Digital Commons Network^™

Implementation Of A Glidescope Educational Program For Novice Student Registered Nurse Anesthesiologists, Joshua F. Snodgrass, Brian Bendel

Doctor of Nursing Practice Projects

GlideScope Video laryngoscopy carries a higher risk of injury to the pharyngeal cavity than direct laryngoscopy. Verathon is aware of this risk and has developed a proprietary “Four-step method” to mitigate it. This project aimed to reduce injuries related to GlideScope video laryngoscopy by providing first-year nurse anesthesiologists at Southern Illinois University Edwardsville with didactic and simulation education related to GlideScope video laryngoscopy and injury prevention. Didactic education was provided via a pre-recorded PowerPoint presentation. Simulation education was provided with the GlideScope and airway trainer manikins. The participants completed an identical 8-question pre-test and post-test to assess for knowledge gain …

Development Of Tom In Autistic Youth: The Potential Impact Of Language, Jaydel Hernandez

Honors Scholar Theses

Theory of Mind (ToM) includes the ability to attribute mental states (e.g., “happy”, “confused”) to oneself and others (Wimmer & Perner, 1983). Typically developing (TD) children demonstrate high performance on ToM tasks, while children with Autism Spectrum Disorder (ASD) may encounter difficulties with ToM (Peterson et al., 2005). The role of language in ToM development is unclear, as Perner et al. (1998) claimed that school-age children’s language levels did not impact their ToM ability but did not formally assess language. However, de Villiers and Pyers (2002) reported relationships between ToM and complex syntax. The current study elaborates on the existing …

Comparison Of Single-Cell Rna Sequencing Between Human Ependymoma And Mouse Models Of Human Ependymoma, Emily Hutchinson

Honors Scholar Theses

Ependymoma (EPN) is a group of central nervous system tumors most commonly observed in young children. EPN is characterized by high intratumoral cellular heterogeneity meaning the cell population within a single tumor is extremely diverse, which makes understanding the disease more complex. Furthermore, different subtypes of EPN have been identified as more or less favorable in terms of prognosis. For example, posterior fossa group A (PF-A) and supratentorial EPN with ZFTA-RELA fusions (ST-RELA) have been identified as the more aggressive groups in young children. Mouse models have been established to further understand the cellular profile of human ependymoma tumors. Much …

Democracy On The Edge: Use The First Amendment To Stop False Speech By Government Officials, William M. Brooks

University of Memphis Law Review

No abstract provided.

Protective Effect Of Betulinic Acid Administration On Kidney Damage In Acetaminophen-Induced Nephrotoxicity Model, Eda Dokumacioglu, Hatice İskender, Armagan Hayirli, Guler Yenice, Kubra Asena Terim Kapakin, Ismail Bolat, Esra Manavoglu Kirman

Makara Journal of Health Research

Background: Acetaminophen (APAP) is the most widely used analgesic drug worldwide, but it may induce renal toxicity. Betulinic acid (BA) ameliorates the oxidative stress and inflammatory response to renal damage. The present study aimed to investigate the potential protective effects of BA treatment through an experimental kidney damage rat model administered with APAP.

Methods: Sprague–Dawley male rats were randomly divided into four groups: control, BA (25 mg/kg for 15 days), APAP (1 g/kg), and APAP + BA groups. BA was administered via oral gavage at a dose of 25 mg/kg for 15 days. APAP was dissolved in hot …

Potential Use Of The Gel Extract Of Butterfly Pea Flower As Topical Therapy To Prevent Photodamage By Downregulating Tnf-Α And Caspase-3 Expression Levels In Uvb-Exposed Rats, Elvana Cahyani, Agung Putra, Prasetyowati Subchan

Makara Journal of Health Research

Background: Prolonged exposure to UVB radiation causes DNA damage in skin cells by raising the levels of reactive oxygen species, resulting in the production of inflammatory factors and skin issues. Plant extracts are frequently used to counteract photodamage due to their antioxidant properties. One example is the floral extract of the butterfly pea plant, which contains flavonoid antioxidants. However, the effect of the extract on inflammatory factors is unknown. This study investigated how tumor necrosis factor-alpha (TNF-α) and caspase-3 expression changed when a butterfly pea flower extract gel was applied topically to UVB-exposed animals.

Methods: Experimental and control …

Motion Control Simulation Of A Hexapod Robot, Weishu Zhan

Dartmouth College Master’s Theses

This thesis addresses hexapod robot motion control. Insect morphology and locomotion patterns inform the design of a robotic model, and motion control is achieved via trajectory planning and bio-inspired principles. Additionally, deep learning and multi-agent reinforcement learning are employed to train the robot motion control strategy with leg coordination achieves using a multi-agent deep reinforcement learning framework. The thesis makes the following contributions:

First, research on legged robots is synthesized, with a focus on hexapod robot motion control. Insect anatomy analysis informs the hexagonal robot body and three-joint single robotic leg design, which is assembled using SolidWorks. Different gaits are …

An Imc Approach To Building Trust Among Nonprofit Donors, Catherine A. Romaine

Honors Theses

This thesis explores the role of a holistic Integrated Marketing Communications strategy within the nonprofit sector. The research aims to identify the effectiveness of different marketing communication tactics in soliciting donations for nonprofit organizations. It examines the influences and motivations of donors when choosing one organization over another for their monetary contributions. The thesis investigates the impact of specific integrated marketing strategies in building and maintaining relationships with different stakeholders such as donors, volunteers, and employees.

Through a literature review of successful nonprofits and missteps within the sector, this thesis identifies various factors that contribute to nonprofit marketing success, including …

Application Of Deep Learning For Classification Of Intertidal Eelgrass From Drone-Acquired Imagery, Krti Tallam, Nam Nguyen, Jonathan Ventura, Andrew G. Fricker, Sadie Calhoun, Jennifer O’Leary, Mauriça Fitzgibbons, Ian C. Robbins, Ryan K. Walter

Physics

Shallow estuarine habitats are globally undergoing rapid changes due to climate change and anthropogenic influences, resulting in spatiotemporal shifts in distribution and habitat extent. Yet, scientists and managers do not always have rapidly available data to track habitat changes in real-time. In this study, we apply a novel and a state-of-the-art image segmentation machine learning technique (DeepLab) to two years of high-resolution drone-based imagery of a marine flowering plant species (eelgrass, a temperate seagrass). We apply the model to eelgrass (Zostera marina) meadows in the Morro Bay estuary, California, an estuary that has undergone large eelgrass declines and the subsequent …

Synthesis Of 2-Bromo-6-Alkylaminopyridines, 2,6-Dialkylaminopyridines, And Tren Based Ligands, Stephanie E. Carter

Honors College Theses

Extended metal atom chains (EMAC) are multimetallic complexes that feature a linear metal chain with metal-metal bonds surrounded by stabilizing ligand molecules. When EMACs are formed with paramagnetic metal ions, unique magnetic properties can be derived from direct metal to metal communication. The challenge is that EMAC complexes are challenging to synthesize due to the inherent weakness of most M-M bonds and the specificity of the ligands required to stabilize EMACs. In prior work by the Guillet group, the silyl aminopyridine (SAP) ligands were observed to stabilize very unique triiron complexes, but they were inherently unstable. In other work, scaffolded …

Bioinformatic Analysis Of Mirna Mechanisms In Circadian Rhythm Using A Zebrafish (Danio Rerio) Model, Layton F. Coursey

Honors College Theses

MicroRNAs are noncoding RNAs found in cells and the bloodstream, which help to maintain proper protein production and overall gene expression1. Typically, microRNAs bind to messenger RNA (mRNA) in the cell cytoplasm, acting as post-transcriptional regulators, and either degrade or repress mRNA2. Due to microRNAs playing a vital role in gene expression by repressing protein production of target genes, if they are underexpressed then the protein it regulates could be overexpressed as a result.

miRNAs have the potential to be biomarkers for numerous neurodegenerative diseases. Neurodegeneration can be seen in many forms such as Dementia, Alzheimer’s (AD), Huntington’s Disease (HD), …

The Genomic Landscape Of Familial Glioma, Dong-Joo Choi, Georgina Armstrong, Brittney Lozzi, Prashanth Vijayaraghavan, Sharon E Plon, Terence C Wong, Eric Boerwinkle, Donna M Muzny, Hsiao-Chi Chen, Richard A Gibbs, Quinn T Ostrom, Beatrice Melin, Benjamin Deneen, Melissa L Bondy, Gliogene Consortium, Genomics England Research Consortium, Matthew N Bainbridge, Christopher I Amos, Jill S Barnholtz-Sloan, Jonine L Bernstein, Elizabeth B Claus, Richard S Houlston, Dora Il'yasova, Robert B Jenkins, Christoffer Johansen, Daniel Lachance, Rose Lai, Beatrice S Melin, Ryan T Merrell, Sara H Olson, Siegal Sadetzki, Joellen Schildkraut, Sanjay Shete, J C Ambrose, P Arumugam, R Bevers, M Bleda, F Boardman-Pretty, C R Boustred, H Brittain, M A Brown, M J Caulfield, G C Chan, A Giess, J N Griffin, A Hamblin, S Henderson, T J P Hubbard, R Jackson, L J Jones, D Kasperaviciute, M Kayikci, A Kousathanas, L Lahnstein, A Lakey, S E A Leigh, I U S Leong, F J Lopez, F Maleady-Crowe, M Mcentagart, F Minneci, J Mitchell, L Moutsianas, M Mueller, N Murugaesu, A C Need, P O'Donovan, C A Odhams, C Patch, D Perez-Gil, M B Pereira, J Pullinger, T Rahim, A Rendon, T Rogers, K Savage, K Sawant, R H Scott, A Siddiq, A Sieghart, S C Smith, A Sosinsky, A Stuckey, M Tanguy, A L Taylor Tavares, E R A Thomas, S R Thompson, A Tucci, M J Welland, E Williams, K Witkowska, S M Wood, M Zarowiecki

Faculty, Staff and Student Publications

Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisposition that accounts for approximately 5% of glioma cases. We performed whole-genome sequencing on an exploratory cohort of 203 individuals from 189 families with a history of familial glioma and an additional validation cohort of 122 individuals from 115 families. We found significant enrichment of rare deleterious variants of seven genes in both cohorts, and the most significantly enriched gene was HERC2 (P = 0.0006). Furthermore, we identified rare noncoding variants in both cohorts that were predicted to …

Understanding Groundwater Flow In A Saturated Buffer Zone ( Sbz ) Using Numerical Models: Case Study Of T 3 Site, Mclean County, Central Illinois, Nnaemeka Henry Nsude

Theses and Dissertations

Loss of nutrients, such as nitrogen and phosphorous, from agricultural lands in the Midwest affects farm productivity and environmental quality. Nutrient runoff from lands discharged into streams degrades the aquatic ecosystem through eutrophication and subsequent hypoxic conditions. The presence of nitrogen also threatens the potability of numerous aquifer bodies globally due to their high solubility in water. To tackle this problem, best management practices such as Saturated Buffer Zone (SBZ) are implemented to reduce nitrogen from nitrate-laden tile water from agricultural lands before being discharged into streams. Groundwater flow and interactions at SBZ are not well understood. To aid the …

E-Module Behavior Counseling Practicum Based On Case Study, Henny Indreswari, Lutfi Fauzan, Devy Probowati, Rizka Apriani

Jurnal Kajian Bimbingan dan Konseling

One of the mandatory courses for students majoring in guidance and counseling is a behavior counseling practicum. The purpose of this research is to develop the behavior counseling e-module based on case studies that can be applied to students of guidance and counseling. The research and development design used in this study is the ADDIE model. The instrument used is a module assessment scale. The assessors are experts in guidance and counseling, media, language, and prospective users. Index agreement result of the product by the guidance and counseling expert validator is 1 (very high), the media expert is 0.93 (very …

Narrowing The Achievement Gap By Increasing Student Opportunities In An Outdoor Project-Based Learning Environment, Britney Christensen

Masters Projects

The nation’s lack of student achievement on standardized tests is a result of the insufficient number of opportunities a student has to interact with their environment. Research indicates racial and economic disparities limit the number of chances these groups have to build the wide range of background knowledge needed to support the academic demands in the classroom. As a result, their performances show a widening of the achievement gap. Therefore, this project speaks to perspectives centered around constructivism as a way to explain how students acquire knowledge over time. The author contends that reading diverse texts, writing for different purposes, …

Enhancing Cancer Diagnosis With Real-Time Feedback: Tumor Metabolism Through Hyperpolarized 1-13c Pyruvate Mrsi, Gaurav Sharma, José S Enriquez, Ryan Armijo, Muxin Wang, Pratip Bhattacharya, Shivanand Pudakalakatti

Faculty, Staff and Student Publications

This review article discusses the potential of hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) as a noninvasive technique for identifying altered metabolism in various cancer types. Hyperpolarization significantly improves the signal-to-noise ratio for the identification of 13C-labeled metabolites, enabling dynamic and real-time imaging of the conversion of [1-13C] pyruvate to [1-13C] lactate and/or [1-13C] alanine. The technique has shown promise in identifying upregulated glycolysis in most cancers, as compared to normal cells, and detecting successful treatment responses at an earlier stage than multiparametric MRI in breast and prostate cancer patients. The review provides a concise overview of the applications …

A Precision Environmental Health Approach To Prevention Of Human Disease, Andrea Baccarelli, Dana C Dolinoy, Cheryl Lyn Walker

Faculty, Staff and Students Publications

Human health is determined by the interaction of our environment with the genome, epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic landscape of cells and tissues. Precision environmental health is an emerging field leveraging environmental and system-level ('omic) data to understand underlying environmental causes of disease, identify biomarkers of exposure and response, and develop new prevention and intervention strategies. In this article we provide real-life illustrations of the utility of precision environmental health approaches, identify current challenges in the field, and outline new opportunities to promote health through a precision environmental health framework.

Metagenomic Analysis Of Dna Viruses With Targeted Sequence Capture Of Canine Lobular Orbital Adenomas And Normal Conjunctiva, Elizabeth A F Schaefer, Shirley Chu, Kristine M Wylie, Todd N Wylie, Obi L Griffith, Jacqueline W Pearce, Gayle C Johnson, Jeffrey N Bryan, Brian K Flesner

2020-Current year OA Pubs

Our study aims are: (1) to evaluate phenotypically normal canine conjunctival and orbital tissue and tissue from canine lobular orbital adenomas (CLOAs) for the presence of viral genomic material and (2) phylogenetically classify detected DNA viruses to determine if a DNA virus is associated with CLOAs. A total of 31 formalin fixed paraffin embedded CLOA tissue samples, 4 papillomas or sarcoid, and 10 fresh clinically normal conjunctival tissues were included in this study. Genomic DNA was isolated from all samples and sequencing libraries were prepared. The libraries were molecularly indexed and pooled and viral DNA was enriched via targeted sequence …

The Comorbidity Of Depression And Neurocognitive Disorder In Persons With Hiv Infection: Call For Investigation And Treatment, Karl Goodkin, Teresa H. Evering, Albert M. Anderson, Ann Ragin, Cynthia L. Monaco, Christina Gavegnano, Ryan J. Avery, Sean B. Rourke, Lucette A. Cysique, Bruce J. Brew

School of Medicine Publications

Depression and neurocognitive disorder continue to be the major neuropsychiatric disorders affecting persons with HIV (PWH). The prevalence of major depressive disorder is two to fourfold higher among PWH than the general population (∼6.7%). Prevalence estimates of neurocognitive disorder among PWH range from 25 to over 47% – depending upon the definition used (which is currently evolving), the size of the test battery employed, and the demographic and HIV disease characteristics of the participants included, such as age range and sex distribution. Both major depressive disorder and neurocognitive disorder also result in substantial morbidity and premature mortality. However, though anticipated …

Machine-Learning-Based Model For Hurricane Storm Surge Forecasting In The Lower Laguna Madre, Cesar E. Davila Hernandez, Jungseok Ho, Dong-Chul Kim, Abdoul Oubeidillah

Civil Engineering Faculty Publications

During every Atlantic hurricane season, storms represent a constant risk to Texan coastal communities and other communities along the Atlantic coast of the United States. A storm surge refers to the abnormal rise of sea water level due to hurricanes and storms; traditionally, hurricane storm surge predictions are generated using complex numerical models that require high amounts of computing power to be run, which grow proportionally with the extent of the area covered by the model. In this work, a machine-learning-based storm surge forecasting model for the Lower Laguna Madre is implemented. The model considers gridded forecasted weather data on …

Abrogation Of Map4k4 Protein Function Causes Congenital Anomalies In Humans And Zebrafish, Victoria Patterson, Dorothy K Grange, Et Al.

2020-Current year OA Pubs

We report 21 families displaying neurodevelopmental differences and multiple congenital anomalies while bearing a series of rare variants in

Impact Of Rural Financial Institutions Building Program (Rufin) On The Productivity Of Women-Owned Farms And Non-Farm Enterprises In Northern Nigeria, Ayodele Abiodun Olaleye, Abigail John Jirgi, Kpotun Mohammed Baba, Usman Shabba Mohammed

Journal of International Women's Studies

This study was undertaken to determine the impact of the Rural Financial Institution Building Program (RUFIN) on the productivity of women-owned farms and non-farm enterprises in Northern Nigeria. The study utilized primary data collected through a questionnaire administered to 390 beneficiaries and an equal number of non-beneficiaries selected through a multi-stage sampling procedure. The productivity of women-owned enterprises was determined using Total Factor Productivity (TFP), which was measured as a ratio of the total annual output of the enterprise to the product of capital input, labor input, and total material input. The propensity score matching approach was used to analyze …

Beautiful, Sexy, And Happy Celebrities: Perfect Mothers Or Instamoms, Ebru Güzel

Journal of International Women's Studies

The development of information technologies and the Internet has created an enormous economy. In line with this digital transformation, cultural change has come about. Global companies create new trends focused on vanity and pleasure in social media that follow the patriarchal capitalist ideology. Motherhood has also been included in this process, and “perfect motherhood,” as an extension to new generation motherhood, has been popularized on social media. Perfect motherhood requires mothers who are responsible for looking after children and the home to also be successful in their professional and personal lives while looking beautiful, young, chic, sexy, and fit. Recently …

The Rise Of Art Therapy As A Robust Treatment For Mental Health Issues, Erin Clark

Academic Festival

Art therapy is a method of treatment used within a broad spectrum of patients. There are many forms of art therapy: it can be done through music, drama, painting or drawing, and dance-movement. These methods of therapy can be used for mentally disabled patients, PTSD victims, persons facing a phobia, non-vocal patients, and patients with psychosis. On top of all these situations, art therapy is also utilized in traditional therapy with neurotypical patients. The common goal of art therapy varies on the patient. In some cases, the common goal is a lift of trauma or even full recovery, in other …

Strategies To Aid Multilingual Learners In Academic Language Acquisition In Elementary Science And Mathematics Classes, Mikayla Grumbacher, Sophia Sladic

James Madison Undergraduate Research Journal (JMURJ)

This qualitative inquiry research study surveys academic language acquisition strategies for teachers of multilingual learners in elementary science and mathematics classes. We paired readings of recent peer-reviewed journal articles with video observations of three elementary school teachers and an interview with a Director of English as a Second Language for a county in Virginia. Thematic analysis helped us identify similar strategies across the different studies, classroom observations, and interview. Our findings suggest that utilizing sensory and interactive supports are especially helpful strategies for teachers seeking to help multilingual learners in academic language acquisition.

Eucalyptus Essential Oil: A Safety Assessment And Causality Evaluation Of Published Case Reports, Cecile Bascoul

Oxford ICSB

Eucalyptus essential oil (EO) and preparations containing eucalyptus EO have been used in traditional medicine for centuries for the treatment of respiratory illnesses such as cold, influenza and sinus congestion. Research, including clinical trials, has been carried out to evaluate the efficacy of eucalyptus alleviating symptoms of such conditions. However, eucalyptus EO and preparations with eucalyptus EO have also been associated with rare cases of CNS depression and seizures. The case reports reviewed showed evidence of CNS depression and/or seizure in patients from all ages (<1 to 74 year-old) with different doses of eucalyptus EO (0.18 mL to 1000 mL). Most of the adverse events were in children; some of them reacting to small doses (4 drops of EO or about 0.24 mL), ingested, inhaled or after topical application. Most children who developed seizures did not have a history of seizures before the event. The main constituent of eucalyptus EO is 1,8-cineole (about 65% to 84% 1,8 cineole for eucalyptus globulus EO, one of the most commonly used eucalyptus species in commercially available …

Nature Or Natures Or Natural Laws? Some Comments On C.S. Lewis's Use Of The Concept Of Nature In Miracles, A Preliminary Study, Thomas Storck

Sehnsucht: The C. S. Lewis Journal

Now, although Lewis, of course, did not think that nature was a closed system inaccessible to any action from outside it, and in fact, his entire book was written to argue the opposite point of view, I hope to show that this continual usage of nature as “total system” prejudices the argument against miracles, at least subconsciously, by suggesting that nature is a closed system, or at least a system which ordinarily is blocked to outside entry or interference. Thus, David Hume’s unfortunately classic definition— “A miracle is a violation of the laws of nature . . .”6—is premised on …

"The Packed Reality Of Heaven": C.S. Lewis's Imaginative Re-Education Of The Modern Pilgrim, Monika B. Hilder

Sehnsucht: The C. S. Lewis Journal

How to think of Heaven then, which Lewis says “is, by definition, outside our experience,” when the fact is that “all intelligible descriptions must be of things within our experience” is a question that Lewis took seriously, especially since the scriptural imagery “[a]t first sight . . . chill[ed], rather than awake[ned], [his] desire.” He asked how a “typical modern” like himself might interpret the heavenly concept of glory. The first idea of fame suggested to him hellish competition; the second idea of brightness suggested the “ridiculous” image of becoming “a kind of living electric light bulb.” Indeed, he contends …

Lee Pitts, Sarah Moss

The Voice

No abstract provided.

Review Of Revisiting Narnia: Fantasy, Myth And Religion In C. S. Lewis’S Chronicles, Joe R. Christopher

Sehnsucht: The C. S. Lewis Journal

Review of Shauna Caughey, ed., Revisiting Narnia: Fantasy, Myth and Religion in C. S. Lewis’s Chronicles (Dallas, 2005). 310 pages. $14.95. ISBN: 9781932100636.