Digital Commons Network^™

Kate 2024: Manifestos, Gracie Barton, Ava Borromeo, Isabel Elliot, A First, Grace Francis, Paula Garcia, Jessie Gourley, Isaac Jones, Taylor Miller, Breanna Mccluskey, Madison Newman, Wes Phillips, Sage Reliford, Jules Richter, Lukas Rhynard, Charlie Ryan, Abi Sinclair, Karina Streeter, Julia Tenbusch, Elizabeth White, Audra Wilson, Harper Wood, Marlo Young

Kate

Each year, Kate seeks to:

• explore ideas about normative gender, sex, and sexuality
• work against oppression and hierarchies of power in any and all forms
• serve as a voice for race and gender equity as well as queer positivity
• encourage the silent to speak and feel less afraid
• build a zine and community that we care about and trust

Reinventing The Silver Screen… Again: The Copyright Licensing Implications Of Using Video Game Technology For Virtual Production On Film And Tv Sets, Nicholas M. Medellin

UC Law SF Communications and Entertainment Journal

No abstract provided.

The Family History Of Greta A. Leader, Greta Leader

Your Family in History: HIST 550/700

Greta Anne Leader authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Spring 2024 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]

Crisis Support Through Policies For Medical Professionals In 2020 And 2021 During The Covid-19 Pandemic, Malik James Fonville-Simmons

Walden Dissertations and Doctoral Studies

No abstract provided.

Annual Research Showcase Program, St. Mary's University

Program - 2024

This program lists events, descriptions and presenters for the 3rd annual Research Showcase. The theme for this year was "Adaptation and Change in the Age of Artificial Intelligence".

Legislating Morality In The Gilded Age And Progressive Era: Moral Panic And The “White Slave” Case That Changed America, Nancy C. Unger

History

This article is based on the presidential address presented to the Society for Historians of the Gilded Age and Progressive Era at the meeting of the Organization of American Historians in Los Angeles in 2023. Its focus is Maury Diggs and Drew Caminetti, two white men from Sacramento, California, charged with violating the Mann Act (known as the White Slave Trafficking Act) in 1913. The Gilded Age and Progressive Era obsession with white slavery, a phenomenon that has particular resonance in today’s climate, reveals the power of moral panics. Examining the steps, and missteps, that various legal, social, and political …

Investigating The Role Of Dna Interval V375 In Spore Killing By Neurospora Crassa Sk-3, Michael Marcheschi

Senior Theses – Biological Sciences

Meiotic drive elements, sometimes called selfish genes, are genetic elements that are passed on to their offspring more favorably than other genes. Meiotic drive elements have been observed in many organisms, including fungi of the Neurospora genus. Three different meiotic drive elements, called Spore killers, have been identified in Neurospora fungi. One of these Spore killers is called Spore killer 3 (Sk-3), and the molecular mechanism by which Sk-3 acts as a meiotic drive element is poorly understood. Previous work has identified a genetic locus within Sk-3 that may control spore killing. In this thesis, I investigate an …

Studying A Spore Killing Gene In Neurospora Crassa, Jalen Lee

Senior Theses – Biological Sciences

Some isolates of the fungus Neurospora crassa possess a chromosomal factor that causes spore killing, leading to death of ascospores. It has been shown that these chromosomal factors are genetic elements called spore killers. For example, if a cross is performed between a parent with an Sk-S (sensitive) allele and a parent with an Sk-K (killer) allele, the cross will produce half viable offspring and half inviable offspring, where the inviable half has been killed by spore killing. This phenomenon can be explained by meiotic drive, wherein a selfish gene disrupts the randomness of sexual transmission, favoring its own success. …

The Analysis Of Notch3 Gene Variants In Cadasil​, Elaine Vanterpool, Raynon Andrews

Student Posters

No abstract provided.

Elucidating The Role Of Protease-Activated Receptor 2 In Elastase-Induced Abdominal Aortic Aneurysms, John Pitstick

Senior Theses

Cardiovascular diseases (CVDs) remain the leading cause of mortality in the world despite extensive research. As a type of CVD, abdominal aortic aneurysm (AAA) represents a critical medical condition characterized by the localized dilation of the abdominal aorta. Complications from aneurysm development results in catastrophic aortic rupture, which leads to mortality more than 80% of the time. As aneurysm development is typically asymptomatic, many AAAs remain untreated until they present a serious risk of rupture. Additionally, no pharmaceutical treatment exists for AAAs, with the only option being surgical intervention. Despite advancements in diagnostic methods and surgical techniques, the pathogenesis of …

‘Kazakh Means Freedom’ - Kazakh Language Policy And National Identity Before And During The Ukraine War, Mclean T. Brown

Senior Theses

This thesis examines the link between language policy and national identity in Kazakhstan, tracing the relationship between the two across history and describing how they have been affected by the Ukraine War. The Kazakh government has put considerable effort into developing a national identity for contemporary Kazakhstan, but conflicting standards of production make it difficult for a cohesive, well-defined Kazakh national identity to be put forth. Through qualitative and quantitative analyses, phenomenological critical discourse analysis, and ethnographic research, this thesis strives to alleviate existing gaps in Central Asian studies research while arguing that language policy is a lens through which …

Lyraquist: Language Learning Via Music App, Vivian D'Souza, Siri Avula, Mahi Patel, Tanvi Singh, Ashley Bickham

Senior Theses

Lyraquist is a new language learning mobile app that encourages the practice of a foreign language through music. Language learners can connect their Spotify Premium account to Lyraquist to listen to music in their target languages and utilize tools such as translation and vocabulary lists to facilitate language practice. Through integration with Spotify, users can import and create Spotify playlists and search the service’s entire catalog. By combining daily listening habits with several tasks associated with language learning in one place, Lyraquist hopes to be a useful language learning tool.

An Antidote To The Necropolitical Path Of Logic: Ice Pick Lodge's Pathologic Classic Hd, Rose Branton

Senior Theses

Much of the existing scholarly literature on video games analyzed with Achille Mbembe’s Necropolitics (2019) focuses on games that replicate the destructive, dehumanizing logic that Mbembe discusses. These are typically games involving the zombie genre or war and conquest that do not challenge Amanda Phillips’s idea of mechropolitics, a further development of Mbembe’s idea that implicates video games specifically. Nor do they challenge the dehumanization and warrant limitless destruction of zombies in the zombie genre of video games. This thesis focuses on Pathologic Classic HD (2015) as an example of a video game that presents a challenge to the logic …

Focus Group And Survey Responses To Postural Feedback During Creative Movement Exploration, Mary C. Matthews

Senior Theses

John H. Riskind’s “appropriateness hypothesis” states that posture, positions, and gestures can be emotionally self-regulating if an individual holds a posture that is appropriate for its context. A litany of studies on power posing suggests expansive postures could increase Feelings of Power. One meta-analytic review demonstrates the “robust” significance for evidence of “power feelings, emotion, or self-esteem” due to postural feedback while cautioning researchers on the empirical invalidity of evidence for behavioral and physiological variables. A qualitative description of individuals’ experiences as they change posture, gesture, and position would direct future research on postural feedback. The current project qualitatively examines …

Trois Chansons De Bilitis And Estampes–The Symbolist Movement And The Works Of Claude Debussy, Emma J. Devine

Senior Theses

“Nothing is dearer than the grey song where the vague and the precise meet.” Paul Verlaine, “Art poétique”

This thesis compiles information from biographies of Claude Debussy and excerpts from performers, musicologists, music commentators, poets, and art historians, in an attempt to examine Debussy’s work through a well-rounded portrait of the artistic climate in France. This qualitative research thesis begins with a brief summary of Claude Debussy’s life, followed by a portrait of Paris at the turn of the twentieth century. The next section explores the birth of the intertwined movements of Symbolism and Impressionism, their similarities and differences, and …

Analysis Of The Sec63 Gene Variants In Polycystic Liver Disease​, Elaine Vanterpool, Megan Woods

Student Posters

No abstract provided.

Foreword, Deborah W. Denno, Erica Valencia-Graham

Fordham Law Review

This Foreword overviews an unprecedented Symposium on these wide ranging topics titled The New AI: The Legal and Ethical Implications of ChatGPT and Other Emerging Technologies. Hosted by the Fordham Law Review and cosponsored by Fordham University School of Law’s Neuroscience and Law Center on November 3, 2023, the Symposium brought together attorneys, judges, professors, and scientists to explore the opportunities and risks presented by AI, especially GenAI like ChatGPT. The discussion raised complex questions concerning AI sentience and personal privacy, as well as the future of legal ethics, education, and employment. Although the AI industry uniformly predicts ever more …

Of Another Mind: Ai And The Attachment Of Human Ethical Obligations, Katherine B. Forrest

Fordham Law Review

We are entering a new world. A world in which we humans will be confronted with our intellectual limitations as we watch the evolution of artificial intelligence (AI) that we have created meet and exceed our capabilities. I have a few predictions about this—based first on how technology changes occur, with a layer of how human nature reacts to those changes.

My first prediction is that we may not initially recognize AI’s actual capabilities. We will find ways of describing what AI can do as somehow mimicry—the advances of a stochastic parrot, perhaps; we will not want to recognize our …

Forage News [2024-04], University Of Kentucky

Forage News

No abstract provided.

Neurotensin Modulates Ovarian Vascular Permeability Via Adherens Junctions, Andrew Pearson, Ketan Shrestha, Thomas E. Curry, Diane M. Duffy

UK CARES Faculty Publications

Neurotensin (NTS) is a 13-amino acid peptide which is highly expressed in the mammalian ovary in response to the luteinizing hormone surge. Antibody neutralization of NTS in the ovulatory follicle of the cynomolgus macaque impairs ovulation and induces follicular vascular dysregulation, with excessive pooling of red blood cells in the follicle antrum. We hypothesize that NTS is an essential intrafollicular regulator of vascular permeability. In the present study, follicle injection of the NTS receptor antagonist SR142948 also resulted in vascular dysregulation. To measure vascular permeability changes in vitro, primary macaque ovarian microvascular endothelial cells (mOMECs) were enriched from follicle aspirates …

The Diverse Musical Traditions Of Appalachian Folk Music, Brooks M. Kidd

Honors Theses

Appalachian folk music has a rich heritage, although society has the misconception that Appalachian music is uncultured and closed off. To the contrary, the folk music of Appalachia has been directly linked to the music traditions of Ireland, Scotland, England, Africa, Germany, Spain, and Italy. The migration of people from other countries to Appalachia has been attributed to significant historical events such as the signing of the Treaty of Paris and the African Slave Trade. These migrants brought with them their musical traditions, which influenced the music of people living in the Appalachian region. These musical influences come in different …

Paradox Lost: Wide Gape In The Ordovician Brachiopod Rafinesquina Explains How Unattached Filter-Feeding Strophomenoids Thrived On Muddy Substrates, Benjamin F. Dattilo, Rebecca L. Freeman, Kyle Hartshorn, David Peterman, Aaron Morse, David L. Meyer, Lindsay G. Dougan, James W. Hagadorn

Earth and Environmental Sciences Faculty Publications

Strophomenoid brachiopods had thin, concavo-convex shells, were ubiquitous colonizers of Palaeozoic muddy seafloors, and are hypothesized to have filter-fed in a concave-upward orientation. This orientation would elevate their line of commissure out of potentially lethal lophophore-clogging mud. The paradox is that epi- biont distributions on strophomenoids support a convex-upward life position, as do studies of strophome- noid stability and trace fossils formed by strophomenoid sediment-clearing. A premise of the concave-upward orientation hypothesis is a narrow gape, which causes narrow, high velocity inhalant currents, leaving strophomenoids vul- nerable to sediment entrainment. Herein we investigate the gape angle of Rafinesquina using serial …

Contributions Of Mouse Genetic Strain Background To Age-Related Phenotypes In Physically Active Het3 Mice., Jake W Willows, Zahra Alshahal, Naeemah M Story, Michele J Alves, Pablo Vidal, Hallie Harris, Rochelle Rodrigo, Kristin I Stanford, Juan Peng, Peter C. Reifsnyder, David E Harrison, W David Arnold, Kristy L Townsend

Faculty Research 2024

We assessed aging hallmarks in skin, muscle, and adipose in the genetically diverse HET3 mouse, and generated a broad dataset comparing these to individual animal diagnostic SNPs from the 4 founding inbred strains of the HET3 line. For middle- and old-aged HET3 mice, we provided running wheel exercise to ensure our observations were not purely representative of sedentary animals, but age-related phenotypes were not improved with running wheel activity. Adipose tissue fibrosis, peripheral neuropathy, and loss of neuromuscular junction integrity were consistent phenotypes in older-aged HET3 mice regardless of physical activity, but aspects of these phenotypes were moderated by the …

Network-Based Analysis Predicts Interacting Genetic Modifiers From A Meta-Mapping Study Of Spike-Wave Discharge In Mice., Montana Kay Lara, Jeffrey L Brabec, Amanda E Hernan, Rod C Scott, Anna L. Tyler, J Matthew Mahoney

Faculty Research 2024

Absence seizures are characterized by brief lapses in awareness accompanied by a hallmark spike-and-wave discharge (SWD) electroencephalographic pattern and are common to genetic generalized epilepsies (GGEs). While numerous genes have been associated with increased risk, including some Mendelian forms with a single causal allele, most cases of GGE are idiopathic and there are many unknown genetic modi- fiers of GGE influencing risk and severity. In a previous meta-mapping study, crosses between transgenic C57BL/6 and C3HeB/FeJ strains, each carrying one of three SWD-causing mutations (Gabrg2 tm1Spet(R43Q), Scn8a8j or Gria4spkw1), demonstrated an antagonistic epistatic interaction between loci on mouse chromosomes 2 and …

Genetic Diversity Promotes Resilience In A Mouse Model Of Alzheimer's Disease., Neelakshi Soni, Lindsay A Hohsfield, Kristine M Tran, Shimako Kawauchi, Amber Walker, Dominic Javonillo, Jimmy Phan, Dina Matheos, Celia Da Cunha, Asli Uyar, Giedre Milinkeviciute, Angela Gomez-Arboledas, Katelynn Tran, Catherine C Kaczorowski, Marcelo A Wood, Andrea J Tenner, Frank M Laferla, Gregory W. Carter, Ali Mortazavi, Vivek Swarup, Grant R Macgregor, Kim N Green

Faculty Research 2024

INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder with multifactorial etiology, including genetic factors that play a significant role in disease risk and resilience. However, the role of genetic diversity in preclinical AD studies has received limited attention.

METHODS: We crossed five Collaborative Cross strains with 5xFAD C57BL/6J female mice to generate F1 mice with and without the 5xFAD transgene. Amyloid plaque pathology, microglial and astrocytic responses, neurofilament light chain levels, and gene expression were assessed at various ages.

RESULTS: Genetic diversity significantly impacts AD-related pathology. Hybrid strains showed resistance to amyloid plaque formation and neuronal damage. Transcriptome diversity was …

Unraveling The Genetics Of Arsenic Toxicity With Cellular Morphology Qtl., Callan O'Connor, Gregory R Keele, Whitney Martin, Tim J Stodola, Daniel M Gatti, Brian Hoffmann, Ron Korstanje, Gary Churchill, Laura G Reinholdt

Faculty Research 2024

The health risks that arise from environmental exposures vary widely within and across human populations, and these differences are largely determined by genetic variation and gene-by-environment (gene-environment) interactions. However, risk assessment in laboratory mice typically involves isogenic strains and therefore, does not account for these known genetic effects. In this context, genetically heterogenous cell lines from laboratory mice are promising tools for population-based screening because they provide a way to introduce genetic variation in risk assessment without increasing animal use. Cell lines from genetic reference populations of laboratory mice offer genetic diversity, power for genetic mapping, and potentially, predictive value …

Animal Plaintiffs, Matthew Liebman

Minnesota Law Review Vols. 106:2 onward (2021-present)

From endangered Hawaiian songbirds to dolphins deafened by Navy sonar to a neglected horse named Justice, nonhuman animals increasingly appear as plaintiffs in lawsuits alleging their subjection to extinction, abuse, and other injustices. These cases are far more than mere novelties or publicity stunts; they raise important jurisprudential questions about what it means to be a plaintiff seeking relief. As we learn more about the richness and diversity of nonhuman life, our legal system will have to rethink its exclusions to meet the demands of interspecies justice. Drawing on a diverse body of philosophical, jurisprudential, and scientific scholarship, this Article …

Escalating Political Violence And The Intersectional Impacts On Latinas In National Politics, Anna Sampaio

Ethnic Studies

Drawing on interviews with Latina congressional members and candidates, this article examines the impacts of escalating political violence on their professional lives and political careers, as well as the implications for the growing body of women of color who are engaging in public service at the national level.

Loose Purse Strings, Loose Cultures: How Resource Increase Affects Cultural Tightness-Looseness And Creativity In Large And Small Organizations, Caleb Chun Kwan Chu

Dissertations and Theses Collection (Open Access)

For over a decade, cultural tightness-looseness (TL) has established itself as a culture construct that is useful in diverse contexts at multiple levels. While most TL research has focused on TL consequences, less attention has been paid to TL antecedents. This dissertation proposes resource increase as a TL predictor and uses a resource-based perspective to review and extend extant TL literature. I empirically examine the effect of resource increase on incremental and radical creativity as mediated by TL at the team level. I also explore the moderating effect of organizational size on these team-level relationships. The data were drawn from …

In Vivo Tissue Distribution Of Polystyrene Or Mixed Polymer Microspheres And Metabolomic Analysis After Oral Exposure In Mice, Marcus M. Garcia, Aaron S. Romero, Seth D. Merkley, Jewel L. Meyer-Hagen, Charles Forbes, Eliane El Hayek, David P. Sciezka, Rachel Templeton, Jorge Gonzalez-Estrella, Yan Jin, Haiwei Gu, Angelica Benavidez, Russell P. Hunter, Selita Lucas, Guy Herbert, Kyle Joohyung Kim, Julia Yue Cui, Rama R. Gullapalli, Julie G. In, Matthew J. Campen, Eliseo F. Castillo

Pathology Research and Scholarship

BACKGROUND: Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals and humans. A growing body of evidence indicates that MPs can cross the gut barrier and enter into the lymphatic and systemic circulation leading to accumulation in tissues such as the lungs, liver, kidney, and brain. The impacts of mixed MPs exposure on …