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A Fine-Scale Understanding Of Sagebrush Islands To Improve Restoration Outcomes In The Intermountain West, Sofia Koutzoukis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In the Intermountain West, rapid expansion of non-native grasses, primarily cheatgrass, has created a repeating cycle where cheatgrass easily ignites and after a fire, more cheatgrass establishes in the burned area, leading to more fire, and more cheatgrass. The primary method to prevent further fires is to plant grass and shrub seeds after a fire because they can deter cheatgrass from establishing and reduce the chance of fire. However, this approach does not always work. There is a need and interest in alternative ways to establish native grasses and forbs.

Sagebrush, the dominant shrub of lower-elevation regions of the Intermountain …

Social Factors Driving Grouping Dynamics In Bighorn Sheep Ewe, Toni Proescholdt

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Understanding and predicting movement is critical for conservation planning and disease risk mitigation, and important environmental drivers of animal movement have received extensive attention in the ecological literature. Social factors surrounding group fission and fusion events also directly affect movement. However, these events are infrequently measured in the wild and rarely linked to underlying mechanisms such as relatedness, agreement in reproductive status, or shared life stage. While some social factors cannot be directly observed in the field, individual animals congregating in groups and moving about a landscape can. In animal societies, groups may merge together in a fusion event, and …

Desert Body, Lauren Mckinnon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This thesis is a collection of poems examining certain paradoxes of my body. As a survivor of sexual violence, my body relives trauma which makes it feel uninhabitable. I compare my experiences with the Southern Utah desert. The physical beauty, destruction and inhabitability of the desert teaches me to accept my body as both beautiful and full of grief. The poems move chronologically through my life, beginning with an abusive relationship at the age of sixteen, a move to Moab at nineteen, and becoming a mother at twenty-five. Ultimately, with the desert as my guide, I learn to accept my …

The Sexual Objectification Experiences Of Non-Binary People, Lee R. Pradell

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Transgender people are a historically marginalized and disenfranchised group, leading to discriminatory interpersonal treatment such as sexual objectification experiences (SOEs), a type of objectification. Women look at themselves the way men look at them, reducing themselves to objects for someone else’s viewing. This flattening of oneself to value your bodily presentation over functioning increases dissociative states and promotes disordered eating behaviors. Non-binary people experience additive stressors within objectification experiences as people with less social power than cisgender women. This thesis is composed of three separate studies aimed at understanding the SOEs of non-binary people.

The first of three studies recruited …

Differing Mastery Criteria Effects On Maintenance Of 1-Step Instruction Following In Children With Disabilities, Kyle Wagner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The majority of Early Intervention clinics throughout the United States are currently using a practice that is not considered evidence based. When teaching skills to children with developmental disabilities, clinicians assign an accuracy standard for those skills. The most common accuracy standard, called a “mastery criterion,” is 80% across three teaching sessions. There is little to no evidence to support using this specific mastery criterion. The purpose of this study was to add more research regarding this topic, and how it affects how the skills taught maintain over time when teaching has ceased for a specific skill. Two children were …

Young Children's Nutrition, Growth, And Cognitive Development In The Ecuadorian Amazon, Kristin N. Murphy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The first few years of life are viewed as a critical period for development. Children who do not grow and develop well in these early years can experience life-long negative implications. Many children under the age of five in Ecuador suffer from high rates of malnutrition, stunting (low height-for-age), and delayed cognitive development. This dissertation aims to better understand why children from Ecuador, specifically from the Amazon region, are experiencing such high rates of delayed development. Fifty children and their mothers living in the Amazon region of Ecuador participated in this research study.

First, interviews were conducted by an Ecuadorian …

Best Practices Are Never Best: Evaluating Primate Conservation Education Programs (Pceps) With A Decolonial Perspective, Michelle Bezanson, Montserrat Franquesa-Soler, Martin Kowalewski, Allison Mcnamara, Rahayu Oktaviani, Michelle A. Rodrigues

Social and Cultural Sciences Faculty Research and Publications

Who do we aim to educate with primate conservation education programs (PCEPs)? In a commentary published in a recent AJP, Annette Lanjouw suggested that many efforts to “educate” habitat-country communities can be neocolonial in their approaches. Forest destruction and habitat loss are a result of global consumption and expansion. We therefore need to approach conservation education from many angles including local stakeholders, policy makers, government officials, and the humans living in industrialized nations who are major consumers of the items that shrink primate habitats. In this review, we investigate PCEPs to determine if the conservation education goals, education methods, and …

A Score Of Voices: Creating And Scoring An Original Film With A Cappella Choir, Zachary James Moore

Electronic Theses and Dissertations

Film scores typically feature large instrumental ensembles, sometimes with choir added at pivotal moments. Rarely, however, is the choir entrusted with a greater percentage of the score, and far too scores explore the sonic potential that vocal music has to offer. In fact, in a recent study of 800 films, none contained a score that was completely c. Thus, the body of unaccompanied choral film scores is practically non-existent. This curious gap in repertoire inspired me to create the documentary Downstream (2023) and score it entirely with an unaccompanied choir. The full score to this new work is contained within …

Approaches For Mitigating Woody Breast In Commercial Broilers Through Nutritional And Management Strategies, Clay Maynard

Graduate Theses and Dissertations

Breast myopathies have caused significant economic losses to the poultry industry over the last decade. The induction of woody breast (WB), white striping (WS), and spaghetti meat (SM) have caused textural issues, functional issues, and a decline in consumer acceptance. Of these three myopathies, WB causes the most pronounced effects on product quality and reduces functional use. Woody breast is also commonly associated with expansive breast meat growth/high performing broilers. However, progress in reducing these myopathies has been limited without hindering other aspects of poultry rearing. Generally, production performance reduces as myopathy occurrence or incidence reduces. This response is primarily …

Queer Need In The Natural State: An Exploratory Needs Assessment Of The 2slgbtqia+ Community In Northwest Arkansas, Leea Jean Johnson

Graduate Theses and Dissertations

This thesis explores the current needs of the 2sLGBTQIA+ community in Northwest Arkansas between the ages of 18-40 and what their experiences have been attempting to get their needs met. Eight semi-structured interviews were completed with members of the 2sLGBTQIA+ population, and ethical considerations were made throughout the process. The findings of this study were expansive and included six overarching themes with various subthemes. The findings report on the specific needs outlined by participants, how participants found the resources to meet their needs, and common positive and negative experiences that participants identified in the process. Findings showed that intersectional identities …

Influence Of Pregnant Cattle Grazing Endophyte-Infected Tall Fescue On Offspring Immune Function, Sidney Nicole Dunkel

Graduate Theses and Dissertations

The objective was to evaluate the influence of pregnant cattle grazing endophyte-infected tall, toxic, fescue (E+) during gestation on innate immune response of male offspring to an endotoxin challenge. Crossbred multiparous cows (n = 36) were bred to Red Angus sires and housed in replicated E+ or novel endophyte-infected, non-toxic, fescue (NE+) pastures prior to breeding and throughout gestation. From this calf-crop, a subset of post-weaned steers (n = 8 E+; n = 8 NE+) were selected for a lipopolysaccharide (LPS) challenge. Blood was collected every 30 min beginning 2 h prior to (Pre-LPS) and continuing 9 h following (Post-LPS) …

Molecular And Physiological Aspects Of Glufosinate Resistance In Amaranthus Palmeri, Matheus Machado Noguera

Graduate Theses and Dissertations

Palmer amaranth is one of the most troublesome weeds in worldwide agriculture. Among the traits that confers extreme weediness to this species, the ability to adapt to herbicide selection pressure stands out. The latest herbicide to which Palmer amaranth developed resistance is glufosinate-ammonium (GFA), an inhibitor of the enzyme glutamine synthetase (GS). The main objectives of this work were: 1) evaluate the resistance level of a Palmer amaranth population from Missouri, USA, 2) determine the mechanisms conferring GFA resistance in Palmer amaranth, 3) elucidate the behavior of amplified GS copies in GFA-resistant Palmer amaranth in terms of inheritance, stability and …

Cartographic Analysis Of Earth-Sun Relationships In Ancient Amazonia, Jackson Bennett Critser

Graduate Theses and Dissertations

The alignments of ancient man-made earthworks across the Amazon Basin, known as geoglyphs, have recently been discovered to predate early societal dates. Although much research indicated that the Amazon was uninhabitable until the last 1000 years (Meggers 1971), new evidence suggests this is not the case. The application of advanced cartographic and GIS technologies were implemented to link solar ‘marker’ days (e.g. solstices, equinoxes) with the alignment of geoglyphs, megaliths, stone architecture, and broader city forms to discover and analyze previously unknown Earth-Sun relationships across the Amazon Basin to conceivably sophisticated urban and architectural plans. The study of these geoglyphs …

An Ecological Perspective Of American Rodent-Borne Orthohantavirus Surveillance, Nathaniel Mull

Graduate Theses and Dissertations

Orthohantaviruses are a global group of viruses found primarily in rodents, though several viruses have also been found in shrews and moles. Many rodent-borne orthohantaviruses are capable of causing one of several diseases in humans, and the mortality associated with these diseases ranges from < 0.1% - 50% depending on the specific etiological virus. In North and South America, orthohantavirus research was ignited by an outbreak of severe disease in the Four Corners region of the United States in 1993. However, despite the discovery of over 20 orthohantaviruses in the Americas, our understanding of orthohantavirus ecology and virus-host dynamics in this region is still limited, and orthohantavirus surveillance is generally restricted in scope to select regions and small portions of host distributional ranges. In Chapter I, I present a literature review on the current understanding of American rodent-borne orthohantavirus ecology. This review focused on under-studied orthohantaviruses, addressing gaps in knowledge by extrapolating information from well-studied orthohantaviruses, general rodent ecology, and occassionally from Eurasian orthohantavirus-host ecology. There were several key conclusions generated from this review that warrant further research: 1) the large number of putative orthohantaviruses and gaps in orthohantavirus evolution necessitate further surveillance and characterization, 2) orthohantavirus traits differ and are more generalizable based on host taxonomy rather than geography, and 3) orthohantavirus host species are disproportionately found in grasslands and disturbed habitats. In Chapter II, I present a prioritized list of rodent species to target for orthohantavirus surveillance based on predictive modeling using machine learning. Probable orthohantavirus hosts were predicted based on traits of known orthohantavirus hosts using two different types of evidence: RT-PCR and virus isolation. Predicted host distributions were also mapped to identify geographic hotspots to spatially guide future surveillance efforts. In Chapter III, I present a framework for understanding and predicting orthohantavirus traits based on reservoir host phylogeny, as opposed to the traditional geographic dichotomy used to group orthohantaviruses. This framework establishes three distinct orthohantavirus groups: murid-borne orthohantaviruses, arvicoline-borne orthohantaviruses, and non-arvicoline cricetid-borne orthohantaviruses, which differ in several key traits, including the human disease they cause, transmission routes, and virus-host fidelity. In Chapter IV, I compare rodent communities and orthohantavirus prevalence among grassland management regimes. Sites that were periodically burned had high rodent diversity and a high proportion of grassland species. However, rodent seroprevalence for orthohantavirus was also highest in burned sites, representing a trade-off in habitat management outcomes. The high seroprevalence in burned sites is likely due to the robust populations supported by the high quality habitat resulting from prescribed burning. In Chapters V and VI, I describe Ozark virus and Sager Creek virus, two novel orthohantaviruses discovered from specimens collected during Chapter IV. Both chapters report full genome sequences of the respective viruses and compare both nucleotide and protein phylogenies with related orthohantaviruses. Additionally in Chapter VI, I support the genetic analyses with molecular and ecological characterizations, including seasonal fluctuations in host abundance, correlates of prevalence, evidence of virus shedding, and information on host cell susceptibility to Sager Creek virus.

Factors That Affect Home Range Of Timber Rattlesnakes (Crotalus Horridus) In Northwest Arkansas, Bannon Gallaher

Graduate Theses and Dissertations

Conservation of animal populations requires knowledge of their habitat and spatial needs. Quantifying spatial requirements involves the analysis of home range. We examined the effects of sex, body size (SVL), body condition (log mass/log SVL), and year on home range in Timber Rattlesnakes (Crotalus horridus) in Northwest Arkansas. Individual locality data from an ongoing, 22+ year radio-telemetry study in Madison Co., Arkansas were analyzed using both minimum convex polygon (MCP) and Kernel Density Estimates (KDE). Plots of the number of sequential observations versus home range (MCP and KDE) determined that a minimum of 25 locations per individual per active season …

Potential Control Of Invasive Mesquite Through Improving The Consumer’S Understanding Of Liquid Smoke Applications., Seth W. Ellsworth

Graduate Theses and Dissertations

Mesquite trees continue to invade forests and range lands in many countries across the world. The cost to remove these trees is staggering. In Texas, landowners spent $25 million over a 10- year period to clear 300,000 ha of mesquite trees, a fraction of the 22 million ha of Texas land affected by this invasion. Estimates are that the mesquite continues to negatively impact one to two percent of additional land in selected counties each year in Texas. However, the problem is not unique to Texas, but rather to the 44 species of mesquite trees, belonging to the genus Prosopis …

Effects Of Landscape And Yard Features On Mammals In Residential Yards In Northwest Arkansas, Emily Johansson

Graduate Theses and Dissertations

The human footprint is rapidly expanding, and wildlife habitat is continuously being converted to human residential properties. Most wildlife residing in developing areas are displaced to nearby undeveloped areas. However, some animals can coexist with humans and acquire the necessary resources (food, water, shelter) within the human environment. This may be particularly true when development is low intensity, as in suburban yards. Due to the wide variety in how homeowners utilize their yards, they can be considered individually managed “greenspaces.” These yards can provide a range of food (e.g., bird feeders, compost, gardens), water (bird baths and garden ponds), and …

Near-Optimal Control Of A Quadcopter Using Reinforcement Learning, Alberto Velazquez-Estrada

Theses and Dissertations

This paper presents a novel control method for quadcopters that achieves near-optimal tracking control for input-affine nonlinear quadcopter dynamics. The method uses a reinforcement learning algorithm called Single Network Adaptive Critics (SNAC), which approximates a solution to the discrete-time Hamilton-Jacobi-Bellman (DT-HJB) equation using a single neural network trained offline. The control method involves two SNAC controllers, with the outer loop controlling the linear position and velocities (position control) and the inner loop controlling the angular position and velocities (attitude control). The resulting quadcopter controller provides optimal feedback control and tracks a trajectory for an infinite-horizon, and it is compared with …

Winter Hardy Small Cereals For Grazing Or Silage In Eastern Nebraska, Abigail M. Sartin

Department of Animal Science: Dissertations, Theses, and Student Research

Two, 3-year studies were conducted to evaluate the value of cereal rye, winter wheat, and winter triticale as forage sources for either for silage or early spring grazing. For silage, the objective was to evaluate species and maturity effects on dry matter yield, nutritive value, and fermentation of small cereal silage. There are no major differences between wheat, rye, or triticale in terms of the relative timing of each species reached each maturity stage. There are no differences among species in dry matter (DM) yield, except for wheat which tends to decline at soft dough due to senescence of the …

Methods To Reduce Nitrogen And Carbon Losses From Finishing Beef Cattle, Hanna K. Cronk

Department of Animal Science: Dissertations, Theses, and Student Research

A finishing experiment evaluated the effect of incremental supplemental rumen-protected lysine on beef cattle performance. All cattle were fed the same diet of high moisture corn, dried rolled corn, modified distillers grains plus solubles, corn silage, and supplement with inclusion levels of lysine ranging from 0 to 7 grams/day, in 1 g increments. Dry matter intake (P ≤ 0.04) and ADG (P ≤ 0.04) decreased linearly as supplemental lysine increased in the diet with no effect on final carcass adjusted feed efficiency (P ≥ 0.34). In the initial 64 days of the experiment, increasing lysine in the …

The Evaluation Of Encapsulated Megasphaera Elsdenii In An Accelerated Beef Step-Up Program And An Acidosis Challenge Model And The Evaluation Of Ramp Versus A Traditional Forage Grain Adaptation Strategy On Methane And Respired Carbon Dioxide, Cindy D. Mansfield

Department of Animal Science: Dissertations, Theses, and Student Research

A metabolism experiment (Exp 1) was conducted to evaluate daily feeding of encapsulated Megasphaera elsdenii (M. elsdenii) NCIMB 41125 along with a one-time drench of 1×10¹¹ CFU of M. elsdenii on dry matter intake (DMI), in-vitro lactate utilization, volatile fatty acid (VFA), and lactate concentration. Treatments consisted of steers which were fed no M. elsdenii (CONTROL), steers drenched with the commercial dose 1×10¹¹ CFU of M. elsdenii (LactiproNXT) on d 1 of the experiment and received no other M. elsdenii (DRENCH), and steers drenched with a commercial dose of LactiproNXT on d …

Maureen Biology: Teaching Environmentalism Through Television, Maureen Kennedy

Senior Honors Projects

Children’s television is proven to be an effective instrument for educational material for young age groups and can be utilized to teach social awareness, traditional educational content, and about worldly issues. Highly successful shows for varying adolescent ages, such as Sesame Street, Reading Rainbow, and Bill Nye the Science Guy, exist for the sole purpose of increasing young viewers’ cognition and knowledge. Differing formats are used to convey educational content, such as narrative and expository structures, depending on the material and target age group. This project will develop the script for a children’s television show in the expository format that …

Alleviating Irinotecan-Induced Diarrhea Using Locally Bioavailable Naturally Occurring Flavonoids, Imoh Etim

Dissertations (2016-Present)

Chemotherapy-induced diarrhea is a frequent side effect that occurs with several chemotherapeutic agents. However, it is an understudied area in the management of cancer. This concern is significant with irinotecan, a camptothecin derivative. Irinotecan hydrochloride (CPT-11) is a prodrug that is hydrolyzed to SN-38, a potent topoisomerase 1 inhibitor used as the first-line agent for the treatment of metastatic colorectal cancer. However, there is a concern regarding gastrointestinal toxicity, especially diarrhea. Many patients have reported experiencing diarrhea, and severe diarrhea episodes (grades 3 and 4) have been recorded in about 40 % of patients (J. J. Lee & Sun, 2016). …

One Immune System Plays Many Parts: The Dynamic Role Of The Immune System In Chronic Pain And Opioid Pharmacology, Sanam Mustafa, Juliana E Bajic, Benjamin Barry, Samuel Evans, Kariel R Siemens, Mark R Hutchinson, Peter M Grace

Faculty, Staff and Student Publications

The transition from acute to chronic pain is an ongoing major problem for individuals, society and healthcare systems around the world. It is clear chronic pain is a complex multidimensional biological challenge plagued with difficulties in pain management, specifically opioid use. In recent years the role of the immune system in chronic pain and opioid pharmacology has come to the forefront. As a highly dynamic and versatile network of cells, tissues and organs, the immune system is perfectly positioned at the microscale level to alter nociception and drive structural adaptations that underpin chronic pain and opioid use. In this review, …

Oral Prevalence Of Akkermancia Muciniphila Among Pediatric And Adult Orthodontic And Non-Orthodontic Patients, Ching Shen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Akkermansia muciniphila (AM) is one of many highly abundant intestinal microbes that influences homeostasis and metabolic disorders and may also play a role in oral disorders. However, there is little evidence regarding the oral prevalence of this organism. Based upon this lack of evidence, the primary goal of this project is to survey an existing saliva repository to determine the overall prevalence of this organism and any associations with demographic or patient characteristics (age, sex, body mass index, race/ethnicity, orthodontic therapy). Using an approved protocol, a total n = 141 pediatric samples from an existing saliva repository were screened using …

The In/Visible Stockade: Sex Offender Management, Governmentality, And The Search For Normal Life, Christopher Wakefield

UNLV Theses, Dissertations, Professional Papers, and Capstones

Over the past thirty-five years, the United States has seen a dramatic expansion of regulatory policy around individuals convicted of sexual offenses. Sex offender management policies include national and state registries, notification laws, treatment mandates, residency restrictions, and numerous exclusions from institutions. A growing body of research from sociologists and criminologists has tracked the effects of this sex offender regime by measuring recidivism and collateral consequences among released offenders. Less attention has been paid to how sex offenders adapt to their regulator context—especially the selective public visibility that the registry generates. Furthermore, sociological scholarship has not yet developed strong theoretical …

Effects Of Cations And Dipicolinic Acid On B. Anthracis Spore Physiology And Cytotoxicity, Chandler P. Hassan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Inhalation of Bacillus anthracis spores leads to the most severe form of anthrax. Following phagocytosis by alveolar macrophages, spores germinate inside the phagolysosome. The mechanism used by the newly germinated B. anthracis cells to survive within macrophages is not completely understood.B. anthracis spores contain large concentrations of calcium in complex with dipicolinic acid (Ca-DPA). Upon germination, the cell excretes the large depot of Ca-DPA. DPA is an amphipathic molecule that could act as a buffer and modulate phagolysosome acidification. Intracellular calcium overload can disrupt signaling pathways required for normal macrophage function and trigger cell death. We hypothesized the release of …

Higher Hippocampal Diffusivity Values In Welders Are Associated With Greater R2* In The Red Nucleus And Lower Psychomotor Performance, Eun-Young Lee, Juhee Kim, Janina Manzieri Prado-Rico, Guangwei Du, Mechelle M Lewis, Lan Kong, Byoung-Gwon Kim, Young-Seoub Hong, Jeff D Yanosky, Richard B Mailman, Xuemei Huang

Faculty, Staff and Student Publications

INTRODUCTION: Chronic excessive welding exposure may be related to higher metal accumulation and structural differences in different subcortical structures. We examined how welding affected brain structures and their associations with metal exposure and neurobehavioral consequences.

METHODS: Study includes 42 welders and 31 controls without a welding history. Welding-related structural differences were assessed by volume and diffusion tensor imaging (DTI) metrics in basal ganglia, red nucleus (RN), and hippocampus. Metal exposure was estimated by both exposure questionnaires and whole blood metal levels. Brain metal accumulations were estimated by R1 (for Mn) and R2* (for Fe). Neurobehavioral status was assessed by standard …

Apoptotic Cell Death In Disease-Current Understanding Of The Nccd 2023, Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A Aaronson, John M Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews, Rami I Aqeilan, Eli Arama, Eric H Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A Barlev, Jiri Bartek, Nicolas G Bazan, Christoph Becker, Francesca Bernassola, Mathieu J M Bertrand, Marco E Bianchi, Mikhail V Blagosklonny, J Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Guo-Qiang Chen, Quan Chen, Youhai H Chen, Emily H Cheng, Jerry E Chipuk, John A Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R Cubillos-Ruiz, Peter E Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M Dawson, Valina L Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J Dixon, Brian D Dynlacht, Wafik S El-Deiry, John W Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J Garcia-Saez, Abhishek D Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R Green, Lloyd A Greene, Hinrich Gronemeyer, Georg Häcker, György Hajnóczky, J Marie Hardwick, Ygal Haupt, Sudan He, David M Heery, Michael O Hengartner, Claudio Hetz, David A Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jäättelä, Ana Janic, Bertrand Joseph, Philipp J Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L Kelly, Oliver Kepp, Adi Kimchi, Richard N Kitsis, Daniel J Klionsky, Ruth Kluck, Dmitri V Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N Lavrik, John J Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A Lipton, Richard A Lockshin, Carlos López-Otín, Tom Luedde, Marion Macfarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J Martin, Jean-Claude Martinou, Pier G Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A Miao, Ute M Moll, Cristina Muñoz-Pinedo, Daniel J Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Núñez, Andrew Oberst, Dimitry Ofengeim, Joseph T Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M Penninger, Francesca Pentimalli, David M Pereira, Shazib Pervaiz, Marcus E Peter, Paolo Pinton, Giovanni Porta, Jochen H M Prehn, Hamsa Puthalakath, Gabriel A Rabinovich, Krishnaraj Rajalingam, Kodi S Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M P Rodrigues, Barak Rotblat, Carla V Rothlin, David C Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M Ryan, Kristopher A Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W G Tait, Daolin Tang, Nektarios Tavernarakis, Carol M Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G Vander Heiden, Jacqueline L Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia Von Karstedt, Anne K Voss, Karen H Vousden, Domagoj Vucic, Daniela Vuri, Erwin F Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi

Faculty, Staff and Student Publications

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. …

Long Noncoding Rna 01534 Maintains Cancer Stemness By Downregulating Endoplasmic Reticulum Stress Response In Colorectal Cancer, Momoko Ichihara, Hidekazu Takahashi, Naohiro Nishida, Cristina Ivan, Daisuke Okuzaki, Yuhki Yokoyama, Masahisa Ohtsuka, Norikatsu Miyoshi, Mamoru Uemura, Shinji Tanaka, George Adrian Calin, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto

Faculty, Staff and Student Publications

Background: Studies have shown that cancer stemness and the endoplasmic reticulum (ER) stress response are inversely regulated in colorectal cancer (CRC), but the mechanism has not been fully clarified. Long noncoding RNAs (lncRNAs) play key roles in cancer progression and metastasis. In this study we investigated lncRNA 01534 (LINC01534) as a possible modulator between cancer stemness and ER stress response.

Methods: In vitro experiments using CRC cell lines were performed to explore a possible role of LINC01534. The expression of LINC01534 in clinical CRC samples was assessed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and in situ hybridization.

Results: Silencing …