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Articles 77131 - 77160 of 742435
Full-Text Articles in Entire DC Network
The Extent Of Drone Education Being Taught In Asc Schools To 4-Year Construction Students, Cheran Teja Dumpati
The Extent Of Drone Education Being Taught In Asc Schools To 4-Year Construction Students, Cheran Teja Dumpati
All Theses
The technology of Unmanned Aircraft Systems (UAS) is growing rapidly in many fields and has become one of the skills in demand in the industry. Universities are one of the primary sources of teaching drone technology with a career-oriented approach. The goal of this study is to investigate the content of the drone curriculum being taught in Associated Schools of Construction (ASC) schools. This includes the topics covered, practical training offered, and the key deliverables taught. This information serves as a foundation for the schools that are looking forward to start drone courses in their department. The research found that …
An Assessment Of Clemson Cooperative Extension Agents’ Perceptions Of Work-Related Factors Leading To Burnout, Erika Hwang
An Assessment Of Clemson Cooperative Extension Agents’ Perceptions Of Work-Related Factors Leading To Burnout, Erika Hwang
All Theses
Turnover and employee burnout are problems the Cooperative Extension System is facing nationwide, and the Clemson University Cooperative Extension System is no exception. There has been previous research done within the Extension system to identify the factors contributing to turnover and burnout, however, both remain an issue. Yet, there has been no research done to examine the Clemson University Cooperative Extension System individually. To further investigate factors contributing to burnout, this pilot study was conducted with Clemson University Clemson Extension agents using a burnout assessment that has not previously been used in Extension research. This study described Clemson University Cooperative …
Identifying Genetic Sources Of Anthracnose Resistance In Global Sorghum Lines, Mary-Frances Behnke
Identifying Genetic Sources Of Anthracnose Resistance In Global Sorghum Lines, Mary-Frances Behnke
All Theses
Anthracnose of sorghum (causal agent: Colletotrichum sublineola) is the most detrimental disease of sorghum (Sorghum bicolor) worldwide, significantly reducing grain yield. This study includes a literature review of the disease and a meta-analysis of genome-wide association studies (GWAS) of anthracnose-resistance in sorghum as means to elucidate genetic sources of the trait. The meta-analysis includes genotypic and phenotypic data from 5 unique studies and 1,071 sorghum lines. Original genotyping-by-sequencing data from were obtained primarily from National Center for Biotechnology Information’s Sequence Read Archive (NCBI-SRA) and prepared and processed using the Tassel 5 GBS v2. pipeline. Phenotypic data were …
Water Quality Land Cover Change And Water Quality In Wetlands At The City Of Gresham, Or, Evelyn Barajas, Michael Gonzalez
Water Quality Land Cover Change And Water Quality In Wetlands At The City Of Gresham, Or, Evelyn Barajas, Michael Gonzalez
altREU Projects
The City of Gresham, Oregon has implemented constructed wetlands around the area as an attempt to collect, filter, and purify water from different sources such as rain, agricultural waste, and domestic waste. We focused our research on three different facilities: Columbia Slough Water Quality Facility (CSWQF), Fairview Creek Water Quality Facility, and Brookside Water Quality Facility. For each of these, we conducted tests and looked at the concentration levels for nitrogen and phosphorus nutrients such as NH3-N (ammonium), NO3-N (nitrate), TKN (total Kjeldahl nitrogen), O-PO4 (phosphate), and Total P (total phosphorus), as well as heavy metals like Total Cu (total …
A Comparison Of Pm-Nato3’S Influence On Neural Progenitors And Mature Dopamine Neurons, Mary E. West
A Comparison Of Pm-Nato3’S Influence On Neural Progenitors And Mature Dopamine Neurons, Mary E. West
Masters Theses
This thesis presents significant findings regarding the role of PM-Nato3 in its interaction with developing neurons in the context of Parkinson's disease (PD) and regenerative medicine. We investigated the effects of PM-Nato3 on dopamine (DA) neurogenesis under different culture conditions, both in vitro and in vivo. In the standard dopaminergic culture condition, PM-Nato3 potentially increased the speed of DA neuron production but did not significantly increase the yield of DA neurons. In a minimal culture condition, there was no notable difference between the control and PM-Nato3 conditions, suggesting minimal impact on DA neurogenesis. In vivo studies using a mouse model …
A Calvinistic Divine Glory Defense, Stephen Thomas Irby
A Calvinistic Divine Glory Defense, Stephen Thomas Irby
Graduate Theses and Dissertations
Calvinists, because they embrace the view that God ordains whatsoever comes to pass, cannot appeal to libertarian free will while trying to defend theism against the problem of evil. However, they can appeal – and, in fact, some have appealed – to God’s desire to be glorified to account for why He has ordained the evils of our world. This is the divine glory defense, and my dissertation aims to develop a version of it. After spending some time framing my defense in the context of the rest of the literature on the problem of evil, an account is provided …
Injectable Immunomodulatory Strategies To Enhance Muscle Recovery Following Injury, Tai Huu Huynh
Injectable Immunomodulatory Strategies To Enhance Muscle Recovery Following Injury, Tai Huu Huynh
Graduate Theses and Dissertations
Although skeletal muscle displays an astonishing regenerative capacity, injuries or diseases that resulted in bedridden or chronic muscle wasting can overwhelm this intrinsic feature of skeletal muscle and lead to functional deficit (range of motion and/or strength) and overall reduction in quality of life. Microenvironmental cues within injured skeletal muscle dictate regenerative and repair process which are tightly coordinated interplay among resident cells, cells recruitment and immune response following an assault in the muscle extracellular matrix (ECM). The successful regeneration of functional tissues requires both appropriate modulation of the inflammatory response, and activation of a variety of cell populations. Biomaterials …
Modeling The Egyptian Goose (Alopochen Aegyptiaca) Invasion; And Future Concerns, Percival Matzinger Marshall
Modeling The Egyptian Goose (Alopochen Aegyptiaca) Invasion; And Future Concerns, Percival Matzinger Marshall
Graduate Theses and Dissertations
In an increasingly interconnected world, the ecological and financial cost of invasive species is expected to continue to climb through the movement of exotic biota. Understanding the driving forces behind how a species invades, what environments promote their establishment, and what impacts they are likely to have on the invaded environment are all critical for management. Waterfowl, order Anseriformes, are one such category of invasive species of concern due to their popularity of accidental introduction, ease of movement, and propensity to affect both terrestrial and aquatic ecosystems. The Egyptian Goose (Alopochen aegyptiaca) is a native to the African continent that …
Evaluation Of Biochar Rate And Hemp Cultivar For The Phytoremediation Of Heavy-Metal-Contaminated Soil From The Tar Creek Superfund Site, Dietrich Thurston
Evaluation Of Biochar Rate And Hemp Cultivar For The Phytoremediation Of Heavy-Metal-Contaminated Soil From The Tar Creek Superfund Site, Dietrich Thurston
Graduate Theses and Dissertations
Soil contamination by cadmium (Cd), lead (Pb), and zinc (Zn) at the Tar Creek Superfund site in Northeast Oklahoma remains a threat to the environment and local ecosystem. Phytoremediation by industrial hemp (Cannabis sativa L.) and the use of biochar (BC) have been independently shown to be effective methods to remediate heavy-metal-contaminated soils. The objective of this greenhouse study was to evaluate the effects of industrial hemp cultivar (‘Carmagnola’ and ‘Jinma’), BC rate (0, 2, 5, and 10% by volume), soil contamination level (low, medium, and high), and their interactions on above- and belowground (AG and BG, respectively) plant dry …
Shedding In The Timber Rattlesnake: Natural Patterns, Endocrinological Underpinnings, Temporal And Energetic Effort, And Integration As A Reptilian Life History Trait, Maxwell D. Carnes-Mason
Shedding In The Timber Rattlesnake: Natural Patterns, Endocrinological Underpinnings, Temporal And Energetic Effort, And Integration As A Reptilian Life History Trait, Maxwell D. Carnes-Mason
Graduate Theses and Dissertations
The semi-frequent replacement of the epidermis (ecdysis) is a characteristic trait of reptiles. Whereas all reptiles regularly engage in some degree of skin shedding, skin morphology in snakes necessitates the synchronous replacement of the entire epidermis and facilitates the subsequent removal of the old layer as a single sheet. To date, the ubiquitous process has garnered little attention from researchers because snakes shed with unpredictable timing and frequency and are exceedingly cryptic during ecdytic cycles; previously impeding detailed physiological or ecological investigations of the process in the clade. Because of the lack of study, ecdysis is often viewed as a …
Components Of Emotional Functioning Among People With Substance Use And Posttraumatic Stress Difficulties: An Idiographic Perspective, Danielle Higuera
Components Of Emotional Functioning Among People With Substance Use And Posttraumatic Stress Difficulties: An Idiographic Perspective, Danielle Higuera
Graduate Theses and Dissertations
Prior research has examined components of emotional functioning (e.g., clarity, physiological sensations, expression, regulation) among people with substance use and/or posttraumatic stress at the group level; however, a more cohesive/comprehensive understanding of how these factors unfold and connect for individual people who comprise these populations is needed. The current study used a qualitative interview design to explore the emotional worlds of participants (N = 44) who comprised four groups (substance use [n ¬= 11], posttraumatic stress [n = 12], co-occurring substance use and posttraumatic stress [n = 11], and healthy controls [n = 10]) to gain a person-level understanding of …
Runoff Water Quality And Crop Growth As Affected By Wastewater-Derived Struvite, Machaela Morrison
Runoff Water Quality And Crop Growth As Affected By Wastewater-Derived Struvite, Machaela Morrison
Graduate Theses and Dissertations
Mined phosphate rock, used to produce phosphorus (P) fertilizers, is a finite resource. Struvite (MgNH4PO4 • 6H2O) that has been synthetically produced from a stock solution of known P and nitrogen (N) concentrations has been shown to be an effective, alternative fertilizer-P source for various crops. However, little is known about the runoff-water-quality implications from and the crop response to soil application of struvite created from an actual municipal wastewater source. This study consisted of two objectives: i) to evaluate the effects of soil [i.e., Creldon (Oxyaquic Fragiudalf), Dapue (Fluventic Hapludoll), Roxana (Typic Udifluvent), and Calloway (Aquic Fraglossudalf) series], fertilizer-P …
Investigation Of Consumer Freezing Practices, Condition And Duration On Palatability Of Beef, Elizabeth Sue Neal
Investigation Of Consumer Freezing Practices, Condition And Duration On Palatability Of Beef, Elizabeth Sue Neal
Graduate Theses and Dissertations
The objective of these studies was to determine: the impact of extended periods of frozen storage duration and packaging type on palatability traits of cooked beef steaks from two muscles and the impact of freezing type and storage duration on objective and subjective measures of ground beef palatability traits. In study 1, no differences were elicited from any of the possible interactions (P= 0.95) for SSF or CL: package × muscle × freezing duration, package × muscle, package × duration or muscle × duration. However, freezing duration did impact both SSF (P < 0.01) and CL (P < 0.001). Generally, for both SSF and CL steaks that were frozen for 9-months elicited both the highest SSF values as well as the greatest percentage of CL among all treatments. In comparison, EM was impacted by the interaction (P = 0.059) of packaging type muscle freezing duration. Samples from OW GM stored for 9-months elicited the highest percentage of EM while fresh OW LL samples resulted in the lowest. Additionally, expressible moisture was impacted by the interaction (P = 0.047) of muscle freezing duration. Among all treatments, GM steaks that were frozen for 9-months elicited the highest EM values and fresh LL samples the lowest EM values. Contrastingly, there was no significant difference observed in expressible moisture for the interaction (P 0.18) of package type freezing duration or for the interaction (P = 0.70) of package type muscle. Generally, fresh OW GM steaks resulted in the greatest concentration of lipid derived volatile compounds such as aldehydes, hydrocarbons and alcohols which contrasted sensory ratings of trained panelists that indicated oxidized and refrigerator-stale ratings increased as storage time increased for OW steaks. In study 2, The interaction of freezer treatment × storage duration impacted gumminess (P = 0.05), a TPA attribute. In greater detail, samples stored in RF for 6-months resulted in the greatest gumminess values (P < 0.001), while those stored in the CF for 12-months elicited the lowest (P < 0.001). Similarly, flavor development was also impacted by the interaction (P = 0.05) of freezer treatment × storage duration. Three lipid derived compounds were of greatest concentration among RF patties stored for 1-month. In contrast, the interaction of freezer treatment × storage duration elicited no impact on consumer ratings, SF or TBARS. Nonetheless, frozen storage duration impacted TPA, flavor development, consumer ratings, SF and TBARS as a main effect (P < 0.05), especially in regard to tenderness and juiciness. Moreover, beef flavor development, tenderness and juiciness are impacted by freezing duration, muscle, freezer type and packaging, however these factors are not necessarily independent of one another. Furthermore, the retail display period is a critical period for fresh beef steaks, especially when packaged in aerobic conditions. For optimal eating experience, beef products should be stored for extended periods in a vacuum packaging, in a designated freezer that is not opened frequently to allow for optimal air flow regulation and minimize freezer burn to improve tenderness and juiciness.
Securing Rice Safety Through Innovative Radiative Heat Treatment And Proper Storage, Faith Achieng Ouma
Securing Rice Safety Through Innovative Radiative Heat Treatment And Proper Storage, Faith Achieng Ouma
Graduate Theses and Dissertations
Securing the microbial safety of rice is a rising priority within the food industry, especially when used as an ingredient to manufacture ready-to-eat, minimally-processed products. Mold contamination is typically the most problematic for rice because certain species of Aspergillus produce toxic secondary metabolites known as aflatoxins, rendering the grain unfit for human and animal consumption. The objectives of this study are to: (1) investigate the effectiveness of using high-power (915 MHz frequency), short-duration microwaves (MWs) to inactivate microbes on rough rice; (2) use a three-level screening design to determine which storage factors, such as temperature, relative humidity (RH), storage duration, …
Isolation And Characterization Of Porcine Endocardial Endothelial Cells, Kathleen N Brown, Hong Kim T Phan, Elysa L Jui, Marci K Kang, Jennifer P Connell, Sundeep G Keswani, K Jane Grande-Allen
Isolation And Characterization Of Porcine Endocardial Endothelial Cells, Kathleen N Brown, Hong Kim T Phan, Elysa L Jui, Marci K Kang, Jennifer P Connell, Sundeep G Keswani, K Jane Grande-Allen
Faculty, Staff and Students Publications
The heart contains diverse endothelial cell types. We sought to characterize the endocardial endothelial cells (EECs), which line the chambers of the heart. EECs are relatively understudied, yet their dysregulation can lead to various cardiac pathologies. Due to the lack of commercial availability of these cells, we reported our protocol for isolating EECs from porcine hearts and for establishing an EEC population through cell sorting. In addition, we compared the EEC phenotype and fundamental behaviors to a well-studied endothelial cell line, human umbilical vein endothelial cells (HUVECs). The EECs stained positively for classic phenotypic markers such as CD31, von Willebrand …
Dietary Effects On Cardiac Lipid Composition And Subsequent Phenotype In The American Lobster (Homarus Americanus), Melissa Colette Butler
Dietary Effects On Cardiac Lipid Composition And Subsequent Phenotype In The American Lobster (Homarus Americanus), Melissa Colette Butler
All Theses And Dissertations
Lipids are fundamental components of many biological structures and compositions of these molecular species can alter with diet. Differences in lipid membrane composition can impact the functioning of membranes and proteins subsequently altering the organism’s ability to respond to stressful conditions. American lobsters (Homarus americanus) are an economically important shellfish in New England and are sometimes kept intermittently in lobster impoundments (pounds) for months where they are often fed herring, which differs from the assumed natural diet of wild-caught lobsters. In this study, we compared the lipid composition of lobsters obtained from the wild and pounds that were …
Recreational Fishing For Western Rock Lobster: Estimates Of Participation, Effort And Catch In 2022/23, Claire B. Smallwood, Karina L. Ryan, Alissa C. Tate, Lucy J. Rudd
Recreational Fishing For Western Rock Lobster: Estimates Of Participation, Effort And Catch In 2022/23, Claire B. Smallwood, Karina L. Ryan, Alissa C. Tate, Lucy J. Rudd
Fisheries Research Reports
The Western Rock Lobster (WRL) (Panulirus cygnus) is the most commonly caught Rock Lobster (RL) species in Western Australia. Catches from the commercial and recreational sectors are required to determine and monitor Total Allowable Commercial Catch (TACC), Total Allowable Recreational Catch (TARC) and proportion of Allowable Harvest Level (AHL) achieved. The TARC is set at 5% of the AHL and evaluated in the harvest strategy based on a 5-year average. Data for the recreational sector are obtained using phone-recall surveys to provide estimates of participation, fishing effort and retained catch (by numbers) from recreational fishers who hold a RL licence. …
“Provisioned, Produced, Procured,” And Purchased?: A Macrobotanical Study Of Enslaved Individuals’ Economic Engagement In The Shenandoah Valley, Linda A. Seminario
“Provisioned, Produced, Procured,” And Purchased?: A Macrobotanical Study Of Enslaved Individuals’ Economic Engagement In The Shenandoah Valley, Linda A. Seminario
Graduate Masters Theses
This research investigates enslaved peoples’ economic engagement in the Shenandoah Valley during the first half of the 19th century. In 2017, archaeologists excavated two features at the Belle Grove enslaved quarters in Middletown, Virginia— a root cellar and subfloor pit that were filled in when a log cabin burned down. The preservation of the macrobotanicals has allowed for an in-depth analysis of the plants with which enslaved individuals engaged and the relationship between plant acquisition and enslaved people’s regional formal economic involvement at a 19th-century plantation in the Shenandoah Valley of Virginia. These data sets have also allowed for an …
Deconstructing Reconstruction: The Portrayal Of The Reconstruction Era In High School History Textbooks, Eleanor Katari
Deconstructing Reconstruction: The Portrayal Of The Reconstruction Era In High School History Textbooks, Eleanor Katari
Graduate Masters Theses
This paper examines the persistence of Dunning School narratives of the Reconstruction Era in high school US History textbooks, despite the thorough rejection of those narratives among academic historians at the college level and above. In examining the reasons for the persistence of these narratives, this paper acknowledges some structural elements of the textbook industry before focusing on the role of white women’s parent activism in shaping textbook content and adoption, stretching backwards to the 1890s and the Daughters of Confederate Veterans, and forward to the present day and organizations such as Moms for Liberty. This paper also points out …
Csf Mtbr-Tau243 Is A Specific Biomarker Of Tau Tangle Pathology In Alzheimer's Disease, Kanta Horie, Nicolas R Barthélemy, Yan Li, Yingxin He, Benjamin Saef, Charles D Chen, Hong Jiang, Chihiro Sato, Brian A Gordon, Tammie L S Benzinger, David M Holtzman, John C Morris, Suzanne E Schindler, Randall J Bateman, Et Al.
Csf Mtbr-Tau243 Is A Specific Biomarker Of Tau Tangle Pathology In Alzheimer's Disease, Kanta Horie, Nicolas R Barthélemy, Yan Li, Yingxin He, Benjamin Saef, Charles D Chen, Hong Jiang, Chihiro Sato, Brian A Gordon, Tammie L S Benzinger, David M Holtzman, John C Morris, Suzanne E Schindler, Randall J Bateman, Et Al.
2020-Current year OA Pubs
Aggregated insoluble tau is one of two defining features of Alzheimer's disease. Because clinical symptoms are strongly correlated with tau aggregates, drug development and clinical diagnosis need cost-effective and accessible specific fluid biomarkers of tau aggregates; however, recent studies suggest that the fluid biomarkers currently available cannot specifically track tau aggregates. We show that the microtubule-binding region (MTBR) of tau containing the residue 243 (MTBR-tau243) is a new cerebrospinal fluid (CSF) biomarker specific for insoluble tau aggregates and compared it to multiple other phosphorylated tau measures (p-tau181, p-tau205, p-tau217 and p-tau231) in two independent cohorts (BioFINDER-2, n = 448; and …
A High-Performance Speech Neuroprosthesis, Francis R Willett, Erin M Kunz, Chaofei Fan, Donald T Avansino, Guy H Wilson, Eun Young Choi, Foram Kamdar, Matthew F Glasser, Leigh R Hochberg, Shaul Druckmann, Krishna V Shenoy, Jaimie M Henderson
A High-Performance Speech Neuroprosthesis, Francis R Willett, Erin M Kunz, Chaofei Fan, Donald T Avansino, Guy H Wilson, Eun Young Choi, Foram Kamdar, Matthew F Glasser, Leigh R Hochberg, Shaul Druckmann, Krishna V Shenoy, Jaimie M Henderson
2020-Current year OA Pubs
Speech brain-computer interfaces (BCIs) have the potential to restore rapid communication to people with paralysis by decoding neural activity evoked by attempted speech into text
Spatial Epidemiologic Analysis And Risk Factors For Nontuberculous Mycobacteria Infections, Missouri, Usa, 2008-2019, Carlos Mejia-Chew, Miguel A Chavez, Min Lian, Angela Mckee, Leighton Garrett, Thomas C Bailey, Andrej Spec, Mansi Agarwal, George Turabelidze
Spatial Epidemiologic Analysis And Risk Factors For Nontuberculous Mycobacteria Infections, Missouri, Usa, 2008-2019, Carlos Mejia-Chew, Miguel A Chavez, Min Lian, Angela Mckee, Leighton Garrett, Thomas C Bailey, Andrej Spec, Mansi Agarwal, George Turabelidze
2020-Current year OA Pubs
Nontuberculous mycobacteria (NTM) infections are caused by environmental exposure. We describe spatial distribution of NTM infections and associations with sociodemographic factors and flooding in Missouri, USA. Our retrospective analysis of mycobacterial cultures reported to the Missouri Department of Health and Social Services surveillance system during January 1, 2008-December 31, 2019, detected geographic clusters of infection. Multilevel Poisson regression quantified small-area geographic variations and identified characteristics associated with risk for infection. Median county-level NTM infection rate was 66.33 (interquartile range 51-91)/100,000 persons. Risk of clustering was significantly higher in rural areas (rate ratio 2.82, 95% CI 1.90-4.19) and in counties with …
Radiofrequency-Based Chondroplasty Creates A Precise Area Of Targeted Chondrocyte Death With Minimal Necrosis Outside The Target Zone: A Systematic Review, Garrett R Jackson, Luis M Salazar, Johnathon R Mccormick, Varun Gopinatth, Alex Hodakowski, Colton C Mowers, Suhas Dasari, Luc M Fortier, Daniel J Kaplan, Zeeshan A Khan, Enzo S Mameri, Derrick M Knapik, Jorge Chahla, Nikhil N Verma
Radiofrequency-Based Chondroplasty Creates A Precise Area Of Targeted Chondrocyte Death With Minimal Necrosis Outside The Target Zone: A Systematic Review, Garrett R Jackson, Luis M Salazar, Johnathon R Mccormick, Varun Gopinatth, Alex Hodakowski, Colton C Mowers, Suhas Dasari, Luc M Fortier, Daniel J Kaplan, Zeeshan A Khan, Enzo S Mameri, Derrick M Knapik, Jorge Chahla, Nikhil N Verma
2020-Current year OA Pubs
PURPOSE: To systematically examine the effects of radiofrequency (RF) ablation or coblation (controlled ablation) on chondrocyte viability following knee chondroplasty in preclinical literature to determine the effectiveness and safety of RF-based techniques.
METHODS: A literature search was performed in September 2022 using PubMed and Scopus using the following search terms combined with Boolean operators: "chondroplasty," "radiofrequency," "thermal," "knee," "chondral defect," "articular cartilage," and "cartilage." The inclusion criteria consisted of preclinical studies examining the effect of RF ablation or coblation on chondrocytes during knee chondroplasty. Exclusion criteria consisted of studies reporting chondroplasty in joints other than the knee, clinical studies, in …
Scca1/Serpinb3 Suppresses Antitumor Immunity And Blunts Therapy-Induced T Cell Responses Via Stat-Dependent Chemokine Production, Liyun Chen, Victoria Shi, Songyan Wang, Lulu Sun, Rebecca Freeman, Jasmine Yang, Matthew J. Inkman, Subhajit Ghosh, Fiona Ruiz, Kay Jayachandran, Yi Huang, Jingqin Luo, Jin Zhang, Pippa Cosper, Clifford J Luke, Perry W. Grigsby, Julie K. Schwarz, Stephanie Markovina, Et Al.
Scca1/Serpinb3 Suppresses Antitumor Immunity And Blunts Therapy-Induced T Cell Responses Via Stat-Dependent Chemokine Production, Liyun Chen, Victoria Shi, Songyan Wang, Lulu Sun, Rebecca Freeman, Jasmine Yang, Matthew J. Inkman, Subhajit Ghosh, Fiona Ruiz, Kay Jayachandran, Yi Huang, Jingqin Luo, Jin Zhang, Pippa Cosper, Clifford J Luke, Perry W. Grigsby, Julie K. Schwarz, Stephanie Markovina, Et Al.
2020-Current year OA Pubs
Patients with cancer who have high serum levels of squamous cell carcinoma antigen 1 (SCCA1, now referred to as SERPINB3) commonly experience treatment resistance and have a poor prognosis. Despite being a clinical biomarker, the modulation of SERPINB3 in tumor immunity is poorly understood. We found positive correlations of SERPINB3 with CXCL1, CXCL8 (CXCL8/9), S100A8, and S100A9 (S100A8/A9) myeloid cell infiltration through RNA-Seq analysis of human primary cervical tumors. Induction of SERPINB3 resulted in increased CXCL1/8 and S100A8/A9 expression, which promoted monocyte and myeloid-derived suppressor cell (MDSC) migration in vitro. In mouse models, Serpinb3a tumors showed increased MDSC and tumor-associated …
Cation Leak Through The Atp1a3 Pump Causes Spasticity And Intellectual Disability, Daniel G Calame, Marwan Shinawi, Et Al.
Cation Leak Through The Atp1a3 Pump Causes Spasticity And Intellectual Disability, Daniel G Calame, Marwan Shinawi, Et Al.
2020-Current year OA Pubs
ATP1A3 encodes the α3 subunit of the sodium-potassium ATPase, one of two isoforms responsible for powering electrochemical gradients in neurons. Heterozygous pathogenic ATP1A3 variants produce several distinct neurological syndromes, yet the molecular basis for phenotypic variability is unclear. We report a novel recurrent variant, ATP1A3(NM_152296.5):c.2324C>T; p.(Pro775Leu), in nine individuals associated with the primary clinical features of progressive or non-progressive spasticity and developmental delay/intellectual disability. No patients fulfil diagnostic criteria for ATP1A3-associated syndromes, including alternating hemiplegia of childhood, rapid-onset dystonia-parkinsonism or cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss (CAPOS), and none were suspected of having an ATP1A3-related disorder. Uniquely among known …
The Flipped Classroom Approach In A Pediatric Anesthesiology Fellowship Curriculum, Rachel Moquin, Megan Dewey, Ashley Weinhold, Ottavia Green, Anna Rebecca Young
The Flipped Classroom Approach In A Pediatric Anesthesiology Fellowship Curriculum, Rachel Moquin, Megan Dewey, Ashley Weinhold, Ottavia Green, Anna Rebecca Young
2020-Current year OA Pubs
Background The flipped classroom approach is well documented to enhance medical education outcomes. Additionally, both the need for online learning materials and the increased demand for medical professionals during the COVID-19 pandemic has made this approach more relevant. The pediatric anesthesiology fellowship curriculum at one institution transitioned from a traditional classroom model to a flipped classroom approach to optimize the educational experience and support learner well-being. Approach Utilizing the American Board of Anesthesiology (ABA) and Accreditation Council for Graduate Medical Education (ACGME) content outlines, a novel, comprehensive curriculum was developed focusing on core clinical material and board review with the …
Symbiotic Bacteria, Immune-Like Sentinel Cells, And The Response To Pathogens In A Social Amoeba, Trey J. Scott, Tyler J. Larsen, Debra A. Brock, So Yeon Stacey Uhm, David C. Queller, Joan E. Strassmann
Symbiotic Bacteria, Immune-Like Sentinel Cells, And The Response To Pathogens In A Social Amoeba, Trey J. Scott, Tyler J. Larsen, Debra A. Brock, So Yeon Stacey Uhm, David C. Queller, Joan E. Strassmann
2020-Current year OA Pubs
Some endosymbionts living within a host must modulate their hosts' immune systems in order to infect and persist. We studied the effect of a bacterial endosymbiont on a facultatively multicellular social amoeba host. Aggregates of the amoeba
An Experimental Model Of Chronic Severe Mitral Regurgitation, Martha M O Mcgilvray, Tari-Ann E Yates, Lynn Pauls, Meghan O Kelly, Nicholas Razo, Stacie Mcelligott, Glenn J Foster, Jie Zheng, Jonathan K Zoller, Christian Zemlin, Ralph J Damiano Jr
An Experimental Model Of Chronic Severe Mitral Regurgitation, Martha M O Mcgilvray, Tari-Ann E Yates, Lynn Pauls, Meghan O Kelly, Nicholas Razo, Stacie Mcelligott, Glenn J Foster, Jie Zheng, Jonathan K Zoller, Christian Zemlin, Ralph J Damiano Jr
2020-Current year OA Pubs
OBJECTIVE: To develop a minimally invasive, reproducible model of chronic severe mitral regurgitation (MR) that replicates the clinical phenotype of left atrial (LA) and left ventricular dilation and susceptibility to atrial fibrillation.
METHODS: Under transesophageal echocardiographic guidance, chordae tendinae were avulsed using endovascular forceps until the ratio of regurgitant jet area to LA area was ≥70%. Animals survived for an average of 8.6 ± 1.6 months (standard deviation) and imaged with monthly transthoracic echocardiography (TTE). Animals underwent baseline and preterminal magnetic resonance imaging. Terminal studies included TTE, transesophageal echocardiography, and rapid atrial pacing to test inducibility of atrial tachyarrhythmias.
RESULTS: …
Striatal Mglu5-Mediated Synaptic Plasticity Is Independently Regulated By Location-Specific Receptor Pools And Divergent Signaling Pathways, Yuh-Jiin I Jong, Yukitoshi Izumi, Steven K Harmon, Charles F Zorumski, Karen L Ómalley
Striatal Mglu5-Mediated Synaptic Plasticity Is Independently Regulated By Location-Specific Receptor Pools And Divergent Signaling Pathways, Yuh-Jiin I Jong, Yukitoshi Izumi, Steven K Harmon, Charles F Zorumski, Karen L Ómalley
2020-Current year OA Pubs
Metabotropic glutamate receptor 5 (mGlu
Resolvin D1 Prevents Injurious Neutrophil Swarming In Transplanted Lungs, Wenjun Li, Hailey M Shepherd, Yuriko Terada, Ashley E Shay, Amit I Bery, Andrew E Gelman, Kory J Lavine, Charles N Serhan, Daniel Kreisel
Resolvin D1 Prevents Injurious Neutrophil Swarming In Transplanted Lungs, Wenjun Li, Hailey M Shepherd, Yuriko Terada, Ashley E Shay, Amit I Bery, Andrew E Gelman, Kory J Lavine, Charles N Serhan, Daniel Kreisel
2020-Current year OA Pubs
Neutrophils are the primary cell type involved in lung ischemia-reperfusion injury (IRI), which remains a frequent and morbid complication after organ transplantation. Endogenous lipid mediators that become activated during acute inflammation-resolution have gained increasing recognition for their protective role(s) in promoting the restoration of homeostasis, but their influence on early immune responses following transplantation remains to be uncovered. Resolvin D1, 7