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Kruppel-Like Factor 8 Regulates Triple Negative Breast Cancer Stem Cell-Like Activity, Giang Le Minh, Emily M Esquea, Tejsi T Dhameliya, Jessica Merzy, Mi-Hye Lee, Lauren E Ball, Mauricio J Reginato Apr 2023

Kruppel-Like Factor 8 Regulates Triple Negative Breast Cancer Stem Cell-Like Activity, Giang Le Minh, Emily M Esquea, Tejsi T Dhameliya, Jessica Merzy, Mi-Hye Lee, Lauren E Ball, Mauricio J Reginato

Kimmel Cancer Center Faculty Papers

INTRODUCTION: Breast tumor development is regulated by a sub-population of breast cancer cells, termed cancer stem-like cells (CSC), which are capable of self-renewing and differentiating, and are involved in promoting breast cancer invasion, metastasis, drug resistance and relapse. CSCs are highly adaptable, capable of reprogramming their own metabolism and signaling activity in response to stimuli within the tumor microenvironment. Recently, the nutrient sensor O-GlcNAc transferase (OGT) and O-GlcNAcylation was shown to be enriched in CSC populations, where it promotes the stemness and tumorigenesis of breast cancer cells in vitro and in vivo. This enrichment was associated with upregulation of the …


Deletion Of The Mrna Stability Factor Elavl1 (Hur) In Pancreatic Cancer Cells Disrupts The Tumor Microenvironment Integrity, Grace A Mccarthy, Roberto Di Niro, Jennifer M Finan, Aditi Jain, Yifei Guo, Cory R Wyatt, Alexander R Guimaraes, Trent A Waugh, Dove Keith, Terry K Morgan, Rosalie C Sears, Jonathan R Brody Apr 2023

Deletion Of The Mrna Stability Factor Elavl1 (Hur) In Pancreatic Cancer Cells Disrupts The Tumor Microenvironment Integrity, Grace A Mccarthy, Roberto Di Niro, Jennifer M Finan, Aditi Jain, Yifei Guo, Cory R Wyatt, Alexander R Guimaraes, Trent A Waugh, Dove Keith, Terry K Morgan, Rosalie C Sears, Jonathan R Brody

Department of Surgery Faculty Papers

Stromal cells promote extensive fibrosis in pancreatic ductal adenocarcinoma (PDAC), which is associated with poor prognosis and therapeutic resistance. We report here for the first time that loss of the RNA-binding protein human antigen R (HuR, ELAVL1) in PDAC cells leads to reprogramming of the tumor microenvironment. In multiple in vivo models, CRISPR deletion of ELAVL1 in PDAC cells resulted in a decrease of collagen deposition, accompanied by a decrease of stromal markers (i.e. podoplanin, αsmooth muscle actin, desmin). RNA-sequencing data showed that HuR plays a role in cell–cell communication. Accordingly, cytokine arrays identified that HuR regulates the secretion of …


The Bg News April 19, 2023, Bowling Green State University Apr 2023

The Bg News April 19, 2023, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. April 19, 2023. Volume 102-Issue 26.


Survey Of Nutrition Education Among Medical Students, Michael P. Duggan, Anahita T. Kodali, Zach A. Panton, Shannon M. Smith, Grant J. Riew, Jack F. Donaghue, Gregory A. Leya, Logan G. Briggs Apr 2023

Survey Of Nutrition Education Among Medical Students, Michael P. Duggan, Anahita T. Kodali, Zach A. Panton, Shannon M. Smith, Grant J. Riew, Jack F. Donaghue, Gregory A. Leya, Logan G. Briggs

Journal of Wellness

Introduction: The current literature regarding both specific interventions and the current level of nutrition education in the United States is scarce. The purpose of this paper is to provide medical student perspectives on both the degree and necessity of nutrition education during medical school.

Methods: Medicine in Motion (MM) is a non-profit student-run organization founded in 2018 that aims to address burnout in medicine through physical activity, community service, and philanthropy. MM issued a survey to nine of its chapters in January 2021 to assess a range of topics including burnout, physical activity, and nutrition education.

Results: Of 5500 invited …


A Review Of Pre-Clinical Studies On Meth-Induced Gut Microbiome Alterations, Payton Brabant Apr 2023

A Review Of Pre-Clinical Studies On Meth-Induced Gut Microbiome Alterations, Payton Brabant

Honors Theses

Substance use disorder (SUD) is a chronic, pervasive disease that affects approximately 40.3 million people aged 12 and over within the United States (SAMHSA, 2021). Recent investigations have emphasized preventive measures targeting the development of SUDs and the occurrence of relapse. However, to date, FDA-approved medications are only available for those with alcohol (AUD) and opioid use disorders (OUD) (Forouzan et al., 2021). Given that about 964,000 people have methamphetamine use disorder (MUD) within the United States, investigation of novel treatment approaches for psychostimulant abuse is warranted (Forouzan, Hoffman, and Kosten, 2020). Several negative effects can occur after using methamphetamine …


Influence Of Ambient Water Coloration On Habitat And Conspecific Choice In The Female Lake Malawi Cichlid, Metriaclima Zebra, Noori Choi, Nicolas Mathevon, Eileen A. Hebets, Marilyn Beauchaud Apr 2023

Influence Of Ambient Water Coloration On Habitat And Conspecific Choice In The Female Lake Malawi Cichlid, Metriaclima Zebra, Noori Choi, Nicolas Mathevon, Eileen A. Hebets, Marilyn Beauchaud

Eileen Hebets Publications

Female cichlid fish living in African great lakes are known to have sensory systems that are adapted to ambient light environments. These sensory system adaptations are hypothesized to have influenced the evolution of the diverse male nuptial coloration. In rock-dwelling Lake Malawi mbuna cichlids, however, the extent to which ambient light environments influence female sensory systems and potentially associated male nuptial coloration remains unknown. Yet, the ubiquitous blue flank coloration and UV reflection of male mbuna cichlids suggest the potential impacts of the blue-shifted ambient light environment on these cichlid’s visual perception and male nuptial coloration in the shallow water …


Children's And Caregivers' Review Of A Guided Imagery Therapy Mobile App Designed To Treat Children With Functional Abdominal Pain Disorders: Leveraging A Mixed Methods Approach With User-Centered Design, John M Hollier, Tiantá A Strickland, C Michael Fordis, Miranda Al Van Tilburg, Robert J Shulman, Debbe Thompson Apr 2023

Children's And Caregivers' Review Of A Guided Imagery Therapy Mobile App Designed To Treat Children With Functional Abdominal Pain Disorders: Leveraging A Mixed Methods Approach With User-Centered Design, John M Hollier, Tiantá A Strickland, C Michael Fordis, Miranda Al Van Tilburg, Robert J Shulman, Debbe Thompson

Faculty, Staff and Students Publications

BACKGROUND: Functional abdominal pain disorders (FAPDs) are highly prevalent and associated with substantial morbidity. Guided imagery therapy (GIT) is efficacious; however, barriers often impede patient access. Therefore, we developed a GIT mobile app as a novel delivery platform.

OBJECTIVE: Guided by user-centered design, this study captured the critiques of our GIT app from children with FAPDs and their caregivers.

METHODS: Children aged 7 to 12 years with Rome IV-defined FAPDs and their caregivers were enrolled. The participants completed a software evaluation, which assessed how well they executed specific app tasks: opening the app, logging in, initiating a session, setting the …


Volume 14, Ireland Seagle, Dalton C. Whitby, Cassandra Poole, Rachel Cannon, Heidi Parker-Combes, Devon G. Shifflett, Antonio Harvey Apr 2023

Volume 14, Ireland Seagle, Dalton C. Whitby, Cassandra Poole, Rachel Cannon, Heidi Parker-Combes, Devon G. Shifflett, Antonio Harvey

Incite: The Journal of Undergraduate Scholarship

Table of Contents:

  • Introduction: Dr. Amorette Barber
  • From the Editor: Dr. Larissa "Kat" Tracy
  • From the Designers: Rachel English, Rachel Hanson
  • Hungry Like the Wolf: The Wolf as Metaphor in Paramount Network’s Yellowstone: Ireland Seagle
  • “Floating Cities”: Illustrating the Commercial and Conservation Conflict of Alaskan Cruise Ship Tourism: Dalton C. Whitby
  • What Can You Do When Your Genes are the Enemy? Current Applications of Gene Manipulation and the Associated Ethical Considerations: Cassandra Poole
  • La doble cara: un tema romántico en las obras de Larra y Hawthorne: Rachel Cannon
  • Resolving a Conflict: How to …


Development And Characterization Of Inducible Astrocyte-Specific Aromatase Knockout Mice, Jing Wang, Uday P Pratap, Yujiao Lu, Gangadhara R Sareddy, Rajeshwar R Tekmal, Ratna K Vadlamudi, Darrell W Brann Apr 2023

Development And Characterization Of Inducible Astrocyte-Specific Aromatase Knockout Mice, Jing Wang, Uday P Pratap, Yujiao Lu, Gangadhara R Sareddy, Rajeshwar R Tekmal, Ratna K Vadlamudi, Darrell W Brann

Faculty, Staff and Student Publications

17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models. The aim of this study was to develop a tamoxifen (TMX)-inducible astrocyte-specific aromatase knockout mouse line (GFAP-ARO-iKO mice) to specifically deplete the E2 synthesis enzymes and aromatase in astrocytes after their development in adult mice. The characterization of the GFAP-ARO-iKO mice revealed a specific and robust depletion in the aromatase expressions of their astrocytes and a significant decrease in their hippocampal E2 levels after …


Modeling Collective Cell Behavior In Cancer: Perspectives From An Interdisciplinary Conversation, Frederick R Adler, Alexander R A Anderson, Abhinav Bhushan, Paul Bogdan, Jose Javier Bravo-Cordero, Amy Brock, Yun Chen, Edna Cukierman, Kathleen E Delgiorno, Gerald V Denis, Meghan C Ferrall-Fairbanks, Zev Jordan Gartner, Ronald N Germain, Deborah M Gordon, Ginger Hunter, Mohit Kumar Jolly, Loukia Georgiou Karacosta, Karthikeyan Mythreye, Parag Katira, Rajan P Kulkarni, Matthew L Kutys, Arthur D Lander, Ashley M Laughney, Herbert Levine, Emil Lou, Pedro R Lowenstein, Kristyn S Masters, Dana Pe'er, Shelly R Peyton, Manu O Platt, Jeremy E Purvis, Gerald Quon, Jennifer K Richer, Nicole C Riddle, Analiz Rodriguez, Joshua C Snyder, Gregory Lee Szeto, Claire J Tomlin, Itai Yanai, Ioannis K Zervantonakis, Hannah Dueck Apr 2023

Modeling Collective Cell Behavior In Cancer: Perspectives From An Interdisciplinary Conversation, Frederick R Adler, Alexander R A Anderson, Abhinav Bhushan, Paul Bogdan, Jose Javier Bravo-Cordero, Amy Brock, Yun Chen, Edna Cukierman, Kathleen E Delgiorno, Gerald V Denis, Meghan C Ferrall-Fairbanks, Zev Jordan Gartner, Ronald N Germain, Deborah M Gordon, Ginger Hunter, Mohit Kumar Jolly, Loukia Georgiou Karacosta, Karthikeyan Mythreye, Parag Katira, Rajan P Kulkarni, Matthew L Kutys, Arthur D Lander, Ashley M Laughney, Herbert Levine, Emil Lou, Pedro R Lowenstein, Kristyn S Masters, Dana Pe'er, Shelly R Peyton, Manu O Platt, Jeremy E Purvis, Gerald Quon, Jennifer K Richer, Nicole C Riddle, Analiz Rodriguez, Joshua C Snyder, Gregory Lee Szeto, Claire J Tomlin, Itai Yanai, Ioannis K Zervantonakis, Hannah Dueck

Faculty, Staff and Student Publications

Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.


Loss-Of-Function Variants In Mycbp2 Cause Neurobehavioural Phenotypes And Corpus Callosum Defects, Lama Alabdi, Muriel Desbois, Domniţa-Valeria Rusnac, Raashda A Sulaiman, Jill A Rosenfeld, Seema Lalani, David R Murdock, Lindsay C Burrage, Ping Yee Billie Au, Shelley Towner, William G Wilson, Lawrence Wong, Theresa Brunet, Gertrud Strobl-Wildemann, Jennifer E Burton, George Hoganson, Kirsty Mcwalter, Amber Begtrup, Yuri A Zarate, Elyse L Christensen, Karla J Opperman, Andrew C Giles, Rana Helaby, Artur Kania, Ning Zheng, Brock Grill, Fowzan S Alkuraya Apr 2023

Loss-Of-Function Variants In Mycbp2 Cause Neurobehavioural Phenotypes And Corpus Callosum Defects, Lama Alabdi, Muriel Desbois, Domniţa-Valeria Rusnac, Raashda A Sulaiman, Jill A Rosenfeld, Seema Lalani, David R Murdock, Lindsay C Burrage, Ping Yee Billie Au, Shelley Towner, William G Wilson, Lawrence Wong, Theresa Brunet, Gertrud Strobl-Wildemann, Jennifer E Burton, George Hoganson, Kirsty Mcwalter, Amber Begtrup, Yuri A Zarate, Elyse L Christensen, Karla J Opperman, Andrew C Giles, Rana Helaby, Artur Kania, Ning Zheng, Brock Grill, Fowzan S Alkuraya

Faculty, Staff and Student Publications

The corpus callosum is a bundle of axon fibres that connects the two hemispheres of the brain. Neurodevelopmental disorders that feature dysgenesis of the corpus callosum as a core phenotype offer a valuable window into pathology derived from abnormal axon development. Here, we describe a cohort of eight patients with a neurodevelopmental disorder characterized by a range of deficits including corpus callosum abnormalities, developmental delay, intellectual disability, epilepsy and autistic features. Each patient harboured a distinct de novo variant in MYCBP2, a gene encoding an atypical really interesting new gene (RING) ubiquitin ligase and signalling hub with evolutionarily conserved functions …


Social Deprivation Induces Astrocytic Trpa1-Gaba Suppression Of Hippocampal Circuits, Yi-Ting Cheng, Junsung Woo, Estefania Luna-Figueroa, Ehson Maleki, Akdes Serin Harmanci, Benjamin Deneen Apr 2023

Social Deprivation Induces Astrocytic Trpa1-Gaba Suppression Of Hippocampal Circuits, Yi-Ting Cheng, Junsung Woo, Estefania Luna-Figueroa, Ehson Maleki, Akdes Serin Harmanci, Benjamin Deneen

Faculty, Staff and Students Publications

Social experience is essential for the development and maintenance of higher order brain function. Social deprivation results in a host of cognitive deficits and cellular studies have largely focused on associated neuronal dysregulation; how astrocyte function is impacted by social deprivation is unknown. Here we show that hippocampal astrocytes from juvenile mice subjected to social isolation exhibit increased Ca2+ activity and global changes in gene expression. We found that the Ca2+ channel TRPA1 is upregulated in astrocytes after social deprivation and astrocyte-specific deletion of TRPA1 reverses the physiological and cognitive deficits associated with social deprivation. Mechanistically, TRPA1 inhibition of hippocampal …


Reversing Dysdynamism To Interrupt Mitochondrial Degeneration In Amyotrophic Lateral Sclerosis, Gerald W Dorn Ii Apr 2023

Reversing Dysdynamism To Interrupt Mitochondrial Degeneration In Amyotrophic Lateral Sclerosis, Gerald W Dorn Ii

2020-Current year OA Pubs

Amyotrophic lateral sclerosis is one of several chronic neurodegenerative conditions in which mitochondrial abnormalities are posited to contribute to disease progression. Therapeutic options targeting mitochondria include enhancing metabolism, suppressing reactive oxygen production and disrupting mitochondria-mediated programmed cell death pathways. Herein is reviewed mechanistic evidence supporting a meaningful pathophysiological role for the constellation of abnormal mitochondrial fusion, fission and transport, collectively designated mitochondrial dysdynamism, in ALS. Following this is a discussion on preclinical studies in ALS mice that seemingly validate the idea that normalizing mitochondrial dynamism can delay ALS by interrupting a vicious cycle of mitochondrial degeneration, leading to neuronal die-back …


The Kemp Foundation’S Teaching Excellence Award Ceremony (2023 Program And Video), Illinois Wesleyan University Apr 2023

The Kemp Foundation’S Teaching Excellence Award Ceremony (2023 Program And Video), Illinois Wesleyan University

The Kemp Foundation's Teaching Excellence Award Ceremony Programs

This video contains the entire event, including the address given by the current Kemp Award winner, Professor of Chemistry Ram Mohan. Retiring faculty are also honored (bios included in the program) and the Kemp Award winner for next year is revealed.


A Somato-Cognitive Action Network Alternates With Effector Regions In Motor Cortex, Evan M Gordon, Roselyne J Chauvin, Andrew N Van, Aishwarya Rajesh, Ashley Nielsen, Dillan J Newbold, Nicole A Seider, Samuel R Krimmel, Kristen M Scheidter, Julia Monk, Ryland L Miller, Athanasia Metoki, David F Montez, Annie Zheng, Tomoyuki Nishino, Michael J Myers, Sydney Kaplan, Carolina Badke D'Andrea, Deanna M Barch, Christopher D Smyser, Cynthia E Rogers, Kelly N Botteron, John R Pruett, Jon T Willie, Peter Brunner, Joshua S Shimony, Benjamin P Kay, Scott Marek, Scott A Norris, Chad M Sylvester, Jarod L Roland, Steven E Petersen, Marcus E Raichle, Timothy O Laumann, Nico U F Dosenbach, Et Al. Apr 2023

A Somato-Cognitive Action Network Alternates With Effector Regions In Motor Cortex, Evan M Gordon, Roselyne J Chauvin, Andrew N Van, Aishwarya Rajesh, Ashley Nielsen, Dillan J Newbold, Nicole A Seider, Samuel R Krimmel, Kristen M Scheidter, Julia Monk, Ryland L Miller, Athanasia Metoki, David F Montez, Annie Zheng, Tomoyuki Nishino, Michael J Myers, Sydney Kaplan, Carolina Badke D'Andrea, Deanna M Barch, Christopher D Smyser, Cynthia E Rogers, Kelly N Botteron, John R Pruett, Jon T Willie, Peter Brunner, Joshua S Shimony, Benjamin P Kay, Scott Marek, Scott A Norris, Chad M Sylvester, Jarod L Roland, Steven E Petersen, Marcus E Raichle, Timothy O Laumann, Nico U F Dosenbach, Et Al.

2020-Current year OA Pubs

Motor cortex (M1) has been thought to form a continuous somatotopic homunculus extending down the precentral gyrus from foot to face representations


Sptssa Variants Alter Sphingolipid Synthesis And Cause A Complex Hereditary Spastic Paraplegia, Siddharth Srivastava, Hagar Mor Shaked, Kenneth Gable, Sita D Gupta, Xueyang Pan, Niranjanakumari Somashekarappa, Gongshe Han, Payam Mohassel, Marc Gotkine, Elizabeth Doney, Paula Goldenberg, Queenie K G Tan, Yi Gong, Benjamin Kleinstiver, Brian Wishart, Heidi Cope, Claudia Brito Pires, Hannah Stutzman, Rebecca C Spillmann, Undiagnosed Disease Network, Reza Sadjadi, Orly Elpeleg, Chia-Hsueh Lee, Hugo J Bellen, Simon Edvardson, Florian Eichler, Teresa M Dunn Apr 2023

Sptssa Variants Alter Sphingolipid Synthesis And Cause A Complex Hereditary Spastic Paraplegia, Siddharth Srivastava, Hagar Mor Shaked, Kenneth Gable, Sita D Gupta, Xueyang Pan, Niranjanakumari Somashekarappa, Gongshe Han, Payam Mohassel, Marc Gotkine, Elizabeth Doney, Paula Goldenberg, Queenie K G Tan, Yi Gong, Benjamin Kleinstiver, Brian Wishart, Heidi Cope, Claudia Brito Pires, Hannah Stutzman, Rebecca C Spillmann, Undiagnosed Disease Network, Reza Sadjadi, Orly Elpeleg, Chia-Hsueh Lee, Hugo J Bellen, Simon Edvardson, Florian Eichler, Teresa M Dunn

Faculty, Staff and Students Publications

Sphingolipids are a diverse family of lipids with critical structural and signalling functions in the mammalian nervous system, where they are abundant in myelin membranes. Serine palmitoyltransferase, the enzyme that catalyses the rate-limiting reaction of sphingolipid synthesis, is composed of multiple subunits including an activating subunit, SPTSSA. Sphingolipids are both essential and cytotoxic and their synthesis must therefore be tightly regulated. Key to the homeostatic regulation are the ORMDL proteins that are bound to serine palmitoyltransferase and mediate feedback inhibition of enzymatic activity when sphingolipid levels become excessive. Exome sequencing identified potential disease-causing variants in SPTSSA in three children presenting …


Rescue Of Glutaric Aciduria Type I In Mice By Liver-Directed Therapies, Mercedes Barzi, Collin G Johnson, Tong Chen, Ramona M Rodriguiz, Madeline Hemmingsen, Trevor J Gonzalez, Alan Rosales, James Beasley, Cheryl K Peck, Yunhan Ma, Ashlee R Stiles, Timothy C Wood, Raquel Maeso-Diaz, Anna Mae Diehl, Sarah P Young, Jeffrey I Everitt, William C Wetsel, William R Lagor, Beatrice Bissig-Choisat, Aravind Asokan, Areeg El-Gharbawy, Karl-Dimiter Bissig Apr 2023

Rescue Of Glutaric Aciduria Type I In Mice By Liver-Directed Therapies, Mercedes Barzi, Collin G Johnson, Tong Chen, Ramona M Rodriguiz, Madeline Hemmingsen, Trevor J Gonzalez, Alan Rosales, James Beasley, Cheryl K Peck, Yunhan Ma, Ashlee R Stiles, Timothy C Wood, Raquel Maeso-Diaz, Anna Mae Diehl, Sarah P Young, Jeffrey I Everitt, William C Wetsel, William R Lagor, Beatrice Bissig-Choisat, Aravind Asokan, Areeg El-Gharbawy, Karl-Dimiter Bissig

Faculty, Staff and Students Publications

Glutaric aciduria type I (GA-1) is an inborn error of metabolism with a severe neurological phenotype caused by the deficiency of glutaryl-coenzyme A dehydrogenase (GCDH), the last enzyme of lysine catabolism. Current literature suggests that toxic catabolites in the brain are produced locally and do not cross the blood-brain barrier. In a series of experiments using knockout mice of the lysine catabolic pathway and liver cell transplantation, we uncovered that toxic GA-1 catabolites in the brain originated from the liver. Moreover, the characteristic brain and lethal phenotype of the GA-1 mouse model was rescued by two different liver-directed gene therapy …


Nomina: Radix, Sophie Morrison Apr 2023

Nomina: Radix, Sophie Morrison

KUCC -- Kutztown University Composition Conference

No abstract provided.


Improving Forage Quality Of Tall Fescue (Festuca Arundinacea) By Genetic Manipulation Of Lignin Biosynthesis, Z. -Y. Wang, L. Chen, C. -K. Auh, A. Hopkins, P. Dowling Apr 2023

Improving Forage Quality Of Tall Fescue (Festuca Arundinacea) By Genetic Manipulation Of Lignin Biosynthesis, Z. -Y. Wang, L. Chen, C. -K. Auh, A. Hopkins, P. Dowling

IGC Proceedings (1977-2023)

Lignification of plant cell walls is a major factor limiting forage digestibility and concomitantly animal productivity. Improvement in forage grass cell wall digestibility has become an important goal of many plant-ruminant animal research programs. Lignins are complex phenolic heteropolymers associated with the polysaccharidic components of the wall in specific plant cells. Lignin in forage grasses comprises guaiacyl (G) units derived from coniferyl alcohol, syringyl (S) units derived from sinapyl alcohol, and p-hydroxyphenyl (H) units derived from p-coumaryl alcohol. Cinnamyl alcohol dehydrogenase (CAD) and caffeic acid O- methyltransferase (COMT) are key enzymes involved in lignin biosynthesis. Tall fescue …


Manipulating The Phenolic Acid Content And Digestibility Of Forage Grasses By Targeted Expression Of Fungal Cell Wall Degrading Enzymes, M. M. De O. Buanafina, P. Morris, T. Langdon, S. J. Dalton, B. Hauck, H. Porter Apr 2023

Manipulating The Phenolic Acid Content And Digestibility Of Forage Grasses By Targeted Expression Of Fungal Cell Wall Degrading Enzymes, M. M. De O. Buanafina, P. Morris, T. Langdon, S. J. Dalton, B. Hauck, H. Porter

IGC Proceedings (1977-2023)

Grass cell walls constitute 30-80% of forage dry matter, representing a major source of energy for ruminants. Ferulic acid (4-hydroxy-3-methoxy-cinnamic acid) and other hydroxycinnamic acids are ester linked to arabinosyl residues in arabinoxylans of grass cell walls and undergo oxidative coupling reactions resulting in the formation of a variety of dehydrodiferulate dimers which cross-link cell wall polymers. Although such cross-links have a number of important roles in the cell wall, they also hinder the rate and extent of cell wall degradation by ruminant microbial and fungal enzymes. We have shown previously the expression of a ferulic acid esterase gene from …


An Agronomic Evaluation Of Grazing Maize Combined With Companion Crops For Sheep In Northwestern Kwazulu-Natal, South Africa, C. S. Dannhauser, E. A. Van Zyl Apr 2023

An Agronomic Evaluation Of Grazing Maize Combined With Companion Crops For Sheep In Northwestern Kwazulu-Natal, South Africa, C. S. Dannhauser, E. A. Van Zyl

IGC Proceedings (1977-2023)

Northwestern KwaZulu-Natal (KZN), in South Africa, is well known for its sheep production from natural rangeland in summer (October to May). During winter however, the nutritional value of the rangeland cannot maintain young growing sheep or pregnant and lactating ewes. With this in mind Lyle (1991) suggested the use of planted pastures for the winter. Crichton, Gertenbach & Henning (1998) and Esterhuizen & Niemand (1989) suggested maize crop residues for both cattle and sheep during winter, whereas Moore (1997) evaluated grazing maize (not harvested) for this purpose. He found that the protein content of the crop was inadequate and for …


Effect Of Pre-Planting Seed Treatment Options On Dormancy Breaking And Germination Of Ziziphus Mucronata, Abubeker Hassen, N. F. G. Rethman, Willem A. Van Niekerk Apr 2023

Effect Of Pre-Planting Seed Treatment Options On Dormancy Breaking And Germination Of Ziziphus Mucronata, Abubeker Hassen, N. F. G. Rethman, Willem A. Van Niekerk

IGC Proceedings (1977-2023)

Ziziphus mucronata (Buffalo thorn) is a multipurpose tree, widely adapted to a range of ecological conditions and tolerant of extreme climatic conditions, including frost and drought (Venter & Venter, 1996). It is a valuable fodder tree for livestock and game animals, especially in the drier parts of Africa (Rothauge et al. 2003). Similar to many other leguminous species, establishment is constrained by low and erratic germination of the seed, which has been attributed mainly to the physical barrier of the stony endocarp and dormancy associated with seed coat impermeability. This experiment aimed to compare the suitability of various seed treatment …


Grazing Animal Production Systems And Grazing Land Characteristics In A Semi-Arid Region Of Greece, I. Hadjigeorgiou, G. Economou, D. Lolis, N. Moustakas, G. Zervas Apr 2023

Grazing Animal Production Systems And Grazing Land Characteristics In A Semi-Arid Region Of Greece, I. Hadjigeorgiou, G. Economou, D. Lolis, N. Moustakas, G. Zervas

IGC Proceedings (1977-2023)

Rough grazing in Greece cover about 40% of the total land area, is publicly owned and managed extensively (Hadjigeorgiou et al., 2002). The Prefecture of Larisa is in the centre of Greece, and has 212,000 ha of rough grazing land, with a variable topography ranging from sea level up to 3,000 m a.s.l. This area is utilized by a total population of 135,000 LU (mainly sheep, goats and some suckler cows), which consumes annually an appreciable fraction of their total nutrient requirements from rough grazing.


The Long Road To Developing Native Herbaceous Summer Forage Legume Ecotypes, James P. Muir, T. J. Butler, W. R. Ocumpaugh Apr 2023

The Long Road To Developing Native Herbaceous Summer Forage Legume Ecotypes, James P. Muir, T. J. Butler, W. R. Ocumpaugh

IGC Proceedings (1977-2023)

Only a handful of well-adapted herbaceous summer forage legumes are currently marketed for drier regions of North America and even fewer are true natives. There is a growing demand for native germplasm in the region as a new generation of landowner attempts to return grasslands to a semblance of their original species and diversity. The objective of this paper is to describe preliminary research results of a grasslands team collecting, studying and promulgating native leguminous germplasm in Texas.


Working Within Constraints: Managing African Savannas For Animal Production And Biodiversity, J. T. Du Toit Apr 2023

Working Within Constraints: Managing African Savannas For Animal Production And Biodiversity, J. T. Du Toit

IGC Proceedings (1977-2023)

The mean density of livestock biomass on African rangelands now greatly exceeds that of indigenous large herbivores, although livestock cannot fully substitute for wildlife with respect to co-evolved ecosystem processes involving herbivory. The dominance of livestock in semi-arid rangelands is largely due to water provision, which uncouples livestock population dynamics from the rainfall-driven trajectories followed by indigenous ungulate species in wildlife areas. Ecological sustainability cannot be achieved with a few exotic species maintained at unprecedented biomass densities in savanna ecosystems, which are evolutionarily adapted for species-rich communities of ungulates of a wise range of sizes. Integrating wildlife and livestock in …


Sustainable Semi-Arid Grazing Management Based On Indigenous Shona Practices Prior To Introduction Of Western Ideas In Zimbabwe, O. Mugweni, R. Mugweni Apr 2023

Sustainable Semi-Arid Grazing Management Based On Indigenous Shona Practices Prior To Introduction Of Western Ideas In Zimbabwe, O. Mugweni, R. Mugweni

IGC Proceedings (1977-2023)

In the Shona culture the land, i.e. the plants, animals, soil, water, air and others, evolved with herding animals. Hence, the absence of one results in the destruction of the other. It is argued that the conventional grazing management belief that too many animals cause overgrazing is a misconception of the semi-arid savanna environments of Southern Africa where these environments evolved with thousands of herding grazers and mega-faunas such as elephants, wildebeests and buffalo. The objective of the research is to establish that grazing with an adequate recovery period for grazed plants, as a result of domesticated animals being managed …


Profitable And Sustainable Grazing Systems For Livestock Producers With Saline Land In Southern Australia, N. J. Edwards, D. G. Masters, Edward G. Barrett-Lennard, M. Hebart, M. Mccaskill, W. King, W. Mason Apr 2023

Profitable And Sustainable Grazing Systems For Livestock Producers With Saline Land In Southern Australia, N. J. Edwards, D. G. Masters, Edward G. Barrett-Lennard, M. Hebart, M. Mccaskill, W. King, W. Mason

IGC Proceedings (1977-2023)

Dryland salinity affects over 2.5 M ha in Australia, mostly in southern states and is expanding at 3-5% per year (NLWRA, 2001). The prognosis is for considerable expansion of the area affected by salinity and waterlogging (12–17 M ha at equilibrium), because groundwater levels continue to rise and only small-scale land management programmes have been implemented. In addition, many waterways are increasingly saline, especially in the Murray Darling Basin and in Western Australia (WA). Sustainable Grazing on Saline Land (SGSL) addresses the need to make productive use of saline land and water resources. Its research component operates at 12 sites …


Cow-Calf Production On Perennial Pastures In The Central Semi-Arid Region Of Argentina, C. A. Frasinelli, K. Frigerio, J. Martínez Ferrer, J. H. Veneciano Apr 2023

Cow-Calf Production On Perennial Pastures In The Central Semi-Arid Region Of Argentina, C. A. Frasinelli, K. Frigerio, J. Martínez Ferrer, J. H. Veneciano

IGC Proceedings (1977-2023)

In cow-calf production systems in San Luis, the annual crops are heavily used (eastern region) or the natural pastures are over-used (western region). Both cases constitute unsustainable systems. In the present study, the possibility of structuring an efficient and stable stockbreeding agroecosystem based exclusively on perennial summer grasses was tested. The objectives were: 1) to test a cow-calf production system based on perennial pastures: Digitaria (Digitaria eriantha Steudel subsp. eriantha cv Irene), without protein supplement during winter, and 2) to determine the physical and economical efficiency of the production system and sustainability of such indicators in the short-term (6 …


Growth Performance Of Crossbred Steers On Unfertilised Mountain Pastures At Low Stocking Rates, A. Chassot, J. Troxler Apr 2023

Growth Performance Of Crossbred Steers On Unfertilised Mountain Pastures At Low Stocking Rates, A. Chassot, J. Troxler

IGC Proceedings (1977-2023)

As a consequence of increasing economic pressure on Swiss agriculture, marginal areas are threatened by abandonment, especially in the mountainous regions. Using these areas for extensive beef production might preserve an open landscape and favour biodiversity. A grazing experiment was conducted with steers on an unfertilised mountain pasture to study the effects of a reduction of stocking rate on the growth of the animals and on changes in the vegetation.


Which Drone Should You Buy To Study Dolphins?: Assessing Dolphin Response Behavior At Various Heights With Commonly Used Platforms, Savannah Damiano Apr 2023

Which Drone Should You Buy To Study Dolphins?: Assessing Dolphin Response Behavior At Various Heights With Commonly Used Platforms, Savannah Damiano

Graduate Research Conference

Drones are becoming a commonly used platform for understanding dolphin behavior However, this can be an intimidating field to approach as data is sparse on which commonly used drone types are the best to use for marine mammal research.

There is a need to further investigate the advantages and disadvantages of various drone types for marine mammal studies when it comes to disturbance factors.

Three commonly used DJI drone platforms were used to evaluate how drones affect the behavior of dolphins, the DJI Mini 2 the DJI Mavic 2 Enterprise Advanced, and the DJI Inspire 2.

The DJI Mavic Enterprise …