Digital Commons Network^™

Paso Robles Children's Museum Redesign, Hannah O. Chan, Shreya Hambir

Graphic Communication

For this project, we plan to redesign the Paso Robles Children's Museum website, utilizing Squarespace. Currently, the website has an outdated look and feel, and the information is somewhat disorganized. Having intuitive navigation is a crucial part of good user experience, as users should not have to dig through the site to find what they are looking for (Hallman, 2022). In our redesign, we plan to regroup related content into sections that mimic websites of other established museums, so the structure is more familiar. The other main issue we want to address is the site’s aesthetic; our goal is to …

University Band And Philharmonic Orchestra

Bailey School of Music Concert Programs

Program for the University Band and Philharmonic Orchestra performance.

Airborne Infection Risks From Covid-19 In Meat Processing Plants And Different Solutions To Mitigate The Risks, Debayan Shom

Durham School of Architectural Engineering and Construction: Dissertations, Theses, and Student Research

Meat processing plants are linked to the rapid spread of COVID-19 cases. A related literature review shows a lack of proper ventilation standards for the meat processing plants for workers’ health and safety. Ventilation rates in these plants are considered adequate if the meat products are unadulterated. Thus, the air distribution and ventilation rate experiments were conducted in three meat processing plants. These measured ventilation rates were either compared to ASHRAE Std. 62.1 (2019) for a similar space or the design values provided by the plant’s administration. The measured values were low in common spaces, such as the cafeteria and …

Metabolic Network Modeling To Unravel The Impact Of Copper Deficiency And High-Fat Diet On Liver Metabolism, Naeun Lee

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Fatty liver disease is a common health problem caused by an imbalance in the intake, utilization, and distribution of energy. High-fat and high-carbohydrate diets have been identified as major risk factors for fatty liver disease. Other contributors and modifiers can also influence the development of liver damage. Intriguingly, inappropriate copper (Cu) levels in the diet and organs are associated with fatty liver disease, though the exact way in which Cu deficiency or toxicity contributes to metabolic issues is not yet clear. Cu is necessary for several biological processes, including energy production and redox balance. Further research should be taken to …

Conflict Of Laws? Tensions Between Antitrust And Labor Law, Matthew Dimick

Journal Articles

Not long ago, economists denied the existence of monopsony in labor markets. Today, scholars are talking about using antitrust law to counter employer wage-setting power. While concerns about inequality, stagnant wages, and excessive firm power are certainly to be welcomed, this sudden about-face in theory, evidence, and policy runs the risk of overlooking some important concerns. The purpose of this Essay is to address these concerns and, more critically, to discuss some tensions between antitrust and labor law, a more traditional method for regulating labor markets. Part I addresses a question raised in the very recent literature, about why antitrust …

Skip The Grid: Solar Powered Systems In The Navajo Nation, Julian A. Chavez

Construction Management

The Skip the Grid initiative, a collaboration between Cal Poly students, SOLV Energy, Goal Zero, and facilitated by the non-profit Heart of America, aimed to enhance the quality of life for Navajo Nation families. Facing disparities in access to electricity and exacerbated by the COVID-19 pandemic, the project installed photovoltaic energy systems with lights in 27 homes, benefiting students of the Red Mesa Unified School District. This initiative addressed the challenges of remote learning by providing reliable, no-cost, off-grid power solutions. Completed on March 30, 2023, the project not only improved the immediate circumstances in the Navajo Nation, but also …

Skip The Grid: Providing Power And Light To The Navajo Nation, Esai Contreras

Construction Management

Skip the Grid was created as an initiative to power communities that are in need. This project was made possible through a collaborative effort from California Polytechnic State University San Luis Obispo (Cal Poly) students, industry partners SOLV Energy and Goal Zero, and facilitated through the educational non-profit organization Heart of America (HOA). The goal of this project was to help families of school age children in the Navajo Nation by providing solar energy systems including a battery and lighting. We hoped to achieve a long-lasting effect on the families by installing necessities for families with school-aged children. For the …

Garden Improvements For "The Ranch", Ayden J. Cole

Construction Management

The Ranch spans over ten-and-a-half acres and provides employment opportunities for individuals with disabilities. The core focus of The Ranch is cultivating small crops and raising livestock, which are tended to and harvested by individuals with disabilities. The ultimate aim is to provide them with hands-on experience of working on a farm and how to take care of livestock and grow food. However, the existing property of The Ranch was not exactly what they wanted for their students' learning environment. The existing area where the crops were being grown was not fenced in so critters were getting into the garden …

Building Artificial Reefs From Recycled Construction Materials: A Feasibility Study, Nicholas H. Lew

Construction Management

Naturally occurring reefs are some of the world’s most biologically diverse ecosystems formed by jagged rocks tucked slightly below sea level. In recent years global warming began to pose a major threat to many reef habitats. Most relevant is the increase in surface seawater temperatures that cause coral to bleach, taking away major food sources for larger marine species. Researchers have combated this by deploying artificial reefs in substitution for naturally formed limestone rock formations in order to promote the expansion of coastal habitats. This project specifically aims to utilize construction waste towards the production of artificial reefs, effectively upcycling …

Future Of Augmented And Virtual Reality In Construction, Cameron Ghoddoucy

Construction Management

A series of virtual design contractors were interviewed regarding the future involvement of augmented and virtual reality software integration with construction processes. Within the construction industry, VDC specialists rely on Building Information Modeling (BIM) and Computer Aided Design (CAD) to create digital models that can be used to analyze the design of a building from all points of view. The interviewees responded to questions about software implementation advantages, and related user experiences. Six interviews were conducted, amongst three industry leading companies. Their assumptions of future AR and VR usage in construction were based on learned knowledge and prior field exploration. …

Macrophage-Derived Mlkl In Alcohol-Associated Liver Disease: Regulation Of Phagocytosis, Xiaoqin Wu, Xiude Fan, Megan R Mcmullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z Day, Josiah E Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S Allende, Arthur J Mccullough, Jon M Jacobs, Daniel M Rotroff, Srinivasan Dasarathy, Laura E Nagy

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury in alcohol-associated liver disease (ALD). Although receptor interacting protein kinase 3 (Rip3)-/- mice are completely protected from ethanol-induced liver injury, Mlkl-/- mice are only partially protected. Therefore, we hypothesized that cell-specific functions of MLKL may contribute to ethanol-induced injury.

APPROACH AND RESULTS: Bone marrow transplants between Mlkl-/- mice and littermates were conducted to distinguish the role of myeloid versus nonmyeloid Mlkl in the Gao-binge model of ALD. Ethanol-induced …

A Potent And Broad Neutralization Of Sars-Cov-2 Variants Of Concern By Darpins, Vikas Chonira, Young D Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G Casner, Darcy R Harris, Adam S Olia, Tyler Stephens, Lawrence Shapiro, Michael F Bender, Hannah Boyd, I-Ting Teng, Yaroslav Tsybovsky, Florian Krammer, Ningyan Zhang, Michael S Diamond, Peter D Kwong, Zhiqiang An, Zhilei Chen

Faculty, Staff and Student Publications

We report the engineering and selection of two synthetic proteins-FSR16m and FSR22-for the possible treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. FSR16m and FSR22 are trimeric proteins composed of DARPin SR16m or SR22 fused with a T4 foldon. Despite selection by a spike protein from a now historical SARS-CoV-2 strain, FSR16m and FSR22 exhibit broad-spectrum neutralization of SARS-CoV-2 strains, inhibiting authentic B.1.351, B.1.617.2 and BA.1.1 viruses, with respective IC

Endotrophin Neutralization Through Targeted Antibody Treatment Protects From Renal Fibrosis In A Podocyte Ablation Model, Yu A An, Wei Xiong, Shiuhwei Chen, Dawei Bu, Joseph M Rutkowski, Joel P Berger, Christine M Kusminski, Ningyan Zhang, Zhiqiang An, Philipp E Scherer

Faculty, Staff and Student Publications

OBJECTIVE: Renal fibrosis is a hallmark for chronic kidney disease (CKD), and often leads to end stage renal disease (ESRD). However, limited interventions are available clinically to ameliorate or reverse renal fibrosis.

METHODS: Herein, we evaluated whether blockade of endotrophin through neutralizing antibodies protects from renal fibrosis in the podocyte insult model (the "POD-ATTAC" mouse). We determined the therapeutic effects of endotrophin targeted antibody through assessing renal function, renal inflammation and fibrosis at histological and transcriptional levels, and podocyte regeneration.

RESULTS: We demonstrated that neutralizing endotrophin antibody treatment significantly ameliorates renal fibrosis at the transcriptional, morphological, and functional levels. In …

Persistent Nociceptor Hyperactivity As A Painful Evolutionary Adaptation, Edgar T Walters, Robyn J Crook, G Gregory Neely, Theodore J Price, Ewan St John Smith

Faculty, Staff and Student Publications

Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized to detect damaging stimuli and/or inflammation. This pain and hyperactivity are considered maladaptive because both can persist long after injured tissues have healed and inflammation has resolved. While the assumption of maladaptiveness is appropriate in many diseases, accumulating evidence from diverse species, including humans, challenges the assumption that neuropathic pain and persistent nociceptor hyperactivity are always maladaptive. We review studies indicating that persistent nociceptor hyperactivity has undergone evolutionary selection in widespread, albeit selected, animal …

Causes Of Clonal Hematopoiesis: A Review, Lijin Joo, Catherine C Bradley, Steven H Lin, Paul A Scheet, Kevin T Nead

Faculty, Staff and Student Publications

PURPOSE OF REVIEW: Clonal hematopoiesis (CH) is an age-dependent process detectable using advanced sequencing technologies and is associated with multiple adverse health outcomes including cardiovascular disease and cancer. The purpose of this review is to summarize known causes of CH mutations and to identify key areas and considerations for future research on CH.

RECENT FINDINGS: Studies have identified multiple potential causes of CH mutations including smoking, cancer therapies, cardiometabolic disease, inflammation, and germline risk factors. Additionally, large-scale studies have facilitated the identification of gene-specific effects of CH mutation risk factors that may have unique downstream health implications. For example, cancer …

Zombies Attack Inadvertent Partnerships!—How Undead Precedents Killed By Uniform Statutes Still Roam The Reporters, Joseph K. Leahy

University of Richmond Law Review

Recently, the Texas Supreme Court breathed new life into some ancient zombies—zombie precedents, that is!—which have long lurked in the shadows of the nation’s partnership formation caselaw. This Article tells the story of those undead cases—describing them, debunking them, and plotting their demise.

This zombie tale begins with the supposed black-letter law of partnership formation. In nearly every state, formation of a general partnership is governed by one of two uniform partnership acts. Under both acts, a business relationship ripens into a partnership whenever the statutory definition of partnership is satisfied. The parties’ intent to become “partners” (or not) is …

Machine-Learning-Aided Design Optimization Of Internal Flow Channel Cross-Sections, Saeel S. Pai, Justin Weibel

CTRC Research Publications

No abstract provided.

Student Information Use During The Covid-19 Pandemic, Heather A. Howard, Annette Bochenek, Zoeanna A. Mayhook, Trena Trowbridge, Steven Lux

Libraries Faculty and Staff Scholarship and Research

Since early 2020, life for students has changed tremendously. It has been a time of stress, turmoil, and trauma for students. Researchers from a large Midwestern university wanted to determine how student information use has changed during the COVID-19 pandemic. This paper examines the results of a mixed-methods study undertaken in 2021 using surveys and follow-up focus groups to determine if and how student information use has changed. To answer this, we explored student use of news sources, social media sources, political affiliations, and information responses, coupled with to what extent these factors demonstrate or impact potential changes in information …

Six Decades Of North American Bird Banding Records Reveal Plasticity In Migration Phenology, Kyle G. Horton, Sara R. Morris, Benjamin M. Van Doren, Kristen M. Covino

Biology Faculty Works

1. The timing of avian migration has evolved to exploit critical seasonal resources, yet plasticity within phenological responses may allow adjustments to interannual resource phenology. The diversity of migratory species and changes in underlying resources in response to climate change make it challenging to generalize these relationships.
2. We use bird banding records during spring and fall migration from across North America to examine macroscale phenological responses to interannual fluctuations in temperature and long-term annual trends in phenology.
3. In total, we examine 19 species of North American wood warblers (family Parulidae), summarizing migration timing from 2,826,588 banded birds from 1961 to 2018 …

Communicating About Extreme Heat: Results From Card Sorting And Think Aloud Interviews With Experts From Differing Domains, Jeannette Sutton, Nicholas Waugh, Savannah Olivas

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

Climate trends indicate that extreme heat events are becoming more common and more severe over time, requiring improved strategies to communicate heat risk and protective actions. However, there exists a disconnect in heat-related communication from experts, who commonly include heat related jargon (i.e., technical language), to decision makers and the general public. The use of jargon has been shown to reduce meaningful engagement with and understanding of messages written by experts. Translating technical language into comprehensible messages that encourage decision makers to take action has been identified as a priority to enable impact-based decision support. Knowing what concepts and terms …

Digitalisation Touches Everything, Havovi Joshi

Asian Management Insights

Digitalisation touches everything

Worldview Themes Among Arab Muslim Women, Linda Smith

Journal of Adventist Mission Studies

No abstract provided.

Two Unlikely Missionaries: A Study In Narrative Theology, Jo Ann Davidson

Journal of Adventist Mission Studies

No abstract provided.

Fables Of Scarcity In Ip, Zahr K. Said

Articles

In this chapter, I use methods drawn from literary analysis to bear on artificial scarcity and explore how literary and legal storytelling engages in scarcity mongering. I find three particular narrative strategies calculated to compel a conclusion in favor of propertization: the spectacle of need, the diversionary tactic, and the rallying cry. First, I unpack the spectacle of need and its diversionary aspects through several literary accounts of scarcity and starvation. I juxtapose Franz Kafka's “A Hunger Artist,” a story explicitly centered on a wasting body, with J.M. Coetzee's The Life and Times of Michael K. Second, to explore how …

Best Practice Marking Of Lambs, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

Lambs should be marked between two and 12 weeks of age, with the youngest animal in the mob at least 24 hours old, to ensure the formation of a maternal bond. If lambing extends for more than six weeks, consider having two mulesing/marking sessions.

Lambs should be tail docked using a gas-heated knife or rubber rings and mulesing should only be carried out when necessary.

The provision of pain relief with routine husbandry procedures benefits animal health and welfare and is now a consumer and community expectation. Producers have access to registered products that can relieve pain associated with mulesing, …

Chalcone Derivative Cx258 Suppresses Colorectal Cancer Via Inhibiting The Top2a/Wnt/Β-Catenin Signaling, Xi Chen, Xiaocheng Lv, Lijie Gao, Jiawei Liu, Wei Wang, Lichao Guo, Mykhaylo S. Frasinyuk, Wen Zhang, David S. Watt, Chunming Liu, Xifu Liu

Markey Cancer Center Faculty Publications

The deregulation in the Wnt/β-catenin signaling pathway is associated with many human cancers, particularly colorectal cancer (CRC) and, therefore, represents a promising target for drug development. We have screened over 300 semisynthetic and natural compounds using a Wnt reporter assay and identified a family of novel chalcone derivatives (CXs) that inhibited Wnt signaling and CRC cell proliferation. Among them, we selected CX258 for further in vitro and in vivo study to investigate the molecular mechanisms. We found that CX258 significantly inhibited β-catenin expression and nuclear translocation, inducing cell cycle arrest at the G2/M phase in CRC cells. Additionally, CX258 reduced …

Endogenous Glycoprotein Gpm6a Is Involved In Neurite Outgrowth In Rat Dorsal Root Ganglion Neurons, Gabriela I. Aparicio, Antonella León, Rocío Gutiérrez Fuster, Baylen Ravenscraft, Paula V. Monje, Camila Scorticati

Markey Cancer Center Faculty Publications

The peripheral nervous system (PNS) has a unique ability for self-repair. Dorsal root ganglion (DRG) neurons regulate the expression of different molecules, such as neurotrophins and their receptors, to promote axon regeneration after injury. However, the molecular players driving axonal regrowth need to be better defined. The membrane glycoprotein GPM6a has been described to contribute to neuronal development and structural plasticity in central-nervous-system neurons. Recent evidence indicates that GPM6a interacts with molecules from the PNS, although its role in DRG neurons remains unknown. Here, we characterized the expression of GPM6a in embryonic and adult DRGs by combining analysis of public …

Exploring Diversity And Depth Of Knowledge, Metacognition, And Individual Ambidexterity, Deddi Tedjakumara

Dissertations and Theses Collection (Open Access)

Recent data show that the average lifespan of a company listed in the Standard and Poor's 500 (S&P 500) Index has declined from 32 years in 1965 to 21 years in 2020 (Clark, 2021), and it is estimated that 75% of the companies listed in the S&P 500 today will disappear from the list by 2027 (Hillenbrand, 2019). Organizational theory holds that for a company to be sustainable, it must strike a balance between exploring new possibilities and exploiting old certainties (March, 1991). The ability to manage the tension between exploration and exploitation is important at both organizational and individual …

Breaking The Cycle: Women’S Experience In Postsecondary Agricultural And Extension Education, Lauren L. Cline, Haley Rosson, Penny Pennington Weeks

Journal of Human Sciences and Extension

The “leaky educational pipeline” metaphor refers to the steady tapering off of women obtaining graduate degrees and reaching the level of a tenured faculty member, although the number of women earning college degrees has surpassed males since the 1980s. Women are disproportionately represented among faculty and leadership at land-grant institutions and in the agricultural education profession. The purpose of this study was to provide a synthesis of women’s experience in postsecondary agricultural and extension education (AEE) by describing the common and diverging challenges, opportunities, and mentoring experiences of women faculty and graduate students in the profession. The study was a …

How Agritourism Operators Make Marketing And Promotion Decisions, Katelyn Miller, Quisto Settle, Audrey E. H. King, Bree Kisling

Journal of Human Sciences and Extension

Agritourism operators in Oklahoma were interviewed to determine how they make promotional decisions. Three themes were found from the interviews. The first was Educated Guessing. Participants were not formally trained in promoting agritourism operations, but they used their past experiences and the resources available to them to make decisions. The second theme was Facebook First. All 10 operations in this interview used Facebook as their primary marketing method based on positive experiences with the site as a promotional tool, followed by other options, such as websites. The third theme was More of the Same. The participants mostly intended to keep …