Digital Commons Network^™

Co-Authorship Between Photographers And Portrait Subjects, Molly Torsen Stech

Vanderbilt Journal of Entertainment & Technology Law

work with the intent of merging their contributions into inseparable or interdependent parts of a unitary whole, the authors are considered joint authors. For photographic works, judicial precedent establishes that the creative contributions necessary to support a copyright claim include the author’s choices concerning elements such as lighting, pose, garments, background, facial expression, and angle. In many visual works, however, those creative elements are determined not solely by a photographer, but also by the subject, who can sulk or smile, stand with good posture or stoop, and be situated in full light or obfuscated by shadow, among many other options. …

Mooting Unilateral Mootness, Scott T. Macguidwin

Michigan Law Review

Several situations cause a case to be moot. These include settlement agreements, party collusion, changes in litigant status, and extrinsic circumstances thwarting the court from granting any relief. The final reason is unilateral mootness—when a defendant ends a lawsuit against a plaintiff’s wishes by giving them everything for which they ask. In practice, this allows defendants to strategically stop lawsuits when it is clear they are not going to win. By doing so, they prevent the court from handing down adverse precedent and preserve the opportunity to engage in similar behavior with impunity. Courts have established a series of mootness …

Economic Evaluation Of An Intervention To Prevent Adolescent Dating Violence (Me & You), Ellerie Weber, Melissa F Peskin, Christine M Markham, Ross Shegog, Elizabeth R Baumler, Robert C Addy, Jeff R Temple, Belinda Hernandez, Paula Cuccaro, Melanie A Thiel, Efrat K Gabay, Susan Tortolero Emery

Faculty, Staff and Student Publications

Me & You: Building Healthy Relationships (Me & You) is a multilevel, technology-enhanced adolescent dating violence (DV) prevention program that aimed to reduce DV among ethnic-minority, early adolescent, urban youth. A group-randomized control trial of Me & You, conducted with 10 middle schools from a large urban school district in Southeast Texas in 2014–2015, found it to be effective in reducing DV perpetration and decreasing some forms of DV victimization. Economic evaluations of DV interventions are extremely limited, despite calls for more economic analyses to be incorporated in research. We help fill this gap by evaluating the cost-effectiveness from the …

Swarming Infrastructures, Jack Greatrex

Research Collection College of Integrative Studies

The first car on the roads of Malacca, a town in the British Straits Settlements colony on the Malay Peninsula, was reportedly nicknamed The Swallow. Images of the eponymous bird were painted onto the vehicle: an avian metaphor fitting for the new, emerging age of the automobile, with its associations with freedom, rapidity and the smoother flows of modern life (Hillier 1961: 99).1

Waterfowl Recently Infected With Low Pathogenic Avian Influenza Exhibit Reduced Local Movement And Delayed Migration, Claire S. Teitelbaum, Michael L. Casazza, Fiona Mcduie, Susan E.W. De La Cruz, Cory T. Overton, Laurie A. Hall, Elliott L. Matchett, Joshua T. Ackerman, Jeffery D. Sullivan, Andrew M. Ramey, Diann J. Prosser

Faculty Research, Scholarly, and Creative Activity

Understanding relationships between infection and wildlife movement patterns is important for predicting pathogen spread, especially for multispecies pathogens and those that can spread to humans and domestic animals, such as avian influenza viruses (AIVs). Although infection with low pathogenic AIVs is generally considered asymptomatic in wild birds, prior work has shown that influenza-infected birds occasionally delay migration and/or reduce local movements relative to their uninfected counterparts. However, most observational research to date has focused on a few species in northern Europe; given that influenza viruses are widespread globally and outbreaks of highly pathogenic strains are increasingly common, it is important …

Ampk Regulates Homeostasis Of Invasion And Viability In Trophoblasts By Redirecting Glucose Metabolism: Implications For Pre-Eclampsia, Ping Xu, Yangxi Zheng, Jiujiang Liao, Mingyu Hu, Yike Yang, Baozhen Zhang, Mark D Kilby, Huijia Fu, Yamin Liu, Fumei Zhang, Liling Xiong, Xiyao Liu, Huili Jin, Yue Wu, Jiayu Huang, Tingli Han, Li Wen, Rufei Gao, Yong Fu, Xiujun Fan, Hongbo Qi, Philip N Baker, Chao Tong

Faculty, Staff and Student Publications

Pre-eclampsia (PE) is deemed an ischemia-induced metabolic disorder of the placenta due to defective invasion of trophoblasts during placentation; thus, the driving role of metabolism in PE pathogenesis is largely ignored. Since trophoblasts undergo substantial glycolysis, this study aimed to investigate its function and regulatory mechanism by AMPK in PE development. Metabolomics analysis of PE placentas was performed by gas chromatography-mass spectrometry (GC-MS). Trophoblast-specific AMPKα1-deficient mouse placentas were generated to assess morphology. A mouse PE model was established by Reduced Uterine Perfusion Pressure, and placental AMPK was modulated by nanoparticle-delivered A769662. Trophoblast glucose uptake was measured by 2-NBDG and 2-deoxy-d-[

Mart 232.01: Interactive Web Ii, Cheryl Galipeau

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Thtr 113a.50: Introduction To Voice Acting, John K. Deboer

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Thtr 221.02: Acting Ii, Pamyla A. Stiehl

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Thtr 391.50: Manga And Anime: History, Practice And Form, Alessia Carpoca

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Artz 231a.02: Ceramics I, Karl Y. Schwiesow

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Artz 331.02: Ceramics Ii - Handbuilding, Karl Y. Schwiesow

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Neur 491.02: Neurolinguistics, Danielle K. Fahey

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Fors 232.01: Forest Insects And Disease, Diana L. Six

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Fors 341.00: Timber Harvesting And Forest Roads, Elizabeth M. Dodson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Wild 472.01: Wildlife Handling And Chemical Immobilization For Wildlife Professionals, Mark R. Johnson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Wild 562.01: Wildlife Habitat Modeling, Mark Hebblewhite

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Csd 396.01: Supporting Autism Inclusion On Campus / Service Learning, Jennifer K. Schoffer Closson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Neur 491.02: Neurolinguistics, Danielle K. Fahey

University of Montana Course Syllabi, 2021-2025

No abstract provided.

The Horse Versus The Ox During Medieval Times………And Horse Power Versus Horsepower Today, Thomas E. Lambert

Faculty and Staff Scholarship

In watching television or other films regarding agriculture in various nations, one can occasionally still see where horses, mules, donkeys, or oxen are used to plow/plough fields or haul produce from farm to market. These practices seem antiquated by today’s farming techniques which mostly employ large combustion engine combines or tractors, trucks, etc. Much has been written about the agricultural revolution that occurred throughout most developed nations between the world wars and especially after the second one in which the use of more and more machinery has been used to grow agricultural produce such as wheat, corn, barley, etc. Even …

Coming-Of-Age Of Teenage Female Arab Gothic Fiction: A Feminist Semiotic Study, Zoe Hurley, Zeina Hojeij

All Works

This feminist semiotic study explores the folkloric imaginary of the jinn in the context of children’s and young adults’ Arab Gothic literature. Across the Middle East, the jinn is a common trope in literature, folklore and oral storytelling who, in diegetic terms, can manifest as the Gothic figure of an aging female, deranged older woman or succubus (known as sa’lawwa in Arabic). In this study, a novel feminist semiotic framework is developed to explore the extent to which the Gothic female succubus either haunts or liberates Arab girls’ coming-of-age fictions. This issue is addressed via a feminist semiotic reading of …

Mediated Locality: Assembling The Independent Music Scene In Brooklyn, New York, Frank Meegan

Dissertations, Theses, and Capstone Projects

This dissertation investigates how independent musicians, concert organizers, and other scene participants in Brooklyn, New York use digital technology and new media in their artistic practice. It is based on three years of participant observation in Brooklyn from 2016 to 2019, where I attended events at small venues like bars and DIY spaces, and interviewed musicians, concert organizers, independent label runners, and other scene participants. I also observed the online activity of musicians and organizers on public Facebook, Instagram, and Bandcamp pages. I argue that Brooklyn independent musicians use digital media, and are themselves mediated, as their activities at physical …

Cotargeting Of Btk And Malt1 Overcomes Resistance To Btk Inhibitors In Mantle Cell Lymphoma, Vivian Changying Jiang, Yang Liu, Junwei Lian, Shengjian Huang, Alexa Jordan, Qingsong Cai, Ruitao Lin, Fangfang Yan, Joseph Mcintosh, Yijing Li, Yuxuan Che, Zhihong Chen, Jovanny Vargas, Maria Badillo, John Nelson Bigcal, Heng-Huan Lee, Wei Wang, Yixin Yao, Lei Nie, Christopher R Flowers, Michael Wang

Faculty, Staff and Student Publications

Bruton's tyrosine kinase (BTK) is a proven target in mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma. However, resistance to BTK inhibitors is a major clinical challenge. We here report that MALT1 is one of the top overexpressed genes in ibrutinib-resistant MCL cells, while expression of CARD11, which is upstream of MALT1, is decreased. MALT1 genetic knockout or inhibition produced dramatic defects in MCL cell growth regardless of ibrutinib sensitivity. Conversely, CARD11-knockout cells showed antitumor effects only in ibrutinib-sensitive cells, suggesting that MALT1 overexpression could drive ibrutinib resistance via bypassing BTK/CARD11 signaling. Additionally, BTK knockdown and MALT1 knockout …

Glucocorticoid Therapy As First-Line Treatment In Primary Hypophysitis: A Systematic Review And Individual Patient Data Meta-Analysis, Brijesh Krishnappa, Ravikumar Shah, Saba Samad Memon, Chakra Diwaker, Anurag R Lila, Virendra A Patil, Nalini S Shah, Tushar R Bandgar

Faculty, Staff and Student Publications

OBJECTIVES: High-dose glucocorticoids are associated with improved recovery of deficits in primary autoimmune hypophysitis (PAH), but optimal dosing, route, and duration are unclear.

DESIGN: We reviewed literature for first-line glucocorticoid treatment in PAH until December 2021 and performed an individual patient data meta-analysis to analyze clinical, hormonal, and radiological outcomes with respect to route, dose, and duration (12 weeks) of glucocorticoid treatment according to disease severity.

RESULTS: A total of 153 PAH patients from 83 publications were included. The median age at presentation was 41 (32.5-48) years with a female preponderance (70.3%). Visual field recovery was significantly better with i.v. …

Base Editing Correction Of Hypertrophic Cardiomyopathy In Human Cardiomyocytes And Humanized Mice, Andreas C Chai, Miao Cui, Francesco Chemello, Hui Li, Kenian Chen, Wei Tan, Ayhan Atmanli, John R Mcanally, Yu Zhang, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N Olson

Faculty, Staff and Student Publications

The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM), which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart muscle thickening. Complications of HCM include heart failure, arrhythmia and sudden cardiac death. The dominant-negative c.1208G>A (p.R403Q) pathogenic variant (PV) in β-myosin (MYH7) is a common and well-studied PV that leads to increased cardiac contractility and HCM onset. In this study we identify an adenine base editor and single-guide RNA system that can efficiently correct this human PV with minimal bystander editing and off-target editing at selected sites. We show that delivery of …

Post-Irradiation Intratumoral Heterogeneity Modulates Response To Immune Checkpoint Inhibition Therapy In A Murine Melanoma Model, Jie Wang, Shivani Sud, Yanli Qu, Liantao Li, Jiajie Zhang, David Marron, Nicole Michelle Knape, Isaiah James Kim, Kyle Thomas Wagner, Tian Zhang, Yuxia Zhao, Genyan Guo, Andrew Z Wang

Faculty, Staff and Student Publications

Purpose: The underlying mechanism for radiation as a potentiator of immune checkpoint inhibition (ICI) is unclear. We developed a novel murine model to investigate the effects of post-irradiation intratumoral heterogeneity (ITH) on response to ICI.

Experimental design: Parental mouse melanoma B16F10 cells were irradiated in vitro (5Gy x 3 fractions), then an a priori determined number of resulting colonies were implanted in C57BL/6J immunocompetent mice creating syngeneic models of unirradiated (parental) and irradiated tumors with low (irradiated-L) and high (irradiated-H) ITH. Mice were treated with placebo, α-PD-L1, α-CTLA-4 or dual ICI. Murine tumors underwent whole exome sequencing (WES). Clinically correlated …

Pkr Induces Tgf-Β And Limits Oncolytic Immune Therapy, Bangxing Hong, Upasana Sahu, Matthew P Mullarkey, Evan Hong, Guangsheng Pei, Yuanqing Yan, Yoshihiro Otani, Yeshavanth Banasavadi-Siddegowda, Huihui Fan, Zhongming Zhao, Jianhua Yu, Michael A Caligiuri, Balveen Kaur

Faculty, Staff and Student Publications

BACKGROUND: Mammalian cells have developed multiple intracellular mechanisms to defend against viral infections. These include RNA-activated protein kinase (PKR), cyclic GMP-AMP synthase and stimulation of interferon genes (cGAS-STING) and toll-like receptor-myeloid differentiation primary response 88 (TLR-MyD88). Among these, we identified that PKR presents the most formidable barrier to oncolytic herpes simplex virus (oHSV) replication in vitro.

METHODS: To elucidate the impact of PKR on host responses to oncolytic therapy, we generated a novel oncolytic virus (oHSV-shPKR) which disables tumor intrinsic PKR signaling in infected tumor cells.

RESULTS: As anticipated, oHSV-shPKR resulted in suppression of innate antiviral immunity and improves virus …

The Alzheimer’S Disease Risk Factor Inpp5d Restricts Neuroprotective Microglial Responses In Amyloid Beta-Mediated Pathology, Mary Claire Tuohy, Elizabeth M C Hillman, Randolph Marshall, Dritan Agalliu

Faculty, Staff and Student Publications

Stroke is a devastating cause of global morbidity and mortality. Ischemic brain injury triggers a profound local and systemic immune response that participates in stroke pathophysiology. In turn, this immune response has emerged as a potential therapeutic target. In order to maximize its therapeutic potential, it is critical to understand how the immune response to ischemic brain injury is affected by age - the strongest non-modifiable risk factor for stroke. The development of multi-omics and single-cell technologies has provided a more comprehensive characterization of transcriptional and cellular changes that occur during aging. In this review, we summarize recent advances in …

Expression And Functions Of Transient Receptor Potential Channels In Liver Diseases, Wenhui Wang, Pengyu Liu, Yalin Zhang, Li Yan, Michael X Zhu, Jin Wang, Ye Yu

Faculty, Staff and Student Publications

Liver diseases constitute a major healthcare burden globally, including acute hepatic injury resulted from acetaminophen overdose, ischemia-reperfusion or hepatotropic viral infection and chronic hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). Attainable treatment strategies for most liver diseases remain inadequate, highlighting the importance of substantial pathogenesis. The transient receptor potential (TRP) channels represent a versatile signalling mechanism regulating fundamental physiological processes in the liver. It is not surprising that liver diseases become a newly explored field to enrich our knowledge of TRP channels. Here, we discuss recent findings revealing TRP functions across the fundamental …

Mitochondria-Containing Extracellular Vesicles (Ev) Reduce Mouse Brain Infarct Sizes And Ev/Hsp27 Protect Ischemic Brain Endothelial Cultures, Kandarp M Dave, Donna B Stolz, Venugopal R Venna, Victoria A Quaicoe, Michael E Maniskas, Michael John Reynolds, Riyan Babidhan, Duncan X Dobbins, Maura N Farinelli, Abigail Sullivan, Tarun N Bhatia, Hannah Yankello, Rohan Reddy, Younsoo Bae, Rehana K Leak, Sruti S Shiva, Louise D Mccullough, Devika S Manickam

Faculty, Staff and Student Publications

Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction integrity of the blood-brain barrier (BBB). We harnessed the innate mitochondrial load of BEC-derived extracellular vesicles (EVs) and utilized mixtures of EV/exogenous 27 kDa heat shock protein (HSP27) as a one-two punch strategy to increase BEC survival (via EV mitochondria) and preserve their tight junction integrity (via HSP27 effects). We demonstrated that the medium-to-large (m/lEV) but not small EVs (sEV) transferred their mitochondrial load, that subsequently colocalized with the mitochondrial network of the recipient primary human BECs. Recipient BECs treated with m/lEVs showed increased relative ATP levels and …