Digital Commons Network^™

Neurotensin Modulates Ovarian Vascular Permeability Via Adherens Junctions, Andrew Pearson, Ketan Shrestha, Thomas E. Curry, Diane M. Duffy

UK CARES Faculty Publications

Neurotensin (NTS) is a 13-amino acid peptide which is highly expressed in the mammalian ovary in response to the luteinizing hormone surge. Antibody neutralization of NTS in the ovulatory follicle of the cynomolgus macaque impairs ovulation and induces follicular vascular dysregulation, with excessive pooling of red blood cells in the follicle antrum. We hypothesize that NTS is an essential intrafollicular regulator of vascular permeability. In the present study, follicle injection of the NTS receptor antagonist SR142948 also resulted in vascular dysregulation. To measure vascular permeability changes in vitro, primary macaque ovarian microvascular endothelial cells (mOMECs) were enriched from follicle aspirates …

The Diverse Musical Traditions Of Appalachian Folk Music, Brooks M. Kidd

Honors Theses

Appalachian folk music has a rich heritage, although society has the misconception that Appalachian music is uncultured and closed off. To the contrary, the folk music of Appalachia has been directly linked to the music traditions of Ireland, Scotland, England, Africa, Germany, Spain, and Italy. The migration of people from other countries to Appalachia has been attributed to significant historical events such as the signing of the Treaty of Paris and the African Slave Trade. These migrants brought with them their musical traditions, which influenced the music of people living in the Appalachian region. These musical influences come in different …

Paradox Lost: Wide Gape In The Ordovician Brachiopod Rafinesquina Explains How Unattached Filter-Feeding Strophomenoids Thrived On Muddy Substrates, Benjamin F. Dattilo, Rebecca L. Freeman, Kyle Hartshorn, David Peterman, Aaron Morse, David L. Meyer, Lindsay G. Dougan, James W. Hagadorn

Earth and Environmental Sciences Faculty Publications

Strophomenoid brachiopods had thin, concavo-convex shells, were ubiquitous colonizers of Palaeozoic muddy seafloors, and are hypothesized to have filter-fed in a concave-upward orientation. This orientation would elevate their line of commissure out of potentially lethal lophophore-clogging mud. The paradox is that epi- biont distributions on strophomenoids support a convex-upward life position, as do studies of strophome- noid stability and trace fossils formed by strophomenoid sediment-clearing. A premise of the concave-upward orientation hypothesis is a narrow gape, which causes narrow, high velocity inhalant currents, leaving strophomenoids vul- nerable to sediment entrainment. Herein we investigate the gape angle of Rafinesquina using serial …

Contributions Of Mouse Genetic Strain Background To Age-Related Phenotypes In Physically Active Het3 Mice., Jake W Willows, Zahra Alshahal, Naeemah M Story, Michele J Alves, Pablo Vidal, Hallie Harris, Rochelle Rodrigo, Kristin I Stanford, Juan Peng, Peter C. Reifsnyder, David E Harrison, W David Arnold, Kristy L Townsend

Faculty Research 2024

We assessed aging hallmarks in skin, muscle, and adipose in the genetically diverse HET3 mouse, and generated a broad dataset comparing these to individual animal diagnostic SNPs from the 4 founding inbred strains of the HET3 line. For middle- and old-aged HET3 mice, we provided running wheel exercise to ensure our observations were not purely representative of sedentary animals, but age-related phenotypes were not improved with running wheel activity. Adipose tissue fibrosis, peripheral neuropathy, and loss of neuromuscular junction integrity were consistent phenotypes in older-aged HET3 mice regardless of physical activity, but aspects of these phenotypes were moderated by the …

Network-Based Analysis Predicts Interacting Genetic Modifiers From A Meta-Mapping Study Of Spike-Wave Discharge In Mice., Montana Kay Lara, Jeffrey L Brabec, Amanda E Hernan, Rod C Scott, Anna L. Tyler, J Matthew Mahoney

Faculty Research 2024

Absence seizures are characterized by brief lapses in awareness accompanied by a hallmark spike-and-wave discharge (SWD) electroencephalographic pattern and are common to genetic generalized epilepsies (GGEs). While numerous genes have been associated with increased risk, including some Mendelian forms with a single causal allele, most cases of GGE are idiopathic and there are many unknown genetic modi- fiers of GGE influencing risk and severity. In a previous meta-mapping study, crosses between transgenic C57BL/6 and C3HeB/FeJ strains, each carrying one of three SWD-causing mutations (Gabrg2 tm1Spet(R43Q), Scn8a8j or Gria4spkw1), demonstrated an antagonistic epistatic interaction between loci on mouse chromosomes 2 and …

Genetic Diversity Promotes Resilience In A Mouse Model Of Alzheimer's Disease., Neelakshi Soni, Lindsay A Hohsfield, Kristine M Tran, Shimako Kawauchi, Amber Walker, Dominic Javonillo, Jimmy Phan, Dina Matheos, Celia Da Cunha, Asli Uyar, Giedre Milinkeviciute, Angela Gomez-Arboledas, Katelynn Tran, Catherine C Kaczorowski, Marcelo A Wood, Andrea J Tenner, Frank M Laferla, Gregory W. Carter, Ali Mortazavi, Vivek Swarup, Grant R Macgregor, Kim N Green

Faculty Research 2024

INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder with multifactorial etiology, including genetic factors that play a significant role in disease risk and resilience. However, the role of genetic diversity in preclinical AD studies has received limited attention.

METHODS: We crossed five Collaborative Cross strains with 5xFAD C57BL/6J female mice to generate F1 mice with and without the 5xFAD transgene. Amyloid plaque pathology, microglial and astrocytic responses, neurofilament light chain levels, and gene expression were assessed at various ages.

RESULTS: Genetic diversity significantly impacts AD-related pathology. Hybrid strains showed resistance to amyloid plaque formation and neuronal damage. Transcriptome diversity was …

Unraveling The Genetics Of Arsenic Toxicity With Cellular Morphology Qtl., Callan O'Connor, Gregory R Keele, Whitney Martin, Tim J Stodola, Daniel M Gatti, Brian Hoffmann, Ron Korstanje, Gary Churchill, Laura G Reinholdt

Faculty Research 2024

The health risks that arise from environmental exposures vary widely within and across human populations, and these differences are largely determined by genetic variation and gene-by-environment (gene-environment) interactions. However, risk assessment in laboratory mice typically involves isogenic strains and therefore, does not account for these known genetic effects. In this context, genetically heterogenous cell lines from laboratory mice are promising tools for population-based screening because they provide a way to introduce genetic variation in risk assessment without increasing animal use. Cell lines from genetic reference populations of laboratory mice offer genetic diversity, power for genetic mapping, and potentially, predictive value …

Animal Plaintiffs, Matthew Liebman

Minnesota Law Review Vols. 106:2 onward (2021-present)

From endangered Hawaiian songbirds to dolphins deafened by Navy sonar to a neglected horse named Justice, nonhuman animals increasingly appear as plaintiffs in lawsuits alleging their subjection to extinction, abuse, and other injustices. These cases are far more than mere novelties or publicity stunts; they raise important jurisprudential questions about what it means to be a plaintiff seeking relief. As we learn more about the richness and diversity of nonhuman life, our legal system will have to rethink its exclusions to meet the demands of interspecies justice. Drawing on a diverse body of philosophical, jurisprudential, and scientific scholarship, this Article …

Escalating Political Violence And The Intersectional Impacts On Latinas In National Politics, Anna Sampaio

Ethnic Studies

Drawing on interviews with Latina congressional members and candidates, this article examines the impacts of escalating political violence on their professional lives and political careers, as well as the implications for the growing body of women of color who are engaging in public service at the national level.

Loose Purse Strings, Loose Cultures: How Resource Increase Affects Cultural Tightness-Looseness And Creativity In Large And Small Organizations, Caleb Chun Kwan Chu

Dissertations and Theses Collection (Open Access)

For over a decade, cultural tightness-looseness (TL) has established itself as a culture construct that is useful in diverse contexts at multiple levels. While most TL research has focused on TL consequences, less attention has been paid to TL antecedents. This dissertation proposes resource increase as a TL predictor and uses a resource-based perspective to review and extend extant TL literature. I empirically examine the effect of resource increase on incremental and radical creativity as mediated by TL at the team level. I also explore the moderating effect of organizational size on these team-level relationships. The data were drawn from …

In Vivo Tissue Distribution Of Polystyrene Or Mixed Polymer Microspheres And Metabolomic Analysis After Oral Exposure In Mice, Marcus M. Garcia, Aaron S. Romero, Seth D. Merkley, Jewel L. Meyer-Hagen, Charles Forbes, Eliane El Hayek, David P. Sciezka, Rachel Templeton, Jorge Gonzalez-Estrella, Yan Jin, Haiwei Gu, Angelica Benavidez, Russell P. Hunter, Selita Lucas, Guy Herbert, Kyle Joohyung Kim, Julia Yue Cui, Rama R. Gullapalli, Julie G. In, Matthew J. Campen, Eliseo F. Castillo

Pathology Research and Scholarship

BACKGROUND: Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals and humans. A growing body of evidence indicates that MPs can cross the gut barrier and enter into the lymphatic and systemic circulation leading to accumulation in tissues such as the lungs, liver, kidney, and brain. The impacts of mixed MPs exposure on …

Mixed Salad, Jacob Zamora

The Chanterelle

No abstract provided.

I Agree With Da Vinci, Karla Rodriguez

The Chanterelle

No abstract provided.

Impacts Of Cannabis Cultivation In Humboldt County, Ramona Sever

The Chanterelle

No abstract provided.

The Truth Of Industrial Agriculture, Nathaniel Worley

The Chanterelle

No abstract provided.

Robert Lande And The Real, New Antitrust Paradox, Joshua P. Davis, Jessica Seigel, Charles Hill

University of Baltimore Law Review

No abstract provided.

Private Law As Morality: A Critique Of Peter M. Gerhart’S Contract Law And Social Morality, P.T. Babie, Claire Williams, Jessica Viven-Wilksch, James Gilchrist Stewart

Missouri Law Review

This review essay offers a constructive critique of Peter M. Gerhart’s Contract Law and Social Morality (‘CLSM’); it examines, in a very preliminary way, whether humans—parties to contractual negotiation—ever behave in other-regarding, or altruistic, ways. The essay does this through three explorations or investigations. The first considers other-regarding behavior, or altruism, from a scientific perspective: is it possible that humans ever act out of concern for others? Second, it considers CLSM using ideas of altruism found in an eclectically selective use of philosophy. Third, it investigates the concept of the other-regarding person in relation to contract law itself which, of …

Understanding University Support For Suicide Bereavement And Bereaved Experiences: A Phenomenological Study, Kristin May Anderson, Neishamia B. Kayizzi, Brittany M. Lee, Addalee K. Lyon

LMU Theses and Dissertations

In recent years, a multitude of literature have discussed the turbulent nature for young adults to navigate the difficulties of suicide bereavement with lack of support. This experience can be further cumbersome when the bereavement is co-occurring within an academic profession, such as attending university. This study explored three participants experience of suicide bereavement support at a university level, utilizing a phenomenological arts-based approach for inquiry. Data analysis revealed eight common themes that reflect the university students' lived experiences of the phenomenon discussed: Acknowledgment of the communicated loss by faculty, provision of academic support, lack/absence of practice, reluctance, emotional response, …

Admissions Magazine Spring 2024, Embry-Riddle Aeronautical University

Admissions Magazine

Altitude: Students Take A Giant Leap Forward

• Science That Works
• Education At A Higher Altitude: At Embry-Riddle Aeronautical University, Daring to Think Big and Push Boundaries Is A Way Of Life
• A Crash Course In Safety
• The Perfect Fit
• Seizing the Moment
• Broadened Perspectives
• The Perfect Bond
• Don't Let the Bed Bugs Bite
• A Well-Balanced Education
• Mechanical Engineering Major Looks to Make Environmental Impact
• Molecular Level Science
• Not An Optical Illusion
• Asia Campus Lab Advances Uncrewed Systems Training
• A Giant Leap Forward
• Getting His Hands on the Future
• An Additive Experience
• Space Launch System
• The M-Star Program
• A Giant Leap …

Joint Environmental And Social Benefits From Diversified Agriculture, Laura Vang Rasmussen, Ingo Grass

Earth and Environmental Sciences Faculty Publications

Agricultural simplification continues to expand at the expense of more diverse forms of agriculture. This simplification, for example, in the form of intensively managed monocultures, poses a risk to keeping the world within safe and just Earth system boundaries. Here, we estimated how agricultural diversification simultaneously affects social and environmental outcomes. Drawing from 24 studies in 11 countries across 2655 farms, we show how five diversification strategies focusing on livestock, crops, soils, noncrop plantings, and water conservation benefit social (e.g., human well-being, yields, and food security) and environmental (e.g., biodiversity, ecosystem services, and reduced environmental externalities) outcomes. We found that …

Unearthing The Past: A Comprehensive Study Of Natural And Anthropogenic Changes At An Archaeological Site Through Hydrogeologic Connectivity Utilizing Gis, Mehlich Ii Phosphorus Extractant, And Ph, Dana L. F. Herren

Theses

This thesis aims to thoroughly analyze the Mehlich II Phosphorus Extractant and pH levels at the Bains Gap Village Site in Anniston, AL., while examining the impact of various environmental factors and human activities on them. Phosphorus is often used in archaeology as an indicator of human activity. Soil core samples were collected to analyze anomalies in phosphorus levels.

To establish any relationships, phosphorus and pH levels from soil cores were correlated with findings from past excavation units and features. The potential effects of hydrogeologic connectivity on soil phosphorus and pH levels were investigated. Geospatial technologies were used to manage …

The Interaction Of Sodium Fluoride And Sodium Selenate On The Developmental Toxicity To Xenopus Laevis And Ambystoma Maculatum Embryos, Shelby Wolfram

Theses

Amphibians play critical roles in the environment's wellness. Fluoride (F) is a widely existing environmental pollutant. It is commonly known for being added to drinking water and as a topical dose on teeth. Selenium (Se) can be found in organic and inorganic forms in nature. Many different fertilizers, pesticides, insecticides, and fungicides contain sodium selenate in them. The range selenium has between deficiency and toxicity is narrow, meaning excess exposure could cause various adverse effects in aquatic organisms. Xenopus laevis is a standard model for developmental toxicity due to being minimal maintenance, cost efficient, and having transparent embryos. Xenopus makes …

Exploring The Potential Pathogenicity Of A Type 2 Diabetes Mellitus Associated Insr Missense Variant Of Uncertain Significance Through Daf-2 In The Caenorhabditis Elegans Model, Brittany White

Theses

Type 2 diabetes mellitus (T2DM) is hallmarked by insulin resistance, with the INSR gene identified as a key player in this condition in humans. This gene is known to harbor genetic variants with a wide range of clinical significance from pathogenic to variants of uncertain significance (VUS) to benign. This project investigates a VUS associated with T2DM identified through ClinVar. A gene mutational analysis, predictive amino acid substitution analysis, and protein modeling predict INSR c.1628C>T (p. Thr543Met) to be likely pathogenic or damaging. PolyPhen-2 predicts this variant to be probably damaging (HumDiv score of 1.000).

Evolutionary conservation of the …

Genetic Analysis Of Hereditary Gingival Fibromatosis Associated Sos1 Missense Variants Of Uncertain Significance In Caenorhabditis Elegans, Himani Patel

Theses

Hereditary gingival fibromatosis (HGF) is a disease that can present as benign overgrowth of gingival tissue in the mouth. The overgrowth can enclose the entire mouth and teeth in severe cases or present itself in a concentrated area. Researchers have identified that mutations in the SOS1 gene can be responsible for HGF. This disease can impair basic functions related to the mouth. Eating, smiling, speaking can all be affected. Additionally, excess inflammation can cause periodontal disease because of the difficulty in maintaining proper oral health. Periodontal disease can lead to severe bone loss which can lead to complete loss of …

Animal Biographies: Measuring The Efficacy Of Empathy Adjacent Language, Mackenzie R. Bennett

Boise State Graduate Student Projects

With the guidance of a 2019 briefing document from the Seattle Aquarium, Zoo Boise created a new type of exhibit signage meant to encourage personal connection with its animals and empathetic engagement that will hopefully translate to more concern for wildlife conservation in zoo visitors. This new signage provides personal information, such as names, birth dates, and life histories, on the individual animals at Zoo Boise. This is in contrast with traditional zoo exhibit signage, which lists impersonal, species-level information alone. In order to test the efficacy of the new signage in eliciting empathetic engagement, we conducted a comparative study …

A Guide For The Breeding Of The Blue Death Feigning Beetle, Joe Maloney

Department of Entomology: Distance Master of Science Projects

Purpose

Asbolus verrucosus, often referred to as the Blue Death Feigning beetle (BDFB) is a species commonly exhibited by zoos, museums, and private individuals due to its beautiful blue color, long life, and fascinating death-feigning behavior. Despite being a very popular species, it is difficult to find specific information regarding breeding requirements and larval care. This is largely due to relatively little being known about the various stages of the BDFB life cycle. My intention in doing this project was to document verified information about the BDFB life cycle from reputable sources and use that information to develop a …

Gsl Researcher (Spring 2024)

GSL Researcher

GSL Researcher (Spring 2024)

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Publications and news

Walking The Tightrope: Protecting Research From Foreign Exploitation While Fostering Relationships With Foreign Scientists, C. John Cox

SLU Law Journal Online

In response to extensive foreign efforts to take advantage of U.S. scientific research, especially by the People’s Republic of China, the United States has taken steps to protect its scientific and technology efforts. Although steps to prevent foreign government exploitation of U.S. research are reasonable and justified, the United States should be cognizant of these actions' impact on collaboration with foreign scientists. It is in the interest of the United States to effect policy that fosters relationships with foreign scientists rather than push them away.

Predicting Biomolecular Properties And Interactions Using Numerical, Statistical And Machine Learning Methods, Elyssa Sliheet

Mathematics Theses and Dissertations

We investigate machine learning and electrostatic methods to predict biophysical properties of proteins, such as solvation energy and protein ligand binding affinity, for the purpose of drug discovery/development. We focus on the Poisson-Boltzmann model and various high performance computing considerations such as parallelization schemes.

Effects Of Global Experiences For The Undergraduate Student, Patricia K. Adams

PhD in Education

The purpose of this non-experimental quantitative study was to determine the effect global experiences have on undergraduate students’ self-confidence, cultural awareness, and career choice. The research took place at a single research site, a private, faith-based university in the Southeastern United States. Students who had participated in a global experience, such as a mission trip or a study abroad experience, were invited to complete the researcher-created survey, the Global Experience Exit Survey. The data from 59 undergraduate students was analyzed using SPSS, specifically one sample t-tests. The results indicated statistically significant findings for all three subconstructs. The findings show that …