Digital Commons Network^™

Exploring The Effects Of Choline Treatment On Dystrophic Phenotype, Brooklyn Morris

Browse all Theses and Dissertations

Duchenne Muscular Dystrophy (DMD) is a devastating progressive muscular disorder caused by a mutation in the dystrophin gene affecting approximately 1 in 3,500 males. However, despite its prevalence, there is currently no cure for this disease. Mutations in dystrophin lead to enhanced inflammation, fibrosis, cell death, development, and decreased skeletal muscle function. Phosphatidylcholine, synthesized by choline, is a major phospholipid that functions in maintaining and synthesizing cell membranes and has previously been found to be decreased in DMD patients. This led us to hypothesize that the dystrophic phenotype could be improved through treatment with choline. In this study, we used …

Comparative Analysis Of Motoneuronal C-Bouton Structural Alterations In Als And Aging, Shelby Nicole Ward

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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron (MN) death resulting in paralysis and eventually death. ALS has greater prevalence in older populations sharing characteristics with aging like muscle weakness and MN type specific degeneration. MNs innervate skeletal muscles and control muscle contraction through their excitability which is altered in both conditions. C-Boutons are a cholinergic, excitatory synaptic input to MNs and have been studied in ALS and aging but have produced inconsistent findings and undesired gaps. We used immunohistochemistry to label mouse lumbar spinal cord and separate MN types. 60x imaging and automated analysis was …

Studies Of Selective And Reversible Inhibitors Of Calcium Entry In Immune Cells, Naga Lakshmi Gandi

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Calcium signaling is a crucial regulator in many cellular processes, from immune response modulation to gene expression and apoptosis. Here, I have investigated the dynamics of calcium entry pathways, namely, store-operated calcium entry and store-independent calcium entry using a variety of cell types such as Jurkat T cells, HEK-293 cells and murine macrophages. Using fluorescence calcium imaging and selective inhibitor compounds, I have investigated the contributions of Orai and related calcium channels to calcium entry in both immune and non-immune cell types. The results demonstrate the pharmacological modulation of store-operated and store-independent calcium entry, showing the ability of compounds such …

Sex-Driven Alterations In Aging Alpha Motoneurons: Exploring Size, Type, Density, And Kv2.1 Channel Expression, Kalin R. Gerber

Browse all Theses and Dissertations

This research explores how motor neurons (MNs) and Kv2.1 clustering change with age, emphasizing sex differences and MN subtypes. We found that MN density decreases with age in both sexes, while soma size increases in male mice. FF MNs were the most affected, and old weak mice had smaller MNs than their stronger counterparts, underscoring FF MN vulnerability. Baseline studies revealed that FF and FI MNs have larger Kv2.1 clusters compared to FR and S MNs. Female mice had smaller, denser Kv2.1 clusters than male mice, suggesting less clustering in females. With age, Kv2.1 clusters grew larger but became less …

Investigating The Effects Of Human Astroviruses On Aquaporins And Tight Junction Proteins In Vitro, Makalia T. Robinson

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Human Astroviruses (HAstV) are positive sense non-enveloped single stranded RNA viruses. HAstV is divided into classical (serotype 1-8) and non-classical (HAstVMLB 1-3 and HAstV-VA1-5) astroviruses. Classical HAstV is known to cause diarrhea in children, elderly, and immunocompromised patients. Additionally, the etiology of nonclassical HAstV remains unknown. However, recent studies have implicated non-classical HAstV closely associated with immunocompromised patients diagnosed neurological diseases like acute encephalitis. The mechanisms by which HAstV cause diarrhea is currently unknown. Aquaporins (AQPs) are integral membrane proteins that regulate the movement of water and small uncharged molecules across the cell membrane in response to osmotic gradients. Tight …

The Price Of Criminal Law, Russell M. Gold

Articles

Should tax dollars pay for more criminal law, better public schools, or a new community center? Different counties will answer the question differently, but facing these tradeoffs is profoundly important to democratic governance. Nonetheless, because the criminal legal system diffuses power and hides and offioads costs, officials and voters do not have to honestly consider that question. These structural features place a hidden thumb on the scale that gives counties more criminal enforcement than they pay for. That is a problem. Too much enforcement is particularly pernicious in criminal law: Incarceration inflicts tremendous suffering, especially in poor communities of color. …

Transgender Students And The First Amendment, Dara Purvis

Faculty Scholarship

Suppose a transgender child experiences teasing and harassment from their classmates, whose hostile reactions interrupt the school day. School administrators tell the transgender child that, in order to allow educational activities to continue, they must dress in more gender-neutral clothing, ideally cionsistent with the sex they were assigned at birth. The student's parents protest, arguing that their child's clothing is speech that expresses their gender identity. The school points to Tinker v. Des Moines, allowing suppression of student speech where it creates a material disruption, as well as recent legislation characterizing discussion of gender identity as lewd and obscene. …

The Nebulous Binaries Of C.S. Lewis' Till We Have Faces, Amantia Menalla

Honors Undergraduate Theses

Much of C.S. Lewis’ novel Till We Have Faces can be examined through one of two binaries. The tension between rationality, or reason, and spirituality, or religion, is one of the core facets of both the text and its main character, Orual. Orual feels the pull of both ideas and thus spends most of the novel in a nebulous space between them. This tension is further complicated by the space between the feminine and the masculine which she also inhabits. By covering her face and body, Orual de-emphasizes her feminine identity and takes on a masculine role, dressing as a …

Msw Portfolio, Courtney R. Nucito

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio encapsulates my transformative journey through the realm of social work, detailing experiences, reflections, and insights gained throughout my academic and professional endeavors. Rooted in a commitment to social justice and ethical practice, my narrative unfolds through various roles and settings, each contributing to my growth as a compassionate and effective social work practitioner.

Addressing The Occupational Needs Of College Students, Amanda Lam, Ashley Keates, Marissa Heirich, Noreen Pervaiz, Albert Andrew Mendoza

Occupational Therapy | MSOT Capstone Projects

The Dominican Occupational Therapy (OT) Coaching project was led by a team of five master's level OT students in collaboration with the Integrative Coaching (IC) team at Dominican University of California. Aligned with the Occupational Therapy Practice Framework 4th edition (2020), the project supported various aspects of student wellness, such as academics, healthy lifestyles, stress management, sleep hygiene, and time management. In the fall of 2022, the team conducted a comprehensive literature review and needs assessment of Dominican's Student Success Center (SSC), actively engaged in SSC and IC meetings, and delivered an educational presentation on OT to SSC staff. The …

Intergenerational Connections: Us College Students’ Attitudes And Expectations Toward Older Adults And Aging In An Online Critical Community Engagement Project, Sandra L. Faulkner, Madison Pollino, Jaclyn Shetterly, Wendy K. Watson

Journal of Communication Pedagogy

We present a critically focused, semester-long community engagement project entitled Intergenerational Connections as a form of critical interpersonal and family communication pedagogy (CIFCP). The project utilized Zoom to connect small groups of undergraduate students in the US enrolled in a course on relational communication with older adults in a long-term care facility to dialogue about close relationships. We were interested in how dialogue across generations maintained or altered students’ attitudes and expectations about communicating with older adults and analyzed student reflections before, during, and after the dialogues using a turning point analysis. The study was framed using Social Identity Theory …

Development Of Novel Hydrogel Materials For Viscoelastically Accurate Brain Phantoms, Lila G. Schandler

Theses and Dissertations

Current methods such as concussion tests and Magnetic Resonance Imaging (MRI) scans only reveal structural damage post-injury. Creating an anatomically accurate model of the brain that mimics brain structure and viscoelastic properties will further allow medical professionals to analyze concussion events and create curated and personalized plans of recovery for a patient’s unique brain injury.

Values have been established for the necessary viscoelastic properties (time constants and elasticity) to mimic the native human brain tissue such as grey matter and white matter. The mechanical properties of the hydrogel are tunable by varying the concentration of Phytagel (PHY), a protein binding …

Parent Motivations For Enrolling Their Young Children In Early Childhood Programs: An Application Of The Theory Of Planned Behaviour, Rachel A. Mcgovern, Camilla Hodge, Edward Ruddell

Faculty Publications

This study used the theory of planned behaviour to identify and determine the relative influence of factors influencing parents’ decisions to enrol their young children (3 to 5 years old) in early childhood programs at a specific museum venue. An eliciting questionnaire was distributed to museum members with at least one child 3–5 years old to elicit outcome expectancies, normative beliefs, and control beliefs, and these responses were developed into items for the main questionnaire. Regression and correlation analyses were conducted to determine factors associated with parents’ intention to enrol their children. Parents across socioeconomic and educational backgrounds indicated they …

Confronting The Wildfire Crisis: Understanding Equity And Decision-Making In Wildfire Management Strategies, Katherine Huerta Sanchez

Dissertations, Master's Theses and Master's Reports

This study investigates how fuel managers incorporate equity and social vulnerability considerations into wildfire fuel reduction treatments on National Forest land and explores the resulting impact on the implementation of wildfire risk reduction policies. Through interviews, managers revealed differing perspectives on prioritizing social vulnerability characteristics and challenges such as insufficient information and resources to inform equitable fuel treatment decisions. These findings illuminate the complexities of integrating considerations of social vulnerability into decision-making processes for wildfire management at the wildland-urban interface, suggesting potential divergence from nationally supported policies aimed at equitably implementing wildfire risk reduction measures. The study findings underscore the …

Restoration Is Repairing Relationships: Bridging Indigenous And Western Sciences To Assess The Socio-Ecological Restoration Of Wild Rice (Zizania Palustris) On Keweenaw Bay Indian Community Homelands, Cassandra M. Reed-Vandam

Dissertations, Master's Theses and Master's Reports

Manoomin (wild rice, Zizania palustris) is an ecologically and culturally significant plant relative for the Keweenaw Bay Indian Community (KBIC). Historically, manoomin was present across much of the Great Lakes, however, their presence has declined since the early 1900s and, by 1990, virtually disappeared within KBIC homelands. Employing ethnography, surveys, focus groups, and conversations with Ojibwa knowledge holders, this research defined successful manoomin restoration for KBIC and developed socio-ecological attributes and indicators to assess restoration presented in the Medicine Wheel Framework for Manoomin Restoration. Surface water, sediment, and pore water samples at six different manoomin sites were analyzed to …

Exploring Usability In Exercise Interventions: From Conceptualization To Measurement And Application, Anne Inger Mørtvedt

Dissertations, Master's Theses and Master's Reports

Exercise interventions hold promise for preventing and treating numerous conditions, diseases, and injuries. However, these interventions will only be effective if they are being used. Unfortunately, uptake and adherence to prescribed exercise and physical activity guidelines are insufficient. Some reasons for this include lack of knowledge, resources, flexibility, and enjoyment. Exercise program developers need to not only consider the effectiveness of the program during the development phase, but also involve end-users and receive feedback on program usability to determine likelihood of uptake and adoption. Usability testing can be used to detect barriers to use and implementation likelihood but has not …

Gis-Based Landscape Prioritization To Guide Invasive Species Survey, Erin R. Mauk

Dissertations, Master's Theses and Master's Reports

Utilizing prioritization models gives invasive species managers the capability to systematically target surveying and management toward priority areas, therefore maximizing limited financial resources by increasing the value that management can have on the landscape. In this report, Geographic Information System (GIS) techniques were utilized to produce an invasion risk model and a quality land model. Combining these two models produced a landscape-level prioritization model, which denoted the land quality and associated invasion risk across the study area. High-quality land was commonly distributed within Isle Royale National Park, along Lake Superior’s coastline, and within coastal wetlands and riparian habitats. Areas of …

Initial Solution Improvements To A Tethered Robotic Path Planner Using Random Geometric Graph Configurations And Biased Sampling, Austen J. Goddu

Dissertations, Master's Theses and Master's Reports

With NASA's ongoing efforts to establish a presence on the lunar surface to eventually move on to exploring mars, the development of intelligent robotic systems is more important than ever. The ability of robotics to explore hazardous and extreme terrain, coupled with long communication times from earth places an ever increasing need on more robust and efficient autonomy. Tethered robotics offer unique advantages to explore scientific targets both on the lunar and martian surfaces, capable of using their tether as a physical or metaphorical lifeline to allow the exploration of slopes, extreme dark regions, or areas in which wireless communication …

The Association Between Patient Race/Ethnicity/Culture, Physician-Patient Communication, And Patient Outcomes: A Systematic Review, Maazen Khan

Honors Undergraduate Theses

Research shows that health disparities exist among patients of varying races, ethnicities, and cultures in the United States. Numerous studies have suggested that these disparities may be partly associated with physician-patient communication. The larger project that this thesis is a part of is a mixed-methods analysis of physician-patient communication across patient race, ethnicity, and culture. This thesis specifically excluded qualitative studies and focused on how such communication can affect health outcomes. Sixty-nine studies were identified and appraised for quality. Of these, only four associated physician-patient communication with the health outcomes of patients. These studies had inconsistent results, highlighting the gap …

Concepts And Measures Of Human Intelligence And Anthropology: A Systematic Review Of Academic Literature From 1930s To 2010s, Leilani Maldonado

Honors Undergraduate Theses

This thesis explores the evolution of intelligence research and its contextualization within historical biases. Using a meta-analysis approach, the study examines word frequencies in academic literature spanning from the 1930s to the 2010s to identify shifting trends in intelligence discourse. Eleven search terms related to intelligence were analyzed to interpret changes in academic focus over time. The findings reveal significant shifts influenced by historical events, societal movements, and advancements in technology and methodology. From the prominence of IQ measures during World War II to the rise of cognitive science in the 1960s and the emergence of emotional intelligence in the …

Antagomir Treatment For Deep-Space Simulated Changes In The Liver Of Mice, Natalie P. Hayslip

Honors Undergraduate Theses

With the start of NASA’s Artemis program, astronauts will soon leave the protection of Earth’s magnetosphere. Previous studies have established a theme of liver dysregulation associated with the harmful radiation and microgravity experienced in deep space. MicroRNAs (miRNAs) are key regulators of many of the pathologies observed during and after spaceflight, including hepatic fibrosis, making them strong potential biomarkers and therapeutic targets. Therefore, in the present study we investigated the effects of simulated microgravity, galactic cosmic radiation (GCR), and solar particle events (SPE) on miRNAs and mRNAs involved in the TGF-β signaling pathway, a key regulator of fibrosis, senescence, and …

Monitoring Faunal Responses To Biodegradable Oyster Reef Restoration Materials With Camera Traps, Tara L. Blanchard

Honors Undergraduate Theses

Restoration of the oyster reefs has become increasingly crucial due to great population declines around the globe. Intertidal oyster reefs provide essential foraging and loafing grounds to many faunal species, including several threatened/endangered wading bird species. Biodegradable oyster reef restoration materials have been introduced to avoid potential plastic pollution from traditional materials. Studies have shown success regarding oyster recruitment rates to these materials. However, their impacts on fauna using restored oyster reefs are unknown. This project aims to evaluate oyster reef restoration using biodegradable materials to increase faunal diversity, abundance, and foraging behaviors. Camera traps were deployed to observe fauna …

Examining Wrack In Mosquito Lagoon To Analyze Biodiversity And Seagrass Viability, Nicole Jerrell

Honors Undergraduate Theses

Seagrass restoration of Halodule wrightii, has become crucial as seagrass coverage in the Indian River Lagoon (IRL) declined by 58% between 2011 and 2019. To understand the abundance of seagrass fragments available for natural recruitment and restoration, we tracked the abundance of viable fragments found in the wrack in Mosquito Lagoon. Wrack is plant material, including seagrass fragments, mangrove propagules, and detritus. Seagrass fragments were considered viable if the fragment had an apical meristem present. Replicate samples were collected from 5 locations every two weeks, starting in September 2022 and ending in September 2023, and the samples were processed …

Exploring The Link Between Neurocognitive Function And Long Covid: A Comprehensive Review, Dinamaris Aguilar

Honors Undergraduate Theses

The intent of this thesis is to provide an in-depth overview of the neurological manifestations associated with long COVID. The review aimed to assess the cognitive functioning symptoms associated with SARS-CoV-2 post-infection (PASC), investigate the potential mechanisms by which SARS-CoV-2 affects the nervous system, contributing to cognitive fatigue, brain fog, and cognitive dysfunction, and explore the parallels between SARS-CoV-2 and Alzheimer’s Disease. Neuroinflammation emerges as a shared element among these mechanisms, significantly impacting cognitive function. The parallels between COVID-19 and Alzheimer's Disease offer insights into how Alzheimer's affects cognition, aiding in understanding COVID-19's impact. The review underscores a notable gender …

The Effects Of Nanobubbles For Gene Delivery For Osteoporosis Treatment, Abel Córdova Flores

Honors Undergraduate Theses

In recent years, the field of nanomedicine has provided promising alternatives to traditional ways of gene and drug delivery, such as nanobubbles instead of viral vectors. Manufacturing these nanomaterials is cost-effective and tends to be safer than previous forms of treatment for clinical use. In the realm of osteoporosis, a disease based around a higher rate of bone resorption to bone formation, leads to weak and brittle bones, leaving sufferers at risk for fractures, which are sudden and unexpected. These fractures are estimated to cost USD 22 Billion annually in the US alone. Reports show a significant effect on the …

Identifying The Use Of Turtles And Tortoises At The Prehistoric Penny Site At Cape Canaveral, Alexandria Griffin

Honors Undergraduate Theses

As people live in an area, they leave behind an assortment of cultural items they once utilized. Some of these items may include pottery or bones from animals they used as food. Analysis of these bones can give a glimpse into how they managed their resources in the environment around them, including which ecosystems they chose to exploit, and which taxa they prioritized for consumption or cultural purposes. The Indian River Lagoon in Florida is a diverse costal lagoon with many various overlapping ecosystems and ecotones available for prehistoric peoples to utilize. Comparing the frequency of taxa representing different local …

Investigating The Role Of Glycemic Control In Cognitive Impairement Risk Among Elderly Individuals With Type 2 Diabetes: A Scoping Review, Julia Pessaia

Honors Undergraduate Theses

Type 2 diabetes mellitus (T2DM), presents a significant health burden globally, affecting millions of individuals, especially in the elderly population. While its association with cardiovascular diseases and cognitive impairments is well-documented, further research on the precise influence of glucose control on cognitive outcomes in elderly T2DM patients is necessary. This scoping review aims to address this gap by investigating the impact of HbA1c levels representing glycemic control on the risk of developing cognitive impairments in elderly patients with T2DM. A literature search was conducted on MEDLINE and eligible studies involved T2DM patients aged 60 or older, with documented cognitive function …

The Promise Of Graphic Medicine In Provider Training To Promote Mental Health, Prevent The Empathy Decline, And Improve Learning, Maeher Sukhija

Honors Undergraduate Theses

As medical students progress through their training, they experience a decline in empathy, mental health struggles, and difficulties in learning. The prevalence of depression, anxiety and burnout among medical students, along with the decline of empathy in medical students can impact their professionalism and quality of patient care as future physicians. This literature review shows how the integration of graphic medicine in provider training can address these problems, giving a new perspective on what medical education should look like. Thirty-three articles were found and reviewed by searching through the databases Academic Search Premier, PubMed, and Google Scholar, along with the …

The Effects Of Exercise On The Immune System Of Older Adults, Brianna Tran

Honors Undergraduate Theses

The purpose of this study was to examine the effects of exercise on the immune system of older adults. Physical exercise has been known to affect one’s health positively. However, specific statistics relating to types of exercise intervention and older adults are dispersed. Autoimmune diseases are a lifelong disease that results in an overactive immune system, causing it to attack healthy cells. Which then leads to symptoms such as fatigue, pain, swelling, and digestive issues. This thesis includes systemic literature reviews that directly discuss the benefits of moderate-intensity exercise regarding the immune system of the elderly population. Results from this …

Religious Trauma And Identity, Kylie N. Angiel

Honors Undergraduate Theses

Religious trauma is most often the result of prolonged emotional and mental trauma, rather than a one-time occurring physical experience, which can thereby lead to complex post-traumatic stress disorder (C-PTSD). This prolonged form of trauma can have negative impacts on one’s psychological well-being and possibly one’s sense of identity. The purpose of this study was to gain a deeper understanding of how religious trauma may be related to identity development. College students (N = 223) completed an anonymous online survey battery for course credit. Scores on a measure of religious and spiritual struggles was positively correlated with identity distress and …