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The Perceived Impact Of Morning Tubs On Elementary Students' Twenty-First Century Skills, Shelby Phillips May 2023

The Perceived Impact Of Morning Tubs On Elementary Students' Twenty-First Century Skills, Shelby Phillips

Honors Theses

Increasing demands for creativity, critical thinking, problem-solving, and collaboration to be taught in schools puts pressure on educators to incorporate non-cognitive skills into the already rigid curriculum (Battelle for Kids, 2019). While there is ample research on play in the classroom and the importance of teaching twenty-first century skills to elementary students, there is very limited research on teaching twenty-first century skills via morning tubs. Morning tubs elicit skills such as collaboration, communication, creativity, motivation, critical thinking, and problem-solving in students (Partnership for 21st Century Skills, 2009). Therefore, this thesis aims to introduce play to educators as a strategy through …


Loneliness And Pain In Individuals With Migraine, Marie-Josée Hymel May 2023

Loneliness And Pain In Individuals With Migraine, Marie-Josée Hymel

Honors Theses

Introduction. Loneliness has been found to affect individuals’ physical and mental health, but there is limited research exploring the effect loneliness has on pain. Some studies suggest that social exclusion numbs pain, and others indicate it can lead to hypersensitivity. This study used a sample of individuals with migraine to investigate the relationship of loneliness to pain and psychological variables. We hypothesized that loneliness would predict lower pain tolerance and pain threshold and that it would be positively correlated with disability and negative emotions.

Methods. Sixty-eight undergraduate females recruited for a larger study manipulating social exclusion among individuals …


Imperfect Immunity And The Stability Of A Modified Kermack-Mckendrick Model, Kaylee Sims May 2023

Imperfect Immunity And The Stability Of A Modified Kermack-Mckendrick Model, Kaylee Sims

Honors Theses

The classic Kermack-McKendrick model of mathematical epidemiology suggests that a population is only in equilibrium when there is no disease present. In the modern era, we have several cyclic infectious diseases that show no signs of eradication, despite global health measures. In this thesis, we introduce a coefficient of waning immunity in order to produce a modified Kermack-McKendrick model and analyze whether the model yields system stability with a certain amount of infection present. Ultimately, the model is incongruent with real-world case data, with its most glaring failure being exponential dampening of the height of each disease case peak due …


An Investigation Into The Common Problems Of Lagoon Wastewater Treatment In Kentucky, Kaylee A. Jones May 2023

An Investigation Into The Common Problems Of Lagoon Wastewater Treatment In Kentucky, Kaylee A. Jones

Honors Theses

Lagoon wastewater treatment systems are commonly used in areas that do not have the available resources for typical mechanical wastewater treatment. Lagoon systems consist of multiple preliminary lagoons, but mainly rely on long-term facultative lagoons for most analyte removal. In this study, one particular lagoon wastewater treatment system (named Municipality A Wastewater Treatment Plant) is investigated due to noncompliance with governmental standards provided by the National Pollutant Discharge Elimination System (NPDES). Samples were collected by researchers at 4 different instances inside of the treatment systems. These samples were sent to an analytical laboratory for testing. The readings from these samples …


A Marketing Analysis On Disney Cruise Line, Erin Bradley May 2023

A Marketing Analysis On Disney Cruise Line, Erin Bradley

Honors Theses

The objective of this thesis is to discuss the SWOT analysis and PEST analysis of Disney Cruise Line and to provide recommendations. The SWOT analysis involves identifying the company's strengths, weaknesses, opportunities, and threats, while the PEST analysis focuses on analyzing external factors that could impact the company's success such as political economic, sociocultural, and technological factors. The SWOT analysis highlights the opportunities for the company to expand into new destinations, form partnerships and acquisitions, and capitalize on industry growth, while also identifying the threats of competition, changing consumer preferences, and economic downturns. The strengths of the company include its …


Heretic Territories: Spells For Fracture, Mia Greenwald May 2023

Heretic Territories: Spells For Fracture, Mia Greenwald

Masters Theses, 2020-current

This monograph accompanies the MFA thesis exhibition, Heretic Territories: spells for fracture. The show uses video, weaving, clay, and bacterial/fungal bodies in three main bodies of work: Inter; Lost, remain, fracture; and For, Of Them. The pieces, and the relationship between them, explore themes of magic, the body, and land in contradiction and opposition to colonial and capitalist structures. I approach the artificial hierarchies that subjugate people, non-human creatures, and land while trying not to replicate the mistakes of posthumanist scholarship that bypasses the fact that not all people are afforded full access to the category …


Common Signaling Pathways Involved In Alzheimer's Disease And Stroke: Two Faces Of The Same Coin, Tushar Kanti Das, Bhanu Priya Ganesh, Kaneez Fatima-Shad May 2023

Common Signaling Pathways Involved In Alzheimer's Disease And Stroke: Two Faces Of The Same Coin, Tushar Kanti Das, Bhanu Priya Ganesh, Kaneez Fatima-Shad

Faculty, Staff and Student Publications

Alzheimer's disease (AD) and stroke are two interrelated neurodegenerative disorders which are the leading cause of death and affect the neurons in the brain and central nervous system. Although amyloid-β aggregation, tau hyperphosphorylation, and inflammation are the hallmarks of AD, the exact cause and origin of AD are still undefined. Recent enormous fundamental discoveries suggest that the amyloid hypothesis of AD has not been proven and anti-amyloid therapies that remove amyloid deposition have not yet slowed cognitive decline. However, stroke, mainly ischemic stroke (IS), is caused by an interruption in the cerebral blood flow. Significant features of both disorders are …


Characterization Of Cellular Senescence In Long-Lived Birds And Mammals, Joshua Shirazi May 2023

Characterization Of Cellular Senescence In Long-Lived Birds And Mammals, Joshua Shirazi

Electronic Theses and Dissertations Archive

Cellular senescence is characterized by a permanent exit from the cell cycle and the maintenance of a very active secretome termed the senescence-associated secretory phenotype (SASP). The accumulation of senescent cells has been associated with several age-related diseases, including cancer, atherosclerosis, osteoarthritis, pulmonary fibrosis, and neurodegenerative disorders such as Alzheimer's disease. For the past two decades, cellular senescence has been intensively studied, but exclusively on laboratory rodents and human cell lines. However, our understandings about cellular senescence in other species are extremely limited. This study aimed to characterize the SASP of long-lived and short-lived species using newly developed cutting-edge proteomic …


Identification And Quantification Of Allelochemicals Associated With Weed Suppression In Sweetpotato, Varsha Varsha May 2023

Identification And Quantification Of Allelochemicals Associated With Weed Suppression In Sweetpotato, Varsha Varsha

Theses and Dissertations

Mississippi ranks among the leading states in sweetpotato production in the US. However, managing weeds in sweetpotato fields presents a significant challenge, and the limited availability of herbicides labeled for use in sweetpotato makes it even more challenging. The widespread and repeated use of herbicides has led to the development of weed resistance. In addition, herbicides are incompatible with the organic production system. Finding sustainable weed management strategies to provide weed control options for organic cultivation and detain the development of herbicide-resistant weeds under conventional crop production is imperative. The natural chemicals released by the plants, also called allelochemicals, can …


Development And Evaluation Of An Automated Tactical Tillage Tool To Control Weeds In Row-Crop Production Systems, Grace Mccormick Friday May 2023

Development And Evaluation Of An Automated Tactical Tillage Tool To Control Weeds In Row-Crop Production Systems, Grace Mccormick Friday

Theses and Dissertations

Weed control is an integral part of a successful overall production strategy in row- cropping systems and has the potential to reduce or eliminate yield losses that negatively affect profitability. Timely and correctly selected herbicide applications are the major keys for effective weed control in a majority of instances. However, there are negative factors that contribute to ineffectiveness and weed escape issues that currently lack viable options for management. Sparsely populated late-season weeds that emerge after lay-by herbicide applications and weeds that have become tolerant and resistant to traditional herbicide chemistries are of greatest concern. Historically, these weeds would have …


Determining The Impact Of Post-Harvest Water Management On Chironomid Abundance, Agrochemical Biomass And Potential Trophic Biomagnification, Mason Thomas May 2023

Determining The Impact Of Post-Harvest Water Management On Chironomid Abundance, Agrochemical Biomass And Potential Trophic Biomagnification, Mason Thomas

Theses and Dissertations

Agriculture has diminished shorebirds’ natural habitat in the Mississippi Alluvial Valley. Remaining natural stopover sites are supplemented with agricultural fields during the fall and winter. This study evaluates the impact of 4 different post-harvest water management strategies on shorebird food abundance and potential agrochemical biomagnification. Chironomid samples estimated abundance, biomass, and chironomid agrochemical concentration in each field. A risk assessment of agrochemical biomagnification to shorebirds was made across all treatments. Of treatments represented on all study sites, winter treatment had greatest chironomid abundance and biomass. Models indicated that days since flood initiation, start date, and temperature are significant predictors of …


The Impact Of Environmental Education Delivery Methods And Outreach Messaging On Attitudes, Interests, And Intended-Behavior Changes Toward Nature, Vanessa Elizabeth Hoffman May 2023

The Impact Of Environmental Education Delivery Methods And Outreach Messaging On Attitudes, Interests, And Intended-Behavior Changes Toward Nature, Vanessa Elizabeth Hoffman

Theses and Dissertations

Environmental education (EE) is important for environmental awareness and stewardship. Involving youth and adults in EE ensures current and future generations will conserve natural resources. This thesis explores impacts of delivery methods on participants’ environmental attitudes and behaviors toward nature through middle school classroom- and camp-based EE instruction, focus group interviews with rural minority youth, and adult responses to aquatic conservation outreach messaging. I observed no difference in environmental attitudes between online versus in-person delivery of EE lessons for middle-schoolers. Outdoor-based learning may be more impactful for EE than experiential, classroom-based learning. Focus group outcomes suggested youth EE programs should …


Physiological And Proteomic Analysis Of Soybean In Response To Drought And Heat Stress, Amandeep Kaur May 2023

Physiological And Proteomic Analysis Of Soybean In Response To Drought And Heat Stress, Amandeep Kaur

Theses and Dissertations

Drought and temperature stress are the two most important factors limiting crop productivity. A physiological and proteomic analysis of soybean was performed to investigate the negative impact of these variables. The previous studies reported the beneficial effect of silicon under stress conditions. Silicon supplementation may promote plant growth under drought stress, although the mechanism to alleviate drought stress is uncertain. The proteomic analysis of chloroplast proteins was carried out to study the response of silicon supplementation under drought stress.

Similarly, temperature stress, mainly heat stress, has an adverse effect on soybean plants. The comparative analysis of two soybean cultivars, DS25-1 …


Development Of Live Attenuated A. Hydrophila Vaccines And Understanding Of Macrophage-Aeromonas Hydrophila Interactions, Eda Ozdemir May 2023

Development Of Live Attenuated A. Hydrophila Vaccines And Understanding Of Macrophage-Aeromonas Hydrophila Interactions, Eda Ozdemir

Theses and Dissertations

Channel catfish farming is the largest aquaculture industry in the U.S., and virulent Aeromonas hydrophila is an important re-emerging bacterial pathogen of farmed catfish. A. hydrophila is ubiquitous in the aquatic environment and causes motile Aeromonas septicemia (MAS) in farmed catfish. A. hydrophila infection is challenging to treat due to rapidly progressive mass mortalities. Although florfenicol has been used in managing outbreaks, acute onset of anorexia, drug cost, and emergence of antimicrobial-resistant strains are significant concerns. Prevention of MAS by vaccination could be a promising approach, but a commercial vaccine is not available. Thus, it is critical to develop effective …


Understanding Dietary And Thermal Influences On Invasive Cichlids In Puerto Rico Reservoir Systems, Jacob A. Moreland May 2023

Understanding Dietary And Thermal Influences On Invasive Cichlids In Puerto Rico Reservoir Systems, Jacob A. Moreland

Theses and Dissertations

Jaguar Guapote (Parachromis managuensis) and Amphilophus spp. were assessed for effects of temperature on standard metabolic rate (SMR) and lower dissolved oxygen tolerance (LDOT), efficacy of gastric lavage for diet analysis, and diet in Puerto Rico reservoirs. Fish were acclimated to 22°C, 28°C, and 34°C and SMR and LDOT were measured using intermittent respirometers. Jaguar Guapote acclimated to 34°C had the greatest SMR, with 22°C and 28°C having similar SMR values. Amphilophus spp. acclimated to 28°C were similar to fish acclimated at 22°C and 34°C. Fish were resilient to high temperatures, losing equilibrium more rapidly at the coldest temperature, 22°C. …


Eating German, The American Way: German And American Cooking Traditions, Potato Salad, And The Culinary Assimilation Of German Immigrants, 1820-1920., Scott Wooley May 2023

Eating German, The American Way: German And American Cooking Traditions, Potato Salad, And The Culinary Assimilation Of German Immigrants, 1820-1920., Scott Wooley

Theses and Dissertations

“Eating German, the American Way” explores how and why the mayonnaise-based potato salad came to be a staple of American culinary tradition. It examines how native-born Americans and German immigrants in the nineteenth century identified themselves based on their culinary traditions and what they ate and how the interactions between, and accessibility of, those traditions created a new identity based on the sharing of recipes as the two groups mingled and assimilated to each other. It uses food as a way to understand the processes of assimilation by defining the distinctions between the two groups based on their separate repertoire …


Molecular Characterization Of Seminal Plasma From Boars With Divergent Sperm Quality, Notsile Hleliwe Dlamini May 2023

Molecular Characterization Of Seminal Plasma From Boars With Divergent Sperm Quality, Notsile Hleliwe Dlamini

Theses and Dissertations

Seminal plasma (SP) is the microenvironment of spermatozoa whose composition reflects semen quality and constitutes an excellent source for detecting non-invasive biomarkers. This study characterizes good vs. poor quality semen using seminal extracellular vesicles coupled proteins and miRNA. Fresh boar semen samples were screened, centrifuged, and SP supernatants were collected for near-infrared spectroscopy (NIRS) analysis. EVs were extracted from SP (SP-EVs), characterized, and those of extremely poor or good sperm quality groups were subjected to proteomics and small RNA sequencing. Significant differences were set for P


Physiological And Yield Responses Of Soybean Cultivars To Heat And Drought Stresses, Sadikshya Poudel May 2023

Physiological And Yield Responses Of Soybean Cultivars To Heat And Drought Stresses, Sadikshya Poudel

Theses and Dissertations

Soybean (Glycine max L.) is an important legume crop often exposed to heat and drought stresses during reproductive and early-seed setting stages, resulting in lower yields and seed quality. Ten soybean cultivars were phenotyped for individual (drought or heat) and combined stress tolerance. Under drought, reduced stomatal conductance and increased canopy temperature significantly reduced seed number (46%) and weight (35%). Heat stress alone reduced seed number (19%) and weight (23%) compared to control. Moreover, a degree increase in daytime temperature above 32 °C during the reproductive stage reduced seed weight by 4% and 7% under well-watered and drought conditions, respectively. …


Evaluation Of Conservation Practices Effect On Water Quality Using The Swat Model, Vivek Venishetty May 2023

Evaluation Of Conservation Practices Effect On Water Quality Using The Swat Model, Vivek Venishetty

Theses and Dissertations

The deterioration of water quality due to human-driven alternations has an adverse effect on the environment. More than 50% of surveyed surface water bodies in the United States (US) are classified as impaired waters as per the Clean Water Act. The pollutants affecting the water quality in the US are classified as point and non-point sources. Pollutant mitigation strategies such as the selective implementation of best management practices (BMPs) based on the severity of the pollution could improve water quality by reducing the amounts of pollutants. Quantifying the efficiency of a specific management practice can be difficult for large watersheds. …


Interspecies Differences In Organophosphate Anticholinesterase Inhibition Potency And Reactivation Using Novel Oximes, Katie Elizabeth Strickland May 2023

Interspecies Differences In Organophosphate Anticholinesterase Inhibition Potency And Reactivation Using Novel Oximes, Katie Elizabeth Strickland

Theses and Dissertations

Organophosphates are insecticides which result in acute adverse signs when exposed at toxic doses by animals and lead to death if left untreated. The current treatment for organophosphate toxicity includes atropine and the federally approved oxime 2-PAM. However, 2-PAM is not very effective at crossing the blood brain barrier which results in prolonged inactivation of acetylcholinesterase, which is the primary target of organophosphates, in the brain even after administration. The novel oximes, Oxime 15 and Oxime 20, are able to cross the blood brain barrier and reactivate the inhibited acetylcholinesterase. In this experiment with six animal species frequently used in …


Evaluation Of The Relationship Between Hair Coat Shedding Ability, Apparent Forage Digestibility, And Mineral Status In Angus Cattle, Margaret P. Loftin May 2023

Evaluation Of The Relationship Between Hair Coat Shedding Ability, Apparent Forage Digestibility, And Mineral Status In Angus Cattle, Margaret P. Loftin

Theses and Dissertations

The objective of this study was to evaluate the relationship between hair coat shedding ability, apparent forage digestibility, and mineral status in Angus cattle. Fecal samples were collected on fall calving Angus cows for one week in March, May, and July from 2019-2022. Liver and plasma samples were collected in March and July each year. Fecal samples were analyzed for DM, ash, NDF, and ADF while liver and plasma were analyzed for mineral concentration. Data were analyzed using MIXED procedure of SAS with significance declared at P0.05. Interactions were detected for DM, NDF, ADF, and liver Fe concentration. The model …


Effects Of Sampling Methodologies On Mycoplasma Gallisepticum Tissue Populations In Commercial Layer Pullets, Sethulakshmi Kattupparayil Sasidharan May 2023

Effects Of Sampling Methodologies On Mycoplasma Gallisepticum Tissue Populations In Commercial Layer Pullets, Sethulakshmi Kattupparayil Sasidharan

Theses and Dissertations

Mycoplasma gallisepticum (MG) can cause chronic respiratory disease in chickens and infectious sinusitis in turkeys. Impacts of MG infections can include increased morbidity and mortality, decreased egg production, hatchability and feed efficiency. Biosecurity and bio-surveillance remain the primary means of deterrence as the current means of control are not wholly effective. Further applications towards the characterization of MG-related disease control requires proper understanding of the characteristics of MG infections with accurate and efficient quantification of in vivo MG populations. To this end, study was conducted to determine the in vivo MG populations in infected pullets and to determine impact of …


Impact Of Daily Sweet Potato Ingestion On Alterations To The Gut Microbiome, Cholesterol, And Exercise Performance, Johneric William Smith May 2023

Impact Of Daily Sweet Potato Ingestion On Alterations To The Gut Microbiome, Cholesterol, And Exercise Performance, Johneric William Smith

Theses and Dissertations

The importance of the gut microbiome is being explored in relation to multiple facets of health and performance. The purpose of this study was to explore the impact of frequent sweet potato ingestion on alterations of the gut microbiome which might in turn alter cholesterol levels and exercise performance. Thirteen recreationally trained males had fecal and blood samples collected and exercised to fatigue with and without exogenous carbohydrate ingestion prior to and following 42 days of daily sweet potato ingestion. Bacterial communities were extracted from fecal samples and bacterial DNA were sequence. Blood samples were analyzed for total cholesterol, low-density …


Evaluation Of Nutrient Digestibility Of Weaned Calves From Early And Late Shedding Dams, Jennifer Keele May 2023

Evaluation Of Nutrient Digestibility Of Weaned Calves From Early And Late Shedding Dams, Jennifer Keele

Theses and Dissertations

Researchers have investigated several factors that could alter fetal growth, including nutrient restriction (Valiente et al., 2021), hair shedding (Gray et al., 2011), and extreme hot and cold temperatures (Davidson et al., 2022). Hot temperatures and increased humidity percentages in the southeast United States caused researchers to investigate the hair coats of Angus cattle in the commercial production setting. An improvement in fiber digestibility and calf birth and weaning weights has been observed in Angus dams that shed 50% of the winter hair coat by May (Gray et al., 2011; Burnett et al., 2021). Our objective of this experiment was …


Marxist Analysis Of Social And Economic Narratives In Childrens' Cartoons, Shane Mcgregor May 2023

Marxist Analysis Of Social And Economic Narratives In Childrens' Cartoons, Shane Mcgregor

Theses and Dissertations

Using a Marxist framework with a grounding in critical literacy, this study employs a content analysis methodology to analyze 25 episodes of five of the most popular children’s television cartoons in order to understand how these cartoons portray economic and social systems, as well as how the messages these cartoons express would tend to support these systems. In so doing, this research hopes to provide a conceptual framework that educators and parents can use as a guide for demonstration of a critical approach to understanding the curriculum of children’s media inside or outside of the classroom. Educators can modify this …


The Neuroprotective Role Of Vitamin D In Humans With A Traumatic Brain Injury: A Systematic Review, Hailey Jarr May 2023

The Neuroprotective Role Of Vitamin D In Humans With A Traumatic Brain Injury: A Systematic Review, Hailey Jarr

Theses and Dissertations

Traumatic brain injuries (TBI) are a leading cause of death worldwide. Previous research supports a relationship between vitamin D and TBI outcomes; however, they rely on animal studies. This review aimed to examine the neuroprotective role of vitamin D in humans with TBIs. A search was completed (PubMed and Scopus) following PRISMA guidelines to review publications investigating the relationship between vitamin D deficiency (VDD) and TBI or the effect of vitamin D supplementation on TBI outcomes; 8 studies were identified. Patients had the
/="/">following ranges: 26-88% deficiency and 62-88% insufficiency compared to 24% and 49% of the general population. …


Patterns Of Distribution And Dispersion Of Silver Carp In An Oxbow Lake, Jordan Besson May 2023

Patterns Of Distribution And Dispersion Of Silver Carp In An Oxbow Lake, Jordan Besson

Theses and Dissertations

Oxbow lakes are highly productive waterbodies that host multiple life stages of many freshwater aquatic species. Oxbow lakes also provide habitat to Silver Carp (Hypophthalmichthys molitrix), which has enabled populations to grow and expand within the United States. Silver Carp are undesirable because they can compete for resources with native fishes. My goal was to identify patterns of distribution and dispersion of Silver Carp in Moon Lake, Mississippi, to assist and inform precise harvesting of fish. I implanted thirty-five adult Silver Carp with acoustic tags that I released into Moon Lake. I observed that Silver Carp were disproportionately …


Identifying Limitations In Using Diagnostic Testing For Absorption Of Passive Maternal Immunity In Neonatal Beef Calves To Predict Pre-Weaning Disease, Alexis Charlotte Thompson May 2023

Identifying Limitations In Using Diagnostic Testing For Absorption Of Passive Maternal Immunity In Neonatal Beef Calves To Predict Pre-Weaning Disease, Alexis Charlotte Thompson

Theses and Dissertations

Calves are born agammaglobulinemic and rely on colostrum consumption for the transfer of maternal passive immunity. Calves that fail to absorb adequate amounts of maternal antibodies from colostrum are commonly referred to as having failed transfer of passive immunity (FTPI). The overall aim of this dissertation was to explore the usefulness of FTPI testing in neonatal beef calves to predict their risk for subsequent illness or death. The objectives were to evaluate the impact of FTPI on pre-weaning disease in beef and dairy calves, quantify and compare the variance in IgG concentrations measured by radial immunodiffusion and serum total protein …


Marginal Agricultural Land Identification In The Lower Mississippi Alluvial Valley, Prakash Tiwari May 2023

Marginal Agricultural Land Identification In The Lower Mississippi Alluvial Valley, Prakash Tiwari

Theses and Dissertations

This study identified marginal agricultural lands in the Lower Mississippi Alluvial Valley using crop yield predicting models. The Random Forest Regression (RFR) and Multiple Linear Regression (MLR) models were trained and validated using county-level crop yield data, climate data, soil properties, and Normalized Difference Vegetation Index (NDVI). The RFR model outperformed MLR model in estimating soybean and corn yields, with an index of agreement (d) of 0.98 and 0.96, Nash-Sutcliffe model efficiency (NSE) of 0.88 and 0.93, and root mean square error (RMSE) of 9.34% and 5.84%, respectively. Marginal agricultural lands were estimated to 26,366 hectares using cost and sales …


The Effect Of Vitamin B-12 Supplementation On Visual Reaction Time In Young Adult Females, Sean M. Servalish May 2023

The Effect Of Vitamin B-12 Supplementation On Visual Reaction Time In Young Adult Females, Sean M. Servalish

Theses and Dissertations

This study investigated the effect of vitamin B-12 supplementation on visual response time (VRT). Menstrual cycle phase (MCP) and 24-hour dietary intake of B-12 were also observed as dependent variables. This blind, placebo-controlled trial observed 14 young adult females in four treatment groups: control, 500mcg (low dose), 2000mcg (moderate dose), and 3000mcg (high dose). The study lasted 28 days, with participants treated weekly, randomly assigned to each of the treatment groups. When comparing B-12 dose treatment groups to VRT baseline, there was significant improvements in VRT. Compared to the placebo, there were no significant differences among treatment groups. Significant differences …