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Inhibition Of The Mtor Signaling Pathway In Clear Cell Renal Cell Carcinoma Cells, Samaneh Farimand

Theses, Dissertations and Capstones

The mammalian target of Rapamycin (mTOR) is a Serine/threonine kinase that is found in two large protein complexes that are known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Torin 1 is an ATP-competitive inhibitor of mTOR that inhibits mTOR activity in both mTORC1 and mTORC2. In this study, we hypothesized that dual inhibition of mTORC1 and mTORC2 with Torin 1 promotes the apoptosis of clear cell renal cell carcinoma cells. The human clear cell renal cell cancer line, 786-0, was treated with Torin 1, and markers of apoptosis, including PARP, Caspase 3, and Caspase 9, and their …

My Travels In Southeast Asia Summer Of 1977, Joanne Besonen

Books

No abstract provided.

The Geology Of El Paso, William Cornell, Diane Doser, Richard Langford, Joshua Villalobos, Jason Ricketts

Books & Monographs

The Geology of El Paso describes the history of El Paso, Texas and its surrounding region from the Precambrian formation of the continent to the modern use of geologic resources. This book is written in an easy to digest format, with definitions or links for specific geologic terms and references for further reading. It reviews the formation and evolution of local landmark features such as the Franklin Mountains, Cerro Cristo Rey, and the Sierra de Juarez. Fossils and stratigraphic units of the El Paso area are described as well as important geologic features. The book puts the events that shaped …

The Widow Of Malabar: A Digital Edition, Mariana Starke

OER Student Projects

Mariana Starke’s The Widow of Malabar (1791) is a tragedy set on India’s Malabar Coast. The play depicts a widow reluctantly preparing to commit sati (the practice of a widow immolating herself on her husband’s funeral pyre). She becomes the point of contention in a conflict between a Hindu Brahmin and her former lover, the general leading an invading British force. Throughout the play, the Brahmins are portrayed as vicious barbarians, the British as noble harbingers of a more civilized way of life. The Widow of Malabar thus provides a valuable look into British views of India (and of its …

Monitoring Blood Flow In Animal Models Using A Camera-Based Technique, Dharminder Singh Langri

Browse all Theses and Dissertations

Blood flow dynamics plays a critical role in maintaining tissue health, as it delivers nutrients and oxygen while removing waste products. It is especially important when there is a disruption in cerebral autoregulation due to trauma, which can induce ischemia or hyperemia and can lead to secondary brain injury. Thus, there is a need for noninvasive techniques that can allow continuous monitoring of blood flow during intervention. Optical techniques have become increasingly practical for measuring blood flow due to their non-invasive, continuous, and relatively lower-cost nature. This research focused on developing a low-cost, scalable optical technique for measuring blood flow …

Unpacking Chemistry Teachers’ Pedagogical Reasoning And Decisions For A Phet Simulation: A Tpack Perspective, Xiaoyang Gong, Bing Wei, Bradley W. Bergey, Ebony Terrell Shockley

Publications and Research

Computer simulations hold great potential for enhancing chemistry instruction. However, effectively integrating simulations in instruction depends in part on teachers’ pedagogical reasoning about simulation affordances and instructional decisions within specific classroom contexts. The objective of this study was to investigate how two chemistry teachers evaluated an interactive simulation and determined pedagogical strategies for integrating the simulation into classroom instruction. Based on the TPACK framework, authors adopted a comparative case study approach to interpret qualitative data from three sources: screen-capture videos, interviews, and instructional plans. Results showed that pedagogical reasoning and decisions of the two participants reflected different TPACK components. One …

Western Buddhism And Transpersonal Psychology: Cross-Hermeneutic And Engaged Approaches, Debashish Banerji

International Journal of Transpersonal Studies

Contemporary Buddhism has been fashioned from cross-cultural interactions between a long history of Asian traditions and the expansionist drive of modernity. As part of this engagement, Buddhism, particularly in the West, has developed a close relation with transpersonal psychology. This essay forms an introduction to the special issue of articles approaching this relation between Buddhism and psychology in different ways. While some articles probe the difference in aims of the two disciplines, some are concerned with the decontextualized uses of Buddhist techniques such as mindfulness, some explore the possibilities of Buddhist practice in cognitive or other psychological terms and some …

Zen And The Art Of Doughnut Economics: When Limits Are Strangely Liberating, Peter Doran

International Journal of Transpersonal Studies

Kate Raworth's celebrated book, Doughnut Economics: Seven ways to think like a 21st century economist, calls for a reconciliation of our design principles for society and the economy with the rhythms and tolerances of ecological systems. It will demand something akin to a new axial revolution that will have to be experienced as much in the body and in the intimacies of a renewed care and appreciation for our relational and ecological selves as in the collective re-design of our societies, democratic decision-making and collective provisioning. Buddhist scholarship offers a distinctive contribution to this conversation invoked in a book that …

Agricultural Dust Derived Bacterial Extracellular Vesicle Mediated Inflammation Is Attenuated By Dha, Art J. Heires, Derrick R. Samuelson, Daniel Villageliu, Tara M. Nordgren, Debra J. Romberger

Journal Articles: Pulmonary & Critical Care Med

Dietary long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and their pro-resolving metabolites are protective against atherosclerotic disease, and ameliorate systemic inflammatory conditions including lupus erythematosus, psoriasis, and bronchial asthma. Organic bioaerosol inhalation is a common and injurious hazard associated with agricultural occupations such as work in swine concentrated animal feeding operations (CAFOs) and is known to increase the risk for developing respiratory conditions such as asthma and COPD. Nearly all cells secrete membrane-bound vesicles (extracellular vesicles, EVs) that have the capacity to transmit protein, nucleic acid, and lipid signaling mediators between cells. Using a polymer-based isolation technique (ExoQuick, PEG) followed …

Gender Bias In Story Recounting, Cecilia Garcia, Zali White, Keeley Trainer, Madison Oliver

[Archive] Belmont University Research Symposium (BURS)

Gendered language permeates sections of our lives in ways that we may not realize. Previous research indicates a relationship between biases and gendered language; however, it has primarily been conducted with children as the participants rather than adults (Seitz, et al., 2020). This study aimed to investigate this and identify the relationship between gendered language and implicit bias. Passages using gendered language can alter the listener's perspective in terms of the gender identification of an otherwise unlabeled protagonist. Therefore, to explore this phenomenon, participants of this study were given an androgynous story with masculine and feminine phrases. Then, a multiplication …

The Crossroad Of Hamsters, Robots & Electropop, Olivia Crimivaroli

[Archive] Belmont University Research Symposium (BURS)

Kia Corporation is an automobile manufacturer based in South Korea, who produces and sells vehicles with one of the most well known of their models being the Kia Soul. There are a number of factors that contribute to the Soul being a well known car but one of the biggest reasons is because of the infamous and out-of-the-box commercials that have been crafted in order to promote this style of car. This critique will encompass the contents of one commercial released in 2012 in an attempt to stimulate sales for this specific model of the Kia Soul. This advertisement is …

Zephyrus, Western Kentucky University

Student Creative Writing

The fine arts magazine of Western Kentucky University at Bowling Green.

Newhouse Impact Magazine 2023, Newhouse School

Newhouse Impact Magazine

Showcasing the research and creative work of faculty, staff and students at the Newhouse School

Review Of The Central And South Atlantic Shelf And Deep-Sea Benthos: Science, Policy, And Management, Amelia E.H. Bridges, Kerry L. Howell, Teresa Amaro, Lara Atkinson, David K. A. Barnes, Narissa Bax, James B. Bell, Angelo F. Bernardino, Lydia Beuck, Andreia Braga-Henriques, Angelika Brandt, María E. Bravo, Saskia Brix, Stanley Butt, Alvar Carranza, Brenda L. Doti, Isa O. Elegbede, Patricia Esquete, André Freiwald, Sylvie M. Gaudron, Maila Guilhon, Dierk Hebbeln, Tammy Horton, Paulus Kainge, Stefanie Kaiser, Daniel Lauretta, Pablo Limongi, Kirsty A. Mcquaid, Rosanna J. Milligan, Patricia Miloslavich, Bhavani E. Narayanaswamy, Covadonga Orejas, Sarah Paulus, Tabitha R. R. Pearman, Jose Angel A. Perez, Rebecca E. Ross, Hanieh Saeedi, Mauricio Shimabukuro, Kerry Sink, Angela Stevenson, Michelle Taylor, Jürgen Titschack, Rui P. Vieira, Beatriz Vinha, Claudia Wienberg

Marine & Environmental Sciences Faculty Books and Book Chapters

128 129The Central and South Atlantic represents a vast ocean area and is home to a diverse range of ecosystems and species. Nevertheless, and similar to the rest of the global south, the area is comparatively understudied yet exposed to increasing levels of multisectoral pressures. To counteract this, the level of scientific exploration in the Central and South Atlantic has increased in recent years and will likely continue to do so within the context of the United Nations (UN) Decade of Ocean Science for Sustainable Development. Here, we compile the literature to investigate the distribution of previous scientific exploration of …

Additional Information - Vicky Batcher Inerview, Urban Green Lab, Tennessee State University

Hear from Vicky Batcher - Nashvillian Who has Experienced Homelessness

No abstract provided.

Charitable Giving_ The Basics To Advanced Applications, Indiana Continuing Legal Education Forum (Iclef)

Indiana Continuing Legal Education Forum 2023

Meeting proceedings of a seminar by the same name, held April 26, 2023.

90 Hot Tips In Estate, Trust And Probate Practice, Indiana Continuing Legal Education Forum (Iclef)

Indiana Continuing Legal Education Forum 2023

Meeting proceedings of a seminar by the same name, held December 20, 2023.

Scurvy And The Ontology Of Natural Kinds, P.D. Magnus

Philosophy Faculty Scholarship

Some philosophers understand natural kinds to be the categories which are constraints on enquiry. In order to elaborate the metaphysics appropriate to such an account, I consider the complicated history of scurvy, citrus, and vitamin C. It may be tempting to understand these categories in a shallow way (as mere property clusters) or in a deep way (as fundamental properties). Neither approach is adequate, and the case instead calls for middle-range ontology: starting from categories which we identify in the world and elaborating their structure, but not pretending to jump ahead to a complete story about fundamental being.

Annual Wild Turkey Status Report 2023, Tennessee. Wildlife Resources Agency

Annual Wild Turkey Status Reports

This document reports on the status of wild turkeys for hunting in spring, fall, and summer.

45th Annual Judge Robert H. Staton Indiana Law Update, Indiana Continuing Legal Education Forum (Iclef)

Indiana Continuing Legal Education Forum 2023

Meeting proceedings of a seminar by the same name, held September 21-22, 2023.

The Best Children's Books Of 2023: Holiday Gift Edition, Bank Street College Of Education. Children's Book Committee

The Center for Children's Literature

Notable titles that have captured the attention of Children's Book Committee members just in time for the holidays!

Influences Of Host Cytokine Signaling On Kshv Infection In Tonsil-Derived B Lymphocytes, Nedaa Alomari

Pharmaceutical Sciences (PhD) Dissertations

Kaposi sarcoma-associated herpesvirus (KSHV) is the etiologic agent of kaposi sarcoma. It is also associated with the B cell lymphoproliferative disorders, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). Existing research reveals that KSHV has developed numerous strategies to alter host cytokine signaling activities to facilitate viral persistence and escape host immune surveillance.

Despite three decades of research, there are still many questions in this field awaiting further investigation. This dissertation will investigate host cytokines as factors influencing the establishment of KSHV infection in the human tonsil. We have identified and characterized different cytokines …

Community In A “Conflict System”: A Case Study Of Facilitating Conflict In Nature Conservation, Gwendolyn Smith, Elena P. Bastidas, Russel Mittermeier, John Goedschalk, Rachelle Bong A Jan, Karin Lachmising, Lindsay Goossens

Conflict Resolution Studies Faculty Articles

Forest conservation has long faced conflicts between traditionally-living indigenous peoples and other more modern stakeholders. Often such conflicts are rooted in differences between the perceived interests of indigenous peoples and other stakeholders, or in ineffective negotiations due to a power-disparity between involved stakeholders. Thus far conservationists have tried to overcome such conflicts by creating different types of collaborative management systems with indigenous peoples. Although co-management appears a good solution to guide all stakeholders towards a conservation target, in practice few such arrangements have proven successful. The co-management model offers a greater potential for success when it is approached as a …

Problem-Based Learning In Dentistry: Learner Satisfaction Survey, Manal Elhijazi, Ihsane Benyahya, Manal Elhijazi

Health Sciences

Background: Problem-based learning (PBL) is an active pedagogical approach based on self-directed learning that promotes knowledge retention and improves educational performance. Materials and methods: We have undertaken a first introduction of the PBL in conservative dentistry, with 91 volunteer students out of a total of 119 students in the 2nd year of dentistry at the Mohamed VI university of sciences and health (UM6SS) . The session was ended by a satisfaction survey through an anonymous and voluntary questionnaire with 4-level Likert scale. The descriptive statistical analysis was performed using SPSS version 23 software. Result: Students greatly appreciated the general concept …

Textures Of Purāṇic Transmission: A Contemporary Vernacular Exposition Of A Sanskrit Purāṇa, Sucharita Adluri Ms.

Philosophy and Religious Studies Department Faculty Publications

It is well known that, contrary to the transmission of the Vedas, the purāṇas continually incorporated ever more information as they circulated as oral texts for centuries. This flexible nature has led to their denotation along with epics as ‘fluid texts’ or textual and/or cultural ‘process[es]’. Integral to popular consumption of purāṇic lore were the exegetes—expounders who were trained in reciting and interpreting the purāṇas and who incorporated material both oral and written in their delivery in temples or other performance spaces. Bailey notes that ‘fully understanding the purāṇa as a cultural phenomenon in the development and transmission of Hindu …

Ok, Zoomer: Teaching Legal Research To Gen Z, Olivia R. Smith Schlinck

Library Staff Articles

Generation Z has entered law school. With each new generation comes new education preferences. While research on Gen Z in the legal academy has grown over the past few years, to date none deal explicitly with teaching legal research to Gen Z. This article connects Gen Z’s childhood and resulting peer personality to 10 tangible pedagogical changes for teaching legal research to Gen Z.

Uab Magazine - Spring 2023, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Introduction: Imagined And Real Ai, Michael Paulus

SPU Works

The increasing role and power of artificial intelligence in our lives and world require us to imagine and shape a desirable future with this technology. Since visions of AI often draw from Christian apocalyptic narratives, current discussions about technological hopes and fears present an opportunity for a deeper engagement with Christian eschatological resources. This book argues that the apocalyptic imagination can transform how we think about and use AI, helping us discover ways artificial agency may help us create a better world.

Town Of Haverhill, New Hampshire Annual Report 2022., Haverhill Town Representatives

Haverhill, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Fetal Alcohol Syndrome And Its Effects On Brain Development, Miriam Bayaz

The Science Journal of the Lander College of Arts and Sciences

Birth defects caused by maternal alcohol use during pregnancy, such as Fetal Alcohol Syndrome (FAS), are well-documented and preventable. The etiology, clinical characteristics, diagnosis, prevalence, and long-term effects of FAS are all covered in this paper’s thorough evaluation of the current state of knowledge. The teratogenic effects of alcohol on the growing fetus, as well as genetic, environmental, and maternal variables, all play a role in the complex etiology of FAS. A wide spectrum of physical, mental, and behavioral problems resulting from prenatal alcohol exposure on fetal development are discussed. FAS is characterized clinically by facial dysmorphology, growth retardation, central …