Digital Commons Network^™

Vol. 66, No. 05 (February 12, 2024)

Indiana Law Annotated

No abstract provided.

Heterogeneity In Maternal Mrnas Within Clutches Of Eggs In Response To Thermal Stress During The Embryonic Stage, Atsuko Sato, Yukie Mihirogi, Christine Wood, Yutaka Suzuki, Manuela Truebano, John Bishop

School of Biological and Marine Sciences

Background: The origin of variation is of central interest in evolutionary biology. Maternal mRNAs govern early embryogenesis in many animal species, and we investigated the possibility that heterogeneity in maternal mRNA provisioning of eggs can be modulated by environmental stimuli. Results: We employed two sibling species of the ascidian Ciona, called here types A and B, that are adapted to different temperature regimes and can be hybridized. Previous study showed that hybrids using type B eggs had higher susceptibility to thermal stress than hybrids using type A eggs. We conducted transcriptome analyses of multiple single eggs from crosses using eggs …

Effects Of Metformin On Glucose Metabolism And Mitochondrial Function In Patients With Obstructive Sleep Apnea: A Pilot Randomized Trial, Elizabeth R.M. Zunica, Elizabeth C. Heintz, Wagner S. Dantas, R. Caitlin Hebert, Ma Kayla Tanksley, Robbie A. Beyl, Edward C. Mader, John P. Kirwan, Christopher L. Axelrod, Prachi Singh

School of Medicine Faculty Publications

Obstructive sleep apnea (OSA) is associated with increased risk for diabetes, and standard treatment with positive airway pressure (PAP) device shows inconsistent effects on glucose metabolism. Metformin is known to treat and prevent diabetes, but its effects on skeletal muscle mitochondrial function are not completely understood. Here, we evaluate the effects of metformin on glucose metabolism and skeletal muscle mitochondrial function in patients with OSA. Sixteen adults with obesity (50.9 ± 6.7 years, BMI: 36.5 ± 2.9 kg/m2) and moderate-to-severe OSA were provided with PAP treatment and randomized to 3 months of placebo (n = 8) or metformin (n = …

Studying Fisher Mortality In The Granite State, Robbin Ray

UNH Today Archive

No abstract provided.

Veggie Meat Alternatives: A Virtue-Ethical View, Carlo Alvaro

Publications and Research

This chapter discusses practical and ethical aspects concerning veggie meat alternatives. Upon consideration, it is argued that while the production, sale, and consumption of veggie meat alternatives seemingly contribute to a solution to environmental problems, we ought to consider veggie meat alternatives from a virtue-ethical perspective concerning human excellence and flourishing. Doing so reveals previously unexplored ethical reasons for not promoting the production, sale, and consumption of veggie meat alternatives. One reason in particular is that veggie meat alternatives stem from the lack of the virtue of temperance.

Understanding The Role Of Palliative Care Within Routine Care Of Advanced Liver Disease, Simone A. Jarrett, Edward Bley, Richard S. Kalman

Einstein Health Papers

Purpose of Review

This paper aims to investigate the crucial role of palliative care in the management of chronic liver disease (CLD) and cirrhosis. Faced with a global surge in liver-related morbidity and mortality, our goal is to understand the impact of early engagement with palliative care specialists on symptom management, quality of life, and the overall trajectory of advanced liver disease.

Recent Findings

While strides have been made in preventing and treating specific etiologies of CLD, such as viral infections, the escalating rates of alcohol use and obesity present new challenges for physicians. Despite advancements, liver transplantation unfortunately remains …

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M. Taylor, Kang Ho Kim, J. Marc Rhoads, Yuying Liu

School of Medicine Faculty Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

United States National Science Foundation (Nsf) Scientific Integrity Policy

Copyright, Fair Use, Scholarly Communication, etc.

United States National Science Foundation (NSF) Scientific Integrity Policy

Online Bilingual Co-Design: Developing Resources With People With Disability And Family Members From Refugee Backgrounds, Angela Dew, Mahmoud Murad, Louisa Smith, Joanne Watson, Kim Robinson, Maree Higgins, Cathy Preston-Thomas, Mardi Stow, Ingrid Culos, Mariano Coello, Shakeh Momartin, Christian Astourian, Kelley Johnson, Caroline Lenette, Katherine Boydell

The Qualitative Report

People with disability from Syrian and Iraqi refugee backgrounds living in Australia have limited access to information and resources in Arabic language. Our study aim was to use a co-design process to create a suite of Arabic-language resources to increase information access and build capacity of people with disability and family members from refugee backgrounds to use services, and of disability and refugee services to provide relevant support. Following a rapid literature review about access to supports and services for people with disability from refugee backgrounds, workshops were held with 38 people with disability and family members from Syrian and …

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M Taylor, Kang Ho Kim, J Marc Rhoads, Yuying Liu

Faculty, Staff and Student Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M Taylor, Kang Ho Kim, J Marc Rhoads, Yuying Liu

Faculty, Staff and Student Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

Physio-Chemical Modifications To Re-Engineer Small Extracellular Vesicles For Targeted Anticancer Therapeutics Delivery And Imaging, Rahmat Asfiya, Lei Xu, Anjugam Paramanantham, Kuanysh Kabytaev, Anna Chernatynskaya, Grace Mccully, Hu Yang, Akhil Srivastava

Chemical and Biochemical Engineering Faculty Research & Creative Works

Cancer theranostics developed through nanoengineering applications are essential for targeted oncologic interventions in the new era of personalized and precision medicine. Recently, small extracellular vesicles (sEVs) have emerged as an attractive nanoengineering platform for tumor-directed anticancer therapeutic delivery and imaging of malignant tumors. These natural nanoparticles have multiple advantages over synthetic nanoparticle-based delivery systems, such as intrinsic targeting ability, less immunogenicity, and a prolonged circulation time. Since the inception of sEVs as a viable replacement for liposomes (synthetic nanoparticles) as a drug delivery vehicle, many studies have attempted to further the therapeutic efficacy of sEVs. This article discusses engineering strategies …

Congenital Disabilities And Gender Nonconforming Identities As Parts Of God’S Intended Creation, Loren Haarsma, Kevin Timpe, Liran Naranjo- Huebl, Emily Helder

University Faculty Publications and Creative Works

Haarsma, Loren, Kevin Timpe, Linda Naranjo-Huebl, and Emily Helder, "Congenital Disabilities and Gender Nonconforming Identities as Parts of God’s Intended Creation" Perspectives on Science and Christian Faith 76.3 (2024): 190-206.

The “Childfree” Movement: How Individuals Negotiate Identities On Reddit, Elizabeth Rivera, Ellis S. Logan, Anne Price

The Journal of Public and Professional Sociology

“Childfree” is a chosen identity, reflecting an individual or couple’s decision to not procreate or parent. This paper explores how individuals who identify as childfree exhibit a high degree of agency while navigating external cultural expectations and social sanctions. We use the online discussion forum, Reddit, to unobtrusively examine how individuals negotiate a childfree identity within an online collective identity group. Analysis was performed on 278 user generated Reddit posts under the “childfree” subreddit in March, 2021 and are coded based on the primary emotional tone individuals express in discussing their decision to remain childfree. We describe the identity construction/management …

Food Labeling: Ingredient Exemptions And Product Claims, Elena Krasovkaia, Bradley J. Rickard, Brenna Ellison, Brandon R. Mcfadden, Norbert Wilson

Agricultural Economics and Agribusiness Faculty Publications and Presentations

New breeding methods have provided scientists with opportunities to improve traits in a wide range of crops, however, there remains resistance to foods that are produced from these crops, and mandates on labels used to describe such processes continue to be a source of policy debate. Here we focus on gene editing and examine (i) whether consumer acceptance varies when the technology is applied to different ingredients (unrefined versus highly refined ingredients) and (ii) the impact of two different claims related to gene editing (health-focused claim versus an environment-focused claim). Our results show that consumers are less likely to purchase …

Mindfulness Resources In The Academic Library, Rebecca Maynite, Beryl White-Bing, Lauren Odom, Robin Mcneil

Library Faculty Presentations & Publications

Listeners describe "tingles" as the ASMR experience, but many others enjoy ASMR even if they don't get tingles. ASMR videos have grown in popularity over the years. Recently, they made a resurgence on TikTok, even in parody form (think of the viral Mercedes ASMR video and all of the responses). Becca and Robin have utilized ASMR videos for relaxation and stress-management for the past 10 years. Beryl and Becca thought this could be a great resource for students.

Circuit-Based Intervention Corrects Excessive Dentate Gyrus Output In The Fragile X Mouse Model, Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, Vitaly A Klyachko

2020-Current year OA Pubs

Abnormal cellular and circuit excitability is believed to drive many core phenotypes in fragile X syndrome (FXS). The dentate gyrus is a brain area performing critical computations essential for learning and memory. However, little is known about dentate circuit defects and their mechanisms in FXS. Understanding dentate circuit dysfunction in FXS has been complicated by the presence of two types of excitatory neurons, the granule cells and mossy cells. Here we report that loss of FMRP markedly decreased excitability of dentate mossy cells, a change opposite to all other known excitability defects in excitatory neurons in FXS. This mossy cell …

Text-To-Video Generation Using Neural Networks

Defensive Publications Series

Systems and methods for text to video conversion are provided. The system may receive text representing a natural language description for generating a video. The system may also provide the text as input to a neural network. The neural network may include a first component comprising a text to image model trained to generate one or more images based on an input text. The neural network may further include a second component comprising one or more spatiotemporal layers trained to generate a video based on the one or more images generated by the first component. The neural network may further …

Kekosongan Normatif Permainan Video Dalam Undang-Undang Nomor 28 Tahun 2014 Tentang Hak Cipta, Abdulatief Zainal

Technology and Economics Law Journal

Perkembangan hak kekayaan intelektual yang terjadi secara global terjadi pula di Indonesia yang dibuktikan dengan lahirnya UU No. 28 Tahun 2014 yang mencabut dan menggantikan UU No. 19 Tahun 2002. Salah satu pengaturan baru yang ditemukan dalam UU No. 28 Tahun 2014 dan tidak ditemukan dalam UU No. 19 Tahun 2002 maupun peraturan perundang-undangan terdahulunya adalah munculnya permainan video sebagai jenis ciptaan baru yang dilindungi oleh hak cipta sebagaimana diatur dalam Pasal 40 ayat (1) huruf r, UU No. 28 Tahun 2014. Kemunculan tersebut merupakan suatu bentuk kemajuan hukum terlebih mengingat Indonesia menjadi satu-satunya negara yang secara eksplisit menyebutkan dan …

The Daily Gamecock: February 2024, University Of South Carolina, Office Of Student Media

February

No abstract provided.

Spartan Daily, February 15, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 162, Issue 10

Pam: Cultivate A Novel Lstm Predictive Analysis Model For The Behavior Of Cryptocurrencies, Mona Mohamed, Mona Gharib

Sustainable Machine Intelligence Journal

The popularity of cryptocurrencies has skyrocketed in the last several years due to the introduction of blockchain technology (BCT). Herein, we are navigating the intersection of sustainable market investment and cryptocurrency predictive analysis against the backdrop of a dynamic and evolving financial landscape marked by the surge of digital assets. This study's goal is to construct the predictive analysis model (PAM) which incorporates Long Short-Term Memory (LSTM) capabilities to predict the price of Bitcoin with high accuracy the next day and to identify the variables that influence price. In constructed PAM, we are using a comprehensive methodology to study temporal …

Thsd1 Suppresses Autophagy-Mediated Focal Adhesion Turnover By Modulating The Fak-Beclin 1 Pathway, Zhen Xu, Jiayi Lu, Song Gao, Yan-Ning Rui

Faculty, Staff and Student Publications

Focal adhesions (FAs) play a crucial role in cell spreading and adhesion, and their autophagic degradation is an emerging area of interest. This study investigates the role of Thrombospondin Type 1 Domain-Containing Protein 1 (THSD1) in regulating autophagy and FA stability in brain endothelial cells, shedding light on its potential implications for cerebrovascular diseases. Our research reveals a physical interaction between THSD1 and FAs. Depletion of THSD1 significantly reduces FA numbers, impairing cell spreading and adhesion. The loss of THSD1 also induces autophagy independently of changes in mTOR and AMPK activation, implying that THSD1 primarily governs FA dynamics rather than …

Rab7 Deficiency Impairs Pulmonary Artery Endothelial Function And Promotes Pulmonary Hypertension, Bryce Piper, Srimathi Bogamuwa, Tanvir Hossain, Daniela Farkas, Lorena Rosas, Adam C. Green, Geoffrey Newcomb, Nuo Sun, Jose A. Ovando-Ricardez, Jeffrey C. Horowitz, Aneel R. Bhagwani, Hu Yang, Tatiana V. Kudryashova, Mauricio Rojas

Chemical and Biochemical Engineering Faculty Research & Creative Works

Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial dysfunction plays a central role in the development and progression of PAH, yet the underlying mechanisms are incompletely understood. The endosome-lysosome system is important to maintain cellular health, and the small GTPase RAB7 regulates many functions of this system. Here, we explored the role of RAB7 in endothelial cell (EC) function and lung vascular homeostasis. We found reduced expression of RAB7 in ECs from patients with PAH. Endothelial haploinsufficiency of RAB7 caused spontaneous pulmonary hypertension (PH) in mice. Silencing of RAB7 in ECs induced broad …

In Vivo Dynamic Volumetric Imaging Of Mouse Testis And Epididymis With Optical Coherence Tomography†, Kohei Umezu, Guzel R Musina, Irina V Larina

Faculty, Staff and Students Publications

The implementation of live imaging in reproductive research is crucial for studying the physiological dynamics. Sperm transport is a highly dynamic process regulated by tubular contractions and luminal flows within the male reproductive tract. However, due to the lack of imaging techniques to capture these dynamics in vivo, there is little information on the physiological and biomechanical regulation of sperm transport through the male reproductive tract. Here, we present a functional in vivo imaging approach using optical coherence tomography, enabling live, label-free, depth-resolved, three-dimensional, high-resolution visualization of the mouse testis and epididymis. With this approach, we spatiotemporally captured tubular contractility …

Mesoscopic Calcium Imaging In A Head-Unrestrained Male Non-Human Primate Using A Lensless Microscope, Jimin Wu, Yuzhi Chen, Ashok Veeraraghavan, Eyal Seidemann, Jacob T Robinson

Faculty, Staff and Students Publications

Mesoscopic calcium imaging enables studies of cell-type specific neural activity over large areas. A growing body of literature suggests that neural activity can be different when animals are free to move compared to when they are restrained. Unfortunately, existing systems for imaging calcium dynamics over large areas in non-human primates (NHPs) are table-top devices that require restraint of the animal’s head. Here, we demonstrate an imaging device capable of imaging mesoscale calcium activity in a head-unrestrained male non-human primate. We successfully miniaturize our system by replacing lenses with an optical mask and computational algorithms. The resulting lensless microscope can fit …

The Effect Of Breastfeeding Practices Of Undernourished Mothers In Rural Sierra Leone On Infant Growth And Mortality, Aminata Shamit Koroma, Kevin B Stephenson, Per O Iversen, Mark J Manary, David Taylor Hendrixson

2020-Current year OA Pubs

Breastfeeding provides optimal infant nutrition; however, <50% of infants are exclusively breastfed (EBF) for 6 months. We aimed to describe breastfeeding practices and their effects on growth and mortality among a high-risk mother-infant cohort in rural Sierra Leone. This was a secondary analysis of data from a randomized nutrition intervention trial among undernourished pregnant women. The study's primary outcomes were infant weight and length gains at 6 weeks of age. We included 1270 singleton infants in the analysis, with 1092 (85.6%) having 24-week outcome data. At 6 weeks, 88% were EBF, but the rate of EBF decreased to 17% at 24 weeks. The EBF infants at 6 weeks had improved length (difference of 0.9 mm/week; 95% CI 0.4 to 1.3;

Evaluation Of Mulberry Leaf Meal Feeding On The Growth And Hematological Profile Of Cross Bred Heifers, Rohit Bishist, Irfana Quadiri, Krishan Lal Gautam, Kamal Kishore

IGC Proceedings (1977-2023)

Mulberry (Morus alba) is a multipurpose fodder tree with a high voluntary intake. Mulberry foliage is characterized by high digestibility and excellent level of protein which makes it comparable to commercial concentrates for dairy cattle. o evaluate the effect of dietary inclusion of mulberry leaf meal as a concentrate replacement (20%) in the crossbred heifers ration the present investigation was carried out at dairy farm Dr YSPUHF Nauni Solan. In the study, a total of 12 cross bred heifers (1-2 yr) were divided into two equal groups of 6 animals each, on the basis of body weight. The …

History Of Endophytic Toxicosis And Novel Variety Solutions, J. H. Bouton

IGC Proceedings (1977-2023)

Associations of Epichloe endophytes with tall fescue [Lolium arundinaceum (Schreb). Darbush.] and perennial ryegrass (Lolium perenne L.) form the basis for the known science and ecology of mutualistic, fungal endophytes, and especially their impact on livestock. In the USA, millions of acres are endophyte infected today due mainly to planting ‘Kentucky 31’ to reduce soil erosion. Health problems emerged later among animals grazing the grass. These toxicity symptoms were listed under the general term ‘Fescue Toxicosis’. Research demonstrated that ergot alkaloids produced by the mutualism were mainly responsible. Developing endophyte-free versions of major varieties reduced host grass persistence …

Comparison Of Two Low-Input Cow/Calf Production Systems On Temperate Grassland, W. B. Bryan, Mata Padrino, E. Felton, E. C. Prigge, V. W. Temu, O. J. Gekara

IGC Proceedings (1977-2023)

Two systems of grass farming were compared in an eight-year experiment in West Virginia, USA. The grassland consisted primarily of cocksfoot (Dactylis glomerara L.), Kentucky bluegrass (Poa pratensis L.), tall fescue (Festuca arundinacea Schreb.), and red (Trifolium pretense L.) and white clover (T. repens L.). The objective was to compare two systems of beef cow calf production. The experiment was a randomized complete block with two replicated treatments. The grassland of treatment 1 (system 1) was overseeded with legumes, grazing started 1 wk earlier and continued 1 wk later than treatment 2 (system 2) and …