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Thymidine Phosphorylase Is A Promising Target In Sars-Cov-2 Spike Protein-Enhanced Thrombosis, Renat Roytenberg

Theses, Dissertations and Capstones

Thrombosis, as an underlying mechanism in cardiovascular diseases, is the leading global cause of death in the 21st century. Infection is a risk factor for thrombosis, and the coronavirus disease 2019 (COVID-19) pandemic has led to a rise in the incidence of thrombosis, thereby increasing mortality. In comparison to previous severe coronavirus outbreaks, rates of thrombosis in COVID-19 have been unprecedented. COVID-19 is caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 spike protein (SP), the key used to enter host cells, is implicated in thrombosis pathology, though mechanisms are not fully understood. The SARS-CoV-2 …

Metabolism Shapes Immune Responses To Staphylococcus Aureus., Prabhakar Arumugam, Tammy Kielian

Journal Articles: Pathology and Microbiology

BACKGROUND: Staphylococcus aureus (S. aureus) is a common cause of hospital- and community-acquired infections that can result in various clinical manifestations ranging from mild to severe disease. The bacterium utilizes different combinations of virulence factors and biofilm formation to establish a successful infection, and the emergence of methicillin- and vancomycin-resistant strains introduces additional challenges for infection management and treatment.

SUMMARY: Metabolic programming of immune cells regulates the balance of energy requirements for activation and dictates pro- versus anti-inflammatory function. Recent investigations into metabolic adaptations of leukocytes and S. aureus during infection indicate that metabolic crosstalk plays a crucial role in …

Elucidating Granulocytic Myeloid-Derived Suppressor Cell Heterogeneity During Staphylococcus Aureus Biofilm Infection, Blake P. Bertrand, Cortney E. Heim, Scott A. Koepsell, Tammy Kielian

Journal Articles: Pathology and Microbiology

Myeloid-derived suppressor cells (MDSCs) are pathologically activated immature myeloid cells with immunosuppressive activity that expand during chronic inflammation, such as cancer and prosthetic joint infection (PJI). Myeloid-derived suppressor cells can be broadly separated into 2 populations based on surface marker expression and function: monocytic myeloid-derived suppressor cells (M-MDSCs) and granulocytic myeloid-derived suppressor cells (G-MDSCs). Granulocytic myeloid-derived suppressor cells are the most abundant leukocyte infiltrate during PJI; however, how this population is maintained in vivo and cellular heterogeneity is currently unknown. In this study, we identified a previously unknown population of Ly6G+Ly6C+F4/80+MHCII+ MDSCs during PJI that displayed immunosuppressive properties ex vivo. …

C1q Is Elevated During Chronic Staphylococcus Epidermidis Central Nervous System Catheter Infection, Matthew K. Beaver, Lara Bergdolt, Anna Dunaevsky, Tammy Kielian, Gwenn Skar

Journal Articles: Pathology and Microbiology

INTRODUCTION: Significant neurologic morbidity is caused by pediatric cerebrospinal fluid (CSF) shunt infections. The underlying mechanisms leading to impaired school performance and increased risk of seizures are unknown, however, a better understanding of these mechanisms may allow us to temper their consequences. Recent evidence has demonstrated important roles for complement proteins in neurodevelopment and neuroinflammation.

METHODS: We examined complement activation throughout

RESULTS: We found that MASP2 predominated early in catheter infection, but that Factor B was elevated at intermediate time points. Unexpectedly C1q was elevated at late timepoints when bacterial burdens were low or undetectable. Based on these findings and …

Antimicrobial Activity Of Gallium(Iii) Compounds: Pathogen-Dependent Targeting Of Multiple Iron/Heme-Dependent Biological Processes, Seoung-Ryoung Choi, Mohammed A. Hassan, Bradley E. Britigan, Prabagaran Narayanasamy

Journal Articles: Pathology and Microbiology

Metals play vital roles in biological systems, with iron/heme being essential for cellular and metabolic functions necessary for survival and/or virulence in many bacterial pathogens. Given the rise of bacterial resistance to current antibiotics, there is an urgent need for the development of non-toxic and novel antibiotics that do not contribute to resistance to other antibiotics. Gallium, which mimics iron, has emerged as a promising antimicrobial agent, offering a novel approach to combat bacterial infections. Gallium does not have any known functions in biological systems. Gallium exerts its effects primarily by replacing iron in redox enzymes, effectively inhibiting bacterial growth …

Aconitate Decarboxylase 1 Mediates The Acute Airway Inflammatory Response To Environmental Exposures, Aaron Schwab, Amy J. Nelson, Angela Gleason, Oliver Schanze, Todd A. Wyatt, Dhananjay Shinde, Peng Xiao, Vinai Chittezham Thomas, Chittibabu Guda, Kristina L. Bailey, Tammy Kielian, Geoffrey M. Thiele, Jill A. Poole

Journal Articles: Pathology and Microbiology

Background: Environmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations involved in disease pathogenesis. Aconitate decarboxylase 1 (Acod1) was one of the most upregulated genes following LPS (vs. saline)exposure of murine whole lungs with transcriptomic profiling of sorted lung monocyte/macrophage subpopulations also highlighting its significance. Given monocyte/macrophage activation can be tightly linked to metabolism, the objective of these studies was to determine the role of the immunometabolic regulator ACOD1 inenvironmentalexposure-induced lung inflammation.

Methods: Wild-type (WT) mice were intratracheally (i.t.) instilled with 10 …

Understanding The Values That Inform Regenerative Ranching In The Northern U.S. Great Plains, T. Pape, G. Meredith, D. Sandal, M. F. Kabir, S. Banerjee, C. R. Allen, E. Dennis, M. Stephenson

School of Natural Resources: Faculty Publications

No abstract provided.

Entomological Observations On A Decomposing Pig (Sus Scrofa) In Nebraska: Late Spring To Early Summer, Leon G. Higley, J. Obafunwa, W. Belcher

School of Natural Resources: Faculty Publications

No abstract provided.

Differential Tail Autotomy Between Two Genetic Clades Of A Woodland Salamander, Plethodon Cinereus, Ryan Mayer

Masters Theses

Following the retreat of glaciers in North America, a wide diversity of organisms rapidly migrated into previously uninhabited regions, including animals with limited dispersal abilities such as amphibians. I wanted to better understand the strategies that salamanders use to aid in their dispersal abilities and to understand if patterns of post-glacial range expansion affect phenotypic traits such as anti-predator strategies. In this study, I used existing phylogeographic evidence of clade membership as a framework to examine whether red-backed salamanders (Plethodon cinereus) differed in tail autotomy behavior at the range edge versus the range core, and across the geographic range of …

Examining Quantitative Honest Signaling In Aposematic Traits Of The Green And Black Poison Frog Dendrobates Auratus From Costa Rica, Katherine Porras-Brenes

Masters Theses

No abstract provided.

A Global Synthesis Of The Relative Impacts Of Habitat Amount, Fragmentation, And Matrix Quality On Forest Biodiversity, Antoinette Esposito

Masters Theses

Aim To assess the relative impact of different landscape variables on species richness and to determine whether species richness declines more rapidly below an extinction threshold of remaining habitat. The results of this study will help to better inform future conservation strategies. Location Global Time period 1997 – 2013 Major taxa studied Amphibians, birds, invertebrates, mammals, and reptiles Methods Data from 71 studies published in the global BioFrag database were used to determine species richness across multiple landscapes and biomes. The Hansen dataset was used to collect data on habitat amount (forest area), fragmentation (patch density), and matrix quality (mean …

Are There Ten Commandments For Latter-Day Zion?, Dennis Newton

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

New faith traditions often modify existing religious tenets to accommodate the particulars of their membership’s needs. A specific example is how different faith communities have modified the Ten Commandments both inside and outside the historic Jewish community. This paper argues that Joseph Smith received a Latter-day Decalogue that was canonized in the Doctrine and Covenants but went unrecognized as such by either Smith or the early Saints. While some of the commands in this new set of commandments are familiar (thou shalt not kill, steal, nor commit adultery), others are specific to the conditions of the latter days. This paper …

Premortal Life And Mortal Life: A Fearful Symmetry, Jeffrey M. Bradshaw

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Bodily weakness, along with the varied circumstances into which we were born, provide the essential initial and ongoing conditions that shape the challenges and opportunities of our mortal probation. In life, we are not expected merely to preserve our innocence in defiance of worldly tendencies, nor are we compelled to cede to cynicism in the face of disheartening earthly experience. Rather, we are meant to follow the Savior in uniting the state of innocence with that of experience, thus joyfully fulfilling the unique mission that has been generously given to each of us.

King Benjamin’S Sermon As A Type Of Temple Endowment, Andrew I. Miller

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

To more permanently unify the Mulekites and the Nephites as a reunited kingdom of Israel, King Benjamin gathered his people at the temple, and in his role as a king and priest after the order of Melchizedek, imparted teachings that bear resemblance to the Latter- day Saint temple endowment ceremony first introduced in Nauvoo. Several of these similarities are explored in depth. Since the book of Mosiah is one of the earliest extant texts of Joseph Smith’s prophetic ministry, this finding adds to a growing body of literature that suggests that temple themes are apparent in the unfolding Restoration earlier …

“Armed With Righteousness And With The Power Of God”: Allusions To Priestly Clothing, Priesthood, And Temple In 1 Nephi 14:14, Matthew L. Bowen

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Nephi saw in vision that in the latter-days “the saints of the church of the Lamb” and “covenant people of the Lord” who, though scattered across the earth, “were armed with righteousness and with the power of God in great glory” (1 Nephi 14:14). Nephi’s prophetic statement is loaded with meaning. This study explores how “armed with righteousness” means “clothed with righteousness” (Psalm 132:9) not merely in a martial, but also in a priestly sense (compare 1 Samuel 17:5; Isaiah 59:17). This concept relates to the latter-day temple and its ordinances, which enable the Lord’s people to “go forth” from …

2023 Milton Annual Town Report., Milton Town Representatives

Milton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

2024 Spring And Winter - Schedule Of Classes, Office Of The Registrar, East Tennessee State University

Registration Resources

No abstract provided.

Incidence Of Pathologic Nodal Disease In Clinically Node Negative, Microinvasive/T1a Breast Cancers, Pranammya Dey

Yale Medicine Thesis Digital Library

Axillary staging in early-staged breast cancer can impact adjuvant treatment options but is also associated with increased morbidity. The incidence of pathologic nodal positivity in patients with microinvasive or T1a disease by histologic subtype is not well characterized and thus, the value of sentinel node biopsy remains controversial in these patients. We sought to analyze patient demographics and tumor characteristics associated with pathologic nodal disease in patients with clinically node negative (cN0), microinvasive and T1a breast cancers.Women >18 years old with clinically node negative (cN0) and pathologic microinvasive or T1a breast cancer who underwent upfront surgery were identified from the …

Barriers To Methadone For Hiv Prevention Among People Who Inject Drugs In Kazakhstan, Amanda Rachel Liberman

Yale Medicine Thesis Digital Library

Background: In Eastern Europe and Central Asia, HIV incidence and mortality continue to increase, and this epidemic is concentrated among people who inject drugs (PWID). In Kazakhstan, the prevalence of HIV among PWID is higher than for any other key population. Opioid agonist therapies like methadone are the only evidence-based treatment for opioid use disorder and thus are crucial tools for HIV prevention. Though methadone has been provided for free in Kazakhstan since 2008, less than 1% of PWID currently access this service. An intervention to increase methadone scale-up is necessary, and the Exploration, Preparation, Implementation, and Sustainment (EPIS) Framework …

Ballistic And Explosive Orthopaedic Trauma Epidemiology And Outcomes In A Global Population, Jamieson M. O'Marr

Yale Medicine Thesis Digital Library

Introduction:This thesis critically examines the epidemiological trends and clinical outcomes associated with ballistic and explosive orthopedic trauma, focusing exclusively on data coming from low- and middle-income countries (LMICs). Given the rising prevalence of civilian casualties in contemporary conflict zones and incidents of urban gun violence, there is an amplified need to bolster our understanding of these injuries. This is particularly important in LMIC civilian settings where a majority of this trauma is occurring but where the current literature is extremely lacking. This research aims to contribute significantly to the global medical community's capacity to provide informed, LMIC relevant evidence-based care …

Health, Susan Geffen Ph.D.

Sample module-themed coursework with Sesame Street examples

This module will investigate the topic of health among children and adolescents, providing an overview of lifestyle factors that impact one’s health, including socioeconomic status, familial involvement, and health programming led by institutions such as public schools. Students will use topical readings and video clips from Sesame Street and other media sources to analyze numerous aspects of young people’s health and methods of health education.

Pakistan: On The Front Line Of Climate Change, Rina Saeed Khan, Farahnaz Zahidi

CEJ Research and Publications

Dive into the intricate landscape of climate change in Pakistan with this comprehensive guidebook designed to illuminate the science, impacts, and actions surrounding this pressing global issue. From the recurrent floods to the melting glaciers, this insightful resource navigates through the complexities of climate change, offering practical tips for journalists, policymakers, and individuals alike. Explore the science, understand the urgency, and discover pathways for meaningful action within the unique context of Pakistan. Embark on a journey toward climate resilience today.

Psilocybin’S Role In Major Depressive Disorder: A Scoping Review, Carlos Barajas

Doctor of Medical Science (DMSc)

Psilocybe cubensis are a group of mushrooms containing psilocybin with a history of consumption dating back to ancient civilization. Researchers believe the ritual use of psilocybin dates back 3,000 years amongst the indigenous people of Mexico and Central America.¹ Psilocybin is responsible for the effects associated with the consumption of “Magic Mushrooms”. These effects include hallucinations, delusions, and feelings of derealization. ² In 1973, the United States federal government classified psilocybin as a Schedule I substance under the Controlled Substance Act, and today the DEA continues to identify the chemical as “high potential for abuse” with “no currently accepted …

Marine Mammal Health Surveillance Workshop Report

United States Marine Mammal Commission

Marine Mammal Health Surveillance Workshop Report

North Atlantic Right Whale Tagging Workshop Report

United States Marine Mammal Commission

North Atlantic Right Whale Tagging Workshop Report

Decreasing The Price Of Fame: Research On The Use Of Child Life Specialists In The Entertainment Industry, Ashley King

Graduate Student Independent Studies

This paper explores how the use of a CCLS in the field of entertainment would positively impact the experiences of child stars while working on set.

2024-2025 Factbook, Tennessee. General Assembly

Factbook

This Fact Book provides an overview of the state's budget for the fiscal year.

A 3d Dlt View Correction Tool For Manual Digitizing: A Cross-Platform Application For Correcting Shifted Image Coordinates Prior To Object Coordinate Reconstruction, William Moynihan

Theses, Dissertations and Capstones

While 3D direct linear transformation is a versatile motion capture method, care must be taken so that the cameras are not bumped or adjusted between the object space calibration phase and the end of video recording. Disturbing the cameras during this time will misalign the view, making the movement data invalid for the associated calibration. The purpose of this study was to design and validate a cross-platform software application for transforming image coordinates from a bumped camera to be compatible with the object space calibration and to determine the relationship between reconstruction error and changes to bumped camera views.

For …

Parodies Of Pleasure: Remedios Varo's Queer Surrealism In Narrative And Painting, Kathryn Everly

Languages, Literatures, and Linguistics - All Scholarship

Remedios Varo (1908-1963) wrote numerous surrealist texts that dialogue with her prolific artistic production. Alchemy, feminism, and psychoanalysis have been studied as central themes in her paintings, yet this paper focuses on humor and parody in Varo’s written works –including her letters, short stories, and dreams– to uncover the seminal ideas and images that emerge in her visual art. Humor and parody are fundamental links between Varo’s narrative and paintings. She embraces the spontaneity of the surrealist écriture automatique and the illogical amor fou but at the same time pushes the limits of surrealist dogma and creates a uniquely nonpatriarchal …

Story, Senses, Community And Fun: Teaching The Bible As Christ Centric Story For The Local Church, Adam Barton

Doctor of Ministry

NPO: The leadership at Harvest has observed that our people need improved methods to combat the trend of decreased understanding of the Christ centered Bible story.

My research identified numerous factors for this trend (too busy, too tired, the Bible is too difficult to understand and is no longer relevant, etc.) Perhaps more than all these, we have lost our Hebrew sensibilities of conveying the truth of the scriptures as a story to be experienced. A story told in community (not isolation), a story that draws in the senses (not a text to be analyzed), a story that is enjoyable …