Digital Commons Network^™

The Effects Of Changing Climate In The Us Western Region, Yaw Twumasi, E. C. Merem, Y. A. Twumasi, S. Fageir, D. Olagbegi, J. Wesley, R. Coney, Y. Babalola, T. Thomas, A. Hines, G. Hirse, G. S. Ochai, E. Nwagboso, M. Crisler, S. Leggett, J. Offiah, S. Emeakpor

Faculty Publications

he Pacific Northwest region of the US has over the years, outpaced other zones in the country in every socio-economic indicator. Known for its enviable physical attributes of high montane ecosystem and warm weather all year round in some places together with abundant biodiversity. The region’s position as among the fastest growing areas in the nation under vast swaths of land with large population concentration in big cities has made it the perennial destination for many. Aside from all these, in the last several years, the zone continues to be the epicenter of the most dangerous natural disasters prompted by …

Analyzing The Capacities Of Cotton Production In Sudan, Yaw Twumasi, E. C. Merem, S. Fageir, D. Olagbegi, J. Wesley, R. Coney, Y. Babalola, T. Thomas, A. Hines, G. Hirse, G. S. Ochai, E. Nwagboso, M. Crisler, E. Nwagboso, M. Crisler, S. Leggett, J. Offiah, S. Emeakpor

Faculty Publications

In the political economy of the nation of Sudan, cotton ranks significantly high as an essential component of the revenue generation sources. Considering the significance of the crop in the country, cotton has not only been exported to various countries, but some portions of the produce are also used up internally. With that also came, large scale cultivation of the cotton produce on vast swaths of land over the years amidst demands and fluctuations in the marketplace. Given the effects of cotton production on the environment from the use of chemicals and widespread water use, there came changes in the …

Exploring Shifts In Yam Production Trends Along Nigeria’S Southern Region, Yaw Twumasi, E. C. Merem, S. Fageir, D. Olagbegi, J. Wesley, R. Coney, Y. Babalola, T. Thomas, A. Hines, G. Hirse, G. S. Ochai, E. Nwagboso, M. Crisler, S. Leggett, J. Offiah, S. Emeakpor

Faculty Publications

Yam as a staple commodity in Nigeria, remains generally grown in different places within the ecological zones and food hubs in the nation. Notwithstanding all that, being integral part of the nation’s food security in a setting where Nigeria ranks high as the largest producer globally. Still, yam continues to find ample use with essential role for numerous purposes. Classified as an important food crop, the use of yam runs deeper, given its high demands for religious, socio-cultural practices, the economy, industries, and the marketplace. Even at that and considering the vast presence of yams over large swaths of land …

Venessa Hammerick And Arthur Mcquiston Full Interview Transcript, Urban Green Lab, Tennessee State University

Hear from Venessa Hammerick & Arthur McQuiston - Nashvillians Living Outside

No abstract provided.

Emerging Perspectives Of Synaptic Biomarkers In Als And Ftd, Karthik Krishnamurthy, Raj Kumar Pradhan

Farber Institute for Neuroscience Staff Papers and Presentations

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are debilitating neurodegenerative diseases with shared pathological features like transactive response DNA-binding protein of 43 kDa (TDP-43) inclusions and genetic mutations. Both diseases involve synaptic dysfunction, contributing to their clinical features. Synaptic biomarkers, representing proteins associated with synaptic function or structure, offer insights into disease mechanisms, progression, and treatment responses. These biomarkers can detect disease early, track its progression, and evaluate therapeutic efficacy. ALS is characterized by elevated neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) and blood, correlating with disease progression. TDP-43 is another key ALS biomarker, its mislocalization linked …

Female Labor Force Rates In South Asia, Shagufta Haque, Caleb Johnson

Pennsylvania Economic Review

Female labor force participation rates are an important element of emerging markets. Yet, there have been relatively few analyses of female labor force participation among countries in Asia. This study investigates the demographic, economic, and global factors that determine the female labor force participation rates (FLFPR) in Bangladesh, India, and Pakistan with a panel data sample of annual data ranging from 2000-2019. Based on the results of a Hausman (1978) test, a two-way fixed effects model is estimated to account for unobserved country-specific and time-specific heterogeneity. Explanatory variables include remittances, internet access, fertility rates, inflation rates, school enrollment rates, foreign …

Questioning Reality: The Progressive Development Of Modern Physics, Joshua Lancman

STEM for Success Showcase

Humanity has a tendency to divide time. The past is distinct from the present which is entirely separate from the future. In supposedly 20-20 vision history is neatly divided into different sections, distinct eras with sharp lines between them. What is present and in the future is always modern. What is past is something else with another name.

Yet time is not divided so neatly. We know this living through it: years and decades blend into one another in a non-uniform progression. To divide human history into separate eras is a necessary simplification, as it helps to ascribe order onto …

Barley As A Human Companion Species - Exploring The Relationship Between Barley And North Atlantic Peoples: 4000 Bc – Ad 1200, Chloe Combs

Theses and Dissertations

Barley (Hordeum vulgare) is an ancient cereal crop originating in the Fertile Crescent approximately 12,000 years ago and is presently one of the most important cereal crops globally. Barley has a long and complex history. This thesis aims to explore one dimension of this history through the lens of human companion species using archaeobotanical data collected from the islands of the North Atlantic from the Neolithic (4,000 BC) to the Norse period (AD 1200).

The Black Arts And Black Power Movements In The Artwork Of John T. Riddle, Jr., Isabella Vitti

Theses and Dissertations

This thesis examines the under-studied work of the Black sculptor John T. Riddle, Jr. and how he was influenced by the politics of Los Angeles in the 1960s and 1970s. Police brutality, the Vietnam War, the Black Power Movement, and the Watts uprising had a major impact on Riddle’s work.

Crucifixion Can Happen To Anyone: Embodying Christ Through The Queer Artist, Xander Guyer

Theses and Dissertations

In the late 20th century, queer artists incorporated the Crucifixion into their artworks, embodying a crucified Christ in the process. This thesis seats these contemporary works within traditional Christian art history, a position long denied to these transgressively queer artists.

A Grid And A Shadow, Henry Glavin

Theses and Dissertations

Henry Glavin's acrylic paintings on panel of architectural interiors and facades use repetition, contrived light, unreliable shadows, photographic posture, and compressed detail to create uncanny spaces that generate an air of silence.

Through Their Eyes: Illuminating The Nature Of Animal Use In Conservation Research Through An Analysis Of Peer-Reviewed Literature In The Journal Conservation Biology, Sarah Hollmann

Theses and Dissertations

Non-human animals habitually have been treated as a resource in the service of humans and human-driven values. The field of conservation is not immune to this fact. But, because conservation is seemingly dedicated to the saving and protection of species and nature, until recently the field historically has been given a pass for the use and treatment of animals that are done “in the name of conservation”. This treatment is evident in common conservation practices such as capture, captivity, invasive sampling, aversive treatment, experimental manipulation, and intentional killing. A principal question we are asking is how individual animals are impacted …

Evaluating Differences In Expression Of Neuroticism In Individual Homed Cats And Feral Cat Colonies Across Varying Degrees Of Human Settlement, Sophie Ambrosino

Theses and Dissertations

Neuroticism is a dimension of personality that was first defined for human psychology as a collective measure of excessive tendencies towards stress, anxiety, fear, unwarranted aggression and/or instability. In a two-part study, this project aimed to identify neuroticism as an observable personality dimension in domesticated cats, and to investigate if the expression of neuroticism varies on an individual and population level in correlation with an increase in environmental stressors and scarcity based upon degree of urbanization of the site. One component of the study surveyed cat owners about personality traits and daily lifestyle of their cats to test the viability …

Francesco Clemente: In One's Self Lies The Whole World, Lorraine Robinson

Theses and Dissertations

Francesco Clemente’s body of work, especially between 1992 and 2014, theoretically draws from the Hindu concept of the avatāra, wherein the figures he portrays interminably exist in a state of flux and unraveling. Many of the figures discussed are inspired by Indian spirituality, mythology, and popular culture. Nonetheless, rather than comprehending them as literal interpretations, they exist through a prism of references.

The research conducted throughout this thesis combines analyses gathered from academic essays and books by notable Indian scholars, such as Jyotindra Jain and Partha Mitter. These two distinct voices coalesce to elucidate deep insight into Clemente’s aesthetic, personal, …

A Year As A Monk Parakeet, Eric Thompson

Theses and Dissertations

Monk parakeets are a species of parrot native to subtropical and temperate regions of Argentina, Brazil, Uruguay, Paraguay, and Bolivia that have been introduced to many parts of the world. Monk Parakeets have lived in Brooklyn, New York since the 1970s and many myths and legends surround how these birds came to live here. This thesis is a description of the behavior of monk parakeets in Brooklyn, New York’s Greenwood Cemetery based on observations I conducted twice a week from January through October of 2023. Because of the unusual nature of this population of parakeets as well as their unique …

Scattered Fragments: Art, Architecture, And Archives In Revolutionary Urban Cairo, Mounira M. Makar

Theses and Dissertations

This thesis analyzes how revolutions impact urban Cairo and its communities, specifically within artistic, architectural and archival practice while acknowledging the central role of public spaces in giving way to such revolutionary practices. Fundamentally, this paper highlights the foundational nature of such practices in developing urban communities.

May The Soil Be Everywhere: Portraying A Family's Love And Revolution Through Oral History, Performance, And Film From A Granddaughter's Perspective, Yehui Zhao

Theses and Dissertations

May the Soil Be Everywhere is a feature-length documentary film that tells an intimate four-generational family story about farming, survival, and regeneration. Set against a backdrop of war, famine, and rapid urbanization, May the Soil Be Everywhere delves into oral history, trauma, family heritage and generational love. It represents a community’s collective effort to preserve its identity.

Individual Concepts And Personal Identity Judgement, Molly M. Ye

Theses and Dissertations

Previous research into personal identity judgments has yielded conflicting outcomes. This paper introduces an alternative argument, proposing that the concept PERSON and HUMAN BEING provide different ways of thinking about the identity of people. Two experiments in this study provide evidence for this claim.

Secreted Igm Modulates Il-10 Expression In B Cells, Shannon Mcgettigan, Lazaro Aira, Gaurav Kumar, Romain Ballet, Eugene Butcher, Nicole Baumgarth, Gudrun Debes

Department of Microbiology and Immunology Faculty Papers

IL-10⁺ B cells are critical for immune homeostasis and restraining immune responses in infection, cancer, and inflammation; however, the signals that govern IL-10⁺ B cell differentiation are ill-defined. Here we find that IL-10⁺ B cells expand in mice lacking secreted IgM ((s)IgM^–/–) up to 10-fold relative to wildtype (WT) among all major B cell and regulatory B cell subsets. The IL-10⁺ B cell increase is polyclonal and presents within 24 hours of birth. In WT mice, sIgM is produced prenatally and limits the expansion of IL-10⁺ B cells. Lack of the high affinity …

Ageannomo: A Knowledgebase Of Multi-Omics Annotation For Animal Aging, Kexin Huang, Xi Liu, Zhaocan Zhang, Tiangang Wang, Haixia Xu, Qingxuan Li, Yuhao Jia, Liyu Huang, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Aging entails gradual functional decline influenced by interconnected factors. Multiple hallmarks proposed as common and conserved underlying denominators of aging on the molecular, cellular and systemic levels across multiple species. Thus, understanding the function of aging hallmarks and their relationships across species can facilitate the translation of anti-aging drug development from model organisms to humans. Here, we built AgeAnnoMO (https://relab.xidian.edu.cn/AgeAnnoMO/#/), a knowledgebase of multi-omics annotation for animal aging. AgeAnnoMO encompasses an extensive collection of 136 datasets from eight modalities, encompassing 8596 samples from 50 representative species, making it a comprehensive resource for aging and longevity research. AgeAnnoMO characterizes …

Stemdriver: A Knowledgebase Of Gene Functions For Hematopoietic Stem Cell Fate Determination, Yangyang Luo, Jingjing Guo, Jianguo Wen, Weiling Zhao, Kexin Huang, Yang Liu, Grant Wang, Ruihan Luo, Ting Niu, Yuzhou Feng, Haixia Xu, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

StemDriver is a comprehensive knowledgebase dedicated to the functional annotation of genes participating in the determination of hematopoietic stem cell fate, available at http://biomedbdc.wchscu.cn/StemDriver/. By utilizing single-cell RNA sequencing data, StemDriver has successfully assembled a comprehensive lineage map of hematopoiesis, capturing the entire continuum from the initial formation of hematopoietic stem cells to the fully developed mature cells. Extensive exploration and characterization were conducted on gene expression features corresponding to each lineage commitment. At the current version, StemDriver integrates data from 42 studies, encompassing a diverse range of 14 tissue types spanning from the embryonic phase to adulthood. In order …

Sirtuin 2 Inhibition Modulates Chromatin Landscapes Genome-Wide To Induce Senescence In Atrx-Deficient Malignant Glioma, Prit Benny Malgulwar, Carla Danussi, Sharvari Dharmaiah, William Johnson, Anand Singh, Kunal Rai, Arvind Rao, Jason T Huse

Faculty, Staff and Student Publications

BACKGROUND: Functional inactivation of ATRX characterizes large subgroups of malignant gliomas in adults and children. ATRX deficiency in glioma induces widespread chromatin remodeling, driving transcriptional shifts and oncogenic phenotypes. Effective strategies to therapeutically target these broad epigenomic sequelae remain undeveloped.

METHODS: We utilized integrated multiomics and the Broad Institute Connectivity Map (CMAP) to identify drug candidates that could potentially revert ATRX-deficient transcriptional changes. We then employed disease-relevant experimental models to evaluate functional phenotypes, coupling these studies with epigenomic profiling to elucidate molecular mechanism(s).

RESULTS: CMAP analysis and transcriptional/epigenomic profiling implicated the Class III HDAC Sirtuin2 (SIRT2) as a central mediator …

Critical-Size Defects Reconstruction With Four Different Bone Grafts Associated With E-Ptfe Membrane: A Histomorphometric Experimental In Vivo Study, Gustavo Fernandes, Filipe Castro, Rafael Martins Pereira, Wendel Teixeira, Sergio Gehrke, Julio Cesar Joly, Juan Blanco Carrion, Juliana Campos Hasse Fernandes

MOSDOH Faculty Publications

Objectives: The goal of this study was to assess the newly formed bone and the remnant biomaterial by comparing four different bone grafts used to treat critical-size defects, associated or not with the non-resorbable membrane.

Materials and methods: Two calvaria critical-size bone defects were created in 50 male Wistar rats. They were divided into blood (G1), autogenous (G2), bioglass (G3), hydroxyapatite (G4), and xenograft (G5) groups, associated or not with e-PTFE. The experimental periods were 15 and 45 days. Sections were prepared for histomorphometric assessment. All data were analyzed by the mixed-effects model with multiple comparisons (significance level, p < .05).

Results: …

Vibroscape Analysis Reveals Acoustic Niche Overlap And Plastic Alteration Of Vibratory Courtship Signals In Ground-Dwelling Wolf Spiders, Noori Choi, Pat Miller, Eileen A. Hebets

School of Biological Sciences: Faculty Publications

To expand the scope of soundscape ecology to encompass substrate-borne vibrations (i.e. vibroscapes), we analyzed the vibroscape of a deciduous forest floor using contact microphone arrays followed by automated processing of large audio datasets. We then focused on vibratory signaling of ground-dwelling Schizocosa wolf spiders to test for (i) acoustic niche partitioning and (ii) plastic behavioral responses that might reduce the risk of signal interference from substrate-borne noise and conspecific/heterospecific signaling. Two closely related species - S. stridulans and S. uetzi - showed high acoustic niche overlap across space, time, and dominant frequency. Both species show plastic behavioral …

Fusionpdb:: A Knowledgebase Of Human Fusion Proteins, Himansu Kumar, Lin-Ya Tang, Chengyuan Yang, Pora Kim

Faculty, Staff and Student Publications

Tumorigenic functions due to the formation of fusion genes have been targeted for cancer therapeutics (i.e. kinase inhibitors). However, many fusion proteins involved in various cellular processes have not been studied for targeted therapeutics. This is because the lack of complete fusion protein sequences and their whole 3D structures has made it challenging to develop new therapeutic strategies. To fill these critical gaps, we developed a computational pipeline and a resource of human fusion proteins named FusionPDB, available at https://compbio.uth.edu/FusionPDB. FusionPDB is organized into four levels: 43K fusion protein sequences (14.7K in-frame fusion genes, Level 1), over 2300 + 1267 …

Examining The Role Of Mononormative Beliefs, Stigma, And Internalized Consensual Non-Monogamy Negativity For Dehumanization, David L. Rodrigues, Thomas R. Brooks, Rhonda N. Balzarini, Amy C. Moors, Diniz Lopes

Psychology Faculty Articles and Research

Interest in consensually non-monogamous (CNM) relationships has been increasing in the general population in recent years. However, given the cultural dominance of monogamy and the normative expectations often imposed through socialization (i.e., mononormativity), people in CNM relationships may experience negativity, which can become internalized and harm their individual and relationship health. The present study investigated if mononormativity beliefs and CNM relationship stigma were associated with more dehumanization and if internalized CNM negativity was an underlying mechanism for these associations. Results showed that participants who endorsed more mononormative beliefs and CNM relationship stigma also reported more internalized CNM negativity. In turn, …

Use Of Patient Diaries In Paediatric Intensive Care: Update Study. A Constructivist Grounded Theory Study Exploring The Child, Parents, And Healthcare Professionals’ Perspectives., Fiona Lynch

School of Nursing and Midwifery Theses

Use of Patient Diaries in pAediatric inTensive carE: UPDATE Study. A Constructivist Grounded Theory Study exploring the child, parents, and healthcare professionals’ perspectives. Fiona Lynch Paediatric Intensive Care Units (PICU) are essential to paediatric healthcare, providing high medical and nursing care to children who have become critically ill. PICUs offer prompt and appropriate interventions for children who have developed physiological instability, whether following surgery, from infection, trauma, or deterioration of a chronic condition. A stay in a PICU is not without potential psychological consequences for the child and family. Interventions to support recovery from the psychological impact of critical illness …

Development Of A Rabbit Human Glioblastoma Model For Testing Of Endovascular Selective Intra-Arterial Infusion (Esia) Of Novel Stem Cell-Based Therapeutics, Peter Kan, Visish M Srinivasan, Joy Gumin, Roberto Garcia, Stephen R Chen, Jeremiah N Johnson, Dalis E Collins, Melissa M Chen, Daniel Ledbetter, Jason Huse, Zean Aaron Evan Luna, Ariadna Robledo, Viren Vasandani, Abhijit Rao, Sanjay K Singh, Elizabeth J Shpall, Juan Fueyo, Candelaria Gomez-Manzano, Frederick F Lang

Faculty, Staff and Student Publications

BACKGROUND: Endovascular selective intra-arterial (ESIA) infusion of cellular oncotherapeutics is a rapidly evolving strategy for treating glioblastoma. Evaluation of ESIA infusion requires a unique animal model. Our goal was to create a rabbit human GBM model to test IA infusions of cellular therapies and to test its usefulness by employing clinical-grade microcatheters and infusion methods to deliver mesenchymal stem cells loaded with an oncolytic adenovirus, Delta-24-RGD (MSC-D24).

METHODS: Rabbits were immunosuppressed with mycophenolate mofetil, dexamethasone, and tacrolimus. They underwent stereotactic xenoimplantation of human GBM cell lines (U87, MDA-GSC-17, and MDA-GSC-8-11) into the right frontal lobe. Tumor formation was confirmed on …

Dimerization Of The 4ig Isoform Of B7-H3 In Tumor Cells Mediates Enhanced Proliferation And Tumorigenic Signaling, Margie N Sutton, Sarah E Glazer, Riccardo Muzzioli, Ping Yang, Seth T Gammon, David Piwnica-Worms

Faculty, Staff and Student Publications

B7-H3 (CD276) has two isoforms (2Ig and 4Ig), no confirmed cognate receptor, and physiological functions that remain elusive. While differentially expressed on many solid tumors correlating with poor survival, mechanisms of how B7-H3 signals in cis (tumor cell) versus in trans (immune cell co-regulator) to elicit pro-tumorigenic phenotypes remain poorly defined. Herein, we characterized a tumorigenic and signaling role for tumor cell-expressed 4Ig-B7-H3, the dominant human isoform, in gynecological cancers that could be abrogated upon CRISPR/Cas9 knockout of B7-H3; tumorigenesis was rescued upon re-expression of 4Ig-B7-H3. Size exclusion chromatography revealed dimerization states for the extracellular domains of both human 4Ig- …

Different Substrate Selectivity And Product Patterns Of Immobilized Thermophilic Lipases From Geobacillus Stearothermophilus, Anoxybacillus Flavithermus, And Thermomyces Lanuginosus For Glyceryl Decanoate Synthesis, Teif A. Najm, Marie K. Walsh, Namhyeon Park

Nutrition, Dietetics, and Food Sciences Faculty Publications

Lipases can catalyze synthesis reactions in a micro aqueous system, producing useful partial glycerides (mono- and diglycerides), and these compounds are commonly utilized in different products as surfactants. Depending on the microbial sources for lipases, immobilization conditions, and starting substrates for synthesis reaction, the composition and yields of the resulting partial glycerides could be variable. These differences could lead to the final efficacy of partial glycerides as surfactants in targeted products. Therefore, it is necessary to establish a group of immobilized lipases from different microbial sources with information about substrate specificity to produce effective partial glycerides for various product types. …