Digital Commons Network^™

Landscape Design That Enhances Socialization And Community Through Climate Resilience, Guidelines For North Texas Universities., Melissa N. Brown

Landscape Architecture Masters & Design Theses - Archive

Landscape architects must balance social, economic, and environmental considerations while creating places that people will love. And, in the words of American Society for Landscape Architects Fellow Mary Margaret Jones: “If we don’t make places people love, they won’t be taken care of”. (ALSA Interview, n.d.) Consideration for the user experience will result in spaces that people are more likely to love.

The growing student population at the University of Texas at Arlington means that every space must be used to its full potential. The green and open spaces on a university campus are more than circulatory routes between buildings. …

Intravenous Contrast Extravasations Of Ct Contrast Media Prevention Bundle, Shakerra T. Brown

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Contrast extravasations pose significant risks during intravenous contrast media imaging procedures, with potential adverse outcomes ranging from minor skin irritation to severe tissue necrosis. Despite technological advancements and procedural safeguards, contrast extravasations remain a concern in healthcare settings. A comprehensive needs assessment at our institution revealed a notable incidence of contrast extravasations, highlighting the need for targeted interventions to mitigate risk and enhance patient safety. This project aims to explore the complexities of contrast extravasations, examining contributing factors, associated complications, and current prevention and management strategies to inform evidence-based practices and improve patient outcomes. This Doctor of Nursing Practice (DNP) …

Chronic Kidney Disease Nutritional Management: Developing A Guideline, Benjamin L. Wallace

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

The global prevalence and incidence of those with chronic kidney disease (CKD) are unknown. Thirty-seven million adults are estimated to have CKD and need nutritional assessment, education, and management to prevent further kidney damage and mortality (Centers for Disease Control and Prevention, 2022; United States Renal Data System, 2022). Maintaining the nutritional requirements for CKD is listed as a global concern in the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline for Nutrition in CKD 2020 (Ikizler et al., 2020). After a review of more than 50 publications, five recommendations were developed and proposed. A team of multidisciplinary stakeholders, …

Glutamate Optimization As A Treatment For Depression: A Clinical Guideline, Luisa Angeles Collins Villares

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Based on the use of drugs to treat hypertension and tuberculosis for depression, the monoamine hypothesis led to the development of antidepressants in 1952. Serotonin was recognized as a deficiency associated with depression in 1967. As a fine-tuning orchestration of neurotransmitters and neuromodulators, the glutamate system became known using Spravato in 2019 and Auvelity in 2022. In this pilot study, mental health experts rated the importance of 24 science-based recommendations to optimize glutamatergic therapy in depression for a proposed guideline on a Likert scale from zero to four. The results were analyzed using a non-parametric predictive modeling method called Chi-Square …

A New Mechanistic Model Of Brain Metabolism With Optimal Parametrization, Alice Lubbe

Mathematics Dissertations - Archive

Models of glucose metabolism in the brain often focus on chemical exchanges and reactions that occur as part of the tricarboxylic acid cycle (TCA cycle). Experiments involving nuclear magnetic resonance (NMR) spectroscopy to detect and measure carbon-labeled isotopomers of metabolites such as glutamate in vivo inform kinetic, mechanistic models used to study metabolic pathways. In the present work, a new model with two compartments, astrocytic and neuronal, is developed using known biochemical processes and fit to experimental data coming from fully labeled glucose infusions. A gradient descent method is introduced and employed to obtain optimal flux parameter values involved in …

Markerless Motion Capture For Dual-Handed Teleportation Of Industrial Robots, Michael F. Vallaro

Open Access Master's Theses

The advancement of teleoperation systems has predominantly focused on single-robot or humanoid systems, leaving a gap in efficient control methods for dual-robot setups. Existing solutions lack the ability to integrate synchronized operations of two robots with intuitive and precise human inputs. This limitation limits the execution of tasks requiring simultaneous coordination, multitasking, and safety measures, particularly in environments that demand precision, such as hazardous material handling, industrial assembly, and automation workflows. To address this issue, a dual-robot teleoperation system is proposed, enabling a single operator to control two Niryo Ned 2 robotic arms using hand motion tracking via Leap Motion …

Developing An Immunomodulatory Strategy Using Biophysical Cues To Modulate Macrophage Phenotype For Fracture Healing And Bone Regeneration, Harshini Suresh Kumar

Theses and Dissertations--Biomedical Engineering

Chronic inflammation is a major cause of the pathogenesis of musculoskeletal diseases such as fragility, fracture, and nonunion. Studies have shown that modulating the immune phenotype of macrophages from proinflammatory to pro-healing can heal recalcitrant bone defects. Current therapeutic strategies predominantly apply biochemical cues, which often lack target specificity, and controlling their release kinetics in vivo is challenging spatially and temporally. We have developed a magnetic iron-oxide nanocomplexes (MNC)-based therapy for resolving chronic inflammation in the context of promoting fracture healing. Here, we show that MNC internalized macrophages, when coupled with an external magnetic field, can exert an intracellular magnetic …

Relating Temperature, Sleep, And Pathology In Mouse Models Of Alzheimer's Disease, Jun Wang

Theses and Dissertations--Biomedical Engineering

It is well established that sleep plays an important role in Alzheimer’s disease (AD) pathology. There is growing evidence that sleep issues may accelerate AD pathology by interrupting the physiological clearance of amyloid‐β (Aβ) from the brain, which mainly occurs in normal sleep. As the over-accumulation of amyloid‐β (Aβ) is believed to lead the cascade effect that eventually causes neurodegeneration in AD patients, development of therapeutic strategies for improving sleep quality may help slow disease progression. It is well documented that the composition and dynamics of sleep are sensitive to changes in ambient temperature. We therefore developed a sleep enhancement …

Development Of Iron Oxide Nanozyme For Cancer Therapy, Zhongchao Yi

Theses and Dissertations--Biomedical Engineering

Cancer therapies that leverage reactive oxygen species (ROS) have shown potential for cancer inhibition due to their ability to induce oxidative stress in tumor cells. Iron oxide nanoparticles (IONPs) have garnered significant attention as a promising platform for ROS-dependent disease treatment, owing to their remarkable biocompatibility and Fenton catalytic activity. However, the low catalytic activity of IONPs has been a major hurdle in their clinical translation. To overcome this challenge, IONPs of different compositions are examined for their Fenton reaction under pharmacologically relevant conditions in this work. The results show that wüstite (Fe_1-xO) nanoparticles exhibit higher catalytic activity …

The Effect Of Visual Signaling On Psychomotor Learning: An Explanatory Mixed Methods Study In Physical Therapy Education, Julie Pfeiffer

Theses and Dissertations--Education Sciences

The signaling principle states that people learn better when cues are used to highlight important information in a multimedia presentation. Prior research has shown that visual signaling improves learning by directing the learner’s attention to the relevant information of the instruction, improving the learner’s ability to select essential words and pictures. While the visual signaling principle has been applied to learning in the cognitive domain, the effect of visual signaling on learning within the psychomotor domain is limited. The purpose of this study is to investigate the effect of the signaling principle on learning psychomotor skills from multimedia instruction, specifically …

The Aesthetics Of Environmental Risk In Paolo Bacigalupi’S The Windup Girl And The Water Knife, David Schwartz

Theses and Dissertations--English

Any work of environmentally oriented fiction that seeks to represent the wide-reaching effects of climate change is faced with the problem of scale. These texts must render visible change which is at once ubiquitous and microscopic, along with the cascade of side-effects generated in the wake of rising temperature, rising sea levels, and winnowing biodiversity. In short order, these texts must fully imagine what it means to live within the modern global risk society. Borrowing this sociological model from the late Ulrich Beck, I analyze the literary work of Paolo Bacigalupi, one of the foremost authors in the growing genre …

The Dark Sides Of Giving: Representations Of Philanthropy And Gifts In Eighteenth-Century Literature, C.1750-1820, Jillian Winter

Theses and Dissertations--English

This dissertation explores representations of the gift in popular women’s novels of the long eighteenth century. Gift transactions in women’s fiction from this period reveal larger cultural reflections about the limitations placed on women who try to give and to help others. The primary works discussed in this project include Frances Burney’s Cecilia; or, Memoirs of an Heiress (1782), Eliza Haywood’s The History of Miss Betsy Thoughtless (1751), Mary Hays’s Memoirs of Emma Courtney (1796), Sarah Fielding’s The History of Ophelia (1760), and Maria Edgeworth’s Belinda (1801). Frequently, the novels considered in this dissertation showcase the complicated conditions, oftentimes troubling …

Trust And Knowing In Nineteenth-Century American Literature: Fictional Genres And Metacognitive Disruptions, Jessica Marie Van Gilder

Theses and Dissertations--English

This dissertation investigates how constructions of trust can be undermined or reinforced by examining trust’s entanglement with our compulsive and subjective desire to know in nineteenth-century American literature. Specifically, I analyze how different fictional genres – satire, historical romance, fantastic, and gothic – respond to our desire to know through the types of trust fictional texts feature and construct with the reader. In doing so, I demonstrate how genres of fiction in nineteenth-century America function as dynamic social contracts that amplify and undermine the reader’s trust in larger sociopolitical systems (e.g., national identity) and the epistemologies that underpin those systems …

Functional Analyses Of The Polycomb-Group Genes In Sea Lamprey Embryos Undergoing Programmed Dna Loss, Cody Saraceno

Theses and Dissertations--Biology

During early embryonic development, the sea lamprey (Petromyzon marinus) undergoes programmatic elimination of DNA from somatic progenitor cells in a process termed programmed genome rearrangement (PGR). Eliminated DNA eventually becomes condensed into micronuclei, which are then physically degraded and permanently lost from the cell. Previous studies indicated that many of the genes eliminated during PGR have mammalian homologs that are bound by polycomb repressive complex (PRC) in embryonic stem cells. To test whether PRC components play a role in the faithful elimination of germline-specific sequences, we used a combination of CRISPR/Cas9 and lightsheet microscopy to investigate the impact …

Effects Of Neonatal Estradiol Treatment On Regulating Sexual Differentiation Of Daily Rhythms Underlying Diet-Induced Obesity In Female Mice, Samuel Nwadialo

Theses and Dissertations--Biology

Sex differences of the brain and behavior often require the combination of organizational and activational effects of sex hormones. The activational effects of estrogens in adult female mice protect daily eating and activity rhythms from disruption by high-fat diet feeding and inhibit diet-induced obesity. However, male mice have disrupted eating rhythms when fed high-fat diet and this causes obesity. Treatment of adult male mice with estradiol does not protect rhythms from disruption by high-fat diet, as it does in females. In this study, we sought to determine whether the organizational effects of estradiol masculinize the daily eating and activity rhythms …

Investigations Across Biology And Education: Exploring The Gut Microbiome Of Freshwater Mussels And Understanding Undergraduate Biology Student Motivation, Mary Foley

Theses and Dissertations--Biology

A PhD aims to make a unique contribution to the current body of knowledge while developing as an independent researcher and critical thinker. This dissertation covers a wide range of topics, from microbiome analysis to biology education. Although there is no broad overarching research theme, all the chapters are connected by the process of scientific inquiry and by their contribution to the completion of a PhD.

Chapter One serves as a comprehensive literature review, delving into the standard methods of measuring the health of at-risk species. It describes direct measures of health (e.g., birth and death rates) crucial for predicting …

Estrogen Signaling Regulates The Sex Difference In Resynchronization To Abrupt Shifts Of The Light-Dark Cycle In A Mouse Model Of Jet Lag, Maria Venegas

Theses and Dissertations--Biology

The circadian system coordinates 24-hour cycles of internal biological processes with the environmental light-dark cycle. Abrupt shifts in the timing of the light-dark cycle misalign internal circadian clocks with the environment and cause jet lag until resynchronization occurs. The objective of this study was to investigate the mechanisms underlying sex differences in jet lag in mice. Female mice resynchronized faster than male mice to 6-hour advances and delays of the light-dark cycle, which mimicked eastward and westward travel, respectively. Circulating estradiol was necessary for rapid resynchronization in female mice since ovariectomized females resynchronized slower than mice treated with estradiol. We …

All Eyes On The Spiny Mouse: An Investigation Into Acomys Dimidiatus As A Model For Retinal Biology And Regeneration, Jessica D. Bills

Theses and Dissertations--Biology

The retina is a complex tissue with six types of neurons, supported by an intrinsic glia cell, that work in concert to input a visual stimulus and relay a visual message to the brain. Efficient communication between neurons is vital to this process and each neuron plays a significant role in vision. When retinal neurons degenerate, that visual signal is lost. Degenerative eye diseases affect the neurons of the retina in millions of people world-wide and can ultimately lead to blindness. While treatments are evolving, most are designed to prevent further damage; the field has yet to piece together how …

Crisis, Genre, And The Informatic Infrastructure Of The Critical Path Aids Project In Philadelphia's Early Epidemic, Sid Feinberg

Theses and Dissertations--Geography

The Critical Path AIDS Project was a grassroots information network that distributed AIDS-related information related to biomedicine, social services, and politics. I explore the ways the project made sense of the shattering social service and care landscapes they emerged within and responded to. I situate Critical Path’s work within Philadelphia’s splintering care infrastructures and the experience of crisis Lauren Berlant argues structures perception of neoliberal life. I focus on the ways that Critical Path’s articulation of crisis and spatial re-orientation pull on the modernist design work of Buckminster Fuller. Fuller’s design work formed a framework through which the project constructed …

Beauty And The Anthropocene: On The Emancipatory Potential Of Experiences Of Beautiful Places In The Natural World, Matthew John

Theses and Dissertations--Geography

This dissertation investigates the proposition that beauty—specifically, experiences of beautiful places in the natural world—can contribute to the emancipation of modern persons (and thereby developed societies) from instrumental rationality, which is theorized as a major driver of contemporary socioecological crises of the Anthropocene. Buber’s concept of the I–Thou relation provides a framework for conceptualizing ideal non-instrumental relations. The project’s methodology, rooted in post-phenomenology, consisted of semi-structured remote interviews and four follow-up focus groups with 35 then current and recently former residents of Juneau, Alaska. Taken together, data confirm that experiences of beautiful places in the natural world can and do …

"Many Fabulous Stories And Idle Tales": The Intersection Of Elizabethan Political Gambits And Indigenous Erasure In The Early American Republic, Daniel Ryan Lewis

Theses and Dissertations--History

Welsh Indian Theory, originating in Elizabethan England, stated that a group of Welsh explorers settled in the Americas in the late 12^th century and intermarried with the Indigenous tribes, thereby explaining “advanced cultures” ranging from the Mississippians to the Aztec Empire. This act of erasure became rooted in Kentucky and the surrounding area in the 18^th and 19^th centuries; a series of prominent individuals from Kentucky in turn contributed to a growing body of false historical narratives that denied Indigenous Americans their cultural identities and connection their ancestral lands in the United States. With a 460-year trail …

Advanced Mathematical Graph-Based Machine Learning And Deep Learning Models For Drug Design, Farjana Tasnim Mukta

Theses and Dissertations--Mathematics

Drug discovery is a highly complicated and time-consuming process. One of the main challenges in drug development is predicting whether a drug-like molecule will interact with a specific target protein. This prediction accelerates target validation and drug development. Recent research in biomolecular sciences has shown significant interest in algebraic graph-based models for representing molecular complexes and predicting drug-target binding affinity. In this thesis, we present algebraic graph-based molecular representations to create data-driven scoring functions (SF) using extended atom types to capture wide-range interactions between targets and drug candidates. Our model employs multiscale weighted colored subgraphs for the protein-ligand complex, colored …

Modulating The Mtor Pathway Using Inducible Retrogradely Transported Aavs As A Novel Approach To Improve Motor Recovery In Spinal Cord Injury, Christopher Bosse-Joseph

Theses and Dissertations--Medical Sciences

Spinal cord injury poses multiple regeneration barriers, including neuronal-intrinsic and extrinsic factors. Overcoming these barriers has stood as a longstanding challenge in neuroscience. A well-studied mechanism to promote spinal cord regeneration and locomotor recovery is activating the PI3K/mTOR pathway by knocking out phosphatase and tensin homolog protein (PTEN). PTEN knockout (PTEN-KO) studies have traditionally used adeno-associated virus (AAV) viral vectors to improve functional recovery. The use of traditional AAV serotypes to induce PTEN-KO has shown promise to improve functional recovery in rodent models; however, these approaches show significant limitations for translational utility. Firstly, the use of traditional AAV serotypes to …

The Role Of Intracellular Growth During The Systemic Spread Of Listeria Monocytogenes, Jamila S. Tucker

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Listeria monocytogenes is a facultative intracellular pathogen transmitted through the consumption of contaminated food products. Typically, infections range from mild, self-limiting gastroenteritis to life-threatening systemic infections; however, the events that occur in the gut to allow for this spread are unclear.

The focus of my thesis aims to determine how L. monocytogenes escape the mesenteric lymph nodes (MLN), the final barrier to systemic spread for both commensal and pathogenic bacteria in the gut. I have shown that intracellular replication of L. monocytogenes in an as-yet-unidentified cell type is essential for the colonization and dissemination of the bacteria from the MLN. …

Effects Of Pancreatic Amylin On The Peripheral And Cns Immune Response In A Model Of Type-2 Diabetic Brain Injury, Edric Da'shon Winford

Theses and Dissertations--Neuroscience

Type-2 diabetes (T2D) is a metabolic disorder that increases the risk for cerebrovascular disease and dementia and is associated with the progression of Alzheimer's Disease; however, the mechanisms responsible for T2D-associated dementia are still poorly understood. T2D leads to alterations of the innate and adaptive immune response that contribute to its progression, but how these cells contribute to cognitive decline during T2D is unknown. As there are no approved therapeutics for T2D that modulate the immune response, it is important that we investigate how peripheral immune cells contribute to cognitive decline during T2D. Amylin is an amyloidogenic hormone synthesized and …

The Effect Of Estrogen And A Mitochondrial Uncoupling Prodrug On Traumatic Brain Injury-Induced Dysfunction In Mice., Olivia J. Kalimon

Theses and Dissertations--Neuroscience

A large percent of both clinical and pre-clinical traumatic brain injury (TBI) studies report better outcomes females after severe injury compared to males. Mitochondrial dysfunction is a well-characterized driver of secondary injury and an attractive neurotherapeutic target; though, there is limited research available on mitochondrial dysfunction in females. However, a few studies have shown total mitochondria from the cortex of females appear protected from TBI-induced bioenergetic dysfunction. These results were replicated in these studies so further characterization was performed. Additionally, protein expression of some oxidative phosphorylation (OXPHOS) complexes were elevated in the uninjured cortex of females relative to uninjured males, …

Caenorhabditis Elegans Rapgef Promotes Synaptic Development Through A Small G Protein Signaling Cascade, Reagan Em Lamb

Theses and Dissertations--Neuroscience

Synaptic dysfunction is a major contributor toward the development of many neurological disorders. For proper development, synapses require a series of signaling pathways to guide them, but not all the mechanisms underlying these processes are understood. Here, we used the neuromuscular junction of Caenorhabditis elegans as a model circuitry for examining underlying pathways that mediate proper development of synapses. We hypothesized that the C. elegans RapGEF2 and RapGEF6 orthologue, PXF-1, contributed toward development of cholinergic synapses at the neuromuscular junction. Using behavioral assays and fluorescence microscopy, we found that pxf-1 mutant animals had decreased neuromuscular junction function and decreased synaptic …

Contributions Of The Replication Initiator Protein Dnaa To Physiology And Virulence Of The Lyme Disease Spirochete, Andrew Krusenstjerna

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Borrelia burgdorferi, the etiological agent of Lyme disease, is the most prevalent vector-borne disease in the United States. The spirochetal population is naturally maintained by consistently cycling between Ixodid ticks and small vertebrates. To survive within these diverse niches, B. burgdorferi has evolved a unique physiology and regulatory network to sense and respond to environmental fluxes. Replication is a hallmark of the Lyme spirochete’s enzootic life cycle, specifically at the nymphal tick-to-vertebrate interface. The mechanisms and regulatory schema for the basic cellular processes in B. burgdorferi, or indeed any member of the phylum spirochaetota, are largely unknown. The central hypothesis …

Enlarged Perivascular Spaces Are A Clinically Relevant Neuroimaging Biomarker Of Cerebral Small Vessel Disease, Timothy Justin Libecap

Theses and Dissertations--Neuroscience

Vascular contributions to cognitive impairment and dementia (VCID) represents the intersection between cerebrovascular disease and cognitive decline. Cerebral small vessel disease (cSVD) is an important risk factor that may precede the onset of VCID by years. cSVD is characterized by in-vivo neuroimaging biomarkers including enlarged perivascular spaces (ePVS). PVS are the site of interchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) which is believed to play a role in the removal of brain waste. Reduced clearance may lead to enlargement of the PVS and subsequent accumulation of toxic solutes characteristic of neurodegeneration. Given the presence of ePVS in brain …

Characterizing Age-Associated Cd19+ B Cells After Stroke In Aged Male And Female Mice Reveals Sex-Dependent Functional Recovery, Katie Colson

Theses and Dissertations--Neuroscience

Age-Associated B cells (ABCs) are atypical memory B cells commonly expressing CD11b, CD11c, and T-bet. We hypothesized that aged female mice would have worse functional outcomes after stroke due to higher brain-localized ABCs. We identified 6 ABC subsets expressed in the brain, with higher levels in uninjured animals versus 3 weeks after stroke. Contradictory to my hypothesis, aged uninjured males with higher numbers of Classical ABCs (CD11bhighCXCR5+/CXCR5-) in the brain exhibited better motor function, though with limited differences by injury or sex for other classical ABC subsets. Rare CD11b+CXCR5+ populations from uninjured mice secreted more IFN-γ when exposed to TLR7/9 …