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Queer Rights After Dobbs V. Jackson Women's Health Organization, Robin Maril May 2023

Queer Rights After Dobbs V. Jackson Women's Health Organization, Robin Maril

San Diego Law Review

Dobbs v. Jackson Women’s Health Organization has ignited a firestorm of commentary warning that the end of Roe v. Wade would inevitably lead to the end of constitutionally protected queer rights. This article argues that it is far too soon to concede that Lawrence v. Texas and Obergefell v. Hodges are destined for the dustbin of history. Queer rights and abortion rights both advance equality and have significant liberatory value, but they are functionally different rights that rest on distinct legal foundations. Although both sets of rights may be essential to a progressive platform for inclusive political and social change, …

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Therapeutic Strategies Targeting Respiratory Recovery After Spinal Cord Injury: From Preclinical Development To Clinical Translation, Pauline Michel-Flutot, Michael A. Lane, Angelo C. Lepore, Stéphane Vinit May 2023

Therapeutic Strategies Targeting Respiratory Recovery After Spinal Cord Injury: From Preclinical Development To Clinical Translation, Pauline Michel-Flutot, Michael A. Lane, Angelo C. Lepore, Stéphane Vinit

Farber Institute for Neuroscience Faculty Papers

High spinal cord injuries (SCIs) lead to permanent functional deficits, including respiratory dysfunction. Patients living with such conditions often rely on ventilatory assistance to survive, and even those that can be weaned continue to suffer life-threatening impairments. There is currently no treatment for SCI that is capable of providing complete recovery of diaphragm activity and respiratory function. The diaphragm is the main inspiratory muscle, and its activity is controlled by phrenic motoneurons (phMNs) located in the cervical (C3–C5) spinal cord. Preserving and/or restoring phMN activity following a high SCI is essential for achieving voluntary control of breathing. In this review, …

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Catecholamine System Function Of The Medial Prefrontal Cortex Following Repetitive Mild Traumatic Brain Injury And The Use Of Benzoyl Chloride To Quantify And Identify Neurotransmitters, Leah Horvat May 2023

Catecholamine System Function Of The Medial Prefrontal Cortex Following Repetitive Mild Traumatic Brain Injury And The Use Of Benzoyl Chloride To Quantify And Identify Neurotransmitters, Leah Horvat

Theses and Dissertations

Traumatic brain injury (TBI) is a serious global health burden that causes a wide range of neurocognitive symptoms. These cognitive processes are regulated by catecholamine signaling within the prefrontal cortex (PFC) region of the brain. To quantify functional deficits in catecholamine signaling after TBI, norepinephrine (NE) and dopamine (DA) levels within the PFC were quantified from microdialysate samples using high-performance liquid chromatography coupled with electrochemical detection. A method for benzoyl chloride derivatization of neurotransmitters and analysis with liquid chromatography and tandem mass spectrometry instrumentation was also developed to detect and analyze these neurotransmitters. Overall, it was found that catecholamine signaling …

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Dissociation Protocols Used For Sarcoma Tissues Bias The Transcriptome Observed In Single-Cell And Single-Nucleus Rna Sequencing, Danh D Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J Lazar, J Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C Daw, Nicholas E Navin, Richard Gorlick, Joseph A Ludwig May 2023

Dissociation Protocols Used For Sarcoma Tissues Bias The Transcriptome Observed In Single-Cell And Single-Nucleus Rna Sequencing, Danh D Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J Lazar, J Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C Daw, Nicholas E Navin, Richard Gorlick, Joseph A Ludwig

Faculty, Staff and Student Publications

BACKGROUND: Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell level. Classification of bulk tumors by their individual cellular constituents has also created new opportunities to generate single-cell atlases for many organs, cancers, and developmental models. Despite the tremendous promise of this technology, recent evidence studying epithelial tissues and diverse carcinomas suggests the methods used for tissue processing, cell disaggregation, and preservation can significantly bias gene expression and alter the observed cell types. To determine whether sarcomas - tumors of mesenchymal origin - are subject to …

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2023-05-31 Annual Seattle U Film Festival Exposes Child-Like Genius, Hannah Mwangi May 2023

2023-05-31 Annual Seattle U Film Festival Exposes Child-Like Genius, Hannah Mwangi

The Spectator Online

No abstract provided.

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Trolley Problems, Private Necessity, And The Duty To Rescue, Laura A. Heymann May 2023

Trolley Problems, Private Necessity, And The Duty To Rescue, Laura A. Heymann

San Diego Law Review

Laidlaw v. Sage is generally, at best, an oddity in Torts casebooks today. A case that captured the imagination of New York newspaper readers at the time, Laidlaw involved an explosion that, William Laidlaw argued, the wealthy Russell Sage survived only because, at the last moment, he pulled Laidlaw in front of him to absorb the brunt of the blast. As taught in Torts classrooms, Laidlaw is either a case about the intent requirement for battery or a case about causation. But the case, assuming the plaintiff’s story was true, also provides an interesting window into what would seem to …

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The Effect Of Digital Literacy And Word Choice Mastery On Students' Writing Skills, Aveny Septi Astriani, Dea Silvani, Sitti Syakira May 2023

The Effect Of Digital Literacy And Word Choice Mastery On Students' Writing Skills, Aveny Septi Astriani, Dea Silvani, Sitti Syakira

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to investigate the effect of digital literacy skills and word choice mastery on students' writing skills. This descriptive qualitative research used survey in the form of questionnaires, multiple choice items, and writing practice as the data collection techniques. The obtained data were analysed by calculating the scores of digital literacy skills, word choice mastery, and writing skills practice, and then calculating the effect of those variables using multiple linear regression tests. The data were then processed through the steps of data reduction, data presentation, and drawing conclusions. The sample of this study were 55 college students who …

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The Development Project Based-Learning Food Microbiology E-Module Based On The Study Of Kombucha Fermentation, Lianto Lianto, Sri Rahayu Lestari, Hendra Susanto May 2023

The Development Project Based-Learning Food Microbiology E-Module Based On The Study Of Kombucha Fermentation, Lianto Lianto, Sri Rahayu Lestari, Hendra Susanto

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This research is research and development based on Lee and Owens’ design that aims to develop a valid and practical food microbiology electronic module based on Project-Based Learning (PjBL). The research and development consisted of five steps: analysis, design, development, implementation, and evaluation. The validity of e-module was assessed by content expert, media and teaching material expert, and biology education practitioner. The practicality of e-module was assessed by The State University of Malang students who had joined food microbiology course. The instruments of this research were validation sheets of content expert, media and teaching material expert, biology education practitioners, and …

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Misogynoir And The Public Woman: Analog And Digital Sexualization Of Women In Public From The Civil War To The Era Of Kamala Harris, Cecilia Cerja, Nicole D. Nave, Kelly L. Winfrey, Catherine Helen Palczewski, Leslie A. Hahner May 2023

Misogynoir And The Public Woman: Analog And Digital Sexualization Of Women In Public From The Civil War To The Era Of Kamala Harris, Cecilia Cerja, Nicole D. Nave, Kelly L. Winfrey, Catherine Helen Palczewski, Leslie A. Hahner

Faculty Publications

This essay identifies how the very conception of public woman is infused with the opprobrium hurled against a wanton woman–a sexualized figure who has lost claims to moral standing or social worth. Our analysis begins diachronically by using thin description to trace the historical conflation of public woman in general, and Black woman in particular, with prostitute to outline the contours of the trope of public woman that have solidified across time. We document how the public woman became equated with prostitute, and then how the label prostitute was affixed to women in public to situate them as promiscuous or …

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Marketing, Personal Branding, And Positioning: Cosplay On Steroids!, Ruby Daniels May 2023

Marketing, Personal Branding, And Positioning: Cosplay On Steroids!, Ruby Daniels

Marketing Faculty Publications (Archived)

No abstract provided.

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Steroidal Or Non-Steroidal Mras: Should We Still Enable Raasi Use Through K Binders?, L Parker Gregg, Sankar D Navaneethan May 2023

Steroidal Or Non-Steroidal Mras: Should We Still Enable Raasi Use Through K Binders?, L Parker Gregg, Sankar D Navaneethan

Faculty, Staff and Students Publications

Renin-angiotensin-aldosterone system inhibitors (RAASi) and mineralocorticoid receptor antagonists (MRAs) are important interventions to improve outcomes in patients with chronic kidney disease and heart failure, but their use is limited in some patients by the development of hyperkalemia. The risk of hyperkalemia may differ between agents, with one trial showing lower risk of hyperkalemia with the novel non-steroidal MRA finerenone compared with steroidal MRA spironolactone. Novel potassium binders, including patiromer and sodium zirconium cyclosilicate, are available interventions to manage hyperkalemia and enable continuation of RAASi and MRAs in patients who could benefit from these treatments. These agents bind free potassium ions …

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Integrating Ocean Observations Across Body‐Size Classes To Deliver Benthic Invertebrate Abundance And Distribution Information, Henry A. Ruhl, Brian J. Bett, Jeroen Ingels, Adrian Martin, Andrew R. Gates, Andrew Yool, Noëlie M.A. Benoist, Ward Appeltans, Kerry L. Howell, Roberto Danovaro May 2023

Integrating Ocean Observations Across Body‐Size Classes To Deliver Benthic Invertebrate Abundance And Distribution Information, Henry A. Ruhl, Brian J. Bett, Jeroen Ingels, Adrian Martin, Andrew R. Gates, Andrew Yool, Noëlie M.A. Benoist, Ward Appeltans, Kerry L. Howell, Roberto Danovaro

School of Biological and Marine Sciences

Invertebrate animals living at the seafloor make up a prominent component of life globally, spanning 10 orders of magnitude in body size over 71% of Earth's surface. However, integrating information across sizes and sampling methodologies has limited our understanding of the influence of natural variation, climate change and human activity. Here, we outline maturing practices that can underpin both the feasibility and impact of establishing Benthic Invertebrate Abundance and Distribution as a Global Ocean Observing System—Essential Ocean Variable, including: (1) quantifying individual body size, (2) identifying the well‐quantified portions of sampled body‐size spectra, (3) taking advantage of (semi‐)automated information processing, …

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Irritability Moderates The Association Between Cognitive Flexibility Task Performance And Related Prefrontal Cortex Activation In Young Children, Yanwei Li, Adam S Grabell, Susan B Perlman May 2023

Irritability Moderates The Association Between Cognitive Flexibility Task Performance And Related Prefrontal Cortex Activation In Young Children, Yanwei Li, Adam S Grabell, Susan B Perlman

2020-Current year OA Pubs

The association between cognitive flexibility and related neural functioning has been inconsistent. This is particularly true in young children, where previous studies have found heterogenous results linking behavior and neural function, raising the possibility of unexplored moderators. The current study explored the moderating role of dimensional irritability in the association between cognitive flexibility task performance and prefrontal activation in young children. A total of 106 3- to 7-year-old children were recruited to complete a custom-designed, child-adapted, cognitive flexibility task, and 98 of them were included in the data analysis. The children's dorsolateral prefrontal cortex activation was monitored using functional near-infrared …

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Chaos In Congress: Masculinity And Violence In The Congressional Struggle Over Kansas, Ian L. Baumer May 2023

Chaos In Congress: Masculinity And Violence In The Congressional Struggle Over Kansas, Ian L. Baumer

The Gettysburg College Journal of the Civil War Era

According to Joanne Freeman's recent book on congressional violence, in the years between 1830 and 1860, members of Congress engaged in 'manly' violence against one another more than seventy times. However, no issue caused more violent personal disputes in the legislature than slavery. In particular, the debate over the legal status of slavery in the Kansas Territory caused a panoply of incidents in Congress, including near-duel between John C. Breckinridge and Francis Cutting in 1854, Preston Brooks' caning of Charles Sumner in 1856, and a brawl in the House of Representatives in 1858. This article examines how these lawmakers' views …

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Towards Urban Biodiversity: Simulating Design Parameters For Wildlife-Inclusive Green Infrastrcuture, Alisa Abdulghany, Baher Farahat May 2023

Towards Urban Biodiversity: Simulating Design Parameters For Wildlife-Inclusive Green Infrastrcuture, Alisa Abdulghany, Baher Farahat

BAU Journal - Creative Sustainable Development

As of 2021, more than half of the global population resides in urban areas. This resulted in an overwhelming footprint affecting species habitat areas leading to biodiversity loss. By definition, urban biodiversity is the diversity of living things within the urban realm. By providing chances for habitat as part of new developments, preserving on-site habitats, and attempting to connect with the local ecosystems, we can help promote biodiversity. Green infrastructure (GI), which includes all semi-natural areas in the urban context, can serve as a vessel for biodiversity. Therefore, the problem can be defined by the urban footprint that expands on …

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Revitalizing The Borderlines Through Architecture Of Green Networking - Case Study: Beirut, Lebanon, Karim Al-Khatib, Maged Youssef, Mona M. Salem May 2023

Revitalizing The Borderlines Through Architecture Of Green Networking - Case Study: Beirut, Lebanon, Karim Al-Khatib, Maged Youssef, Mona M. Salem

BAU Journal - Creative Sustainable Development

Borders are an essential part of cities and countries, and they can create both physical and cultural divides. Inner-city borders can lead to social isolation and inequality, which can contribute to tensions and conflicts. Borders around the world have become a symbol of conflict, racism, fear, inequity, and division. One single line could divide between opportunity and hope and poverty and oblivion. Accordingly, some borders create social isolation between various cultures in cities that increase socio-political problems and remove urban connectivity. Green networking involves using urban green spaces, such as parks and gardens, to connect different areas of a city …

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Economics & Economic Substance, Terrance O'Reilly May 2023

Economics & Economic Substance, Terrance O'Reilly

Florida Tax Review

The economic substance doctrine has no basis in economics. The fact that a transaction has an after-tax profit but not a pretax profit is not an indication of inefficient resource allocation. Nor does economic analysis suggest that denying tax benefits to arrangements lacking economic substance will reduce the deadweight loss of taxation. Because a pretax profit requirement has no economic foundation, it is irrelevant whether the calculation of pretax profit takes account of implicit taxes. Both the conventional definition of economic substance based on pretax profit and competing formulations that give less or no weight to pretax profit appear to …

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Hidden Foreign Aid, David E. Pozen May 2023

Hidden Foreign Aid, David E. Pozen

Florida Tax Review

Few issues in global politics are as contentious as foreign aid—how much rich countries should give, in what ways, to whom. For years, it has been a commonplace that U.S. policies are stingy. The Organization for Economic Cooperation and Development (OECD) routinely ranks the United States far behind its industrialized peers in official development assistance (ODA), measured as a percentage of gross national income (GNI). An endless parade of critics has implored the government to do more; some suggest that the Bush Administration's support for the Monterrey Consensus, which sets a goal of increasing assistance to 0.7% of GNI, commits …

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Executive Committee - Minutes, 5/30/2023, Academic Senate May 2023

Executive Committee - Minutes, 5/30/2023, Academic Senate

Academic Senate Minutes

No abstract provided.

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Reproductive Inequality In Humans And Other Mammals, John Ziker, Karl J. Mertens May 2023

Reproductive Inequality In Humans And Other Mammals, John Ziker, Karl J. Mertens

Anthropology Faculty Publications and Presentations

To address claims of human exceptionalism, we determine where humans fit within the greater mammalian distribution of reproductive inequality. We show that humans exhibit lower reproductive skew (i.e., inequality in the number of surviving offspring) among males and smaller sex differences in reproductive skew than most other mammals, while nevertheless falling within the mammalian range. Additionally, female reproductive skew is higher in polygynous human populations than in polygynous nonhumans mammals on average. This patterning of skew can be attributed in part to the prevalence of monogamy in humans compared to the predominance of polygyny in nonhuman mammals, to the limited …

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Reexamining The Functions Of Urban Bridges With Nature And People In Mind: A Vision For North Main Street Bridge Fort Worth, Texas, Amanda Hinton May 2023

Reexamining The Functions Of Urban Bridges With Nature And People In Mind: A Vision For North Main Street Bridge Fort Worth, Texas, Amanda Hinton

Landscape Architecture Masters & Design Theses - Archive

How can nature be incorporated into infrastructure bridges to promote connections in urban landscapes? The Paddock Viaduct, known today as the North Main Street Bridge in Fort Worth, Texas was formally opened on July 3, 1914. Designed by Brenneke and Fay to improve transportation to the North Fort Worth district, the bridge was the first reinforced concrete arch bridge in the nation to use self-supporting reinforcing steel and ball and socket joints (Paddock Viaduct - Main - Historic Fort Worth, 2017). Fort Worth in the mid-1900s, like many growing cities, was experiencing the repercussions of heavy flooding issues that come …

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Exploration To Brand Communication On Tiktok, Victoria M. Priola May 2023

Exploration To Brand Communication On Tiktok, Victoria M. Priola

Student Theses and Dissertations

The purpose of this study was to explore the connection between the video-sharing social media platform TikTok and companies that use it to publish corporate branding content. The research intends to compare TikTok to other social media outlets. The motivation behind this study was fueled by the want to understand where TikTok lands within a company’s social media content planning process. Can TikTok ever become a solid foundation in social media content planning like Facebook, Instagram and Twitter have been? Most of the previous research on TikTok has proven how unique the platform is compared to other social media, but …

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Investigating And Mitigating The Harmful Impact Of Precarious Employment On The Health And Well-Being Of New York City Food Workers, Emilia F. Vignola May 2023

Investigating And Mitigating The Harmful Impact Of Precarious Employment On The Health And Well-Being Of New York City Food Workers, Emilia F. Vignola

Dissertations and Theses

Much of the United States (US) food chain – from production to processing, wholesale, retail, and services – is characterized by precarious employment, defined as work with little employment security, inadequate income, and limited rights and protections. Studies show that precarious employment is associated with adverse mental and physical health and well-being outcomes. Separate research indicates numerous health issues in certain segments of the food workforce; little scholarly work has explored the contribution of precarious employment as an upstream driver of these health issues. Gaps remain in our understanding of 1) the health needs and status of workers across the …

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Alcohol As A Modifiable Risk Factor For Alzheimer’S Disease—Evidence From Experimental Studies, Devaraj V. Chandrashekar, Ross A. Steinberg, Derick Han, Rachita K. Sumbria May 2023

Alcohol As A Modifiable Risk Factor For Alzheimer’S Disease—Evidence From Experimental Studies, Devaraj V. Chandrashekar, Ross A. Steinberg, Derick Han, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment and memory loss. Epidemiological evidence suggests that heavy alcohol consumption aggravates AD pathology, whereas low alcohol intake may be protective. However, these observations have been inconsistent, and because of methodological discrepancies, the findings remain controversial. Alcohol-feeding studies in AD mice support the notion that high alcohol intake promotes AD, while also hinting that low alcohol doses may be protective against AD. Chronic alcohol feeding to AD mice that delivers alcohol doses sufficient to cause liver injury largely promotes and accelerates AD pathology. The mechanisms by which alcohol can …

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Exploring The Use Of Innovative Sustainable Proteins In Marine Finfish Diets, Luke Pilmer, Lindsey Woolley, Md Reaz Chaklader May 2023

Exploring The Use Of Innovative Sustainable Proteins In Marine Finfish Diets, Luke Pilmer, Lindsey Woolley, Md Reaz Chaklader

Conference papers and presentations

No abstract provided.

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Microrna (Mirna) Complexity In Alzheimer’S Disease (Ad), Walter J. Lukiw May 2023

Microrna (Mirna) Complexity In Alzheimer’S Disease (Ad), Walter J. Lukiw

School of Medicine Faculty Publications

AD is a complex, progressive, age-related neurodegenerative disorder representing the most common cause of senile dementia and neurological dysfunction in our elderly domestic population. The widely observed heterogeneity of AD is a reflection of the complexity of the AD process itself and the altered molecular-genetic mechanisms operating in the diseased human brain and CNS. One of the key players in this complex regulation of gene expression in human pathological neurobiology are microRNAs (miRNAs) that, through their actions, shape the transcriptome of brain cells that normally associate with very high rates of genetic activity, gene transcription and messenger RNA (mRNA) generation. …

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Plant Sentience: Getting To The Roots Of The Problem, Krzysztof Dolega, Savannah Siekierski, Axel Cleeremans May 2023

Plant Sentience: Getting To The Roots Of The Problem, Krzysztof Dolega, Savannah Siekierski, Axel Cleeremans

Animal Sentience

Segundo-Ortin’s (2023) target article invites us to consider the possibility that plants can experience subjectively felt states. We discuss this speculation on the basis of the functional neurobiology of consciousness. We suggest that demonstrating plant sentience would require that we identify not only behaviors analogous to those exhibited by sentient creatures, but also the functional analogues of the mechanisms causing such behaviors. The lack of clear evidence for any kind of integration between self-states, self-movement, environmental states, memory, or affective communication within plants suggests that plant sentience remains an admittedly fascinating, but ultimately merely provocative speculation.

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Collusive Prosecution, Ben A. Mcjunkin, J.J. Prescott May 2023

Collusive Prosecution, Ben A. Mcjunkin, J.J. Prescott

Law & Economics Working Papers

In this Article, we argue that increasingly harsh collateral consequences have surfaced an underappreciated and undertheorized dynamic of criminal plea bargaining. Collateral consequences that mostly or entirely benefit third parties (such as other communities or other states) create an interest asymmetry that prosecutors and defendants can exploit in plea negotiations. In particular, if a prosecutor and a defendant can control the offense of conviction (often through what some term a “fictional plea”), they can work together to evade otherwise applicable collateral consequences, such as deportation or sex-offender registration and notification. Both parties arguably benefit: Prosecutors can leverage collateral consequences to …

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Enhanced Evasion Of Neutralizing Antibody Response By Omicron Xbb15, Ch11, And Ca31 Variants, Panke Qu, Julia N Faraone, John P Evans, Yi-Min Zheng, Claire Carlin, Mirela Anghelina, Patrick Stevens, Soledad Fernandez, Daniel Jones, Ashish R Panchal, Linda J Saif, Eugene M Oltz, Baoshan Zhang, Tongqing Zhou, Kai Xu, Richard J Gumina, Shan-Lu Liu May 2023

Enhanced Evasion Of Neutralizing Antibody Response By Omicron Xbb15, Ch11, And Ca31 Variants, Panke Qu, Julia N Faraone, John P Evans, Yi-Min Zheng, Claire Carlin, Mirela Anghelina, Patrick Stevens, Soledad Fernandez, Daniel Jones, Ashish R Panchal, Linda J Saif, Eugene M Oltz, Baoshan Zhang, Tongqing Zhou, Kai Xu, Richard J Gumina, Shan-Lu Liu

Faculty, Staff and Student Publications

Omicron subvariants continuingly challenge current vaccination strategies. Here, we demonstrate nearly complete escape of the XBB.1.5, CH.1.1, and CA.3.1 variants from neutralizing antibodies stimulated by three doses of mRNA vaccine or by BA.4/5 wave infection, but neutralization is rescued by a BA.5-containing bivalent booster. CH.1.1 and CA.3.1 show strong immune escape from monoclonal antibody S309. Additionally, XBB.1.5, CH.1.1, and CA.3.1 spike proteins exhibit increased fusogenicity and enhanced processing compared with BA.2. Homology modeling reveals the key roles of G252V and F486P in the neutralization resistance of XBB.1.5, with F486P also enhancing receptor binding. Further, K444T/M and L452R in CH.1.1 and …

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Therapeutic Potential Of A Small-Molecule Stat3 Inhibitor In A Mouse Model Of Colitis, Prema Robinson, Kelsey Montoya, Emily Magness, Emma Rodriguez, Viviana Villalobos, Nikita Engineer, Peng Yang, Uddalak Bharadwaj, Thomas Kris Eckols, David John Tweardy May 2023

Therapeutic Potential Of A Small-Molecule Stat3 Inhibitor In A Mouse Model Of Colitis, Prema Robinson, Kelsey Montoya, Emily Magness, Emma Rodriguez, Viviana Villalobos, Nikita Engineer, Peng Yang, Uddalak Bharadwaj, Thomas Kris Eckols, David John Tweardy

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) predisposes to colorectal cancer (CRC). In the current studies, we used the dextran sodium sulfate (DSS) murine model of colitis, which is widely used in preclinical studies, to determine the contribution of STAT3 to IBD. STAT3 has two isoforms: (STAT3 α; which has pro-inflammatory and anti-apoptotic functions, and STAT3β; which attenuates the effects of STAT3α). In the current study, we determined the contribution of STAT3 to IBD across all tissues by examining DSS-induced colitis in mice that express only STAT3α and in mice treated with TTI-101, a direct small-molecule inhibitor of both isoforms …

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