Digital Commons Network^™

Biophysical Characterization Of Phlip And Phlip-Cargo Conjugates Developed For Imaging And Therapy, Hannah Visca

Open Access Dissertations

Acidity is considered an alternative biomarker for targeting diseased tissues, such as in the acute phase of inflammation or tumors with poor prognosis. The family of pH Low Insertion Peptides (pHLIPs) are known markers of tissue acidity which provide a useful method for the diagnosis and/or treatment of disease by extracellular or intracellular delivery of imaging agents or therapeutic molecules. In my research, I employ fluorescence and CD spectroscopic techniques to understand how pHLIP's pH-dependent interactions with and insertion into the lipid bilayer of the cell membrane are affected by its sequence and conjugation with cargo and how this correlates …

The (Mis)Formation Of Identity In Joseph Conrad’S Novels: Ideology, Community, And The Self, Youngji Cho

Open Access Dissertations

Joseph Conrad’s Heart of Darkness, Nostromo, and The Secret Agent contain two broad themes: on the one hand, they critically portray the dominant influence of society or societal ideologies on the individual from a socio-political standpoint; on the other hand, they focus on the (dis)illusion of the protagonists regarding their own “ideal” identities from a personal standpoint. Rather than addressing one or the other, as many previous studies of Conrad’s novels have done, this dissertation argues for the intimate continuity between socio-political ideologies and personal identity by finding the point of contact between these two seemingly disparate issues. …

Computational Close Reading: A Critique Of Digital Literary Methodology, Damiano Consilvio

Open Access Dissertations

Computational Close Reading intervenes in digital humanities and American literary scholarship to negotiate a significant institutional and disciplinary problem: the devaluation of close reading and interpretation in digital humanities applications to literary studies in favor of more distant modes of reading. To remedy this issue, I pursue a core question meant to bring the literary and the digital into a more perfect confluence, as a demonstration of possibilities meant to run counter to these preconceptions about computational reading: how “close,” if close at all, can digital technologies bring us to the interpretive elements of literary texts? I argue that they …

Clonal Diversity, Antibiotic Resistance, And Virulence Factor Prevalence Of Community Associated Staphylococcus Aureus In Southeastern Virginia, Katelyn D. Cranmer, Mohan D. Pant, Suzanne Quesnel, Julia A. Sharp

EVMS School of Health Professions Faculty Publications

Staphylococcus aureus is a significant human pathogen with a formidable propensity for antibiotic resistance. Worldwide, it is the leading cause of skin and soft tissue infections (SSTI), septic arthritis, osteomyelitis, and infective endocarditis originating from both community- and healthcare associated settings. Although often grouped by methicillin resistance, both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains are known to cause significant pathologies and injuries. Virulence factors and growing resistance to antibiotics play major roles in the pathogenicity of community-associated strains. In our study, we examined the genetic variability and acquired antibiograms of 122 S. aureus clinical isolates from SSTI, blood, and urinary …

How The Supreme Court Ghosted The Phosita: Amgen And Legal Constructs In Patent Law, Timothy R. Holbrook, Mark D. Janis

Articles by Maurer Faculty

This Essay is an invited response to The Ghost in the Patent System: An Empirical Study of Patent Law’s Elusive “Skilled Artisan,” by Professors Laura Pedraza-Fariña and Ryan Whalen. In their piece, Pedraza-Fariña and Ryan Whalen offer an empirical study and use it to argue for a new conception of the Person Having Ordinary Skill in the Art (“PHOSITA”), patent law’s nod to the “reasonable person” construct.

As Professors Pedraza-Fariña and Whalen suggest, the PHOSITA should be understood as a crucial concept in patent law, warranting more scholarly attention. Pedraza-Fariña and Whalen provide that attention. They assert, based on an …

2022-23 Annual Report, Tennessee. Wildlife Resources Agency

Annual Reports

This annual report presents an overview of the Tennessee Wildlife Resources Agency programs and management.

Application Of Metagenomic And Molecular Microbiology Techniques To Elucidate Sources Of Fecal Pollution And Anthropogenic Antibiotic Resistance Genes To Surface Water: A Step Towards A “One Health” Approach To Watershed Management, Mehedi Hasan Tarek

Graduate Theses, Dissertations, and Problem Reports (ETD)

The use of fecal indicator bacteria, such as Escherichia coli, is a widely established regulatory and monitoring practice to detect surface water contamination associated with fecal pollution. However, the detection or quantification of fecal indicator bacteria alone does not accurately inform the sources of fecal pollution. The development of molecular and metagenomic methods that target the DNA of microorganisms has resulted in a host of new tools for monitoring fecal pollution and its sources, as well as for understanding emerging microbial threats, such as antimicrobial resistance. Antimicrobial resistance is a critical “One Health” challenge presenting a high risk to …

Shear Bond Strength Comparison Of Bioceramics To Root Dentin., Yasmin Alma Hoffman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: The purpose of this study is to compare the push-out bond strength of four bioceramic materials to root dentin that are used during regenerative endodontics. The bioceramics being tested are: 1. Biodentine®(Septodont); 2. EndoSequence BC Putty Fast Set® (Brasseler); 3. NeoPutty® (Avalon Biomed); and 4. ProRoot MTA White® (Dentsply). A high bond strength of a bioceramic material to root dentin will provide excellent seal. An improved seal may correlate with less potential for contamination of the pulp space that is undergoing regenerative activity. This in turn will lead to long-term clinical success. The null hypothesis is that there is …

Forage Grass Growth Habit And Allelopathy In Birdsfoot Trefoil Germination And Establishment, Nathan El Blake

Graduate Theses, Dissertations, and Problem Reports (ETD)

Birdsfoot trefoil (Lotus corniculatus L.) (BFT) is a high quality, tanniniferous forage legume that has been shown to mitigate gastrointestinal nematode (GIN) infection in sheep. Reliable establishment of birdsfoot trefoil in existing pastures is difficult due to BFT’s poor seedling vigor, susceptibility to crown and root rot, and, perhaps chiefly, competition from other pasture plants. Most existing pastures in the Northeastern United States are primarily composed of cool-season grasses, many of which can be highly competitive. A common form of interplant competition is allelopathy, which occurs when secondary metabolites produced by a plant inhibit a necessary growth process of …

Analysis Of Experimental Antimicrobial Prevention Strategies Against Microbial Contamination Of Locally Harvested Poultry And Produce In West Virginia, Rebecca Breanne Stearns

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fresh produce and poultry have been associated with several foodborne illness outbreaks. Strategies to mitigate these risks are a much-needed research priority; therefore, five experiments were conducted to analyze pathogen cross-contamination capabilities on produce and poultry. Microbial contamination prevention and reduction strategies were also studied.

In Chapter Two, three antimicrobial delivery methods in combination with increasing concentrations of hydrogen peroxide-peroxyacetic acid (H₂O₂-PAA) (0.05-0.25 ml/dL) were compared to evaluate their ability to reduce and prevent cross-contamination of Listeria monocytogenes (L. monocytogenes) and Listeria innocua (L. innocua) on inoculated apples. Apples have been …

“Courting Anarchy”: Roman Catholic Diocese Of Brooklyn V. Cuomo (2023), Shannon Leonard

UIC Law Review

No abstract provided.

Ce 432 Syllabus: Stress Management, Karen Cathey

Counselor Education Syllabi

This course will provide an introduction to important concepts, issues, skills, and interventions related to the identification and management of personal stress.

Ce 611 Syllabus: Development Over The Lifespan, Anquinetta V. Calhoun

Counselor Education Syllabi

The purpose of this course is to promote students’ thinking and learning about human growth, adaptation, and change throughout the lifespan. Major theories, issues, eras, and trends in human development will be addressed.

The Right To Personality: Navigating The Brave New World Of Personality-Altering Interventions, Christopher S. Sundby

Connecticut Law Review

As neuroscience progresses, policy makers will have an increasing arsenal of behavior-modifying interventions at their disposal to deploy in the hopes of reducing recidivism and making the criminal justice system more rehabilitative. While these interventions are promising, they also can pose grave risks to individual liberty interests that are insufficiently acknowledged, much less protected, by current jurisprudence. Specifically, the current legal regimes and proposed alternatives either fail to identify the nature of the liberty at stake by overly focusing on physical side effects to the exclusion of thought- and personality-altering side effects, reject completely the potential for these interventions to …

Resilience Grammar: A Value Sensitive Design Method For Resilience Thinking, David G. Hendry, Batya Friedman

Tech Policy Lab

The resilience grammar is a method for bringing a value sensitive design sensibility to resilience thinking. The method provides a systematic process for researchers, designers, and policymakers to identify and trace resilience pathways in the context of real world responses to stressors and obstacles. The grammar is composed of seven statement types, which bring forward aspects of resilience. Each statement type is composed of a connecting phrase and an element, in the form of “resilience connecting-phrase .” In this report, we define each statement type in the resilience grammar, provide two brief illustrations of the grammar in action, and conclude …

Tattoos, Norms, And Implied Licenses, Aaron Perzanowski

Minnesota Law Review Headnotes, Vols. 107 onward (2022-present)

No abstract provided.

The Battle For The Soul Of The Gdpr: Clashing Decisions Of Supervisory Authorities Highlight Potential Limits Of Procedural Data Protection, Jordan Francis

Minnesota Law Review Headnotes, Vols. 107 onward (2022-present)

No abstract provided.

Narrative Report Of The Town Officers Of Amherst, New Hampshire, For The Year Ending December 31, 2022, And Financial Records For Fiscal Year Ending June 30, 2022., Amherst Town Representatives

Amherst, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Temple, New Hampshire 2022 Annual Report For The Year Ending December 31, 2022., Temple Town Representatives

Temple, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Annual Report Of The Town Office Of Dalton, New Hampshire For The Year Ending December 31, 2022, Dalton Town Representatives

Dalton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Annual Reports Of The Selectmen, Treasurer, Collector Of Taxes, Town Clerk, Trustees Of The Trust Funds, All Other Town Officers, And The School Board Of The Town Of South Hampton, Nh, For The Year Ending December 31st, 2022, South Hampton Town Representatives

South Hampton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

City Of Berlin, Nh, Annual Report, Fiscal Year July 1, 2021 To June 30, 2022., Berlin Town Representatives

Berlin, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Town Of Colebrook Annual Town Report Year Ending December 31, 2022., Colebrook Town Representatives

Colebrook, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

The Effectiveness Of The Teaching Interaction Procedure For Young Children With Developmental Delay, Bailey Nicole Swain

Dissertations and Theses

Developmental Delay (DD) is an IDEA classification for young children who fail to meet developmental milestones at typical times. Young children with delays in social or emotional development may show deficits in social skills. Noting the importance of early intervention, identifying effective social skills interventions for children aged 3-5 is essential. Kopp et al. (1992) note the differences in social skills between preschoolers with DD and typically developing peers. This study investigated the effects of the Teaching Interaction Procedure on skill acquisition and generalization to a free play activity in the general education classroom.

Teen Appeal, Memphis, 04.04, 2000

Documents

Issue 4.4 of the “Teen Appeal” published by the University of Memphis Journalism Department and Commercial Appeal, Memphis, Tennessee, on December 5, 2000.

Dynamic Luminescence Of Lead Doped Calcium Zinc Germanate For Anti-Counterfeiting, Levi Spencer

Dissertations and Theses

As counterfeited goods appear in the consumer market through various trade routes, unsuspecting buyers are left with products that are potentially dangerous and in poor quality. Products intended for the automotive and aerospace industry are often counterfeited due to their easy market accessibility. Once these products make their way into the supply chain, it leaves the end users with a significant risk due to voided warranties and inferior product quality and design. Therefore, advanced anti-counterfeiting measures need to be developed to assure the products are genuine, as well as allow the end users to authenticate the product. Luminescent materials have …

Submission Of Amici Briefs In Arbitration Related To Environmental Concerns: Developing A Better Framework For Their Consideration Under Icsid Rule 37(2), Clarissa Galaviz Lizarraga

Northwestern Journal of International Law & Business

This note examines the consideration of amicus curiae briefs in international arbitration matters under the International Centre for Settlement of Investment Disputes (“ICSID”), specifically focusing on arbitration cases involving environmental concerns. The note explores trends in consideration of amicus briefs in environmental arbitration by taking a historical look at cases and the rationales behind the decisions of the tribunals to consider amicus briefs and raises concerns regarding a better, uniform approach to amicus briefs.

To achieve a better system of consideration of amicus briefs when environmental concerns are at play, given their public and ecologic interest, the author suggests reworking …

Ruffled: Examining Feminism & Femininity Through Animation, Savannah Berry

Electronic Theses and Dissertations, 2020-2023

The animated short film Ruffled confronts the subjects of Feminism and Femininity through the after-hour musings of a young seamstress. Sewing to patterns and working from their papered paradigms she discovers her unique voice that is both referential of the past while remaining distinctly modern. The struggle twenty-first century Feminists may encounter when determining their place within a history rich with prejudice, confrontation, and triumph is metaphorically represented in each of the character's attempts at garment creation. Within the film, not only does this clothing harken back to vintage apparel but whimsically transforms her surroundings to reflect three visually distinct …

Preclinical Assessment Of Psychoplastogens For Treatment Of Psychiatric Symptoms And Neuroplasticity Deficits In Huntington Disease, Nicholas Skiados

Electronic Theses and Dissertations, 2020-2023

Huntington disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD manifests as a triad of psychiatric, cognitive, and motor symptoms, the latter of which defines symptomatic onset of the disease. Psychiatric symptoms including aggression and depression often emerge decades prior to motor symptom onset. Psychiatric disorders are closely linked with dysregulated neural plasticity, the ability of the brain to form new synaptic connections. Neural plasticity is impaired in HD, potentially playing a role in psychiatric symptoms. However, the association between plasticity and psychopathology in HD has yet to be thoroughly …

A Pilot Study Of An Immersive Folktale User Experience, Iulia Popescu

Electronic Theses and Dissertations, 2020-2023

Immersive media provides new avenues for preserving and sharing traditional folktales. To keep up with modern generations and continue to cultivate an interest in the arts as well as different cultures, this researcher argues that storytellers need to keep on adapting by conveying stories in new ways. Virtual Reality (VR) offers an interesting medium to present and preserve folktales. The goal of this study is to evaluate the user and learner experience of an immersive digital media application design using a think aloud protocol, surveys, and tests to document what worked and what did not in the design, including if …