driven by respectfulness and responsibility facets. Negative emotionality, particularly the depression facet, was associated with more frequent sexual fantasizing. Extraversion and open-mindedness showed minimal relationships with sexual fantasy frequency. These results underscore the importance of personality dimensions in understanding sexual thoughts, emphasizing the heterogeneity of …
Ubiquitination Of Oncogenic Mutant P53 Via Attenuation Of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth, Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez, Andrew Massey, Vivek K Kashyap, Neeraj Chauhan, Emmanuel Anning, Manish K Tripathi, Dae J Kim, Nirakar Sahoo, Tamer Oraby, Murali M Yallapu, Mohammad Moshahid Khan, Manu M Sebastian, Subhash C Chauhan, Bilal B Hafeez
Ubiquitination Of Oncogenic Mutant P53 Via Attenuation Of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth, Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez, Andrew Massey, Vivek K Kashyap, Neeraj Chauhan, Emmanuel Anning, Manish K Tripathi, Dae J Kim, Nirakar Sahoo, Tamer Oraby, Murali M Yallapu, Mohammad Moshahid Khan, Manu M Sebastian, Subhash C Chauhan, Bilal B Hafeez
Faculty, Staff and Student Publications
Dysregulated ribosome biogenesis and p53 mutations are known to play oncogenic roles in various cancers, including pancreatic cancer. In this study, we demonstrated the therapeutic potential of BMH-21, a pharmacologic inhibitor of RNA polymerase I, against pancreatic cancer by uncovering a novel molecular mechanism involving RPA194-mediated ubiquitination of mutant p53 without affecting the ubiquitination of wild-type p53. Our key findings are that (i) BMH-21 selectively induces apoptosis and cell growth inhibition of pancreatic cancer cells with no effect on normal human pancreatic ductal epithelial cells; (ii) BMH-21 degrades RPA194; (iii) BMH-21 inhibits recruitment of both RPA194 and RPA135 on rDNA …
Tumor Radiosensitization With Gold Nanoparticles: Evolving Strategies To Improve Tumoral Gold Uptake And Catalyze Future Clinical Translation, Prapannajeet Biswal, Geraldine V Vijay, Gabrielle Krouse, Phuoc Minh Quan Mai, Bhoomika Muruvekere Lakshmisha, Sanaz Keshavarz Shahbaz, Mahdieh Yousefi Taba, Aria Sabbagh, Lydia Wt Cheung, Yuri Mackeyev, Khadijeh Koushki, Sunil Krishnan
Tumor Radiosensitization With Gold Nanoparticles: Evolving Strategies To Improve Tumoral Gold Uptake And Catalyze Future Clinical Translation, Prapannajeet Biswal, Geraldine V Vijay, Gabrielle Krouse, Phuoc Minh Quan Mai, Bhoomika Muruvekere Lakshmisha, Sanaz Keshavarz Shahbaz, Mahdieh Yousefi Taba, Aria Sabbagh, Lydia Wt Cheung, Yuri Mackeyev, Khadijeh Koushki, Sunil Krishnan
Faculty, Staff and Student Publications
Radiation therapy is integral to the treatment regimens of over 50% of cancer patients. However, it is not biologically targeted to just the tumor, leading to adverse effects in peritumoral normal tissue. Selective uptake of gold nanoparticles (AuNPs) by tumors realizes tumor-specific radiosensitization via increased secondary electron release from high atomic number gold atoms. Here, we review AuNP-mediated radiosensitization and outline strategies to optimize tumor-targeted AuNP delivery. Modifying the physicochemical characteristics of AuNPs, including size, shape, charge, and surface chemistry, can increase their ability to evade the reticuloendothelial system (RES) and penetrate the dense tumor stromal architecture, thereby promoting tumor …
Repurposing Of The Macrolide Antibiotic Clarithromycin For The Prevention Of Lung Cancer, Shanshan Deng, Tabish Hussain, Thais F Bartelli, Manu M Sebastian, Melody Zarghooni, Walter V Velasco, Brandon Somerville, Linda Phan, Michelle I Savage, Yurong Song, John L Clifford, Humam Kadara, Florencia Mcallister, Powel H Brown, Seyed Javad Moghaddam, C Marcelo Aldaz
Repurposing Of The Macrolide Antibiotic Clarithromycin For The Prevention Of Lung Cancer, Shanshan Deng, Tabish Hussain, Thais F Bartelli, Manu M Sebastian, Melody Zarghooni, Walter V Velasco, Brandon Somerville, Linda Phan, Michelle I Savage, Yurong Song, John L Clifford, Humam Kadara, Florencia Mcallister, Powel H Brown, Seyed Javad Moghaddam, C Marcelo Aldaz
Faculty, Staff and Student Publications
Drug repurposing is the process of reusing existing pharmaceuticals for novel clinical purposes, which offers advantages such as streamlined clinical trial access and reduced drug development costs. Clarithromycin (CAM), a member of the macrolide antibiotics family, is a promising candidate for repurposing in cancer therapy due to its known preclinical and clinical immunomodulatory and anticancer properties. In the current study, we investigated whether CAM could be repurposed as a preventive treatment for KRAS-mutant lung cancer, a subtype of lung adenocarcinoma that is strongly associated with heavy smoking. CCSPCre; LSL-KrasG12D mice at an early stage of tumor development were treated with …
The Story Of Documentary Film: Episode 1, “The Beginning", Sheila Nayar
The Story Of Documentary Film: Episode 1, “The Beginning", Sheila Nayar
Journal of Religion & Film
This is a film review of The Story of Documentary Film: Episode 1, “The Beginning" (2026), directed by Mark Cousins.
The Incomer, Sheila Nayar
The Incomer, Sheila Nayar
Journal of Religion & Film
This is a film review of The Incomer (2026), directed by Louis Paxton.
Time And Water, Sheila Nayar
Time And Water, Sheila Nayar
Journal of Religion & Film
This is a film review of Time and Water (2026), directed by Sara Dosa.