Digital Commons Network^™

Market Integration And Agricultural Efficiency Of Communal Amana, Metin M. Cosgel

Communal Societies

No abstract provided.

What The Amana Inspirationists Were Reading, Jonathan Andelson

Communal Societies

No abstract provided.

Lust, "A Snare Of Satan To Beguile The Soul": New Light On Shaker Celibacy, Glendyne R. Wergland

Communal Societies

No abstract provided.

Review Of Torches Extinguished: Memories Of A Communal Bruderhof Childhood In Paraguay, Europe, And The Usa, Thomas Mansheim

Communal Societies

No abstract provided.

Damanhur: A Magical Community In Italy, Massimo Introvigne

Communal Societies

No abstract provided.

Motivating Passion And Purpose In Grade Six Students Through Game-Based Learning, Violet H. Harada, Patricia Louis

Learning Hub

This article examines how a sixth-grade pathways course at Kamehameha Schools in Hawai‘i leveraged Game-Based Learning (GBL) and Indigenous knowledge to foster student agency, creativity, and environmental stewardship. Designed and taught by school librarian Patricia Louis with support from a multidisciplinary instructional team, the Nā Lawai‘a Hawai‘i (Fishing, Hawaiian Style) elective engaged students in researching the ‘Ama‘ama (Hawaiian striped mullet) and the ecological challenges it faces, then translating their learning into the design of a board game, ‘Ama‘ama Escape. Grounded in constructivist, learning-by-making principles, the course guided students through an iterative design process that included inquiry, collaboration, prototyping, and playtesting. …

Examining Fort Vancouver Curatorial Practices: How Do Museums Interact With And Represent The Public?, Karryn Meharchand Pillay

Dissertations and Theses

Historically, the work of curators has always been somewhat opaque and mysterious to the public, with knowledge of curatorial practices only being passed from mentor to student, creating a small elite of those in the know, which is something that has only begun to change in the modern era (Meyer-Krahmer 2015). So, if museum operations are not accessible to the public, what does that mean for communities whose culture and history are being presented by the museum? How are they meant to reclaim their cultural heritage? How are they supposed to approach conversations regarding misrepresentation in museum exhibits?

Through this …

Ex Vivo Microfluidic Model Identifies A Role For Shear Stress During Ovarian Tumor Cell Attachment To Peritoneal Mesothelial Cells, Vasilios A Morikis, Breanna Baker, Jillian A Martin, Angela Schab, Alessandra Dimauro, Gregory D Longmore, Whitney R Grither

2020-Current year OA Pubs

Ascites, or a pathologic accumulation of intra-abdominal fluid, is a key feature of intraperitoneally disseminating cancers, such as ovarian cancer. This pathological fluid buildup can influence the adhesive abilities of ovarian cancer cells, as they spread throughout the abdominal cavity to form metastatic implants on organs lined with a specialized monolayer of mesothelial cells. Robust methods for assessing the impact of fluid shear stress on this cell-cell interaction are lacking. Here, we develop and characterize a novel microfluidic device that allows for the determination of the attachment of ovarian tumor cells to mesothelial cells under the influence of fluid flow. …

Phytic Acid (Insp6) Activates Hdac3 Epigenetic Axis To Maintain Intestinal Barrier Function, Sujan Chatterjee, Katherine Huang, Kayci Huff-Hardy, Richard Rood, Anas Gremida, Martin Gregory, Chien-Huan Chen, Parakkal Deepak, Et Al.

2020-Current year OA Pubs

HDAC inhibition shows promise in cancer treatment but pan-HDAC inhibitors cause gastrointestinal issues in 48% of patients. Understanding HDAC activation mechanisms is crucial to treating diverse diseases beyond cancer. Our study reveals that inositol polyphosphate multikinase (IPMK) and inositol hexakisphosphate (InsP

Ex Vivo Microfluidic Model Identifies A Role For Shear Stress During Ovarian Tumor Cell Attachment To Peritoneal Mesothelial Cells, Vasilios A Morikis, Breanna Baker, Jillian A Martin, Angela Schab, Alessandra Dimauro, Gregory D Longmore, Whitney R Grither

2020-Current year OA Pubs

Ascites, or a pathologic accumulation of intra-abdominal fluid, is a key feature of intraperitoneally disseminating cancers, such as ovarian cancer. This pathological fluid buildup can influence the adhesive abilities of ovarian cancer cells, as they spread throughout the abdominal cavity to form metastatic implants on organs lined with a specialized monolayer of mesothelial cells. Robust methods for assessing the impact of fluid shear stress on this cell-cell interaction are lacking. Here, we develop and characterize a novel microfluidic device that allows for the determination of the attachment of ovarian tumor cells to mesothelial cells under the influence of fluid flow. …

Explore Uncharted Ideas With Tedx University Of Mississippi, Staff Report

University of Mississippi News

OXFORD, Miss. – With topics ranging from groundbreaking science to frontier education, TEDx University of Mississippi invites the community to "Uncharted," a TED-licensed event with seven thought-provoking speakers set for 7 p.m. Feb. 20 in the Gertrude C. Ford Center for the Performing Arts.

Ubiquitination-Directed Cytosolic Dna Degradation Governs Cgas-Sting-Mediated Immune Response To Dna Damage, Lei Li, Qi Ye, Jinlu Ma, Zixi Wang, Tianjie Liu, Yuzeshi Lei, Mingming Lu, Jialu Kang, Haohan Xiang, Buyun Li, Shan Xu, Ke Wang, Yule Chen, Jiaqi Chen, Bohan Ma, Wenyue Huang, Mengjiao Cai, Nan Wu, Yanqiang Li, Jiale An, Chongming Jiang, Rui Ye, Jing Liu, Steven H Lin, Yang Gao, Jian Ma, Lei Li

Faculty, Staff and Student Publications

Activation of cGAS-STING signaling in cancer cells requires cytosolic DNA produced by intrinsic or treatment-induced DNA damage. However, clinical efforts to exploit this pathway to improve immunotherapy have yielded limited success, highlighting gaps in understanding the link between DNA damage and immunotherapy. Here, we identify ubiquitination-directed cytosolic DNA degradation as a critical determinant for cGAS-STING activation following DNA damage. Mechanistically, the cytosolic DNA exonuclease TREX1 is degraded by the E3 ubiquitin ligase SPOP but is reversely stabilized by the deubiquitinase USP7. Cancer-associated SPOP mutations or USP7 overexpression elevate TREX1 levels, promoting cytosolic DNA degradation and impairing cGAS-STING-mediated immune activation. Notably, …

Multimodal Spatial-Omics Reveal Co-Evolution Of Alveolar Progenitors And Proinflammatory Niches In Progression Of Lung Precursor Lesions, Fuduan Peng, Ansam Sinjab, Yibo Dai, Warapen Treekitkarnmongkol, Sujuan Yang, Lorena I Gomez Bolanos, Tieling Zhou, Minyue Chen, Alejandra G Serrano, Avantika Krishna, Nastaran Karimi, Manvi Sharma, Akshay Basi, Guangsheng Pei, Jianlong Liao, Yunhe Liu, Jiping Feng, Zahraa Rahal, Yang Liu, Jiahui Jiang, Kai Yu, Tala Noun, Yuejiang Liu, Khaja Khan, Kyung Serk Cho, Jichao Chen, Luisa M Solis, Sarah Mazzilli, Steven Dubinett, Tina Cascone, Avrum E Spira, Stephen Swisher, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Tomoo Itoh, Takashi Yao, Kenji Suzuki, Neda Kalhor, Ignacio I Wistuba, Mingyao Li, Seyed Javad Moghaddam, Junya Fujimoto, Jared Burks, Jeffrey Myers, Kadir Akdemir, Linghua Wang, Humam Kadara

Faculty, Staff and Student Publications

The co-evolution of different cell subsets in the progression of precursor lesions to lung adenocarcinoma (LUAD) is incompletely understood. We generated spatial transcriptomic maps of 56 human precursor lesions and LUADs from 25 patients and of an independent cohort of 36 lesions from 19 patients, analyzing a total of 486,519 spots and 5.4 million cells. We identify region-specific programs that distinguish precursors from LUADs. Spatially resolved clonal architectures reveal patient-specific heterogeneity in evolution of precursors to LUADs. We find epithelial alveolar progenitors expressing tumor-associated meta-programs and residing in niches enriched with proinflammatory subsets including IL1B high macrophages. Epithelial-proinflammatory niches are …

High-Throughput Multi-Organ Proteomics Workflow For Drug Efficacy And Toxicity Analysis, Yun Xiong, Lin Tan, Wai-Kin Chan, Dandan Zhu, Huimin Zhang, Eric S Yin, Sri Ramya Donepudi, Jibin Ding, Bo Wei, Bao Tran, Sara Martinez, Iqbal Mahmud, Faiza Hanif Waghu, Hamish I Stewart, Daniel J Hermanson, Rehan Akbani, John N Weinstein, Junjie Chen, Philip L Lorenzi

Faculty, Staff and Student Publications

Rapid and comprehensive analysis of complex proteomes across large sample sets is vital for unlocking the potential of systems biology. We present a high-throughput mass spectrometry (MS) proteomics method that integrates narrow-window data-independent acquisition (nDIA) with short-gradient micro-flow chromatography, enabling profiling of >240 samples per day. This optimized MS approach identifies 6,201 and 7,466 human proteins with 1- and 2-min gradients, respectively. As a practical application, we analyzed 507 samples composed of 13 different tissues from mice treated with the enzyme-drug L-asparaginase (ASNase) or its glutaminase-free Q59L mutant, generating a quantitative profile of 11,472 proteins following drug treatment. The MS …

Multimodal Spatial-Omics Reveal Co-Evolution Of Alveolar Progenitors And Proinflammatory Niches In Progression Of Lung Precursor Lesions, Fuduan Peng, Ansam Sinjab, Yibo Dai, Warapen Treekitkarnmongkol, Sujuan Yang, Lorena I Gomez Bolanos, Tieling Zhou, Minyue Chen, Alejandra G Serrano, Avantika Krishna, Nastaran Karimi, Manvi Sharma, Akshay Basi, Guangsheng Pei, Jianlong Liao, Yunhe Liu, Jiping Feng, Zahraa Rahal, Yang Liu, Jiahui Jiang, Kai Yu, Tala Noun, Yuejiang Liu, Khaja Khan, Kyung Serk Cho, Jichao Chen, Luisa M Solis, Sarah Mazzilli, Steven Dubinett, Tina Cascone, Avrum E Spira, Stephen Swisher, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Tomoo Itoh, Takashi Yao, Kenji Suzuki, Neda Kalhor, Ignacio I Wistuba, Mingyao Li, Seyed Javad Moghaddam, Junya Fujimoto, Jared Burks, Jeffrey Myers, Kadir Akdemir, Linghua Wang, Humam Kadara

Faculty, Staff and Student Publications

The co-evolution of different cell subsets in the progression of precursor lesions to lung adenocarcinoma (LUAD) is incompletely understood. We generated spatial transcriptomic maps of 56 human precursor lesions and LUADs from 25 patients and of an independent cohort of 36 lesions from 19 patients, analyzing a total of 486,519 spots and 5.4 million cells. We identify region-specific programs that distinguish precursors from LUADs. Spatially resolved clonal architectures reveal patient-specific heterogeneity in evolution of precursors to LUADs. We find epithelial alveolar progenitors expressing tumor-associated meta-programs and residing in niches enriched with proinflammatory subsets including IL1B high macrophages. Epithelial-proinflammatory niches are …

Lanthorn, Vol. 60, No. 11, February 9, 2026, Grand Valley State University

Volume 60, August 4, 2025 – current

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Fear From Eating Outside? Assessing The Impact Of Covid-19 Pandemic On Consumer’S Willingness To Utilize Catering Services In China, Yunwei Li, Qiuping Ji, Vivian Valdmanis, Jingqi Li, Guanrou Deng, Rui Guo, Yu Hao, Zhi-Nan Lu

Bulletin of Monetary Economics and Banking

Since the onset of economic reforms, the catering industry has been playing a crucial role in China’s economic development. However, due to the outbreak of the COVID-19 pandemic, the Chinese government has implemented strict pandemic prevention policies such as (home quarantine and suspending work and production facilities) leading to losses for a variety of industries, especially catering industry. As the main driving force on the demand side, residents’ willingness to pay for catering can play an important role in the post-pandemic economic recovery. In this study, we employ primary data of 1,072 respondents from an online survey to investigate the …

Consensus Paper: Models Of Cerebellar Functions, Shinji Kakei, Andreea C Bostan, Timothy J Ebner, Mohammad Amin Fakharian, Hiroaki Gomi, Xavier Guell, Marie Hemelt, Huu Hoang, Court Hull, Masato Inoue, Takahiro Ishikawa, Masashi Kameda, Mitsuo Kawato, Shigeru Kitazawa, Mario Manto, Javier F Medina, Hiroshi Mitoma, Keiko Ohmae, Shogo Ohmae, Ken-Ichi Okada, Laurentiu S Popa, Jeremy D Schmahmann, Reza Shadmehr, Peter L Strick, Hirokazu Tanaka, Masaki Tanaka, Tadashi Yamazaki

Faculty, Staff and Students Publications

For a long time, from the nineteenth century to most of the twentieth century, the cerebellum was thought to be an organ that regulates movement. Towards the end of the twentieth century, the brain functions associated with the cerebellum began to extend beyond motor control. Now, there is a consensus that the cerebellum is involved not only in motor functions but also in the most basic autonomic functions and the most complex cognitive and emotional functions, with a focus on predictions and internal models. A new functional model of the cerebellum is needed to explain all layers of brain functions …

Myokine Sirpα Exacerbates Kidney Disease In Diabetes, Jiao Wu, Elisa Russo, Daniela Verzola, Qingtian Li, Helena Zhang, Bhuvaneswari Krishnan, David Sheikh-Hamad, Zhaoyong Hu, William E Mitch, Sandhya S Thomas

Faculty, Staff and Students Publications

Mechanisms responsible for skeletal muscle kidney crosstalk have not been defined. We have determined that a circulating mediator, signal regulatory protein α (SIRPα), impairs intracellular insulin-mediated functions. To elucidate the effect of myokine SIRPα on diabetic kidney disease (DKD), flox mice and muscle-specific (m-specific) SIRPα-KO mice were subjected to an obesity-induced model of diabetes, high-fat diet (HFD; 60%) or insulin-deficient hyperglycemia model, streptozotocin (STZ), and were subsequently exposed to anti-SIRPα monoclonal antibodies. In the obesity-induced diabetic mice, serum SIRPα increased. Genetic deletion of muscle SIRPα protected against obesity and improved intracellular insulin signaling in muscle and adipose tissue, with reduced …

Vines In The Landscape: Virginia Creeper, Saroj Burlakoti, Youping Sun, Shital Poudyal

All Current Publications

Virginia creeper (Parthenocissus quinquefolia) is a vigorous and aggressive deciduous vine in the grape family (Vitaceae), known for its rapid growth, dense foliage, and striking fall color. Some landscapers consider this plant a nuisance because of its aggressive growth, potential damage to weak structures, and difficulty in removing, but others love it for its potential for erosion control, rapid coverage, fall color, and as a bird and pollinator habitat.

Chimes: February 9, 2026, Calvin University

Chimes

Turning Point USA opens new chapter at Calvin by Ian Tjoelker

CTC's "Peter and the Starcatcher": Magic, imagination and childhood play by McKenna Wilkinson

Architectural History Exhibition presents Knollcrest architect's market plan by Alec DeYoung & Ella Vanden Berg

SAGA: "Seen, known and loved" by Sarah Sparling

Project Neighborhood coming to an end in 2027 by Evangeline Anga

"Wake Up Dead Man" is an investigation of murder and the church by Maya Oeverman

Computational Investigation Of Cavitation Inception In Centrifugal Pumps, Mohamed Ibrahim Eldesouky, Asmaa Khater, Abdel-Rahim Dohina, Mohamed Rabie

Mansoura Engineering Journal

This study examines the effects of suction chamber baffle configurations on both hydraulic efficiency and cavitation characteristics in a low specific speed centrifugal pump. Four baffle configurations (zero, one, two, and three baffles) were tested at three different heights using refined computational fluid dynamics simulations. The Zwart-Gerber-Belamri cavitation model was enhanced by adjusting nucleation site radius and evaporation coefficient values to better align with previous research findings. Results revealed that the optimal baffle height is approximately one-third of the impeller suction eye radius, significantly improving cavitation resistance. Under non-cavitation conditions, all baffled configurations outperformed the no-baffle setup, with a single …

Justice For Animals In Climate Change Integrated Assessment Models, Bob Fischer, Avram Hiller

Philosophy Faculty Publications and Presentations

Integrated assessment models (IAMs) exclude individual non-human animal welfare, despite clear evidence that climate change will harm billions of animals through habitat loss, extreme weather, and ecosystem disruption. We argue that this is a significant moral oversight. Further, incorporating animal welfare into IAMs is technically feasible, using traditional economic methods or novel ones. Crucially, accounting for animal welfare in IAMs need not undermine considerations of justice for humans.

Discovery And Characterization Of A Novel Pseudomonas Phage Of A New Genus, Paul Nicholls, Justin R Clark, Anthony Maresso

Faculty, Staff and Students Publications

Background: Bacteriophages exhibit great diversity and are classically divided into lytic and temperate lifestyles. Commonly, bioinformatics is used to predict the temperate lifestyle. As the nosocomial pathogen Pseudomonas aeruginosa is common in freshwater, this biome represents an ideal location for the discovery of Pseudomonas phages.

Materials and methods: We characterized a genetically distinct species of Pseudomonas phage using next-generation sequencing and conventional microbiological methods. We characterized its lifestyle by purifying infected colonies and identifying persistent phage production.

Results: Genetics revealed a phage of a novel genus. Characterization showed a narrow host range and bioinformatics suggested a lytic lifestyle. Experimental data …

Addressing The Pitfalls Of Misinformation In The Classroom Through Game Based Learning, Taylor S. Strong, Jerome Bingham

Georgia International Conference on Information Literacy

As instruction librarians we must strive to strengthen students' literacy when it comes to research. Only a 3rd of American high school students are graduating with the necessary reading and math skills needed for college-level classes. In conjunction with these low reading levels.The current and incoming students are a part of the Gen-Z or Zoomer generation.One of the largest problems Gen Z students face in their daily lives is combating misinformation. The University of Virginia in conjunction with the University of Cambridge conducted a recent study about generations and misinformation. Only 11% of 18 to 29 year olds earned a …

Microrna Expression In Putative Cancer Stem Cells Isolated From Canine Mammary Gland Tumour Cells With Differing Sensitivity To Doxorubicin, Kabiru Sahabi, Gayathri Thevi Selvarajah, Mohd Mokrish Md Ajat, Rasedee Abdullah, Cheah Y. Kqueen

The Thai Journal of Veterinary Medicine

Cancer stem cells (CSCs) are capable of initiating tumour development and causing recurrence after treatment. The objective of this study was to determine the miRNAs, downstream target mRNAs, and signalling pathways in CSCs isolated from doxorubicin-sensitive and doxorubicin-resistant canine mammary adenocarcinoma cell lines. MicroRNA expression was profiled using Agilent SurePrint^® microarrays. MicroRNA data were analyzed using Agilent GeneSpring^® software, and TargetScan and WikiPathways were used to identify genes and pathways targeted by the differentially expressed miRNAs. Six miRNAs were differentially expressed in CSCs isolated from doxorubicinsensitive cells, while fourteen miRNAs were differentially expressed in CSCs isolated from doxorubicin-resistant …

Preliminary Development Of Visual And Real-Time Loop-Mediated Isothermal Amplification Assays For Megalocytivirus Detection In Betta Fish (Betta Splendens), Kitikarn Sakuna, Supaporn Noochu, Kittichon U-Taynapun, Nion Chirapongsathonkul, Saransiri Nuanmanee

The Thai Journal of Veterinary Medicine

This study developed rapid detection of Megalocytivirus using visual and real-time loop-mediated isothermal amplification (LAMP) assays. The primer was designed with the major capsid protein gene of Megalocytivirus, including red sea bream iridovirus (RSIV), infectious spleen and kidney necrosis virus (ISKNV), and turbot reddish body iridovirus (TRBIV). The visual and real-time LAMP assays were evaluated using DNA extracted from symptomatic betta fish that tested negative for Megalocytivirus by the broad-range PCR assay, as well as a chemically synthesized Megalocytivirus DNA template. Visual LAMP was found sensitive enough to detect up to 10 pg per reaction of the target DNA …

What Future For Moroccan Arabic In Morocco?, Zahra Zaid

Faits de Langue et Société (FLS)

Our reflection is about the statute of Moroccan Arabic and his future. We are going to demonstrate with concrete examples if this language constructs or deconstructs itself in the movement of modernism that Morocco knows. We will also see the degree of implication of its users in this construction / deconstruction.

Violent Linguistic Behavior: A Psycholinguistic Approach, Mourad Mawhoub

Faits de Langue et Société (FLS)

The violence is a subject that concerns psychologists, sociologists, lawyers, educators and anthropologists. It also interests linguists and psycholinguists. First of all, the violence is a linguistic sign, a speech act that expresses an emotional attitude. It is a kind of conflicting interpersonal communication relating two or several persons in an antagonist and conflicting context. In this article, we will try to treat some psycholinguistic aspects of the violent speech. We will show how violent voice is phonetically produced. We will extract physiological factors and acoustical-physical parameters of violent vocalization. We will also show how violent voice reflects aggressive feels …

Proper Names In The Fictional Works Of Guy De Maupassant, Ouafae Benzina

Faits de Langue et Société (FLS)

We suggest in this article studying the proper noun in the romantic work of Guy de Maupassant. For that purpose, we shall approach the problem of the definition of the proper noun which remains so far the object of several debates. Then, we shall distinguish three functions of the proper noun: the reference function, the function vocative and the function of appointment. We shall present, finally, a thematic classification of the proper nouns appearing in the corpus of the romantic works of Maupassant, supplied by the Hyperbase software.