Digital Commons Network^™

Effects Of Diet On Lcn2 Expression And Onset Of Neuroinflammation In An Alzheimer’S Disease Mice Model, Abdirahman A. Hayir

Neuroscience Honors Projects

This project covers the findings regarding the impact of diet on lipocalin 2 (LCN2) and the effects it has on neuroinflammation Alzheimer’s Disease (AD). LCN2 is a protein that is critical to the functionality of mitochondria and inflammatory responses. Evidence has shown that mitochondrial dysfunction is a potential central event in driving AD pathogenesis and contributing to formation of pathological hallmarks such as chronic inflammation. Furthermore, studies have shown that LCN2 can be deficient under metabolic conditions such as high-fat-diet (HFD). This study investigates if HFD induces LCN2 deficiency and increased neuroinflammation in an AD mice model.

Effects Of Coordinated Reset Deep Brain Stimulation Of Subthalamic Nucleus On Parkinsonian Gait In The Non-Human Primate Model, Kanon Nakajima

Neuroscience Honors Projects

Parkinson’s Disease (PD) is a neurodegenerative disorder that affects over 10 million people worldwide. Deep Brain Stimulation (DBS) has been a successful treatment for advanced PD, however, can be accompanied with current spread related side effects. Coordinated Reset (CR) DBS is a novel therapeutic approach that could reduce the risk of side-effects by using lower current. Previous research has shown therapeutic effects of CR DBS on PD motor symptoms including akinesia, bradykinesia, rigidity, and tremor that sustained after stimulation cessation (i.e., carryover effect), however its effect on gait dysfunction is unknown even though it can be one of the most …

Effects Of Heavy Metal Uptake On Growth, Chlorophyll Content, And Calcium Oxalate Crystals In Lemna Minor (Duckweed), Olivia F. Miller

Undergraduate Honors Thesis Projects

Lemna minor L., duckweed, is a common aquatic plant used for the phytoremediation of wastewater. Heavy metal contamination poses a significant issue, and numerous studies have been conducted on the efficiency of L. minor’s hyperaccumulation ability of these metals. Calcium oxalate crystals are an important aspect of the growth and development of L. minor, but how they are influenced by the uptake of heavy metal has not been extensively studied. This study aims to determine the effects that lead, cadmium, and copper have on the formation of calcium oxalate crystals, vegetative growth, and chlorophyll a and b content on L. …

Law School Record, Vol. 69, No. 2 (Spring 2023), Law School Record Editors

Law School Record

• Message from the Dean
• How Disagreement Remade Corporate Law
• “So Deeply Our Hearts Were Allied”
• Clearing a Path for Entrepreneurs
• Teaching and Mentorship That ‘Students Treasure and Universities Celebrate’
• ‘You Get a Toe in the Water’
• Alumni News: Books Published by Alumni in 2022
• Development News
• Alumni in Memoriam

Role Of Age And Sex In The Effects Of Repeated Methamphetamine Exposure On Hedonic Tone In Sprague Dawley Rats, Cameron Lewis, Conor Strumberger, Joshua M. Gulley

PRECS student projects

Anhedonia is defined as a reduced or complete loss of pleasure from a previously pleasurable stimulus, and it is comprised of two dimensions:

• Hedonic anhedonia consists of a distinct loss of pleasure in consumption of a normally pleasurable stimulus.
• Motivational anhedonia involves the goal directed behavior to obtain a reward.

Withdrawal induced anhedonia following use of methamphetamine (METH) is thought to contribute to relapse behaviors^1,2 . The anhedonic effects of drug withdrawal largely depend on dose, frequency, and the duration of drug exposure^4,5,6.

The role of sex and age of exposure in this context has yet to …

A Comparative Life Cycle Assessment Of Cork Versus Traditional Shoe Insole Material, Alexandra Lum

Independent Study Project (ISP) Collection

Shoes are conventionally produced from materials like plastic or rubber that have detrimental impacts on the environment such as exacerbating existing waste accumulation, increasing global amounts of greenhouse gasses, or releasing toxic chemicals into soils and groundwater. These impacts have pushed footwear companies to introduce more sustainable and ecologically-friendly materials in their products. Roughly half of all cork production occurs in Portugal. The present work employs a comparative life cycle assessment approach between traditional plastic and rubber insole material and cork insole material to investigate the environmental impact of each. Results show that during each stage of the insole life …

Women In Sustainable Leadership: A Case Study On The Perspectives, Opportunities, And Challenges Of Biologist And Conservationist Estrela Matilde, Ella Lyons

Independent Study Project (ISP) Collection

Despite the relatively small population of 8,000 occupants and the minimal international recognition of the Island of Príncipe, located off of the Gulf of Guinea on the Western Coast of Central Africa, the region has increasingly become a leading example of sustainable practices to be taken on a global scale in the near future to combat our current climate crisis. This case study explores the sustainable practices that Príncipe has learned to embrace under the leadership of Portuguese conservation biologist and project manager for the NGO Fundação Príncipe, Estrela Matilde. Estrela integrates social, cultural, and environmental conservation to align with …

Neoliberalismo Y La Mar: Los Efectos Del Sistema Neoliberal Y La Pesca Artesanal De Caleta Portales, Isaac Bronfine

Independent Study Project (ISP) Collection

This study is meant to explore the fundamental conflict between the neoliberal system implemented in Chilean society and the artisanal fishing sector, represented by Caleta Diego Portales in Valparaíso, Chile. The struggle of the artisanal fishing sector has been made more salient in the minds of the general Chilean public due to the estallido social or “social explosion” in 2019 which lead to a process of drafting a new constitution, and the recent corruption scandals regarding government officials and fishing law reforms.

Beginning with how neoliberal theory gained traction in intellectual spaces around the world, this study then examines how …

Hydrological Patterns Of The Chimborazo Reserve: Streamflow, Climate, And Glacier Recession Data Show A Loss Of Glacial Influence On The Southwestern Aspect Of The Chimborazo Volcano, Ecuador., William F. M. Patrick

Independent Study Project (ISP) Collection

The Chimborazo volcano of the central Ecuadorian Andean Cordillera (6310 m) has been shown to currently be undergoing extreme glacial recession due to climate change. For this reason, this study sought to analyze climate and glacier recession data in conjunction with streamflow from kryal (glacial-fed), rhithral (non-glacial-fed), and intermediate streams to not only evaluate the current health of Chimborazo’s glaciers, but also determine how hydrology in the region will respond to future climate change. The rate of glacial recession on the volcano was determined using satellite imagery between 1965 and 2019. Measurements of stream elevation, pH, water temperature, width, depth, …

Tropical Tree Carbon Storage At Drago Dos Forest In Boca Del Drago, Panama, Ben Dwyer

Independent Study Project (ISP) Collection

Currently, anthropogenic carbon emissions pose a significant, global threat, contributing to Global Warming and Climate Change (CC). Today, the most effective carbon sinks are natural. Trees are highly effective carbon sinks that sequester large amounts of atmospheric carbon dioxide (CO2), most greatly in tropical areas. However, tropical tree carbon storage needs to be more accurately estimated to provide valuable information toward mitigating CC and its negative environmental effects. This study aimed to estimate CO2 sequestration at a tropical forest in Boca Del Drago, Panama, and compare it to that of a nearby mangrove forest. It was hypothesized that the tropical …

Anuran Species Diversity And Abundance Between Three Locations In El Valle De Antón, Coclé, Panamá, Xena Gehring

Independent Study Project (ISP) Collection

Panama is an incredibly biodiverse country that houses 230 species of amphibians including 188 species of frogs, 35 of which are endemic to Panama. Commonly found in terrestrial and aquatic habitats, frogs play a very important role in the regulation of insect populations and serve as a valuable food resource to other predators. The greatest threat to amphibian species at this time is Chytridiomycosis, a fungal pathogen that infects the skin and often results in death. Many species of amphibians have already gone completely extinct or are extinct in the wild due to the proliferation of this disease. The skin …

Rocky Intertidal Community Structure Along An Upwelling Gradient Between Playa Venao And Nueva Gorgona On Panama’S Pacific Coast, Claire Brady

Independent Study Project (ISP) Collection

Ecological research on rocky intertidal ecosystems has increasingly focused on the regional oceanographic processes that shape community structure over functional group interactions. Intertidal communities’ dependence on onshore and offshore transport of intertidal species larvae, dissolved inorganic nutrients, and phytoplankton signal that upwelling and nearshore currents can have an influential role in determining the growth and composition of intertidal systems. The community structure of rocky intertidal areas was compared between two locations along an upwelling gradient in the Gulf of Panama: Nueva Gorgona, with intermittent seasonal upwelling, and Playa Venao, with fringe seasonal upwelling. The surface cover of algae, barnacles, and …

Troop Composition And Behavior Of Mantled Howler Monkeys (Alouatta Palliata) In Mangroves And Forested Islands South Of David, Panama, Slate Hyacinthe

Independent Study Project (ISP) Collection

The mantled howler monkey, Alouatta palliata, is one of the most commonly studied and widely distributed primate species in Central America. They have been reported to inhabit mangrove environments in Panama, but few studies have undertaken to describe their demography and behavior in these particular ecosystems. For my study, I spent 12 days studying A. palliata populations in both the mangrove and forested island ecosystems (Isla Parida and Isla Boca Brava) south of David. Seven groups were found in the mangrove environments, and 11 groups were found on the island environments. The mangrove groups were significantly smaller and at a …

Understanding Invasive Predation: Detections Of Feral Cats (Felis Catus) On Kangaroo Island’S Western River Refuge, Leah Boget

Independent Study Project (ISP) Collection

Feral cats (Felis catus) are a priority-level threat for small to medium-sized native vertebrates across Australia and especially so in insular environments like that of Kangaroo Island, South Australia. The island is home to several endangered and geographically restricted species, including the Kangaroo Island Dunnart (Sminthopsis aitkeni), an endangered marsupial endemic to Kangaroo Island. When bushfires spread across the island and burned x percent of native vegetation in late 2019 to early 2020, these populations were critically impacted and post-fire feral cat predation on the island risked their extinctions, motivating the creation of a refuge with …

Sunan Kalijaga: The Birth Of A Self-Actualized Pilgrimage Culture, F. P. Meachem

Independent Study Project (ISP) Collection

Javanese Islam is incredibly unique in its style and practice. Despite boasting a Muslim population larger than the entire Middle East, Indonesia and its Islamic cultural practices are largely unknown in academic circles. This has made an introduction to Islam in the archipelago even more difficult for the rare interested Western reader. Frustratingly, what is lost on the rest of the world is basically second nature to 155 million Javanese Muslims, who learn from their families, schools, and pilgrimages about the Wali Songo, a group of nine semi-mythical figures credited with spreading Islam to Java. When we stop casting …

Agroforestry For The Future: Motivations Behind Tasmanian Farmers Planting Trees, Josh Lipp

Independent Study Project (ISP) Collection

Agroforestry is the act of combining farming and tree planting, and many Tasmanian farmers are starting to plant trees on their properties for multiple reasons. Through conducting 9 interviews with farmers and researchers and visiting field sites, 3 main themes were identified to answer the question: why are Tasmanian farmers planting trees, and what are the benefits and downsides to agroforestry? Interviews help us understand farmers’ perceptions of agroforestry, and field data collection will prove the benefits of agroforestry in the future. Tasmania was chosen as the location of study as it is a state in Australia that largely focuses …

Impact Of Wildlife Provisioning On Species Diversity, Relative Frequency, And Richness In New South Wales, Alanah Cohen-Tigör

Independent Study Project (ISP) Collection

Wildlife provisioning and camera trapping are two recently evolving methods of conservation and wildlife management, aimed at protecting animals in the face of ever worsening climate change. Habitats are being destroyed by climate disruption, decreasing species diversity and abundance worldwide. It is imperative that methods of protecting species are developed to slow or reverse this era of extinction. By providing supplementary food and water to ecological communities, the hope is that species will have improved survivorship and reproduction, making them more resilient and resistant to population decline. Camera trapping is product of modern technology, allowing researchers to monitor species without …

Bridging The Education Gap: Series Of Infographic Guides To Sustainable Living For Low-Income Communities, Brianna Mateo

Independent Study Project (ISP) Collection

Low-income communities in Australia face numerous negative impacts, such as health issues, social exclusion, educational disparities, and discrimination, which limit their opportunities to improve their quality of life (The Public Defenders,2022). As a result, students from these communities often have fewer resources and less funding, contributing to poor educational outcomes and underrepresentation in STEM fields, which includes environmental education (Australian Department of Education, 2022).

To address these challenges, I created an 8-page infographic series titled “Sustainable Living: On a Budget.” The series includes a cover page, an overview page, and four infographics covering : climate change, waste, preserving biodiversity, and …

Inside The Wave: How “The 100 Foot Wave” Changed The Lives Of The Local Community In Nazaré, Emilie Cohen

Independent Study Project (ISP) Collection

Surfing and surfing tourism are a critical part of Portugal’s economy and culture. Nazaré is a town that embodies a transition from a traditional fishing village to one that lives and breathes surf. Such a quick change in the leading industry of a town raises concerns about the impacts it has on the community. Therefore, the project focuses on the economic, social and cultural, and environmental impacts of tourism intensification on the local community in Nazaré through the perspective of the local people who are directly impacted and witness these changes. Other stakeholders are included, such as the Garrett McNamara …

Echoes Of The Zong Confronting Legal Realism In The Arguments For Reparations From The Atlantic Slave Trade And Modernday Human Trafficking, Glenys Spence

Faculty Scholarship

This Article is based on the premise that modern day human trafficking, like the transatlantic slave trade, violates jus cogens norms, and thus the practice was and still is a violation of US laws under customary international law. The analysis will examine the laws that were applied to chattel slavery in England and her colonies through the lens of some seminal slavery cases to unearth the tyranny of interpretation in human trafficking reparations and liability claims under the current Supreme Court jurisprudence and the Alien Tort Statute (“ATS”). The featured cases will reveal that the same philosophies undergirding the jurisprudence …

White Coat Color Of A Black Angus Calf Attributed To An Occurrence Of The Delr217 Variant Of Mitf, Jessica Lynn Petersen, Renae L. Sieck, David J. Steffen

Department of Animal Science: Faculty Publications

A white calf, with minimal pigmented markings, was born to two registered Black Angus parents. Given the possibility of an unknown recessive or de novo dominant mutation, whole-genome sequencing was conducted on the trio of individuals. A 3-bp in-frame deletion in MITF was identified; this mutation was unique to the calf but identical to the delR217 variant reported in both humans and murine models of Waardenburg syndrome type 2A and Tietz syndrome. Given the coat color phenotype and identity of the mutation, our data support that this calf represents the first instance of this recurring MITF mutation in cattle.

The Development Of A Parent Report Instrument Of Early Communication And Language Skills Of Infants And Toddlers In Mainland China, Xueman Lucy Liu, Wendy Lee, Eric Rolfhus, Teresa Hutchings, Liqun Yao, Jingqiu Xie, Yaqing Xu, Yongmei Peng, Jill De Villiers

Philosophy: Faculty Publications

This study was designed to produce a new parent-report measure, the Diagnostic Receptive Expressive Assessment of Mandarin-Infant Toddler Assessment of Communication and Language (DREAM-IT) in order to provide norms for the developmental skills of children aged 0–36 months in four areas: expressive language, receptive language, cognitive play and social skills.

Exploring The Development Of An Agribusiness Ecosystem For Singapore: Lessons From Taiwan, Kuo-Chang Fu

Dissertations and Theses Collection (Open Access)

The COVID-19 pandemic and complex global circumstances have prompted a heightened level of apprehension about food security in Singapore. With a land area of slightly over 700 square kilometers, of which a mere 1% is dedicated to agricultural purposes, Singapore's overall level of food self-sufficiency is less than 10%. Historically, Singapore has relied on imports to address its food deficits. However, due to the pandemic's impact and geopolitical tensions, which have resulted in instability within the global supply chain, Singapore is now compelled to re-evaluate its approach to food security. Consequently, there has been a substantial focus on exploring strategies …

Probenecid Slows Disease Progression In A Murine Model Of Autosomal Dominant Polycystic Kidney Disease, Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov

Hypertension and Vascular Research Articles

Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst-lining cells, and thus results in cystic fluid accumulation. Earlier, we demonstrated that Pkd1(RC/RC) mice, a hypomorphic model of ADPKD, exhibit increased expression of pannexin-1, a membrane channel capable of ATP release. In the current study, we found that human ADPKD cystic epithelia have higher pannexin-1 abundance than normal collecting ducts. We hypothesized that inhibition of pannexin-1 function with probenecid can be used to attenuate ADPKD development. …

Assessing The Generalizability Of Early Life Stress Effects On Aggression, Sophia Aaflaq, Jacob Nordman Dr.

2023

The project entitled Assessing the Generalizability of Early Life Stress Effects on Aggression aims to enhance our understanding of the intricacies of human aggression associated with childhood trauma. Early life stress is a reliable predictor of aggression in adults. Previous studies have used rodent models to establish a link between early life stress and aggression, but many of these studies employed stressors that are not commonly experienced by humans, such as foot shock. This project intends to focus on more human-relevant stressors like social isolation and social defeat that will provide a better understanding of the brain pathways of human …

Insomniac - A Collection Of Poetry, Fiction, And Creative Non-Fiction, Jason Abishekaraj John

English Senior Capstone

As the title would suggest, Insomniac is a multi-genre collection which represents a handful of my written works that were born during bouts of insomnia and depression. The poems I have placed in this collection revolve around my friendships with specific (and at times multiple) individuals. The creative non-fiction pieces focus on my experiences with depression, dissociation, suicide, anxiety, hypersensitivity, epilepsy, and self-harm in hopes that they might promote conversation. Lastly, the short stories are my own spin on Bhoot (Ghost) and ¬Shikari (Hunter) stories I hungrily devoured in my childhood. My hope is that each of these pieces can …

Drawing Empathy: The Benefits Of Utilizing Graphic Memoirs In Secondary Classrooms, Hailey Simmons

English Senior Capstone

The use of graphic novels and graphic memoirs in the classroom is an active discussion in many schools. Some individuals who oppose using the genre with students argue that it does not provide enough depth to have an effect on the reader. By analyzing Art Spiegelman’s Maus and Nora Krug’s Belonging, this paper explains how graphic memoirs can provide depth for readers. As Spiegelman and Krug learn of their family history with the Holocaust and World War II, they utilize the techniques of representational art, the repetition of structural elements, and the use of color and shading to portray …

The Osprey, Spring 2023, The Osprey Staff

Osprey

The student magazine of Cal Poly Humboldt.

What Before Means: Teaching About The Communicative Contribution Of The English Pluperfect, Max Miller

Publications and Research

This paper presents a text-based analysis of the communicative functions of the simple past and pluperfect tenses of English, and offers a pedagogical approach to assist learners in acquiring them. Following a functional, usage-based linguistics perspective, the analysis holds that the simple past expresses Time PAST, while the pluperfect expresses Time PAST, BEFORE. Thus only the latter tense signals a speaker's subjective creation of a linkage in time. The understanding of these meanings can enhance an English language teacher's effectiveness in the classroom (as in selecting texts and activities) and a language user's effectiveness in communication. A classroom-based pedagogical application …

Expressions 2023, Norah Case, Emma Windholz, Taryn Smith, Brody Nicholaisen, Adysen Miller, Samuel Thomsen, Benjamin Krdzalic, Kristi Skinner Rathjens, Grace Clingan

Expressions

No abstract provided.