Digital Commons Network^™

High-Fat Diet Feeding Exacerbates Hiv-1 Rectal Transmission, Saroj Chandra Lohani, Amanda E. Ramer-Tait, Qingsheng Li

Department of Food Science and Technology: Faculty Publications

High-fat diet (HFD) is well known to impact various aspects of gut health and has been associated with many diseases and inflammation. However, the impact of HFD feeding on HIV-1 rectal transmission has not yet been well addressed. With an increasing threat of HIV-1 infection in men who have sex with men (MSM), where the rectal route is the primary mode of infection, it is imperative to understand the impact of HFD on gut microbiota and inflammation and consequently, its effect on HIV-1 rectal transmission. Here, we utilized our double humanized bone marrow, liver, thymus (dHu-BLT) mouse model to assess …

Left Ventricle Function And Post-Transcriptional Events With Exercise Training In Pigs, Stephanie L. Samani, Shayne C. Barlow, Lisa A. Freeburg, Traci L. Jones, Marlee Poole, Mark A. Sarzynski Facsm, Michael R. Zile, Tarek Shazly, Francis G. Spinale

Faculty Publications

Background

Standardized exercise protocols have been shown to improve overall cardiovascular fitness, but direct effects on left ventricular (LV) function, particularly diastolic function and relation to post-transcriptional molecular pathways (microRNAs (miRs)) are poorly understood. This project tested the central hypothesis that adaptive LV remodeling resulting from a large animal exercise training protocol, would be directly associated with specific miRs responsible for regulating pathways relevant to LV myocardial stiffness and geometry.

Methods and results

Pigs (n = 9; 25 Kg) underwent a 4 week exercise training protocol (10 degrees elevation, 2.5 mph, 10 min, 5 days/week) whereby LV chamber stiffness (KC) …

Habitat Associations And Species Distribution Modeling Of The Plains Spotted Skunk (Spilogale Interrupta) In Kansas, Daniel Benson

Electronic Theses & Dissertations

While once abundant across the central United States, the plains spotted skunk (Spilogale interrupta formerly Spilogale putorious) has experienced range wide population declines. In Kansas, the plains spotted skunk has suffered a particularly dramatic decline and is currently listed as a state-threatened species. Due to the deficit of knowledge on this species, we have paired a long-term, large-scale camera trap survey with the a regional, temporally discrete Species Distribution Model (SDM) to determine the ecology and presence of the plains spotted skunk in Kansas. We deployed camera traps for 40,393 trap nights across 29 counties between 2016 and …

The Beacon, February 2, 2024, Beacon Staff

The Beacon, 2023-2024

Pros and cons of raider relationships; Day in the life of Dr. Koerselman; A bloated project with little innovation; "Mean Girls" musical exceeds expectations; Senior Spotlight: Artist Naomi Lief; What to expect during music's biggest night; Book study to give post-college advice; Students opinions on Relationships in college; New eatery option graces Orange City; Dr. Koerselman's fashionable day; Horsegirls verses cowgirls; Finding my identity in Christ; Van Kalsbeek shatters two school records; Softball and baseball to start spring season; Raider cheer standing out at season opener; The importance of black history; Latino Raider Day: inclusivity made priority;

Association Between Malaria Educational Message Exposure And Malaria Prevalence Among Children In Nigeria, Eberechukwu Jacob Ajiwe

Walden Dissertations and Doctoral Studies

No abstract provided.

The Rider (2024-02-02), Natalie Lapsley

The Rider Archives

Vol.9 No.18

Nature Of The Evidence Base And Approaches To Guide Nutrition Interventions For Individuals: A Position Paper From The Academy Of Nutrition Sciences, Mary Hickson, Constantina Papoutsakis, Angela M. Madden, Mary Anne Smith, Kevin Whelan

School of Health Professions

This Position Paper from the Academy of Nutrition Sciences is the third in a series which describe the nature of the scientific evidence and frameworks that underpin nutrition recommendations for health. This paper focuses on evidence which guides the application of dietary recommendations for individuals. In some situations, modified nutrient intake becomes essential to prevent deficiency, optimise development and health, or manage symptoms and disease progression. Disease and its treatment can also affect taste, appetite and ability to access and prepare foods, with associated financial impacts. Therefore, the practice of nutrition and dietetics must integrate and apply the sciences of …

Tumor-Specific Polycistronic Mirna Delivered By Engineered Exosomes For The Treatment Of Glioblastoma, Malcolm F Mcdonald, Anwar Hossain, Eric N Momin, Irtiza Hasan, Sanjay Singh, Satoshi Adachi, Joy Gumin, Daniel Ledbetter, Jing Yang, Lihong Long, Marc Daou, Sricharan Gopakumar, Lynette M Phillips, Brittany Parker Kerrigan, Frederick F Lang

Faculty, Staff and Student Publications

Background: Glioblastoma (GBM) has poor prognosis due to ineffective agents and poor delivery methods. MicroRNAs (miRs) have been explored as novel therapeutics for GBM, but the optimal miRs and the ideal delivery strategy remain unresolved. In this study, we sought to identify the most effective pan-subtype anti-GBM miRs and to develop an improved delivery system for these miRs.

Methods: We conducted an unbiased screen of over 600 miRs against 7 glioma stem cell (GSC) lines representing all GBM subtypes to identify a set of pan-subtype-specific anti-GBM miRs and then used available TCGA GBM patient outcomes and miR expression data to …

Targeting Prostate Tumor Low-Molecular Weight Tyrosine Phosphatase For Oxidation-Sensitizing Therapy, Stephanie M Stanford, Tiffany P Nguyen, Joseph Chang, Zixuan Zhao, G Lavender Hackman, Eugenio Santelli, Colton M Sanders, Madhusudhanarao Katiki, Eleonora Dondossola, Brooke L Brauer, Michael A Diaz, Yuan Zhan, Sterling H Ramsey, Philip A Watson, Banumathi Sankaran, Claudia Paindelli, Vanessa Parietti, Antonios G Mikos, Alessia Lodi, Aditya Bagrodia, Andrew Elliott, Rana R Mckay, Ramachandran Murali, Stefano Tiziani, Arminja N Kettenbach, Nunzio Bottini

Faculty, Staff and Student Publications

Protein tyrosine phosphatases (PTPs) play major roles in cancer and are emerging as therapeutic targets. Recent reports suggest low-molecular weight PTP (LMPTP)-encoded by the ACP1 gene-is overexpressed in prostate tumors. We found ACP1 up-regulated in human prostate tumors and ACP1 expression inversely correlated with overall survival. Using CRISPR-Cas9-generated LMPTP knockout C4-2B and MyC-CaP cells, we identified LMPTP as a critical promoter of prostate cancer (PCa) growth and bone metastasis. Through metabolomics, we found that LMPTP promotes PCa cell glutathione synthesis by dephosphorylating glutathione synthetase on inhibitory Tyr270. PCa cells lacking LMPTP showed reduced glutathione, enhanced activation of eukaryotic initiation factor …

Point-Of-Care Diagnostic Test For Beta-Thalassemia, Ran An, Umut A. Gurkan

Faculty Scholarship

Hemoglobin (Hb) disorders are among the most common monogenic diseases affecting nearly 7% of the world population. Among various Hb disorders, approximately 1.5% of the world population carries β-thalassemia (β-Thal), affecting 40,000 newborns every year. Early screening and a timely diagnosis are essential for β-thalassemia patients for the prevention and management of later clinical complications. However, in Africa, Southern Europe, the Middle East, and Southeast Asia, where β-thalassemia is most prevalent, the diagnosis and screening for β-thalassemia are still challenging due to the cost and logistical burden of laboratory diagnostic tests. Here, we present Gazelle, which is a paper-based microchip …

The Student Movement Volume 108 Issue 14: Elevating Our Way To Black History Month, Lauren Kim, Grace No, Nick Bishop, Amelia Stefanescu, Audrey Lim, Madison Vath, Andrew Francis, Melissa Moore, Anna Rybachek, Jonathan Clough, Katie Davis, Reagan Westerman, Nate Miller, Nicole Compton-Gray, Wambui Karanja, Caitlin Adap, Gio Lee

The Student Movement v. 108 (2023-2024)

HUMANS

BSCF President & Black History Month: Skyler Campbell, Interviewed by Lauren Kim

A Modern Renaissance man: Nate Miller, Interviewed by Nick Bishop

Brushstrokes of Hope: Painting Smiles and Building Bonds in Honduras, Interviewed by Nick Bishop

ARTS & ENTERTAINMENT

A Little Taste of "A Little Life", Amelia Stefanescu

Bring Fall Fest Back!, Amelia Stefanescu

Remakes and Reboots, Audrey Lim

"Wild Geese" and the Acceptance of Being Human, Madison Vath

NEWS

Student Speakers "Activate" Peers' Faith at Week of Prayer, Andrew Francis

New BOBA Shop Offers Students Tea-licious Drinks, Melissa Moore

Recording Policy Rules 101, Anna Rybachek

Warmer in the …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

A Relational Approach To Knowledge Exchange In Higher Education, Harriet Dismore, Verity Campbell-Barr, Rachel Manning, Paul Warwick

School of Law, Humanities and Social Sciences

Reference to Knowledge Exchange (KE) in UK Higher Education Institutions (HEIs) has become common place, reflecting the continued changing role of universities within society. Arguably, KE draws together notions of HEIs as purveyors of knowledge, with students helping to create a tripartite relationship with HEIs and the wider community as well as a civic responsibility to contribute to the wider public good. Realising the potential benefits of this inter-relationship required a problematising of the meanings of both knowledge and the notion of an exchange, drawing on the work of Dewey and Bernstein. Our paper offers an analysis of the different …

Brain Injury Drives Optic Glioma Formation Through Neuron-Glia Signaling, Jit Chatterjee, Joshua P Koleske, Astoria Chao, Andrew D Sauerbeck, Ji-Kang Chen, Xuanhe Qi, Megan Ouyang, Lucy G Boggs, Rujuta Idate, Lara Isabel Marco Y Marquez, Terrence T Kummer, David H Gutmann

2020-Current year OA Pubs

Tissue injury and tumorigenesis share many cellular and molecular features, including immune cell (T cells, monocytes) infiltration and inflammatory factor (cytokines, chemokines) elaboration. Their common pathobiology raises the intriguing possibility that brain injury could create a tissue microenvironment permissive for tumor formation. Leveraging several murine models of the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome and two experimental methods of brain injury, we demonstrate that both optic nerve crush and diffuse traumatic brain injury induce optic glioma (OPG) formation in mice harboring Nf1-deficient preneoplastic progenitors. We further elucidate the underlying molecular and cellular mechanisms, whereby glutamate released from damaged neurons …

Chronic Wasting Disease: State Of The Science, Jason C Bartz, Rebeca Benavente, Byron Caughey, Sonja Christensen, Allen Herbst, Edward A Hoover, Candace K Mathiason, Debbie Mckenzie, Rodrigo Morales, Marc D Schwabenlander, Daniel P Walsh, The Nc North American Interdisciplinary Chronic Wasting Disease Research Consortium Members

Faculty, Staff and Student Publications

Chronic wasting disease (CWD) is a prion disease affecting cervid species, both free-ranging and captive populations. As the geographic range continues to expand and disease prevalence continues to increase, CWD will have an impact on cervid populations, local economies, and ecosystem health. Mitigation of this "wicked" disease will require input from many different stakeholders including hunters, landowners, research biologists, wildlife managers, and others, working together. The NC1209 (North American interdisciplinary chronic wasting disease research consortium) is composed of scientists from different disciplines involved with investigating and managing CWD. Leveraging this broad breadth of expertise, the Consortium has created a state-of-the-science …

A Comparative Biochemical And Pathological Evaluation Of Brain Samples From Knock-In Murine Models Of Gaucher Disease, Makaila L Furderer, Bahafta Berhe, Tiffany C Chen, Stephen Wincovitch, Xuntian Jiang, Nahid Tayebi, Ellen Sidransky, Tae-Un Han

2020-Current year OA Pubs

Gaucher disease (GD) is a lysosomal storage disorder stemming from biallelic mutations in

Exosome-Based Smart Drug Delivery For Cancer Treatment, Shabnam Malik, Mohammed Sikander, Sheema Khan, Daniel Zubieta, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Advances in nanoscale materials have become indispensable for targeted drug delivery, early detection, and personalized approaches for cancer treatment. Among various nanoscale materials investigated, exosomes hold significant promise in drug delivery. Exosomes are nanoscale vesicles that are usually 30–150 nm in size and produced by cells for intercellular communication. Due to their unique composition and inherent tumor-targeting capacity, these particles are well suited for tumor-specific delivery systems. This chapter discusses exosome isolation, therapeutic loading methods, key roles of exosomes in the tumor microenvironment, current applications of exosomes in drug delivery, and possible clinical implications.

The Impact Of English Language Propagated By The Advancements Of Information And Technology Services In Libraries On The Vernacular Languages Of Sri Lanka, Anurin Diwakara Prof., P.D.D.D. Wickramasinghe, N.S. Gunawardana, Chaminda Chiran Jayasundara

Library Philosophy and Practice (e-journal)

The development of information and communication technology has become the prominent reason for language contact in the native language varieties spoken in the South Asian region. The island nation Sri Lanka is home to a multi-ethnic population and the main vernacular spoken in the country is Sinhala Language. Using materials drawn from social media platforms, websites, internet forums and personal knowledge, this study sets out to examine the ways in which the English language has been making significant contact with the Sinhala language, which is the dominant vernacular language spoken in Sri Lanka due to the advancements in information technology. …

Prenatal Exposure To Maternal Disadvantage-Related Inflammatory Biomarkers: Associations With Neonatal White Matter Microstructure, Ashley F P Sanders, Brian Tirado, Nicole A Seider, Regina L Triplett, Rachel E Lean, Jeffrey J Neil, J Philip Miller, Rebecca Tillman, Tara A Smyser, Deanna M Barch, Joan L Luby, Cynthia E Rogers, Christopher D Smyser, Barbara B Warner, Et Al.

2020-Current year OA Pubs

Prenatal exposure to heightened maternal inflammation has been associated with adverse neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness. In mothers experiencing socioeconomic disadvantage, immune activation can be a product of the chronic stress inherent to such environmental hardship. While growing preclinical and clinical evidence has shown links between altered neonatal brain development and increased inflammatory states in utero, the potential mechanism by which socioeconomic disadvantage differentially impacts neural-immune crosstalk remains unclear. In the current study, we investigated associations between socioeconomic disadvantage, gestational inflammation, and neonatal white matter microstructure in 320 mother-infant dyads over-sampled for poverty. We analyzed maternal …

Rapid And Accurate Remethylation Of Dna In Dnmt3a- Deficient Hematopoietic Cells With Restoration Of Dnmt3a Activity, Yang Li, Haley J Abel, Michelle Cai, Taylor A Lavalle, Tiankai Yin, Nichole M Helton, Amanda M Smith, Christopher A Miller, Timothy J Ley

2020-Current year OA Pubs

Here, we characterize the DNA methylation phenotypes of bone marrow cells from mice with hematopoietic deficiency of

Using Ar To Teach Ar: Learning Outcomes Of A Guided, Augmented Reality Hearing Loss And Auditory Rehabilitation Simulation With Slp Graduate Students, Alice Henton, Mathew Vansant

Teaching and Learning in Communication Sciences & Disorders

Recent research has found that practicing speech-language pathologists report feeling underprepared to provide services for individuals with hearing loss. At the same time, graduate SLP programs report that students have fewer training opportunities with low-incidence populations. This study examines learning outcomes for a cohort of graduate SLP students using a novel application of an immersive, augmented reality, hearing loss simulation. Results show encouraging outcomes for the simulation experience’s effects on empathy, knowledge, and clinical skills. This simulation offers a unique way to provide training related to auditory rehabilitation in SLP.

Using Natural Language Processing And Patient Journey Clustering For Temporal Phenotyping Of Antimicrobial Therapies For Cat Bite Abscesses, Brian Hur, Karin M. Verspoor, Timothy Baldwin, Laura Y. Hardefeldt, Caitlin Pfeiffer, Caroline Mansfield, Riati Scarborough, James R. Gilkerson

Natural Language Processing Faculty Publications

Background: Temporal phenotyping of patient journeys, which capture the common sequence patterns of interventions in the treatment of a specific condition, is useful to support understanding of antimicrobial usage in veterinary patients. Identifying and describing these phenotypes can inform antimicrobial stewardship programs designed to fight antimicrobial resistance, a major health crisis affecting both humans and animals, in which veterinarians have an important role to play. Objective: This research proposes a framework for extracting temporal phenotypes of patient journeys from clinical practice data through the application of natural language processing (NLP) and unsupervised machine learning (ML) techniques, using cat bite abscesses …

Phenotypic Features Determining Visual Acuity In Albinism And The Role Of Amblyogenic Factors., Frank A Proudlock, Rebecca J Mclean, Viral Sheth, Sarim Ather, Irene Gottlob

Cooper Medical School of Rowan University Departmental Research

Albinism is a spectrum disorder causing foveal hypoplasia, nystagmus, and hypopigmentation of the iris and fundus along with other visual deficits, which can all impact vision. Albinism is also associated with amblyogenic factors which could affect monocular visual acuity. The foveal appearance in albinism can range from mild foveal hypoplasia to that which is indistinguishable from the peripheral retina. The appearance can be quickly and easily graded using the Leicester Grading System in the clinic. However, interquartile ranges of 0.3 logMAR for the grades associated with albinism limit the accuracy of the grading system in predicting vision. Here, we discuss …

Visual Field Deficits In Albinism In Comparison To Idiopathic Infantile Nystagmus., Viral Sheth, Rebecca J Mclean, Zhanhan Tu, Sarim Ather, Irene Gottlob, Frank A Proudlock

Cooper Medical School of Rowan University Departmental Research

PURPOSE: This is the first systematic comparison of visual field (VF) deficits in people with albinism (PwA) and idiopathic infantile nystagmus (PwIIN) using static perimetry. We also compare best-corrected visual acuity (BCVA) and optical coherence tomography measures of the fovea, parafovea, and circumpapillary retinal nerve fiber layer in PwA.

METHODS: VF testing was performed on 62 PwA and 36 PwIIN using a Humphrey Field Analyzer (SITA FAST 24-2). Mean detection thresholds for each eye were calculated, along with quadrants and central measures. Retinal layers were manually segmented in the macular region.

RESULTS: Mean detection thresholds were significantly lower than normative …

Santa Clara Review, Vol. 111, No. 1, Santa Clara University

Santa Clara Review

No abstract provided.

2023 Celebration Of Rollins Scholarship, Olin Library, Rollins College, The Office Of The Dean Of The College Of Liberal Arts, Rollins College

Celebration of Rollins Scholarship

No abstract provided.

Dna Playbill, Providence College

Playbill and Promotion

Providence College Department of Theatre, Dance & Film

Angell Blackfriars Theatre

DNA, written by Dennis Kelly

February 1-3, 2024, 7:30pm

February 3 & 4, 2024, 2pm

Director, Aaron Andrade

Scenic Design, Renee Surprenant Fitzgerald

Lighting Design, Elissa Cerros

Vocal Coach, Megan Chang

Costume Design, Jaimy Escobedo

Sound Design, Stuart Holland

Properties Design, Claire Dancause

Makeup Design, Maxine Wheelock

Cast: Luke MacDonald - Mark; Maddie Rich - Jan; Sarah D'Andrea - Leah; Jack Jozefowski - Phil; Molly McGoldrick - Lou; Anthony Maldonado - John Tate; Anthony Joseph - Danny; Holli Hay - …

Lindenwood Student Government Newsletter -February 2024, Lindenwood University

Lindenwood Student Government Newsletters

A newsletter from the Lindenwood University Student Government.

Cc Magazine, Winter 2024, Connecticut College

Alumni News/Connecticut College Magazine

No abstract provided.

Shadows Or Forgeries? Explaining Legal Normativity, Alma Diamond

Fellow, Adjunct, Lecturer, and Research Scholar Works

Legal norms serve as practical standards for individuals and officials. While this ‘normative aspect’ of law is widely acknowledged, its significance for theories of law remains contested. In this paper, I examine three views on the matter. First, that we should explain legal norms as reason-giving. Second, that we should explain legal discourse as being about reasons for action. Third, that we should explain law as capable of being reason-giving. I survey some challenges associated with each of these views. What they have in common is an implicit assumption about the form that normative explanation must take: that it must …