Digital Commons Network^™

Cxcr2 Expression During Melanoma Tumorigenesis Controls Transcriptional Programs That Facilitate Tumor Growth, J Yang, K Bergdorf, C Yan, W Luo, S C Chen, G D Ayers, Q Liu, X Liu, M Boothby, V L Weiss, S M Groves, A N Oleskie, X Zhang, D Y Maeda, J A Zebala, V Quaranta, A Richmond

Faculty, Staff and Student Publications

Background: Though the CXCR2 chemokine receptor is known to play a key role in cancer growth and response to therapy, a direct link between expression of CXCR2 in tumor progenitor cells during induction of tumorigenesis has not been established.

Methods: To characterize the role of CXCR2 during melanoma tumorigenesis, we generated tamoxifen-inducible tyrosinase-promoter driven BrafV600E/Pten-/-/Cxcr2-/- and NRasQ61R/INK4a-/-/Cxcr2-/- melanoma models. In addition, the effects of a CXCR1/CXCR2 antagonist, SX-682, on melanoma tumorigenesis were evaluated in BrafV600E/Pten-/- and NRasQ61R/INK4a-/- mice and in melanoma cell lines. Potential mechanisms by which Cxcr2 affects melanoma tumorigenesis in these murine models were explored using RNAseq, mMCP-counter, …

Freedom Is A Leaky System: Living Together In The Mess, Calgary Haines-Trautman

Masters Theses

Litter is upsetting.

People upset by litter often misunderstand its sources. Those for whom state power has worked look for simple solutions that seek to surveil, fine, and punish culprits.

Reality is messy.

The path of trash from hand to landfill requires a series of successful transfers between receptacles and responsibility. Wind, accidents, and spills in automated systems complicate trash’s path from here to away. Out of this complexity, leaks accumulate—visible issues without clear causes or responsibility.

Leaks are unavoidable.

There is an irreducible gap between the world as it is and our models of it. In this mismatch, …

The Common Destiny Of Living Creatures, Xiaodai Huang

Masters Theses

This thesis explores the transformation of recycled materials and trash, into materials for jewelry making, and investigates the effects of human consumption on the environment. It is also concerned with ecological damage and biological harm by combining physical research methods with literature and data review. It also calls for consumers to reflect on their behavior and actively participate in the collective action of protecting the environment.

In this thesis, I collected and analyzed studies and information related to consumptive behavior, environmental pollution, and ecological damage. This includes academic papers, reports, statistics, and perspectives from professional organizations on consumption patterns, waste …

Vanishing Ice, Zhehao Tang

Masters Theses

Many northern cities’ magnificent civilizations, especially coastal cities, have relied on the glacial ruins left by the melt in the past. These bustling metropolises get opportunities from glacial disappearance. But now, they face potential threats from remote alpine glacial melting. Most people view this glacial disappearance indifferently. Moreover, they do not seem aware that we have a potential connection with these remote landscapes. This thesis proposes to use landscape design to raise public awareness of the glacial geological history of cities and the concern for the glacier melt, including the impact of glacial changes in the past, present, and future. …

Sensible Nature: To “See” As We Once Did, Yuhan Su

Masters Theses

This thesis starts with the premise that our growing dependence on tools and digital technologies has led to a gradual decline in our sensory acuity, causing a disconnect between people and nature.

To address this issue, the thesis aims to re-establish lost connections by utilizing plant-based sensorial designs that evoke emotions and instincts, reigniting empathy and intimacy with the natural world.

By utilizing these strategies, this thesis seeks to enhance our ability to perceive, connect with, and appreciate the world around us, thereby creating a stronger, more intimate relationship between humanity and the environment.

Liquid Border, Yingfan Jia

Masters Theses

A River is a mighty and constantly-evolving force, leaving behind an intricately designed and constantly changing system. Not just a river, the Rio Grande stretches all the way from Colorado before intersecting with the US-Mexico Border in southern Texas - a point where the powerful forces of nature now merge with a clearly-defined political boundary. The outcome of this is a unique ecological niche, which may often go unnoticed despite its distinctiveness.

Texas is famous for its farms and ranches, and the Rio Grande Valley of South Texas was once an agricultural hub. However, urbanization and the depletion of water …

Landscape De/Re-Construction Through Art, Manuel Gonzalez

Masters Theses

Contemporary landscape architecture practice and education primarily focus on ecological and technical interventions. The climate crisis we find ourselves in demands scientifically informed decisions and well-engineered execution of projects, but, more importantly, creativity and innovation.

The fine arts, which were once integral and foundational to design, are today largely unappreciated and appropriated. The spiritual power of Art, Aesthetics, and Beauty, explored at length through art history and theory, are often viewed as indulgent or secondary to execution. The gap between Art & Design has widened. As a result, designers face challenges in fostering in individuals the kind of care and …

City As Cemetery, Siqiao Zhao

Masters Theses

The traditional funeral service industry has enormous environmental and financial costs. In contrast, green burial, and Natural Organic Reduction (NOR), accelerate the human body’s degradation and reduce toxic substances in the land, assuming responsibility for our burden on the earth. They provide a gateway between us and the processes of nature and ask us to set aside self-consciousness to accept our oneness with the universe. By gifting our bodies back to the earth, where decomposition enriches soils and nurtures the growth of other life forms, we honor those who have transitioned to another state by continuing the cycle of renewal. …

Toronto Rewilded, Forrest Meyer

Masters Theses

Global urbanism has left almost no room for native ecology, this has an adverse effect on biodiversity, so adverse that biodiversity has been lost at an alarming rate globally, accounting for between 50-70% of species eradication. Having witnessed firsthand on the land I grew up on, the immense positives of native plantings on the creation of biodiversity, I am eager to implement native plantings in an architectural thesis. Not only is this important to flora and fauna, and the environment, but also for the biophilic connection humans crave with their environs. The reintroduction and preservation of native plantings, species, and …

Unpacked: Consumer Culture In Suburban Spaces, Jaime Dunlap

Masters Theses

The thesis critically analyzes the ways in which the sacredness of man-made goods and consumption culture have shaped the American home and the ways in which the single-family American home acts as both an architectural enforcer and container of consumer culture.

Consumption culture is the never-ending yearning to purchase our right of being in this world. The idea that, through the ownership of things, we feel connected to, equal to, and even above others. This can be examined not only through the relationships and constant acquisition of things but also through the relationships and acquisitions to the built environment.

There …

The Miacomet Movement, Charles Duce

Masters Theses

Nantucket MA, is an island that has failed to refine and regulate the unreasonable uses of freshwater supply, and re-establish the purification processes involved with filtering our wastewater. The validity in claiming re-evaluation for Nantucket’s immoderacies in freshwater consumption and implausibility's in existing wastewater treatments, is seemingly irrefutable. Along with these detriments, Nantucket experiences harsh coastal erosion conditions that are rapidly altering beach profiles and diminishing irreplaceable habitats. Similarly, coastal flooding is causing ecological displacement and in some instances ecological degradation.

The relentlessness and fleetingness sparked by Nantucket’s climatic realities require willing and able action to mitigate impacts; but our …

Unearthing Complexity: Tangible Histories Of Water And Earth, Alexis Violet

Masters Theses

Unearthing Complexity investigates conceptions of time and surface through geological stories of the water and earth. Building on theories of deep time, hydrofeminism, critical zones, and grounding, I hope to foster a deeper awareness of time scales other than our own and a more tangible understanding of the embodied experience of matter in the universe. Working toward a new literacy of the water and earth in which they are recognized as living, changing bodies to which we are inherently tied at a molecular level, the site of this multiscalar inquiry occurs in the coastal zones of the Narragansett Bay where …

Crossover Logics, Serena Ho

Masters Theses

As more and more of modern life is measured and calculated by computational machines, our realities are flattened into streams of data, bits, and binary. As a graphic designer operating under societal and technological systems that unrelentingly speed up, simplify, and reduce the individual into a digital form legible to machines, my response to these conditions is to search for moments of imagination, poetry, and play within these structures. In my practice, I pair machined forms with human gestures to bridge the duality between computer and human logics, the rational and the emotional, and the measurable and unmeasurable aspects of …

A Presence Of P____ And W__Th, Riley Wilson

Masters Theses

This body of work examines the involvement of association as it relates to our cultural interpretations of natural phenomena. Flowers and animals, both real and imagined, have been used as symbols for human morality since the beginning of human history. Two sources with which I drew inspiration from are medieval bestiaries and the Victorian practice of flower language. By combining elements from these references, I aim to pair this idea about the human need for classification with my own considerations about my identity. In combination, I also aim to highlight the responsibility that is intrinsic to curiosity. When faced with …

We Have A (Home) - Co-Operative Homes For Sunset Park, Lisa Qiu

Masters Theses

The thesis believes that the speculative nature of land as property is at the root of the rising cost of quality living space. The combination of profit-driven market force and policies has produced inequality in the accessibility of property ownership.This reality is entangled with a culture that perceives exclusive rights and private ownership as superior to sharing for almost everything, especially the home.

This project believes affordable urban density can be achieved in a city like New York by pushing forward a sense of possibility and desirability in collaborative efforts to create and manage homes. These homes will not be …

Partial Eclipse, Christopher Pak

Masters Theses

A meditation on the interior and exterior in physical space can help us to think about the relationship between the self and other. This thesis explores the boundary between the inside and outside, and between absence and presence through silkscreen printed fabrics. Using an improvisational process guided by chance, residual marks are layered to create an illusion of ephemeral architecture. These textiles offer an experience of time and space that exists between interior and exterior worlds.

Invisible Systems, Mina Kim

Masters Theses

We are immersed in an efficiency-and-profit-obsessed world where products are advancing for the sake of updates without meaningful outcomes. The products’ seemingly simple and seamless interfaces bear the marks of deception and promote the world’s obsessions as a norm. My work defines the visual language and methods that hide complex truth within invisible systems. I aim to strike through invisibility for greater transparency and visibility.

I employ techniques that dis-organize the guidelines and components of invisible systems, reframing expectations and opening up new ways of understanding our surroundings. I intend whimsical reconfigurations to act as a mirror, providing a moment …

From John Street To Union, Andrew Shea

Masters Theses

I have been making paintings constructed loosely from my experience of walking about one mile each morning from my apartment in Fox Point to my studio in downtown Providence, and of walking back each night. My goal is to rediscover the feeling of these outdoor places—their lights, atmospheres, colors, and topographies—through the process of painting inside the studio. As such, the visual representations of these paintings are not straight-forward and objective, but oblique and affective.

I hope that these works draw one’s attention to the idiosyncrasies of natural life and to the particularities of weather. I want the paintings to …

Fungi In Flux | Designing Regenerative Materials And Products With Mycelium, Arvind Bhallamudi

Masters Theses

As the world grapples with the escalating crisis of climate threats and environmental degradation, this research delves into the synergistic potential of design and biology, developing safe and sustainable materials for applications in prototyping, furniture and interior design. Harnessing the power of a unique organism - fungi, the study proposes an accessible, efficient, and resilient material resource system. It utilizes local waste streams and mycelium (the vegetative part of fungi) to grow functional structures. An experimental and small-scale protocol is modeled by testing bio-fabrication and bio-printing methods. The composites' performance qualities and characteristics are evaluated through mechanical testing and a …

Cfp1 Governs Uterine Epigenetic Landscapes To Intervene In Progesterone Responses For Uterine Physiology And Suppression Of Endometriosis, Seung Chel Yang, Mira Park, Kwon-Ho Hong, Hyeonwoo La, Chanhyeok Park, Peike Wang, Gaizhen Li, Qionghua Chen, Youngsok Choi, Francesco J Demayo, John P Lydon, David G Skalnik, Hyunjung J Lim, Seok-Ho Hong, So Hee Park, Yeon Sun Kim, Hye-Ryun Kim, Haengseok Song

Faculty, Staff and Students Publications

Progesterone (P4) is required for the preparation of the endometrium for a successful pregnancy. P4 resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the underlying epigenetic cause remains unclear. Here we demonstrate that CFP1, a regulator of H3K4me3, is required for maintaining epigenetic landscapes of P4-progesterone receptor (PGR) signaling networks in the mouse uterus. Cfp1f/f;Pgr-Cre (Cfp1d/d) mice showed impaired P4 responses, leading to complete failure of embryo implantation. mRNA and chromatin immunoprecipitation sequencing analyses showed that CFP1 regulates uterine mRNA profiles not only in H3K4me3-dependent …

Intrinsic Tgf-Β Signaling Attenuates Proximal Tubule Mitochondrial Injury And Inflammation In Chronic Kidney Disease, Merve Kayhan, Judith Vouillamoz, Daymé Gonzalez Rodriguez, Milica Bugarski, Yasutaka Mitamura, Julia Gschwend, Christoph Schneider, Andrew Hall, David Legouis, Cezmi A Akdis, Leary Peter, Hubert Rehrauer, Leslie Gewin, Roland H Wenger, Stellor Nlandu Khodo

2020-Current year OA Pubs

Excessive TGF-β signaling and mitochondrial dysfunction fuel chronic kidney disease (CKD) progression. However, inhibiting TGF-β failed to impede CKD in humans. The proximal tubule (PT), the most vulnerable renal segment, is packed with giant mitochondria and injured PT is pivotal in CKD progression. How TGF-β signaling affects PT mitochondria in CKD remained unknown. Here, we combine spatial transcriptomics and bulk RNAseq with biochemical analyses to depict the role of TGF-β signaling on PT mitochondrial homeostasis and tubulo-interstitial interactions in CKD. Male mice carrying specific deletion of Tgfbr2 in the PT have increased mitochondrial injury and exacerbated Th1 immune response in …

A Single-Cell Trajectory Atlas Of Striatal Development, Ashley G Anderson, Ashwinikumar Kulkarni, Genevieve Konopka

Faculty, Staff and Students Publications

The striatum integrates dense neuromodulatory inputs from many brain regions to coordinate complex behaviors. This integration relies on the coordinated responses from distinct striatal cell types. While previous studies have characterized the cellular and molecular composition of the striatum using single-cell RNA-sequencing at distinct developmental timepoints, the molecular changes spanning embryonic through postnatal development at the single-cell level have not been examined. Here, we combine published mouse striatal single-cell datasets from both embryonic and postnatal timepoints to analyze the developmental trajectory patterns and transcription factor regulatory networks within striatal cell types. Using this integrated dataset, we found that dopamine receptor-1 …

Film Review: Indigenous Epistemology, Media, And The Representation Of Women In Kantara, Argha Basu, Priyanka Tripathi

Journal of International Women's Studies

Cinematic works around indigenous lives in India have long been marginalized within the scope of “film as an entertaining art form.” Striking a balance between a faithful rendition of an indigenous community and the infusion of entertainment seemed impossible within the Indian film industry until Kantara struck the silver screen. Since its release, the film has been subjected to constructive and positive criticism, but the representation of women in the film has either remained unattended to or viewed negatively. This research paper intends to approach the use of indigenous media and epistemology in the film as a symptomatic representation of …

Ignatian Leadership As A Mechanism For Human Liberation: “What’S Love Got To Do With It?”, Jennifer Tilghman-Havens

Jesuit Higher Education: A Journal

Leadership that draws upon Ignatian wisdom has the potential to heal the divides which plague our local, national and global communities. This chapter weaves together elements of Ignatian Spirituality, critical leadership studies, feminist theory, and critical race concepts to propose a conception of Ignatian leadership that is liberatory for both leader and those being led. Drawing upon Ignatian sources as well as contemporary social science theorists, it illustrates the relevance of the Ignatian worldview for today’s context, as leaders engage critical consideration of race, gender and class in shaping a more just, humane, and sustainable world. It invites the reader …

At The Foot Of The Black Cross In America, Christopher Pramuk

Jesuit Higher Education: A Journal

The colloquy with Christ on the cross during the First Week of the Spiritual Exercises frames a consideration of the possibilities of, and obstacles to, white metanoia and solidarity across the color line in the face of egregious racial injustice. The author highlights the role of the imagination and desire in the birthing of empathy and in the merging of Christ crucified with the suffering of peoples of color in US society, even while insisting that the beauty and richness of “Black Lives” cannot be reduced to suffering. Drawing from Thomas Merton and Pope Francis, the author underscores the importance …

What Does The Ignatian Leader Do?, Michelle Wheatley D.Min.

Jesuit Higher Education: A Journal

Plenty of resources exist regarding the history of the Society of Jesus (Jesuits), Ignatian spirituality, and Jesuit education. Yet many colleagues still wonder how best to apply Ignatian principles in their everyday work and leadership, especially in the context of adaptive challenges and heated disagreement. Therefore, this article seeks to build bridges between Jesuit wisdom and concrete personal, interpersonal, and organizational strategies, particularly by bringing foundational Jesuit resources into conversation with contemporary leadership theories and practices. With four focus areas born from study, relationships, prayer, and a desire to be of help, these reflections explore practical ways of answering the …

A Race Against Death: Renwu Magazine’S Exposé On The Working Conditions Of Chinese Food-Delivery Drivers, William James Mccormack

Student Work

Forty pages long with an eleven-page bibliography that shows wide reading in Chinese and English, William McCormack’s essay, “A Race Against Death: Renwu Magazine’s Exposé on the Working Conditions of Chinese Food-Delivery Drivers,” reads beautifully and proceeds in a clear, logical progression.

In its pages, the author offers a close reading of a 22,000-character article on the working conditions of food delivery drivers from Renwu magazine. McCormack’s analysis of a key source for the Renwu investigation, Sun Ping, a Chinese Academy of Social Sciences (CASS) official, displays his ability to ask probing questions. The author of the Renwu article, …

Examining The Validity Of The Cubed Narrative Language Measures Listening And Reading Subtests, Trevor David Read

Theses and Dissertations

Purpose: The purpose of this study was to examine the concurrent and predictive validity of the CUBED Narrative Language Measures Listening and Reading subtests to evaluate their psychometric properties as defined by Deno (2003). Method: Evidence of concurrent validity for the NLM Listening and Reading subtests was examined using data from 1,146 preschool through third grade students. The NLM subtests were compared to similar subtests from other assessments administered at approximately the same time. Evidence of predictive validity was examined using data from these same NLM subtests from 1,512 kindergarten through third grade students, including 71 third grade students for …

When Do Parts Form Wholes? Integrated Information As The Restriction On Mereological Composition, Kelvin J. Mcqueen, Naotsugu Tsuchiya

Philosophy Faculty Articles and Research

Under what conditions are material objects, such as particles, parts of a whole object? This is the composition question and is a longstanding open question in philosophy. Existing attempts to specify a non-trivial restriction on composition tend to be vague and face serious counterexamples. Consequently, two extreme answers have become mainstream: composition (the forming of a whole by its parts) happens under no or all conditions. In this paper, we provide a self-contained introduction to the integrated information theory (IIT) of consciousness. We show that IIT specifies a non-trivial restriction on composition: composition happens when integrated information is maximized. We …

Spatiotemporal Variability In Total Dissolved Solids And Total Suspended Solids Along The Colorado River, Godson Ebenezer Adjovu, Haroon Stephen, Sajjad Ahmad

Civil and Environmental Engineering and Construction Faculty Research

The Colorado River is a principal source of water for 40 million people and farmlands in seven states in the western US and the Republic of Mexico. The river has been under intense pressure from the effects of climate change and anthropogenic activities associated with population growth leading to elevated total dissolved solid (TDS) and total suspended solid (TSS) concentrations. Elevated TDS- and TSS-related issues in the basin have a direct negative impact on the water usage and the ecological health of aquatic organisms. This study, therefore, analyzed the spatiotemporal variability in the TDS and TSS concentrations along the river. …