Digital Commons Network^™

Development Of Potent Nanosized Carbonic Anhydrase Inhibitor For Targeted Therapy Of Hypoxic Solid Tumors, Ekram Hany Mohamed, Wagdy M. Eldehna,, Mahmoud A. El Hassab, Nahla A. Abdelshafi,

Pharmacy

Overexpression of two carbonic anhydrase (CA) isoforms, CA IX and XII, in several hypoxic solid tumors provides an extracellular hypoxic microenvironment, interferes with extra- and intracellular pH regulation, thus favoring hypoxic tumor cell survival, proliferation and metastasis. In the current study, a selective inhibitor for human CA isoforms IX and XII (isatin-bearing sulfonamide, WEG-104), was incorporated into nanosized spherical niosomes at high encapsulation efficiency to allow for an enhanced and sustained antitumor activity. In vivo, administration of WEG-104 that is either free (10 mg/kg) or loaded into niosomes (5 mg/kg) into a mice model of Ehrlich ascites solid tumor resulted …

Polyethyleneimine Shell Nucleic Acid Nanostructures From Gold Nanoparticle Template For Chemotherapeutic Drug Delivery, Brendan Guy Rucci

Theses and Dissertations

The next generation of anticancer agents will emerge from rationally designed nanostructured materials. This work involved the synthesis and characterization of novel hollow DNA-conjugated gold nanoparticles (DNA-AuNPs) for controlled drug delivery. Polyethyleneimine (PEI) was bound to citrate-capped AuNPs, forming polymer-shell nanoparticles. Dissolution of the gold core via iodine formed hollow core polymeric nanoparticles (HCPPs) and a high density of DNA (85 molecules/particle) containing daunorubicin was conjugated. Particles were spherical with an average diameter of 105.7±17.3 nm and zeta potential of 20.4±3.54 mV. We hypothesize the DNA backbone electrostatically condensed to the primary amines on the surface of the particle toroidally, …

Quantification Of Localized Nad+ Changes Reveals Unique Specificity Of Nad+ Regulation In The Hypothalamus, Sean Johnson, Kiyoshi Yoshioka, Cynthia S Brace, Shin-Ichiro Imai

2020-Current year OA Pubs

Recently, it has become a consensus that systemic decreases in NAD

Crotona Ave. Assoc. L.P. V. Lynch

All Decisions

No abstract provided.

The Effect Of Spinal Muscle Fatigue And Psychosocial Factors On Pressure-Pain Threshold In Healthy Adults, Susan Mais, Jo Armour Smith

Physical Therapy Faculty Articles and Research

Objective. Pain sensitivity decreases following isometric exercise. It is not clear whether this exercise-induced hypoalgesia (EIH) occurs to the same extent in men and women. It is also unclear if the effect is systemic or local to the exercised musculature. The aim of our study was to investigate whether fatiguing isometric exercise of the spinal and hip extensors would result in increased pressure pain threshold (PPT) at sites local to and remote from the exercised muscles in healthy men and women and whether there is a relationship between central sensitization, psychosocial factors, and PPT. Subjects. 35 healthy adults …

Paternalism In International Human Rights Law, Lucas Lixinski, Noam Peleg

Duke Journal of Comparative & International Law

This article argues that international human rights law (IHRL) at a system-wide level produces paternalistic effects that undermine the work it is meant to do for rightsholders. Analyzing the work of four key United Nations human rights treaty bodies, we show how institutional arrangements exclude rightsholders from having a say on their own interests in what IHRL should mean for them, and we are instead left with a body of norms, guidelines, and institutions with self-serving dynamics that reinforce the position of IHRL institutions and only secondarily benefit rightsholders.

White Christian Nationalism Enters The Political Mainstream: Implications For The Roberts Court And Religious Freedom, Stephen M. Feldman

Seton Hall Law Review

No abstract provided.

A Major Answer To The Major Questions Doctrine, Edward L. Rubin

Vanderbilt Law School Faculty Publications

The Supreme Court’s use of the major questions doctrine in West Virginia v. Environmental Protection Agency to invalidate the agency’s regulation of greenhouse gas emission has elicited widespread criticism from commentators. David Driesen’s contribution to this chorus of condemnation goes to the heart of the issue, focusing on the role that the Supreme Court has arrogated to itself in reaching this decision.

The Court’s based its decision on the relationship between Congress and the Executive, speaking at length about the structural roles of these two institutions. What it forgot, as Professor Driesen notes, is that the Court is also an …

Learning From Buddhist Teachings And Ethical Practices In Qualitative Research, Pei-Jung Li

The Qualitative Report

This paper aims at conceptualizing research ethics in qualitative research with Buddhist teachings. As a Buddhist, I first introduce how Buddhism came to be central in my life and eventually influenced me as a qualitative researcher. I exemplify how the concepts of all-beings-are-equal, karma, the five precepts, and repentance might inspire a qualitative practice that centers ethics and informs a researcher’s interactions with participants. I suggest that researchers not only work on reflecting on their body (actions), speech (talk), and mind (thoughts) but more importantly, move beyond just reflection and reflexivity to facing and resolving “unwholesome” moments that may arise …

Beyond The Usual Suspects: Emerging Uropathogens In The Microbiome Age, Robert B. Moreland, Brian I. Choi, Wilson Geaman, Caroline Gonzalez, Baylie R. Hochstedler-Kramer, Jerrin John, Jacob Kaindl, Nikita Kesav, Jyoti Lamichhane, Luke Lucio, Malika Saxena, Aditi Sharma, Lana Tinawi, Michael E. Vanek, Catherine Putonti, Linda Brubaker, Alan J. Wolfe

Biology: Faculty Publications and Other Works

The advent of sensitive enhanced culture (metaculturomic) and culture-independent DNA-based (metagenomic) methods has revealed a rich collection of microbial species that inhabit the human urinary tract. Known as the urinary microbiome, this community of microbes consists of hundreds of distinct species that range across the entire phylogenetic spectrum. This new knowledge clashes with standard clinical microbiology laboratory methods, established more than 60 years ago, that focus attention on a relatively small subset of universally acknowledged uropathogens. Increasing reports support the hypothesis that this focus is too narrow. Single uropathogen reports are common in women with recurrent urinary tract infection (UTI), …

Inspection Assignment Form For Product Quality Control Using Neutrosophic Logic, Maissam Jdid, Florentin Smarandache, Said Broumi

Neutrosophic Systems with Applications

During the production process, production companies need to monitor the finished products and ensure their quality, which imposes on them the appointment of inspectors for auditing, and this appointment costs the company amounts that affect the general profit, so it strives to make this cost as low as possible and that the audit process is carried out with high accuracy because in case that the finished products do not conform to the basic specifications of the product, the company is required to pay a fine. In this research, we will formulate the text of the problem appropriately for such a …

Selective Infrared Neural Inhibition Can Be Reproduced By Resistive Heating, Junqi Zhuo, Chloe E. Weidrick, Yehe Liu, Michael A. Moffitt, Hillel J. Chiel, Michael W. Jenkins

Faculty Scholarship

Objectives: Small-diameter afferent axons carry various sensory signals that are critical for vital physiological conditions but sometimes contribute to pathologies. Infrared (IR) neural inhibition (INI) can induce selective heat block of small-diameter axons, which holds potential for translational applications such as pain management. Previous research suggested that IR–heating-induced acceleration of voltage-gated potassium channel kinetics is the mechanism for INI. Therefore, we hypothesized that other heating methods, such as resistive heating (RH) in a cuff, could reproduce the selective inhibition observed in INI. Materials and Methods: We conducted ex vivo nerve-heating experiments on pleural-abdominal connective nerves of Aplysia californica using both …

Gut Microbiota And Microbiota-Derived Metabolites Promotes Endometriosis, Sangappa B Chadchan, Sumanta K Naik, Pooja Popli, Chandni Talwar, Satwikreddy Putluri, Chandrasekhar R Ambati, Michael A Lint, Andrew L Kau, Christina L Stallings, Ramakrishna Kommagani

Faculty, Staff and Students Publications

Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the age 15 and 49 in the USA. However, currently there is no reliable non-invasive method to detect the presence of endometriosis without surgery and many women find hormonal therapy and surgery as ineffective in avoiding the recurrences. There is a lack of knowledge on the etiology and the factors that contribute to the development of endometriosis. A growing body of recent evidence suggests an association between gut microbiota and endometriosis pathophysiology. However, the direct …

Gut Microbiota And Microbiota-Derived Metabolites Promotes Endometriosis, Sangappa B Chadchan, Sumanta K Naik, Pooja Popli, Chandni Talwar, Satwikreddy Putluri, Chandrasekhar R Ambati, Michael A Lint, Andrew L Kau, Christina L Stallings, Ramakrishna Kommagani

Faculty, Staff and Students Publications

Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the age 15 and 49 in the USA. However, currently there is no reliable non-invasive method to detect the presence of endometriosis without surgery and many women find hormonal therapy and surgery as ineffective in avoiding the recurrences. There is a lack of knowledge on the etiology and the factors that contribute to the development of endometriosis. A growing body of recent evidence suggests an association between gut microbiota and endometriosis pathophysiology. However, the direct …

Engineered Protac-Cid Systems For Mammalian Inducible Gene Regulation, Dacheng Ma, Qichen Yuan, Fei Peng, Victor Paredes, Hongzhi Zeng, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Anika Patel, Megan S Liu, Zheng Sun, Xue Gao

Faculty, Staff and Students Publications

Gene regulation via chemically induced dimerization (CID) is useful for biomedical research. However, the number, type, versatility, and in vivo applications of CID tools remain limited. Here, we demonstrate the development of proteolysis-targeting chimera-based scalable CID (PROTAC-CID) platforms by systematically engineering the available PROTAC systems for inducible gene regulation and gene editing. Further, we show orthogonal PROTAC-CIDs that can fine-tune gene expression at gradient levels or multiplex biological signals with different logic gating operations. Coupling the PROTAC-CID platform with genetic circuits, we achieve digitally inducible expression of DNA recombinases, base- and prime-editors for transient genome manipulation. Finally, we package a …

Gut Microbiota And Microbiota-Derived Metabolites Promotes Endometriosis, Sangappa B Chadchan, Sumanta K Naik, Pooja Popli, Chandni Talwar, Satwikreddy Putluri, Chandrasekhar R Ambati, Michael A Lint, Andrew L Kau, Christina L Stallings, Ramakrishna Kommagani

2020-Current year OA Pubs

Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the age 15 and 49 in the USA. However, currently there is no reliable non-invasive method to detect the presence of endometriosis without surgery and many women find hormonal therapy and surgery as ineffective in avoiding the recurrences. There is a lack of knowledge on the etiology and the factors that contribute to the development of endometriosis. A growing body of recent evidence suggests an association between gut microbiota and endometriosis pathophysiology. However, the direct …

Degrowth And The Future Of Capitalism: A Critical Review Of Recent Literature, Larry Alan Busk

Emancipations: A Journal of Critical Social Analysis

No abstract provided.

From Extractivism To Adjacency. A Research Manifesto, Margarita Palacios, Anette Baldauf

Emancipations: A Journal of Critical Social Analysis

This essay concerns with the ways in which extractivism continues to be reproduced in academic frameworks despite innumerous initiatives of decolonization. Engaging with artistic research and embracing a materialist approach that emphasizes embeddedness and embodiment, as well as acknowledging the affective-aesthetic flows that accompany research, the authors locate the heart of the problem at the disjuncture between critical epistemology and research practices. This disavowed space of knowledge production, they argue, is where the logics of extractivism and its racialized epistemic dualism are reproduced. The authors put forward the notion of adjacency, as in their view, dwelling on the power of …

A Map To Ecosocialism, Marco Armiero, Erik Swyngedouw, Massimo De Angelis, Stefania Barca, Sutapa Chattopadhyay, Mina Lorena Navarro Trujillo, Theordore Steinberg, David N. Pellow, Salvotore Engel-Dimauro

Emancipations: A Journal of Critical Social Analysis

No abstract provided.

Materialism In The Anthropocene: A Critique Of The 'Domination Of Nature' In The Frankfurt School., Killian Favier

Emancipations: A Journal of Critical Social Analysis

No abstract provided.

Waste In The Limits To Capital: How Capitalism Lays Waste To The Web Of Life, And Why It Can’T Stop, Jason W. Moore

Emancipations: A Journal of Critical Social Analysis

No abstract provided.

Metabolite Profiling Of Premium Civet Luwak Bio-Transformed Coffee Compared With Conventional Coffee Types, As Analyzed Using Chemometric Tools, Mohamed A. Farag, Tarik A. Mohamed, Enas A. El-Hawary, Amr Abdelwareth

Faculty Journal Articles

No abstract provided.

The Indiana Statesman, January 24, 2023, Indiana State University

Student Newspaper

Roxane Gay to be next speaker in Speaker Series; Karaoke: Sycamores sang their hearts out last week in the HMSU; Police investigate single-car crash; How a man disarmed the Monterey Park shooter

The Influence Of Relational Aggression And Attachment Insecurity On Sexual Dissatisfaction: Using The Actor-Partner Interdependence Mediation Model, Min Xu Phd Lmft, Lee N. Johnson, Sarah M. Coyne

School of Leadership and Education Sciences: Faculty Scholarship

The majority of studies on couple aggressive behaviors have focused on more overt forms (e.g., intimate partner violence), while findings on covert patterns of aggression are lacking. This study aims to explore the direct and indirect effects of two types of relational aggression (i.e., love withdrawal and social sabotage) on sexual dissatisfaction, with attachment anxiety and attachment avoidance as the mediators. Participants were 324 married couples from a large northwestern city in the United States. Direct actor effects from love withdrawal were found for both partners, while direct actor effects from social sabotage were only found for husbands. Direct partner …

Tmem161b Modulates Radial Glial Scaffolding In Neocortical Development., Lu Wang, Caleb Heffner, Keng Ioi Vong, Chelsea Barrows, Yoo-Jin Ha, Sangmoon Lee, Pablo Lara-Gonzalez, Ishani Jhamb, Dennis Van Der Meer, Robert Loughnan, Nadine Parker, David Sievert, Swapnil Mittal, Mahmoud Y Issa, Ole A Andreassen, Anders Dale, William B Dobyns, Maha S Zaki, Stephen A Murray, Joseph G Gleeson

Faculty Research 2023

TMEM161B encodes an evolutionarily conserved widely expressed novel 8-pass trans- membrane protein of unknown function in human. Here we identify TMEM161B homozygous hypomorphic missense variants in our recessive polymicrogyria (PMG) cohort. Patients carrying TMEM161B mutations exhibit striking neocortical PMG and intellectual disability. Tmem161b knockout mice fail to develop midline hem- ispheric cleavage, whereas knock-in of patient mutations and patient-derived brain organoids show defects in apical cell polarity and radial glial scaffolding. We found that TMEM161B modulates actin filopodia, functioning upstream of the Rho-GTPase CDC42. Our data link TMEM161B with human PMG, likely regulating radial glia apical polarity during neocortical development.

Plant Production Of A Virus-Like Particle-Based Vaccine Candidate Against Porcine Reproductive And Respiratory Syndrome, Jordan T. Vanderburgt, Ondre Harper, Christopher P. Garnham, Susanne E. Kohalmi, Rima Menassa

Biology Publications

Porcine reproductive and respiratory syndrome (PRRS) is a disease leading to spontaneous abortions and stillbirths in sows and lowered life quality and expectancy in growing pigs. PRRS is prevalent worldwide and has significant economic impacts to swine industries around the globe. Co-expression of the two most abundant proteins in the viral envelope, the matrix protein (M) and glycosylated protein 5 (GP5), can produce a neutralizing immune response for the virus providing a potentially effective subunit vaccine against the disease, but these proteins are difficult to express. The goal of this research was to display antigenic portions of the M and …

Evaluation Of Pollination Traits Important For Hybrid Wheat Development In Great Plains Germplasm, Nicholas Garst, Vikas Belamkar, Amanda Easterly, Mary J. Guttieri, Hannah Stoll, Amir M. H. Ibrahim, P. Stephen Baenziger

Department of Agronomy and Horticulture: Faculty Publications

Hybrid wheat (Triticum aestivumL.) offers potential yield advantages over conventional inbred cultivars. For hybrid wheat to be a commercial success, the cost to produce the hybrid seed needs to be minimized. Although wheat is naturally selfpollinated, hybrid wheat seed production can be improved by increasing the amount and availability of pollen for cross-pollination. This research examined 19 pollination traits using the Hard Winter Wheat Association Mapping Panel for 3 years. Anther extrusion, pollen 50 date (date at which a genotype has 50% of spikes pollinating), plant height, and pollination duration (last spike pollen 50 date minus first spike …

Ancient Pathogens Provide A Window Into Health And Well-Being, Cecil M. Lewis Jr., Mercy Y. Akinyi, Sharon Dewitte, Anne C. Stone

Faculty Publications

This perspective draws on the record of ancient pathogen genomes and microbiomes illuminating patterns of infectious disease over the course of the Holocene in order to address the following question. How did major changes in living circumstances involving the transition to and intensification of farming alter pathogens and their distributions? Answers to this question via ancient DNA research provide a rapidly expanding picture of pathogen evolution and in concert with archaeological and historical data, give a temporal and behavioral context for heath in the past that is relevant for challenges facing the world today, including the rise of novel pathogens.

The End Of The “Chemical Imbalance” Theory Of Depression - What Now?, Austin Brown

Population Health Research Brief Series

For decades, those diagnosed with depression have been told they suffer from a “chemical imbalance.” This explanation involves neurotransmitters, such as serotonin, thought to be the main neurochemical responsible for major depressive disorders. Growing research challenges this theory and the need for medication therapies for depressive symptoms. This brief summarizes new findings examining the theory that depression is caused by a chemical imbalance and calls for healthcare professionals and patients to consider the market influences and social structures that impact health.

Jv Socratic Society Brings Philosophy Talk To Teens, Keith Testa

UNH Today Archive

No abstract provided.