Digital Commons Network^™

Sting-Induced Blood-Brain Barrier Opening Combined With Radiotherapy Potentiates Antitumor Response In A High-Grade Glioma Model, Shashwat Tripathi, Hinda Najem, Lisa Hurley, Ruochen Du, Crismita Dmello, Heba Ali, Kathleen Mccortney, Karl J Habashy, Peng Zhang, Craig M Horbinski, Lara Leoni, Ryan J Avery, Rimas V Lukas, Timothy L Sita, David R Raleigh, Sean Sachdev, Roger Stupp, Maciej S Lesniak, David M Ashley, Daniele Procissi, Michael A Curran, Irina Balyasnikova, Amy B Heimberger

Faculty, Staff and Student Publications

Radiation therapy (RT) is the standard of care for glioblastoma but is not curative. Triggering the cGAS/stimulator of interferon genes (STING) pathway with potent agonists, such as 8803, exerts activity across high-grade glioma preclinical models. To determine if the combination of 8803 with RT warrants consideration in the up-front treatment setting and to clarify the underlying mechanisms of therapeutic activity, C57BL/6J mice harboring intracerebral CT-2A or QPP8v gliomas were treated with RT, intratumoral 8803, or both. The treatment with the combination resulted in 80% long-term survival in the CT-2A model but not in the radiation-resistant QPP8v model. This therapeutic effect …

Mutant Kras In Brain Endothelial Cells Promotes Vascular Inflammation And Impairs Vascular Integrity In Brain Arteriovenous Malformation, Jung-Eun Park, Bridger H Freeman, Hyejin Park, Sehee Kim, Adrian E Bafor, Ohnmar Myint, Song Gao, Zhen Xu, Jakob Körbelin, Jaroslaw Aronowski, Peng Roc Chen, Eunhee Kim, Eun S Park

Faculty, Staff and Student Publications

Somatic KRAS (KRASG12V) mutation in endothelial cells (EC) induces brain arteriovenous malformation (bAVM) that could lead to vascular instability and ultimately bleeding. However, the causes of bAVM instability remain unclear. Here we demonstrate that KRASG12V expressing cultured ECs (KRAS-G12V-EC) have increased expression of pro-inflammatory mediators and reduced expression of blood-brain-barrier (BBB) junction constituents. The conditioned medium from KRAS-G12V-EC can activate BV2-microglia (BV2-MG) and conditioned media from this primed BV2-MG can compromise the expression of EC-junction constituents when added to wild-type ECs. In an in vitro BBB model, KRAS-G12V-EC form a dysfunctional EC barrier that is further disrupted, leading to lower …

Transformative Technology And Shortening The Statute Of Limitations Applicable To Taxpayers, Jay A. Soled, Leslie Book

Faculty Publications

When it comes to submitting tax returns and paying taxes, most taxpayers understand the nature of their civic duties and do so dutifully, if not willingly. However, many taxpayers fail to grasp why the IRS has such an elongated time period—namely, three years— to audit their tax returns and propose an assessment. Indeed, when the IRS exercises its oversight authority, records may no longer be available, and memories may be dulled.

Since the original institution of the three-year tax assessment limitations period nearly a century ago, tremendous technological strides have been made. Indeed, over ninety percent of income tax returns …

Development Of Animation-Based Cooperative Learning Media On Lampung Folk Tales To Improve Learning Outcomes In Elementary School Students, Aprilia Nursanti, Farida Ariyani, Ryzal Perdana, Hendri Firmansyah

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This study aimed to develop and examine the feasibility and preliminary effectiveness of an animation-based learning medium integrated with Cooperative Learning for teaching Lampung folk tales in elementary schools. The study was motivated by low student achievement and the limited availability of culturally contextualized digital media in local language instruction. Using a Research and Development (R&D) approach, the learning media was developed through the ADDIE model, encompassing Analysis, Design, Development, Implementation, and Evaluation. The participants consisted of 25 fourth-grade students from SDN 3 Rajabasa, Bandar Lampung. Expert validation indicated a high level of feasibility, with an average score of 88%. …

Novel Technique For Enhancing The Therapeutic Efficacy Of Coenzyme Q10 In Transdermal Drug Delivery Systems For Skin Rejuvenation, L. M. Hettihewa, K. G. P. Wasana, Y. M. Imendra, G. P. C. Weerasooriya, W. M. K. M. Rathnayake

Journal of Innovation in Science, Engineering and Technology

Coenzyme Q10 (CoQ10) is a very imperative compound for electron transport chain in mitochondria and exerts its effects as cutaneous antioxidant. All human cells have CoQ10, and sometime deficiency had been identified due to genetic defects or with ageing. Supplements with COQ 10 are commonly used enteral and dermal application for the prevention and treatment of aging. Delivery of dermal CoQ10 is very limited due to its poor penetration and unstable compounds. systematic review was conducted by our research group through electronic databases using preclinical and randomized controlled trials to evaluate the efficacy and stability of improved delivery systems of …

Assessment Of In-Vitro Anti-Diabetic And Antioxidant Activities Of Selected Edible Mushrooms, Agaricus Bisporus (Button Mushroom), Pleurotus Cystidiosus (Abalone) And Pleurotus Ostreatus (American Oyster) In Sri Lanka, E. J. Siriwardene, G. S. D. Nawaruwan, A. H. M. A. N. Abesinghe, H. D. Dedigama, K. H. E. Fernando, K. D. K. P. Kumari, W. M. K. M. Ratnayake

Journal of Innovation in Science, Engineering and Technology

Mushrooms are a valuable source of proteins and vitamins as well as a food source with several pharmacological values. Hence, Higher mushroom consumption can lower the risk of certain diseases. However, a literature survey revealed that published scientific information on the therapeutic potential of some edible mushrooms is still being determined. Hence, this study evaluated and compared the antioxidant and α -amylase potential of some of the three commonly used mushroom varieties in Sri Lanka i.e. Agaricus bisporus (Button mushroom), Pleurotus cystidiosus (Abalone mushroom) and Pleurotus ostreatus (American oyster). The antioxidant activity of hot aqueous extracts of the above three …

Conceptual Analysis Of Ārthavavaha Srotas (Female Reproductive System): A Review Of The Theories And Literature, Pushpa Kulanatha, H. L. M. G. Sajeewani

Journal of Innovation in Science, Engineering and Technology

The reproductive health of females during their fertile years is foundational for individual well-being and societal prosperity. The purpose of this study was to bridge the analytical and epistemological gaps currently existing in the literature regarding Ārthavavaha Srotas (ĀvS), the Ayurvedic concept of the female reproductive system. A comprehensive literature review was conducted using forward and backward searches to analyse authentic Ayurvedic texts (Caraka and Sushruta Samhitas) alongside contemporary research articles published between 2014 and 2024. The analysis identified ten specific aspects of the ĀvS where prior interpretations were superficial or unclear. The results of this study epistemologically validate ancient …

Modeling Spasticity: A Systematic Review, Gaby Gonzalez Chan, Jonathan Marsden, Alexander Besinis, Pablo Borja, Hilary Gunn

School of Health Professions

Spasticity, a type of hypertonia characterized by a velocity-dependent increase in muscle tone, is associated with damage to the brain and/or spinal cord in different neurological conditions. However, secondary non-neurological factors, such as soft tissue changes, can complicate the assessment and differentiation of the underlying causes. Accurate assessment is crucial for effective treatment planning, with clinicians relying on passive movement to grade the ‘feel’ of the spastic limb. This review aims to identify and evaluate the feasibility of spasticity models or simulations for clinical teaching. Models based on human spastic limbs were examined, with no restrictions on specific conditions or …

Ontology-Based E-Commerce Recommender System: A Hybrid Semantic Filtering Approach, Shaymaa Al-Juboori, Jocelyn Pua, Su-Cheng Haw, Lucia Dwi Krisnawati, Gee-Kok Tong

School of Engineering, Computing and Mathematics

The rapid growth of e-commerce has led to product overload, which has resulted in personalized product discovery becoming a crucial problem for consumers. Classic recommender systems (RS), which rely heavily on content-based filtering or collaborative filtering, tend to face well-known problems such as cold start, data sparsity, and ignorance of semantics. Such constraints frequently result in irrelevant or redundant suggestions, thereby lowering the user satisfaction and conversions. This study presents a hybrid ontology-based e-commerce recommender system that combines symbolic reasoning with deep semantic matching. The system is based on a Neo4j graph database to capture structured product relationships and is …

Molecular Detection Of Genes Encoded For Biofilm Formation In Bacteria Isolated From The Oral Cavity Of Patients, Tebarek Al-Taei, Ali A. Al-Hisnawi

Karbala International Journal of Modern Science

Background: A biofilm is a collection of the microbial cells attached to the surface that are encased in a matrix of extracellular polymers. Biofilm formation creates a physical and chemical barrier that prevents antibiotics from reaching bacterial cells, resulting in treatment failure and reinfection. The present study aimed to investigate the biofilm formation in bacteria isolated from the oral cavity of patients.

Methods: In this study, 150 bacterial isolates were obtained from tooth and gum surface swabs of male and female patients of different ages who visited specialized centers and dental clinics in Babylon City after they were clinically diagnosed …

The Feminist Impostor Phenomenon Approach (Fipa): A Feminist Approach To Addressing Impostor Phenomenon In Novice Counselors, Isabel Springer, Kelly Emelianchik-Key

Journal of Counselor Preparation and Supervision

Impostor Phenomenon (IP) is known to affect new professionals in health professions, yet there is little to no academic literature available on how it affects early career counselors and how it can be addressed. Novice counselors (NC) frequently experience extreme anxiety and feelings of fraudulence around their professional performance. Feminist mentorship and interventions can help alleviate IP and foster self-efficacy and confidence in new counseling professionals. The Feminist Impostor Phenomenon Approach (FIPA) consists of a three-hour workshop educating participants through a feminist lens about IP and relevant coping strategies, and subsequent weekly consciousness-raising groups where coping strategies are reinforced, and …

Seismic Behavior Of Slender Cable-Supported Braced Frame Structures, Aya Aboelnaga, Mohamed Mortagi, Mohamed E. El Madawy, A.H.A. Abdelrahman, M. Naguib

Mansoura Engineering Journal

This research investigates advanced strategies to enhance the seismic performance and global stability of slender steel frames by integrating cable-supported and braced systems. To address these challenges, the study develops finite element (FE) models of multi-story slender frames in SAP2000, incorporating both cable-supported configurations and diagonal bracing systems. Nonlinear time-history analyses are performed using selected earthquake ground motions to evaluate structural response, inter-story drift, and mode shape behavior. Results highlight the efficiency of cablesupported frames in controlling lateral displacements and redistributing forces, while also emphasizing the role of bracing in providing additional stiffness. The findings demonstrate that guided frames with …

Encounter: Erik Larson 2

Creative Nonfiction Magazine

No abstract provided.

The Discovery Of My Father’S Gun, Ester Bloom

Creative Nonfiction Magazine

No abstract provided.

Six Ways Of Looking At A Car Crash, Christopher Mohar

Creative Nonfiction Magazine

No abstract provided.

The Addict, Lacy M. Johnson

Creative Nonfiction Magazine

No abstract provided.

Grave Robber: A Love Story, Joyce Marcel

Creative Nonfiction Magazine

No abstract provided.

Speaking Of Ears And Savagery, Steven Church

Creative Nonfiction Magazine

No abstract provided.

Encounter: Erik Larson 1

Creative Nonfiction Magazine

No abstract provided.

Quotidian Nonfiction, Patrick Madden

Creative Nonfiction Magazine

No abstract provided.

A Murderer’S Work, J. Nicholas Geist

Creative Nonfiction Magazine

No abstract provided.

Blot Out, Colleen Kinder

Creative Nonfiction Magazine

No abstract provided.

Then & Now, Adam Regn Arvidson

Creative Nonfiction Magazine

No abstract provided.

Exogenous Myrosinase From Mustard Seed Increases Bioavailability Of Sulforaphane From A Glucoraphanin-Rich Broccoli Seed Extract In A Randomized Clinical Study, Angela Mastaloudis, Lola Holcomb, Jed W. Fahey, Camila Olson, David C. Nieman, Colin Kay, Robert O'Donnell, Alessandra Pecorelli, Marissa Kinney, Yanyan Li, Suzanne L. Ishaq, Giuseppe Valacchi

Pharmacy Faculty Scholarship

Inactive glucoraphanin (GR) in broccoli is converted to the antioxidant, anti-inflammatory, and anti-bacterial sulforaphane (SF) by cruciferous vegetable enzyme myrosinase (Myr), or similar enzymes from specific gut bacteria; both sources have variable efficiency. The effects of exogenous Myr on the conversion efficiency of GR to SF was compared to gut microbial Myr-like activity. In a randomized, double-blind, crossover study, sixteen subjects (9 F: 7 M) received a single oral dose of GR in broccoli seed extract with Myr-containing mustard seed powder, or broccoli seed extract alone, both with ascorbic acid. GR + Myr, on average, doubled the bioavailability of SF …

Evolving Strategies In Prostate Cancer: Emerging Approaches And Unmet Needs From The Bridging The Gaps In Prostate Cancer Expert Panel, Rana Mckay, Benjamin Maughan, Alicia Morgans, Neal Shore, Evan Yu, Ravi Madan, Jacob Berchuck, Bradley Carthon, Steven Finkelstein, Leonard Gomella, Michael Gorin, Andrew Hahn, Stacy Loeb, Vivek Narayan, Daniel Petrylak, Charles Ryan, Karine Tawagi, Phuoc Tran, Tanya Dorff

Department of Urology Faculty Papers

BACKGROUND: The expansion of treatment options for prostate cancer (PC) has improved disease-specific and overall survival outcomes but has also raised questions about the optimal level of treatment needed for patients based on their individual prognosis and accounting for potential toxicity, incorporating quality of life considerations.

METHODS: A panel of experts met to discuss current controversies in the care of patients with PC across the disease continuum. Multidisciplinary experts review advances and persistent uncertainties in biomarker-guided assessment, imaging, and systemic therapy for prostate cancer. The discussion outlines priority gaps in evidence that must be addressed to optimize individualized patient care. …

The Indeterminacy Of Customary International Law, Mohamed Diaa Tawfik

Theses and Dissertations

This thesis explores the judicial formation of customary international law and examines how international courts oscillate between interpretive and law-making functions. It analyzes key theoretical frameworks—including Kelsen’s Pure Theory of Law, Dworkin’s Law as Integrity, Kennedy’s radical indeterminacy, and Koskenniemi’s Descending-Ascending Approach—to understand how courts assert and shape customary norms beyond mere state practice and opinio juris. The work concludes that the International Court of Justice and other tribunals increasingly act as de facto lawmakers under the guise of interpretation, advocating the indeterminacy they try to avoid.

Reconfiguring The Category Of 'Sudan' Through The Literary Field: Representation, Disposability, Ambiguity And The 'Magical' In Four Post-Colonial Novels (2002-2022), Mourad Farahat

Theses and Dissertations

In this thesis I shall argue that contemporary African literature, with ‘’both its ethnographic imagination and anthropological complexity’’ (Orock, 2022, p.3), its use of ‘disruptive’ characters, and its focus on the embeddedness of the ‘collective’, the ‘common’ and the ‘vulgar’ in the personal (Mbembe, 2003), may help us mitigate some social scientific limitations on the study of Africa, and may aid us in understanding relations of power within the post-colony. I seek to show how contemporary Sudanese literature has already moved beyond the fixed social categories, lines, and limits which dominate some of the social scientific literature on Sudan. Literature …

Uncovering Potential Therapeutic Targets For Spinal Cord Injury; Insights From Single-Cell And Cross-Species Transcriptomics, Sara Samy Abouzekry

Theses and Dissertations

Central nervous system (CNS) injury remains a devastating healthcare problem. Despite years of research, it remains almost impossible to achieve meaningful functional repair following traumatic brain injury (TBI) and spinal cord injury (SCI). Spinal cord injury (SCI), a highly devastating subset of CNS trauma, is considered a challenge due to the extremely limited regenerative capacity of the nervous system in adult mammals. In contrast, certain species display remarkable repair abilities followed by moderate regenerative ability in neonatal mammals, indicating that regeneration is shaped by the evolutionary context as well as the developmental age.

To uncover the core molecular mediators of …

Research As A Reciprocal Act: How Rural Grade 5 And 6 Co-Researchers Transformed Their Adult Research Mentors, Bonnie Stelmach, Leah Peters, Rae Ann Van Beers

The Qualitative Report

Including children and youth in research contributes to their academic and life skills development, but how do co-researching experiences transform adult mentors?  Walkerdine (1997) stated that research “provides not only ways of seeing others, but ways of understanding ourselves” (p. 15). In this spirit, we report on our experiences to share how co-researching with eight Grade 5 and 6 students in a rural K-9 school in Alberta, Canada, which gave us insights into research and teaching assumptions and practices. Data were collected from observations of the students co-conducting interviews with K-6 research participants, students’ self-assessments of their co-researching experiences, transcripts …

A Learning Model For Effective Literacy Instruction In Diverse Papuan Contexts, E. Oos M. Anwas, Anggi Afriansyah, Muhammad Mulyadi, Dwi Purwoko, Zulfikri Anas, Virgiawan Listanto, Dini Dwi Kusumaningrum, Fikri Muslim, Dayu Rifanto

The Qualitative Report

This study seeks to address the persistent challenge of low literacy rates among Papuan primary school children by answering the research question: What factors hinder literacy development, and how can a holistic learning model improve literacy outcomes in this context? Conducted in Keerom and South Manokwari Regencies, the research adopts a qualitative approach to design an inclusive and effective learning model. The study involved a multi-stakeholder approach, engaging primary school students, educators (teachers and principals), parents, community leaders (village heads, religious leaders, and traditional leaders), government officials (education office and local government), legislative representatives (DPRD members), and academic experts from …