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Articles 79171 - 79200 of 734429
Full-Text Articles in Entire DC Network
The Value Of Therapeutic Farming As An Art Therapy Intervention For Emerging Adults: A Literature Review, Neva Callaghan
The Value Of Therapeutic Farming As An Art Therapy Intervention For Emerging Adults: A Literature Review, Neva Callaghan
Expressive Therapies Capstone Theses
This literature review examines the role of place, space, and environment in art therapy and proposes therapeutic farms as alternative mental health care for emerging adults. The writing explores concepts of nature-based art therapy, therapeutic metaphors, and self-determination theory in regard to how these approaches can enhance engagement in the therapeutic process. The COVID-19 pandemic has had a significant impact on emerging adults’ mental health and feelings of connection to nature. The developmental needs of this population are not met by the current mental health care system, and there is a need to consider alternative forms of treatment. This research …
Exploring The Effects Of Intersectionality On Mental Health And Identity Development With Adolescents Through Culturally Humble Art Therapy, Cal Loiselle
Expressive Therapies Capstone Theses
This study investigated the implementation of culturally humble art therapy directives centered around identity development and social justice with adolescents. Intersectionality theory was applied to examine the ways operating from a culturally humble lens benefits clients and art therapists. Existing research supports the application of cultural humility with various populations as a method of validating client’s experiences and strengthening the therapeutic alliance. A series of art therapy interventions were implemented at a private non-profit children's psychiatric hospital with the adolescent inpatient units. The participants were between the ages of 13-18 and receiving treatment for mental health conditions, short-term stabilization, and …
66th University Of San Diego School Of Law Commencement Program, 2023, University Of San Diego School Of Law
66th University Of San Diego School Of Law Commencement Program, 2023, University Of San Diego School Of Law
Commencement Programs
No abstract provided.
Physiological And Behavioral Stress-Induced Responses Of Dogs During Veterinary Examinations, Jessica Ellen Vester
Physiological And Behavioral Stress-Induced Responses Of Dogs During Veterinary Examinations, Jessica Ellen Vester
Honors Projects
This study investigated whether stress responsiveness in dogs is more significant when the owner is present or absent during a veterinary examination. The study consisted of two experimental groups: "owner absent" and "owner present." Both groups consisted of 25 dogs each, totaling 50 dogs observed. A veterinarian and veterinary assistant recorded the dog's behavioral and physiological stress responses. Each group's behavioral and physiological stress-induced responses were compared using a Fischer Exact test and an Analysis of Covariance. The findings showed that dogs whose owners are present during the veterinary examination display fewer stress responses than dogs whose owners are absent …
The Role Of Complement In Stroke And Traumatic Brain Injury, Christine Couch
The Role Of Complement In Stroke And Traumatic Brain Injury, Christine Couch
MUSC Theses and Dissertations
Brain and neural injury are a non-specific disease category that includes traumatic brain injury (TBI) and stroke. Both TBI and stroke are common, costly, and leading causes of severe disability in adults. Both stroke and TBI are responsible for substantial disability in working age adults, with stroke being the second leading cause of death worldwide [1] and TBI a major cause of disability in people younger than their 40's [2]. The immune response after brain injury is multifactorial and involves both local and systemic events at the cellular and molecular level. The complement system is a component of both the …
The Effects Of Urban Landscape, Soundscape, And Light Pollution On Avian Diversity And Nesting In South San Antonio, Texas, Alfredo Llamas
The Effects Of Urban Landscape, Soundscape, And Light Pollution On Avian Diversity And Nesting In South San Antonio, Texas, Alfredo Llamas
Masters Theses (Archived)
As critical habitat continues to dwindle due to the expansion of urbanization, alternative habitat in urban ecosystems becomes a necessary natural resource for the survival of birds. In the last decade, local San Antonio environmental authorities have focused their efforts on restoring the San Antonio Mission Reach. Ecological revitalization of the San Antonio Mission Reach could increase avian, and flora biodiversity with ongoing restoration, yet how birds use restored habitat has not been assessed. Additionally, south of the Reach, two more peri-urban sites have great potential to be high quality habitat for birds but have not been surveyed for nesting …
The Effects Of Anthropogenic Sensory Pollution On Arthropod Diversity And Pollinator Behavior, Sierra Dee Rodriguez, Jennifer N. Phillips Phd
The Effects Of Anthropogenic Sensory Pollution On Arthropod Diversity And Pollinator Behavior, Sierra Dee Rodriguez, Jennifer N. Phillips Phd
Masters Theses (Archived)
Pollinators provide a key ecological function in terrestrial ecosystems, yet in recent years, they have encountered unprecedented declines, likely due to anthropogenic change. Light and noise pollution, which can interfere with the visual and auditory systems of animals that regulate daily behaviors, are important factors to consider when communities are encroached by human development. While many researchers have looked at how vertebrate species behaviorally react to human caused habitat degradation and sensory pollution, little is known about how invertebrates, including arthropod pollinators, are affected, and whether there is a negative cascading effect on the plants that they pollinate. This research …
The Influence Of Prison Skills Programming On The Reentry Process, Jennifer Tatten
The Influence Of Prison Skills Programming On The Reentry Process, Jennifer Tatten
Educational Studies Dissertations
Prison skills programming that is focused on employment readiness, reentry skills, parenting and family relationships, life skills, and anger management is offered with an understanding that the information will support individuals with reentry in areas such as family reintegration and employment. The purpose of this mixed-methods dissertation study was to explore the reasons that individuals chose to participate in skills programming during incarceration and their perceptions about the ways in which skills programming influenced their experiences with family and employment during reentry. Data were collected from diverse participants using a Reentry Experiences Survey (RES) (Appendix A), in-depth interviews, and archival …
Active Imagination, Wellbeing And Ways Of Seeing: A Phenomenological Inquiry Into Experiences Of Adult Learners With Visual Impairments, Steinberg Henry
Active Imagination, Wellbeing And Ways Of Seeing: A Phenomenological Inquiry Into Experiences Of Adult Learners With Visual Impairments, Steinberg Henry
Educational Studies Dissertations
Six female and two male adult learners who became blind between the ages of 20 and 75 years participated in this study conducted by a blind researcher. The purposely sampled eight were interviewed virtually by way of Zoom. In combination with Johnny Saldana’s work on codes, this study used the NVivo framework for determining structuring categories, selecting node themes, code frameworks and final codes from the first interview. 291 codes were clustered under 26 node themes. NVivo’s word frequency search and Word Tree were applied to clarify and lend a number value to participants’ codes. The second interview, administered after …
Social Creatures: The Impact Of Solitary Confinement On Psychophysiological Health And How Inmates Percieve Their Humanity And Social Well-Being, Julia Austin
Honors Projects
This paper will define and examine the use of solitary confinement within the United States prison system and review its mental, physical, and social impacts. As social creatures, human mental and physical well-being depends on meaningful social interactions absent in segregation units. As it currently stands, vulnerable populations, including racial minorities, LGBTQIA+ individuals, and those with developmental disabilities or psychological disorders, are at risk of irrevocable harm and abuse within these facilities from staff as well as other inmates. With a rotating 80,000 inmates held in solitary confinement every day, the current structure of the prison system deemphasizes rehabilitation and …
Humanity In Animals: A Exploration Of The Complexity Of Elephants As Intellectual Beings, Xing Z. Huang
Humanity In Animals: A Exploration Of The Complexity Of Elephants As Intellectual Beings, Xing Z. Huang
Honors Projects
Loxodonta (Elephants) are endangered species with only around 40,000-50,000 left in the world. They are part of the Elephantidae family with only three known existing species. Known for their cognitive capacity in their ability to recognize themselves in a mirror among many other actions, such as using self-made tools to aid them in their daily lives. Through past studies, it can be seen that vocalization and physical touch are the key steps of communication. Elephants have demonstrated their ability to distinguish between different frequencies and utilize them to communicate changes in the environment or indicate the absence of a herd …
Interactions Between Marine Megafauna And Plastic Pollution In Southeast Asia, Lucy C.M. Omeyer, Emily Duncan, Neil Angelo S. Abreo, Jo Marie V. Acebes, Lea A. Angsinco-Jimenez, Sabiqah T. Anuar, Lemnuel V. Aragones, Gonzalo Araujo, Luis R. Carrasco, Emilyn Q. Espiritu
Interactions Between Marine Megafauna And Plastic Pollution In Southeast Asia, Lucy C.M. Omeyer, Emily Duncan, Neil Angelo S. Abreo, Jo Marie V. Acebes, Lea A. Angsinco-Jimenez, Sabiqah T. Anuar, Lemnuel V. Aragones, Gonzalo Araujo, Luis R. Carrasco, Emilyn Q. Espiritu
Environmental Science Faculty Publications
Southeast (SE) Asia is a highly biodiverse region, yet it is also estimated to cumulatively contribute a third of the total global marine plastic pollution. This threat is known to have adverse impacts on marine megafauna, however, understanding of its impacts has recently been highlighted as a priority for research in the region. To address this knowledge gap, a structured literature review was conducted for species of cartilaginous fishes, marine mammals, marine reptiles, and seabirds present in SE Asia, collating cases on a global scale to allow for comparison, coupled with a regional expert elicitation to gather additional published and …
Gp38 As A Vaccine Target For Crimean-Congo Hemorrhagic Fever Virus, Gabrielle Scher, Dennis A. Bente, Megan C. Mears, Maria N.B. Cajimat, Matthias J. Schnell
Gp38 As A Vaccine Target For Crimean-Congo Hemorrhagic Fever Virus, Gabrielle Scher, Dennis A. Bente, Megan C. Mears, Maria N.B. Cajimat, Matthias J. Schnell
Department of Microbiology and Immunology Faculty Papers
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic disease in humans. There is a great need for effective vaccines and therapeutics against CCHFV for humans, as none are currently internationally approved. Recently, a monoclonal antibody against the GP38 glycoprotein protected mice against lethal CCHFV challenge. To show that GP38 is required and sufficient for protection against CCHFV, we used three inactivated rhabdoviral-based CCHFV-M vaccines, with or without GP38 in the presence or absence of the other CCHFV glycoproteins. All three vaccines elicited strong antibody responses against the respective CCHFV glycoproteins. However, only vaccines containing GP38 …
Fever Dive: A Novel, Sofia Ohrynowicz
Fever Dive: A Novel, Sofia Ohrynowicz
Seton Hall University Dissertations and Theses (ETDs)
This is the craft reflection, prologue, and first five chapters of Fever Dive, a novel in progress.
Synthesis, Characterization And Biological Evaluation Of Polyarginine Derived Bone-Targeting Peptides, Gina L. Antuono
Synthesis, Characterization And Biological Evaluation Of Polyarginine Derived Bone-Targeting Peptides, Gina L. Antuono
Seton Hall University Dissertations and Theses (ETDs)
Osteoblast-targeting peptides in the treatment of bone disease is a new and novel approach to offering effective treatment of various cancers and can be used in bio-medical, medicinal chemistry and biotechnology applications. By targeting adhesion proteins produced by osteoblast cells, certain cancers which migrate and metastasize to the bone may be more effectively treated. An osteoblast-targeting peptide composed of Ser-Asp-Ser-Ser-Asp (SDSSD) which selectively binds to osteoblast cells via periostin has recently been identified. This peptide was functionalized with polyurethane, generating nanomicelles which encapsulated RNA for the therapeutic treatment of osteoporosis. This study has served as the basis for the research …
Toll-Like Receptors 2, 4, And 9 Modulate Promoting Effect Of Copd-Like Airway Inflammation On K-Ras-Driven Lung Cancer Through Activation Of The Myd88/Nf-ĸb Pathway In The Airway Epithelium, Walter V Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T Grimaldo, Avantika Krishna, Michael J Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina De La Garza, Marco Ramos-Castaneda, Scott E Evans, Seyed Javad Moghaddam
Toll-Like Receptors 2, 4, And 9 Modulate Promoting Effect Of Copd-Like Airway Inflammation On K-Ras-Driven Lung Cancer Through Activation Of The Myd88/Nf-ĸb Pathway In The Airway Epithelium, Walter V Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T Grimaldo, Avantika Krishna, Michael J Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina De La Garza, Marco Ramos-Castaneda, Scott E Evans, Seyed Javad Moghaddam
Faculty, Staff and Student Publications
INTRODUCTION: Toll-like receptors (TLRs) are an extensive group of proteins involved in host defense processes that express themselves upon the increased production of endogenous damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) due to the constant contact that airway epithelium may have with pathogenic foreign antigens. We have previously shown that COPD-like airway inflammation induced by exposure to an aerosolized lysate of nontypeable
METHODS: In the present study, we have dissected the role of TLRs in this process by knocking out TLR2, 4, and 9 and analyzing how these deletions affect the promoting effect of COPD-like airway inflammation on …
Mitochondrial Replication Assay (Mira) For Efficient In Situ Quantification Of Nascent Mtdna And Protein Interactions With Nascent Mtdna (Mitosirf), Macy Lozen, Yue Chen, Rebecca A Boisvert, Katharina Schlacher
Mitochondrial Replication Assay (Mira) For Efficient In Situ Quantification Of Nascent Mtdna And Protein Interactions With Nascent Mtdna (Mitosirf), Macy Lozen, Yue Chen, Rebecca A Boisvert, Katharina Schlacher
Faculty, Staff and Student Publications
Mitochondria play decisive roles in bioenergetics and intracellular communication. These organelles contain a circular mitochondrial DNA (mtDNA) genome that is duplicated within one to two hours by a mitochondrial replisome, independently from the nuclear replisome. mtDNA stability is regulated in part at the level of mtDNA replication. Consequently, mutations in mitochondrial replisome components result in mtDNA instability and are associated with diverse disease phenotypes, including premature aging, aberrant cellular energetics, and developmental defects. The mechanisms ensuring mtDNA replication stability are not completely understood. Thus, there remains a need to develop tools to specifically and quantifiably examine mtDNA replication. To date, …
Digitizing The American West: Analyzing Rhetoric In Red Dead Redemption 2, Amalia Mcevoy
Digitizing The American West: Analyzing Rhetoric In Red Dead Redemption 2, Amalia Mcevoy
Seton Hall University Dissertations and Theses (ETDs)
High-budget, long-form storytelling games offer dozens of hours of content for audiences to explore and learn from. Although far different from sitting and reading a book, there is a distinct connection to be made between how literature is experienced and how audiences can experience a narrative-heavy video game. Based on this connection, there are bridges to be built between video games and literature, understanding how one field can benefit from the other as well as how one field can be informed by the other. An analysis of the video game Red Dead Redemption 2 using reader response theory can illustrate …
Toward Mutual Recognition: An Investigation Of Oral Tradition Evidence In The United States And Canada, Kalae Trask
Toward Mutual Recognition: An Investigation Of Oral Tradition Evidence In The United States And Canada, Kalae Trask
Washington Journal of Social & Environmental Justice
United States (“U.S.”) courts have long failed to recognize the value of oral traditional evidence (“OTE”) in the law. Yet, for Indigenous peoples, OTE forms the basis of many of their claims to place, property, and political power. In Canada, courts must examine Indigenous OTE on “equal footing” with other forms of admissible evidence. While legal scholars have suggested applying Canadian precedent to U.S. law regarding OTE, scholarship has generally failed to critically examine the underlying ethos of settler courts as a barrier to OTE admission and usefulness. This essay uses the work of political philosopher, James Tully, …
Creating A Strong Group Culture, Tianyi He
Creating A Strong Group Culture, Tianyi He
The Gettysburg Journal for Public Policy
This book review of The Culture Code summarizes three significant skills that contribute to creating a highly successful group. These skills include building safety, sharing vulnerability, and establishing purpose. Audiences are encouraged to appreciate the book for two reasons. First, it conveys that the approaches to strong group culture are multiple. Second, culture is one of the significant factors that policymakers should consider. By reading The Culture Code, readers can better understand how culture can help society be more inclusive and dynamic.
New Cultivars For High Quality, Persistent Legume-Grass Pastures In The Southern Usa, J. H. Bouton
New Cultivars For High Quality, Persistent Legume-Grass Pastures In The Southern Usa, J. H. Bouton
IGC Proceedings (1977-2023)
In the southern USA one cannot depend on perennial legume-grass pasture systems to have persistently high nutritive quality. 'Jesup' tall fescue, a cultivar with better persistence in the region than 'Kentucky 31', was re-infected with a non-ergot alkaloid producing strain of the Neotyphodium coenophialum fungal endophtye (MaxQTM) and found to give persistence equal to Jesup with its endemic strain (E+), but without animal toxins (Bouton et al., 2002). 'Durana' white clover (Bouton et al., 2004) was developed from regional ecotypes of Trifolium repens f. hollandicum germplasm and found to improve animal performance in both E+ and …
Comparing Yield And Quality Of Milk From Dairy Cows Fed Stockpiled Annual Ryegrass (Lolium Multiflorum L.) And Cereal Rye (Secale Cereale L.), L. E. Meinhardt, R. L. Kallenbach
Comparing Yield And Quality Of Milk From Dairy Cows Fed Stockpiled Annual Ryegrass (Lolium Multiflorum L.) And Cereal Rye (Secale Cereale L.), L. E. Meinhardt, R. L. Kallenbach
IGC Proceedings (1977-2023)
Stockpiling annual ryegrass and cereal rye provides a low cost substitute to hay and creates an excellent source of feed during winter (Kallenbach et al., 2003). In addition to lowering feed costs, grazing increases the conjugated linoleic acid (CLA) content of milk compared to feeding hay. Previous research suggested that forage species might differ in their ability to alter milk CLA content during the growing season (Wu et al., 1997). However, research is needed to determine if different forage species used for winter and early spring grazing impacts the CLA content of milk. The objective of this experiment …
A Grazing Method To Solve The Lack Of Pastures In The Dry Season Of Tropical Areas With Long Periods Of Drought, R. O. Martinez, R. Tuero, M. F. Díaz
A Grazing Method To Solve The Lack Of Pastures In The Dry Season Of Tropical Areas With Long Periods Of Drought, R. O. Martinez, R. Tuero, M. F. Díaz
IGC Proceedings (1977-2023)
Rotational grazing systems used in tropical areas in Latin America do not solve the great difference in pasture availability between the dry and the rainy season. The main studies on rational grazing (Voisin, 1963) were performed in temperate areas where the deficit of feeds in winter may only be solved with external feeds such as forages and silages produced out of the grazing system. The objective of this work was to demonstrate that it is possible to maintain pasture availability throughout the year with the use of a Pennisetum purpureum clone (Cuba CT-115) adapted to grazing (Martínez et al., …
Biologically Inspired Multi-Robot System Based On Wolf Hunting Behavior, Zachary Hinnen, Chance Hamilton, Alfredo Weitzenfeld
Biologically Inspired Multi-Robot System Based On Wolf Hunting Behavior, Zachary Hinnen, Chance Hamilton, Alfredo Weitzenfeld
Florida Conference on Recent Advances in Robotics
Studies involving the group predator behavior of wolves have inspired multiple robotic architectures to mimic these biological behaviors in their designs and research. In this work, we aim to use robotic systems to mimic wolf packs' single and group behavior. This work aims to extend the original research by Weitzenfeld et al [7] and evaluate under a new multi-robot robot system architecture. The multiple robot architecture includes a 'Prey' pursued by a wolf pack consisting of an 'Alpha' and 'Beta' robotic group. The Alpha Wolf' will be the group leader, searching and tracking the 'Prey.' At the same time, the …
Design, Fabrication, And Verification Of A Robot Leg For Multimodal Locomotion, Cameron Ryals, Ben Labiner, Justin Cheesborough, Carlos Sanchez-Sarmiento, Dane Seal, Ashley Chase
Design, Fabrication, And Verification Of A Robot Leg For Multimodal Locomotion, Cameron Ryals, Ben Labiner, Justin Cheesborough, Carlos Sanchez-Sarmiento, Dane Seal, Ashley Chase
Florida Conference on Recent Advances in Robotics
In robotics, there is a variety of general forms of locomotion for a quadruped. This paper focuses on the design challenges for three of the most common forms: walking, climbing, and swimming. Many robots have been designed that can perform a combination of these modalities with the use of interchangeable parts. However, there is limited research on a design that incorporates the requirements of compliance and robustness for walking on rugged terrain, multiple attachment points for climbing, and sufficient drag properties for swimming and walking through resistive media within a singular leg configuration. In this paper, the design, fabrication, and …
Covid-19 Pandemic, Climate Change, And Conflicts On Agriculture: A Trio Of Challenges To Global Food Security, Devendra Paudel, Ram Chandra Neupane, Sailesh Sigdel, Pradip Poudel, Aditya R. Khanal
Covid-19 Pandemic, Climate Change, And Conflicts On Agriculture: A Trio Of Challenges To Global Food Security, Devendra Paudel, Ram Chandra Neupane, Sailesh Sigdel, Pradip Poudel, Aditya R. Khanal
Agricultural and Environmental Sciences Faculty Research
Global food security is a worldwide concern. Food insecurity is a significant threat to poverty and hunger eradication goals. Agriculture is one of the focal points in the global policy agenda. Increases in agricultural productivity through the incorporation of technological advances or expansion of cultivable land areas have been pushed forward. However, production growth has slowed in many parts of the world due to various endemic challenges, such as decreased investment in agricultural research, lack of infrastructure in rural areas, and increasing water scarcity. Climate change adversities in agriculture and food security are increasing. Recently, the COVID-19 pandemic has severely …
Managing Refractory Status Epilepticus With Early Ketamine Administration, Ashlyn Shavers
Managing Refractory Status Epilepticus With Early Ketamine Administration, Ashlyn Shavers
Yale School of Medicine Physician Associate Program Theses
Status epilepticus is a time-sensitive neurological emergency that can be associated with severe disability and mortality. Approximately 20% of patients with status epilepticus will fail to respond to existing first and second-line therapies that act on similar receptors. There is a need for additional therapeutic options. One candidate drug, ketamine, has a novel mechanism of action and may work synergistically to terminate seizures. This study seeks to examine whether ketamine administration along with other second-line medications can reduce seizure burden in patients with status epilepticus. Using an open-label randomized clinical trial of 436 patients, we will examine the proportion of …
Coming To Peace In The Presence Of Wild Things: A Personal Exploration Of The Intersections Of The Environment And Faith, Hampton T. Randall
Coming To Peace In The Presence Of Wild Things: A Personal Exploration Of The Intersections Of The Environment And Faith, Hampton T. Randall
Student Scholarship
From a young age, I have felt the power that certain places have over me. Some made me feel an overwhelming sense of awe, some freedom, and some made me feel depths of peace unknown like Wendell Berry describes in the poem above. Considering my natural restlessness, a disposition that has been there since birth, the fact these places invoke a feeling of peace that washes over me speaks volumes to their power.
It wasn’t until college that I truly recognized this power of place, but since learning that fact I have sought its connection. A professor of mine gave …
Voluntary Wheel Running Promotes Resilience To The Behavioral Effects Of Unpredictable Chronic Mild Stress In Male And Female Mice., Elias Elias, Ariel Y Zhang, Abigail G White, Matthew J Pyle, Melissa T Manners
Voluntary Wheel Running Promotes Resilience To The Behavioral Effects Of Unpredictable Chronic Mild Stress In Male And Female Mice., Elias Elias, Ariel Y Zhang, Abigail G White, Matthew J Pyle, Melissa T Manners
College of Science & Mathematics Departmental Research
Besides significant benefits to physical health, exercise promotes mental health, reduces symptoms of mental illness, and enhances psychological development. Exercise can offset the impact of chronic stress, which is a major precursor to the development of mental disorders. The effects of exercise on chronic stress-induced behaviors are contradictory in preclinical studies, primarily due to the lack of data and sex-specific investigations. We sought to evaluate the effects of exercise on chronic stress-induced behavioral changes in both male and female mice. Mice were subjected to an Unpredictable Chronic Mild Stress (UCMS) paradigm with accessibility to running wheels for 2 h daily. …
Dextromethorphan/Quinidine For The Treatment Of Bulbar Impairment In Amyotrophic Lateral Sclerosis., Lauren Tabor Gray, Eduardo Locatelli, Terrie Vasilopoulos, James Wymer, Emily K. Plowman
Dextromethorphan/Quinidine For The Treatment Of Bulbar Impairment In Amyotrophic Lateral Sclerosis., Lauren Tabor Gray, Eduardo Locatelli, Terrie Vasilopoulos, James Wymer, Emily K. Plowman
HPD Articles
OBJECTIVE: No efficacious treatments exist to improve or prolong bulbar functions of speech and swallowing in persons with amyotrophic lateral sclerosis (pALS). This study evaluated the short-term impact of dextromethorphan/quinidine (DMQ) treatment on speech and swallowing function in pALS.
METHODS: This was a cohort trial conducted between August 2019 to August 2021 in pALS with a confirmed diagnosis of probable-definite ALS (El-Escorial Criteria-revisited) and bulbar impairment (ALS Functional Rating Scale score ≤ 10 and speaking rate ≤ 140 words per minute) who were DMQ naïve. Efficacy of DMQ was assessed via pre-post change in the ALS Functional Rating Scale-Revised bulbar …