Digital Commons Network^™

Natural Warming Differentiates Communities And Increases Diversity In Deep-Sea Ridge Flank Hydrothermal Systems, Anne M. Hartwell, Anna E. Wheat, Jennifer A. Dijkstra

Center for Coastal and Ocean Mapping

Ridge Flank Hydrothermal Systems have discrete pockets of fluid discharge that mimic climate-induced ocean warming. Unlike traditional hydrothermal fluids, those discharged by Ridge Flank Hydrothermal Systems have a chemical composition indistinguishable from background water, enabling evaluation of the effect of warming temperature. Here we link temperature and terrain variables to community composition and biodiversity by combining remotely operated vehicle images of vent and non-vent zone communities with associated environmental variables. We show overall differences in composition, family richness, and biodiversity between zones, though richness and diversity were only significantly greater in vent zones at one location. Temperature was a contributing …

The Nuclear Import Receptor Kapβ2 Modifies Neurotoxicity Mediated By Poly(Gr) In C9orf72-Linked Als/Ftd, Maria Elena Cicardi, V. Kankate, Sindhu Sriramoji, Karthik Krishnamurthy, S. S. Markandaiah, B. M. Verdone, Amandeep Girdhar, A. Nelson, L. B. Rivas, A. Boehringer, Aaron R. Haeusler, Piera Pasinelli, Lin Guo, Davide Trotti

Farber Institute for Neuroscience Faculty Papers

Expanded intronic G₄C₂ repeats in the C9ORF72 gene cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These intronic repeats are translated through a non-AUG-dependent mechanism into five different dipeptide repeat proteins (DPRs), including poly-glycine-arginine (GR), which is aggregation-prone and neurotoxic. Here, we report that Kapβ2 and GR interact, co-aggregating, in cultured neurons in-vitro and CNS tissue in-vivo. Importantly, this interaction significantly decreased the risk of death of cultured GR-expressing neurons. Downregulation of Kapβ2 is detrimental to their survival, whereas increased Kapβ2 levels mitigated GR-mediated neurotoxicity. As expected, GR-expressing neurons displayed TDP-43 nuclear loss. Raising Kapβ2 levels …

The Comment, March 28, 2024, Bridgewater State University

The Comment

No abstract provided.

2024 Academic & Creative Excellence Reception Program, Lynn University

Academic and Creative Excellence (ACE) Reception Programs

The program for the 2024 Academic and Creative Excellence (ACE) Reception - the 16th annual - organized by the Lynn Library, working in conjunction with the Office of Academic Affairs. The reception is held on March 28, 2024 in the Salon at the Keith C. and Elaine Johnson Wold Performing Arts Center.

The Faculty Scholarship and Creative Activities Award is presented to Dr. David G. Wolf.

Design, Deployment, And Operation Of An Experimental Offshore Seaweed Cultivation Structure, Zachary Moscicki, M Robinson Swift, Tobias Dewhurst, Michael Macnicoll, Michael Chambers, Igor Tsukrov, David W. Fredriksson, Peter Lynn, Melissa E. Landon, Beth Zotter, Noah Macadam

Faculty Publications

Seaweed cultivation systems suitable for offshore and exposed locations have the potential to enable expansion of global seaweed production to levels capable of substantially supplementing or offsetting terrestrial agriculture. A demonstration scale, experimental seaweed cultivation system (farm) intended to withstand exposed ocean environments was designed, deployed, planted with kelp (a type of seaweed), monitored and decommissioned. Objectives for the field program included: [1] observation of the farm's behavior and survivability in exposed ocean conditions, [2] demonstration of novel farm system design features and component technologies, and [3] evaluation of farm operability. Novel design features included a lattice mooring system geometry, …

Role Of Electronegativity In Environmentally Persistent Free Radicals (Epfrs) Formation On Zno, Syed Monjur Ahmed, Reuben A. Oumnov, Orhan Kizilkaya, Randall W. Hall, Phillip T. Sprunger, Robert L. Cook

Faculty Publications

Environmentally persistent free radicals (EPFRs), a group of emerging pollutants, have significantly longer lifetimes than typical free radicals. EPFRs form by the adsorption of organic precursors on a transition metal oxide (TMO) surface involving electron charge transfer between the organic and TMO. In this paper, dihalogenated benzenes were incorporated to study the role of electronegativity in the electron transfer process to obtain a fundamental knowledge of EPFR formation mechanism on ZnO. Upon chemisorption on ZnO nanoparticles at 250 °C, electron paramagnetic resonance (EPR) confirms the formation of oxygen adjacent carbon-centered organic free radicals with concentrations between 10¹⁶ and 10 …

Introductory Geology Laboratory Students' Learnings From And Perceptions Of Physical And Virtual Polarizing Light Microscopes – An Exploratory Mixed Methods Study, Christy M. Bebeau

USF Tampa Graduate Theses and Dissertations

Undergraduate geoscience laboratory courses provide hands-on learning about earth materials. However thin section analysis is not typically included in introductory geology laboratories, likely due to the polarizing light microscope (PLM) costs. Therefore, there is a lack of research about the educational outcomes of novices learning these skills.

In this inquiry, I conducted mixed methods research about novice students' learning of thin section analysis in an introductory geology laboratory and evaluated learning and perception differences between students who used a virtual PLM and those who used a physical PLM. I collected data from Creative Exercise (CE) assessments in student midterm and …

Integrated Process Modeling, Techno-Economic Analysis And Life Cycle Assessment For Enhanced Biogas-To-Energy Sustainability And Efficiency, Rarosue Jennifer Amaraibi

USF Tampa Graduate Theses and Dissertations

This dissertation aims to enhance the cost competitiveness and minimize the environmental footprint of technologies that convert biogas to energy, contributing to global climate change mitigation efforts. Biogas, a by-product of the anaerobic decomposition of organic waste from various sources, is a renewable energy source with the potential to reduce carbon emissions and meet local energy needs. However, widespread adoption requires the development of economically viable and environmentally friendly technologies.The central hypothesis of this dissertation suggests that by adopting a holistic strategy that combines cutting-edge techniques to purify biogas and improve its conversion into valuable liquid fuels, we can substantially …

Safety Of Potentised Dilutions Of Rhus Toxicodendron In Wistar Albino Rats, Abanti Goswami, Narasimha Kumar Gv, Vara Prasad Saka, Pankaj Gupta, Bibaswan Biswas, Digvijay Verma

Indian Journal of Research in Homoeopathy

Background: Rhus toxicodendron (Rhus tox.) is a well-known homoeopathic medicine used to treat inflammatory disorders supported by historical and modern scientific evidence. Objective: The safety testing of 6C, 30C and 200C potencies of Rhus tox. through acute and sub-acute oral toxicity tests as per the Organisation for Economic Cooperation and Development test guidelines. Methods: For the acute oral toxicity study, Rhus tox. (2000 μL/kg) was administered to rats and observed for 14 days. For the subacute oral toxicity study, Rhus tox. (200 μL/kg) was administered for 28 days and additional recovery groups were included to monitor reversibility, persistence, or delayed …

Zeros And Ones: Digital Video Aesthetics And Geopolitical Economy In Blackhat, Everett Barnett

USF Tampa Graduate Theses and Dissertations

Film and media theory has been fundamentally altered by the advent of digital technology, both in terms of film production and broader aesthetic overtures but also in terms of greater digital mediation. Blackhat (Michael Mann, 2015), although not a commercial or critical success, articulates many of the exact circumstances and broader consequences of digital technology in relation to its digital video aesthetics but also its narratives content involving global telecommunication and data systems. As a wholly digital film, Blackhat is uniquely situated to speak not only developments in digital filmmaking but also, by way of its plot line involving stateless …

Human Motion-Inspired Inverse Kinematics Algorithm For A Robotics-Based Human Upper Body Model, Urvish Trivedi

USF Tampa Graduate Theses and Dissertations

The goal of this research is to develop a human motion-inspired inverse kinematics algorithm framework specifically designed for a Robotics-Based Human Upper Body Model (RHUBM). This framework offers solutions to challenges in various fields. In humanoid robotics, the framework addresses the problem of unnatural robot movement by enabling the development of motion planning algorithms that incorporate human-like movements. For prosthetics, the framework tackles the challenge of amputee difficulty in learning and controlling prosthetics by providing a user-friendly interface that predicts and visualizes upper limb movements, enabling learning and practice. In rehabilitation therapy, the framework tackles …

Quaker Campus, March 28, 2024 (Vol. 22, Issue 12), Whittier College

Quaker Campus

No abstract provided.

Necked Keelback Fowlea Schnurrenbergeri (Kramer, 1977) In Northeastern Punjab, Pakistan, Mudassar Basri, Zohaib Nasar

Journal of Bioresource Management

The bar-necked keelback snake plays a vital ecological role as a natural pest controller, effectively regulating populations of fish, frogs, and rodents. Through their predatory behavior, they contribute significantly to maintaining ecological balance by managing the numbers of these smaller creatures, thereby contributing to the overall health of ecosystem. We have documented Fowlea schnurrenbergeri in the urban center of Tehsil Zafarwal and Dariyapur village, within Narowal district, Punjab. Previously, Sindh-Thatta represented the southeastern most known locality for this species in Pakistan. This study presents new insights into the distribution range of this less-frequently observed species.

Tinea Cruris Managed With A Single Dose Of Individualised Homoeopathic Medicine: A Case Report, K Sivakumar

Indian Journal of Research in Homoeopathy

Introduction: Tinea cruris is an infection of the skin over groins by a species of dermatophyte. It is a common ringworm infestation that affects the groin and is caused by Trichophyton rubrum, characterised by red, itchy erythematous plaques extending from the Groin and flexures onto the thighs, buttocks and perianal region of the skin. More than eight million people visit primary care physicians annually to treat tinea-related symptoms. Topical agents are the mainstay in conventional medicine. However, a holistic approach with Homoeopathy for treating tinea cruris can make a difference in terms of both cure and preventing relapse. Case …

The Hagfish Genome And The Evolution Of Vertebrates, Ferdinand Marlétaz, Nataliya Timoshevskaya, Vladimir A. Timoshevskiy, Elise Parey, Oleg Simakov, Daria Gavriouchkina, Masakazu Suzuki, Kaoru Kubokawa, Sydney Brenner, Jeramiah James Smith, Daniel S. Rokhsar

Markey Cancer Center Faculty Publications

As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a crucial window into early vertebrate evolution1–3 . Here we investigate the complex history, timing and functional role of genome-wide duplications4–7 and programmed DNA elimination8,9 in vertebrates in the light of a chromosome-scale genome sequence for the brown hagfish Eptatretus atami. Combining evidence from syntenic and phylogenetic analyses, we establish a comprehensive picture of vertebrate genome evolution, including an auto-tetraploidization (1RV) that predates the early Cambrian cyclostome–gnathostome split, followed by a mid–late Cambrian allo-tetraploidization (2RJV) in gnathostomes and a prolonged Cambrian–Ordovician hexaploidization (2RCY) in cyclostomes. Subsequently, hagfishes underwent …

Axodetect: An Automated Nerve Image Segmentation And Quantification Workflow For Computational Nerve Modeling, David A Lloyd, Maria Alejandra Gonzalez-Gonzalez, Mario I Romero-Ortega

Faculty, Staff and Students Publications

Objective: Bioelectronic treatments targeting near-organ innervation have unprecedented clinical applications. Particularly in the spleen, the inhibition of the cholinergic inflammatory response by near-organ nerve stimulation has potential to replace pharmacological treatments in chronic and autoimmune diseases. A caveat is that the optimization of therapeutic stimulation parameters relies on in vivo experimentation, which becomes challenging due to the small nerve diameters (2 m), complex anatomy, and mixed axon type composition of the autonomic nerves. Effective development of in silico models requires tools which allow for fast and efficient quantification of axonal composition of specific nerves. Current approaches to generate such …

Attenuation Of Polycyclic Aromatic Hydrocarbon (Pah)-Induced Carcinogenesis And Tumorigenesis By Omega-3 Fatty Acids In Mice In Vivo, Guobin Xia, Guodong Zhou, Weiwu Jiang, Chun Chu, Lihua Wang, Bhagavatula Moorthy

Faculty, Staff and Students Publications

Lung cancer is the leading cause of cancer death worldwide. Polycyclic aromatic hydrocarbons (PAHs) are metabolized by the cytochrome P450 (CYP)1A and 1B1 to DNA-reactive metabolites, which could lead to mutations in critical genes, eventually resulting in cancer. Omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are beneficial against cancers. In this investigation, we elucidated the mechanisms by which omega-3 fatty acids EPA and DHA will attenuate PAH-DNA adducts and lung carcinogenesis and tumorigenesis mediated by the PAHs BP and MC. Adult wild-type (WT) (A/J) mice, Cyp1a1-null, Cyp1a2-null, or Cyp1b1-null mice were exposed …

Drug Modification Of Synaptic Plasticity At The Inhibitory Synapses Involving Gaba Neurons In The Ventral Tegmental Area, Jie Wu

Theses and Dissertations

The neurobiological underpinnings of substance use disorders (SUDs) involve complex alterations in synaptic plasticity within the mesolimbic dopamine system, particularly within the ventral tegmental area (VTA). While dopamine neurons in the VTA are extensively studied in addiction research, less attention has been given to the plasticity exhibited by VTA GABAergic neurons, despite their established regulatory role in modulating dopamine cell activity. Building upon the ground-breaking work of Bocklisch et al. (2013), we investigated the plasticity at the GABAergic to VTA GABA neuron (VTA GABA-to-GABA) synapse utilizing whole-cell electrophysiology in GAD67 GFP knock-in mice. Our findings revealed an exceptionally rare duo-plasticity …

Review Of The Potential Use Of Poly (Lactic-Co-Glycolic Acid) As Scaffolds In Bone Tissue Recovery, Kushendarsyah Saptaji, Asriyanti Asriyanti, Nisa Khoiriyah, Laely Muryanti, Iwan Setiawan

Makara Journal of Science

Scaffolds are used as temporary tissue in the human body to expedite healing. Biocompatible materials play a vital role in the field of tissue engineering. Therefore, they can be used to reduce human pain as soon as possible. Polymeric materials are widely used to replicate bone tissue. Poly(lactic-co-glycolic acid) (PLGA) is a potential material for bone tissue scaffolds because of its superior properties, including compatibility with the human body. Accordingly, adding hydroxyapatite and introducing different fabrication methods can enable the production of PLGA scaffolds with good abilities to help cells grow, expand, differentiate, and proliferate. The paper reviews the current …

A Review On The Role Of Tomatoes In Pakistan's Agricultural Economy: Challenges And Strategies For White Fly (Bemisa Tabaci: Hemiptera) Management, Muhammad Wahid Khan, Zahid Hussain, Shahid Sattar, Fazal Maula

Journal of Bioresource Management

The largest sector of Pakistan's economy is agriculture. Tomatoes, considered both vegetables and fruits, are an essential part of the daily diet for people in the economy class as well as those with limited means, with per capita food consumption of 8.00 kg recorded in Pakistan. Tomatoes are a rich source of essential nutrients such as Vitamin C, A, and Iron, and naturally contain Lycopene, known for its antioxidant properties that can help prevent cancer. In Pakistan, tomato crops yield approximately 40 kg per acre, which is below the world average of 4.00 tons per acre. The Pakistan renowned tomato …

Synthesis, Molecular Characteristics, And Antibacterial Assessment Of Marine Hydroid Aqueous Extract-Based Silver Bio-Nanoparticles, Fredryk Mandey, Aulia Rhamdani Arfan, Rugaiyah Andi Arfah

Makara Journal of Science

This investigation aims to synthesize, analyze the molecularity, and test the ability of bacterial inhibition capability of silver nanoparticles that have been synthesized by simply mixing silver nitrate and aqueous extracts of marine natural products with and without the addition of amylum as a stabilizing agent. This research, with and without the addition of amylum as a stabilizing agent, obtained 39.0 and 55.2 mg of solids of round-shaped morphology silver nanoparticles with diameters of 87.9 and 103.0 nm., respectively. In addition, the antibacterial testing assay against Staphylococcus aureus and Escherichia coli showed some considerably good results. S. aureus with the …

Faculty Senate Agenda, Georgia Southern University, Faculty Senate

Faculty Senate Agendas

No abstract provided.

Embracing Cancer Complexity: Hallmarks Of Systemic Disease, Charles Swanton, Elsa Bernard, Chris Abbosh, Fabrice André, Johan Auwerx, Allan Balmain, Dafna Bar-Sagi, René Bernards, Susan Bullman, James Degregori, Catherine Elliott, Ayelet Erez, Gerard Evan, Mark A Febbraio, Andrés Hidalgo, Mariam Jamal-Hanjani, Johanna A Joyce, Matthew Kaiser, Katja Lamia, Jason W Locasale, Sherene Loi, Ilaria Malanchi, Miriam Merad, Kathryn Musgrave, Ketan J Patel, Sergio Quezada, Jennifer A Wargo, Ashani Weeraratna, Eileen White, Frank Winkler, John N Wood, Karen H Vousden, Douglas Hanahan

Faculty, Staff and Student Publications

The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifestations and the underlying causes of cancer-related death remains incomplete. Looking forward, elucidating how tumors interact with distant organs and how multifaceted environmental and physiological parameters impinge on tumors and their hosts will be crucial for advances in preventing and more effectively treating human cancers. In this perspective, we discuss complexities of cancer as a systemic disease, including tumor initiation and promotion, tumor micro- and immune macro-environments, aging, metabolism …

Assessment Of The Genotoxic Effect Of Pesticide (Profenophos And Cypermethrin) On Allium Cepa L. Through Comet Assay, Ali Hasnian, Muhammad Rizwan, Hamed Dadkhah-Aghdash ., Zahid Mehmood, Ayesha Iqbal, Zarbab Zulfiqar, Bin Yameen, Hafiz Naveed Anjum, Sohaib Muhammad, Muhammad Luqman, Andleeb Anwar Sardar, Muhammad Umer Farooq

Journal of Bioresource Management

Pesticides are specially designed to control pests and help in increasing the yield of crops. This study aims to investigate the genotoxic effect of the major ingredients of commonly used pesticides (Profenophos and Cypermethrin) on Allium cepa L. in different regions of the province of Punjab, Pakistan. Profenophos and Cypermethrin pesticides are extensively used by local farmers. Six different dilutions of Profenophos and Cypermethrin pesticide ranging from, 0.5 ml/L, 1 ml/L, 1.5 ml/L, 2 ml/L, 2.5 ml/L and 3.0 ml/L were applied initially on seeds germination. Seeds grown in a 3.0 ml/L concentration showed a lower radical length percentage as …

Unlocking The Promise Of The ″Miracle Tree: A Review On Therapeutic Applications And Phytochemistry Of Moringa Oleifera L., Ali Zeeshan, Mubashrah Munir, Sehrish Sadia

Journal of Bioresource Management

Moringa oleifera, commonly known as the "miracle tree", has been used for centuries in traditional medicine and has recently garnered interest from the scientific community for its therapeutic potential. This review summarizes the current knowledge on the phytochemistry, nutritional composition, and medicinal properties of different parts of M. oleifera. The leaves, pods, bark, roots, seeds, and flowers contain various essential nutrients like vitamins, minerals, amino acids, antioxidants, and phytochemicals such as flavonoids, glucosinolates, and phenolic acids. These bioactive compounds confer anti-diabetic, anti-cancer, cardioprotective, anti-inflammatory, antimicrobial, immunomodulatory, anti-venom, and wound healing properties. Extracts and isolates from M. oleifera have shown …

Open Notes In Psychotherapy: An Exploratory Mixed Methods Survey Of Psychotherapy Students In Switzerland, Anna Kharko, Sarah Buergler, Annika Bärkås, Maria Hägglund, Jens Gaab, Asbjørn Johansen Fagerlund, Cosima Locher, Charlotte Blease

School of Psychology

Background: In a growing number of countries, patients are offered access to their full online clinical records, including the narrative reports written by clinicians (the latter, referred to as “open notes”). Even in countries with mature patient online record access, access to psychotherapy notes is not mandatory. To date, no research has explored the views of psychotherapy trainees about open notes. Objective: This study aimed to explore the opinions of psychotherapy trainees in Switzerland about patients’ access to psychotherapists’ free-text summaries. Methods: We administered a web-based mixed methods survey to 201 psychotherapy trainees to explore their familiarity with and opinions …

Comparative Lipidome Study Of Maternal Plasma, Milk, And Lamb Plasma In Sheep, Soundara Viveka Thangaraj, Adel Ghnenis, Brooke Pallas, Arpita Kalla Vyas, Brigid Gregg, Vasantha Padmanabhan

2020-Current year OA Pubs

Lipids play a critical role in neonate development and breastmilk is the newborn's major source of lipids. Milk lipids directly influence the neonate plasma lipid profile. The milk lipidome is dynamic, influenced by maternal factors and related to the maternal plasma lipidome. The close inter-relationship between the maternal plasma, milk and neonate plasma lipidomes is critical to understanding maternal-child health and nutrition. In this exploratory study, lipidomes of blood and breast milk from Suffolk sheep and matched lamb blood (n = 13), were profiled on day 34 post birth by untargeted mass spectrometry. Comparative multivariate analysis of the three matrices …

Role Of Trpv6 In Mitigating Alcohol-Induced Disruption Of Tight Junctions, Barrier Function, And Hepatic Injury, Avtar S. Meena, Radhakrishna K. Rao

Research Symposium

Background: Persistent alcohol consumption is widely recognized as a precursor to alcoholic liver disease. However, the intriguing observation persists that only a minority, approximately 20%, of individuals with alcohol use disorder succumb to this liver ailment. The factors contributing to this variability remain elusive. Studies indicate that individuals with alcoholic liver disease exhibit endotoxemia, with endotoxins primarily originating from colonic microflora. Moreover, these patients manifest disruptions in epithelial tight junctions, leading to compromised barrier function in the gastrointestinal tract. In this context, the transient receptor vanilloid receptor 6 (TRPV6) emerges as a crucial regulator of calcium absorption and transport, particularly …

Evaluation Of Vascular Aging On Measures Of Cardiac Function And Mechanical Efficiency: Insights From, Lawrence J Mulligan, Julian Thrash, Ludmil Mitrev, Douglas Folk, Alyssa Exarchakis, Daniel Ewert, Jeffrey C Hill

Cooper Medical School of Rowan University Departmental Research

INTRODUCTION: This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct.

METHODS: A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases. In phase I, the CM included five settings of aortic compliance (CA) from normal to stiff, studied at a heart rate of 80 bpm, and phase II included the normal to stiff CA settings evaluated at 60, 100, and 140 bpm. The PV construct provided steady-state and transient data through a simulated vena caval occlusion (VCO). …

Nonpharmacologic Rate Control Of Postoperative Atrial Fibrillation In The Canine Sterile Pericarditis Model, Seungyup Lee, Don Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita, Gregory Rushing, Jayakumar Sahadevan

Faculty Scholarship

Introduction: Postoperative atrial fibrillation (POAF) is common following open heart surgery, and is associated with significant morbidity. Medications used for ventricular rate control of POAF may not be effective in controlling rapid ventricular rates during the postoperative period because of increased sympathetic tone. The purpose of this study was to develop nonpharmacologic rate control of POAF by atrioventricular node (AVN) fat pad stimulation using clinically available temporary pacing wires in the canine sterile pericarditis model. Methods: We studied 10 sterile pericarditis dogs in the closed-chest state on postoperative days 1−3. The AVN fat pad stimulation (amplitude 2–15 mA; frequency 20 …