Digital Commons Network^™

An Epigenetic Timer Regulates The Transition From Cell Division To Cell Expansion During Arabidopsis Petal Organogenesis, Ruirui Huang

Yale Graduate School of Arts and Sciences Dissertations

Epigenetic changes, such as histone modifications or DNA methylation, can modify gene expression without affecting the genetic code. Such alterations can persist for many cell generations, and often are induced by various environmental inputs in both plants and animals. A number of studies have demonstrated that epigenetic factors regulate plant developmental timing in response to environmental changes. However, we still have an incomplete view of how epigenetic factors can regulate developmental events such as organogenesis, and the transition from cell division to cell expansion, in plants. The small number of cell types and the relatively simple developmental progression required to …

Diverse Models Of Immunoediting: Exploring Tumor-T Cell Interactions In Developing Cancers, Julie F. Cheung

Yale Graduate School of Arts and Sciences Dissertations

Cancer's complexity is characterized by its genetic diversity, adaptability to environmental changes, and the extent of immunoediting that results from interactions with the immune system. T cells, tasked with eliminating mutated cells, have entered the cancer research spotlight due to their therapeutic potential to restore the natural host immune response against established tumors. However, their effectiveness is limited to a subset of cancers, and their inability to eradicate all tumors from the outset has perplexed researchers. Consequently, immunoediting, which encapsulates the interplay between T cells and developing tumor cells within their specific microenvironment, is a linchpin in determining cancer fate. …

Developing Metabolism-Targeting Adjuvants To Immunotherapy In Murine Melanoma, Xinyi Zhang

Yale Graduate School of Arts and Sciences Dissertations

Melanoma is the deadliest skin cancer type, causing 8000 deaths per year in the United States. The development of immunotherapy significantly prolongs the survival of cancer patients, including patients with melanoma. By impairing the inhibitory signaling pathway, immunotherapy, for example anti-PD-1 monoclonal antibody, reinforces the anti-tumor effector function of T cells that recognize cancer cells and therefore suppresses tumor progression. However, the problem of low responsiveness and development of resistance significantly prevents a large proportion of patients from benefiting from immunotherapy. Therefore, it is of great importance to develop adjuvants to increase the efficacy of immunotherapy. Metabolic alterations have long …

Character In Conflict: Soldiers And Eighteenth-Century English Literary Character, Adam C. Keller

Yale Graduate School of Arts and Sciences Dissertations

“Character in Conflict” explores the function of the soldier as a literary character in multiple genres of literature across the long eighteenth century. It constructs a series of literary case studies drawn from multiple genres, supplemented at times by soldier memoirs, drill manuals, political pamphlets, and other historical materials, to argue that soldiers make an ideal test case for literary characterization. To that end, this project examines soldier-characters that appear in Theophrastan character books, early eighteenth-century comedy, and the mid eighteenth-century novel. “Character in Conflict” uses these character case studies to explore the transhistorical properties of martial form and situates …

Secrets Of Inheritance: Modernism And The Afterlives Of Jewish Literature, Evan Goldstein

Yale Graduate School of Arts and Sciences Dissertations

This dissertation offers a new theory of the relationship between Jewish literature and Jewish identity in European modernity. Taking up the perennially troubling case of literary modernism, I argue that Jewish writers reject the reproductive logics of Jewish identity politics by theorizing a literary mode of relationality. I term this mode of relationality aesthetic afterlife. This concept refuses the figures of blood, descent, and race that dominate Jewish identity discourse in the twentieth and twenty-first centuries. Amid a biopolitical imaginary that privileges the legibility of Jewish bodies as the sign of Jewish collective vitality and continuity, Jewish modernists celebrate the …

Transcriptional Regulation Of Fate Specification In Human Megakaryocytic-Erythroid Progenitors, Nayoung Kwon

Yale Graduate School of Arts and Sciences Dissertations

Megakaryocytic-erythroid progenitors (MEP) are a population of bipotent hematopoietic progenitors that give rise to the megakaryocytic (Mk) or erythroid (E) lineages. The Mk lineage produces platelets, and the E lineage produces RBCs, that govern coagulation and oxygen transport, respectively. Both are critical components of the blood system, and maintaining an adequate and balanced pool of platelets and red blood cells is essential for life. As MEP stand as a final branchpoint before committing to Mk or E lineages, understanding the fate specification mechanism of MEP may provide insight into treating conditions that involve platelets and/or red blood cells.This thesis focuses …

Resting-State Functional Connectivity Correlates Of Inhibitory Control Over Emotional Stimuli, Makayla Mattson

All NMU Master's Theses

Inhibitory control is defined as the stopping or overriding of a mental process with or without intention. It is known as a motor process in which executive control suppresses an automated motor response. Currently, there is no existing research discussing the neural mechanisms of an emotional anti-saccade task, therefore with the use of resting-state functional magnetic resonance imaging (fMRI) and an emotional anti-saccade task, this study aims to identify the neural correlates of inhibitory control over emotional stimuli. The anti-saccade task is known as an effective measure of inhibitory control since it requires inhibiting a reflexive response and re-orienting attention …

The Magazine, Spring 2024, Morehead State University. Office Of Communications & Marketing.

Morehead State Alumni Association Publications

The Magazine of Morehead State University from spring of 2024.

Volume 102, Number 1 - Spring 2024

The Alembic

The Alembic - Volume 102, Number 1 - Spring 2024. 143 pages including covers and advertisements.

Table of Contents

Editors’ Note, vii

Poetry

S. Yarberry

Catherine’s Poem, 3

Looking at Robert Blake, 4

The Tyger , 6

Ethan Cunningham

Woman Under Water, 7

William Heath

A Bar in Santa Cruz, 8

In Asturias, 9

Joan Barker

Hometown, 10

Ella Bloom

Loneliness, 12

The Fog/A Lighthouse, 14

Found, 16

Tom McFadden

Where the Light May End, 17

If It Were Spring, 18

Bruce McRae

Daydreamers, 20

Does Your Dog Bite?, 21

A Strained Affair, 22

Erin Bolger

19 reasons, 23

Richard …

A Message Of Encouragement - Exegesis Of Romans 8:17-28, Verne Weir

Harding School of Theology Dissertations and Theses

No abstract provided.

An Introduction To The Yanomami Humanitarian Crisis And An Interview With Carlos Messiass On Contemporary Brazilian Indigenous Issues, Ethan Mccullough

Four Valleys Archive Scholarship

The following document covers how the rise of Jair Bolsonaro, based around a coalition of expansionist cattle ranchers and extractive industry representatives, has led to the massive explosion of illegal gold mining within the Yanomami in the Amazon. This increase in mining has led to a rapid increase of malnutrition, malaria, and mercury poisoning within the Yanomami population, as well as a significant rise in violence and human rights abuses. Other topics covered include, the previous increase of illegal mining on Yanomami land in the 1980s, Bolsonaro's anti-Indigenous rhetoric while campaigning for presidency, the role of the U.S. in Operation …

Full Issue

Brigham Young University Prelaw Review

No abstract provided.

Negotiating With The Collective Ear, Jessica Myers

School of Architecture - All Scholarship

This article presents sound studies as a critical framework for architectural analysis. It positions architecture’s long-honored monogamy with visual communication as limited and instead connects the collective decision-making that constitutes listening with dynamics of power in shared and personal space. With this understanding, I argue that architects can be attuned to the audiosocial spaces they help to enforce and make different collective decisions about the removal and discipline of sound.

Section Intro: Chronicles Of Precarity, Rachel Jane Donato, Aidan Shane, Camren Wyche

Intertext

No abstract provided.

What’S Up, Doc? The Underfunded Artist, Ilhy Gomez Del Campo Rojas

Intertext

No abstract provided.

Full Issue - Intertext 2024, Intertext Full Issue

Intertext

No abstract provided.

Bringing Occupational Therapy Outdoors: The Impact Of Nature-Based Interventions On Mental Health And Attention In Children With Developmental Disabilities, Caitlin Hankins

MOT Student Capstones

This paper explores the emerging practice area of nature-based occupational therapy (OT) and its potential impact on the mental health and attentional outcomes of children and adolescents with developmental disabilities. Drawing from the Occupational Therapy Practice Framework (OTPF) and existing literature, it highlights the benefits of nature-based practice approaches on the overall well-being of children and adolescents. The project aims to disseminate current evidence regarding nature-based practice approaches to various professionals, including OT practitioners, physical therapists, and speech-language pathologists, particularly those who work in the nature-based adjacent setting of Hippotherapy. The process included conducting research through a thorough literature review, …

Exploration Of Cytotoxicity Of _Rabidosa Rabida_ Venom On Invertebrate And Vertebrate Cell Cultures, Martina Gooden

Honors Theses

Venom has been observed in thousands of species across different taxa. It can be adapted for different purposes, including prey capture or predator defense. Venom is found almost universally in spiders, but there has been little exploration of spiders that are not medically significant. Rabidosa rabida, the rabid wolf spider, is a common species whose venom has not been adequately investigated. Previous studies indicate that they do not require venom to apprehend easy prey in a laboratory setting, raising a question as to what their venom is adapted to do. To evaluate its effect on mammalian cells, L929 murine fibroblasts …

Exploring Narrative Strengths In Animated Storytelling, Amelia Kretzer

Honors Theses

This thesis explores tactics for effective narrative development for animation through the analyses of key works of strong animated films synthesized with literature discussing narrative frameworks. This research resulted in a shortlist of animated storytelling best practices—six principles to reflect on in the creation of effective stories for animation. Additionally, an original 2D animated short film was created utilizing the principles on the shortlist in its development as an outpouring of this research.

2024 University Research Symposium Program Book, The Graduate School

University Research Symposium Programs

Program book for the 2024 University Research Symposium.

2024 Spring Quiz & Quill Magazine, English Department

Quiz and Quill

No abstract provided.

Experiential Learning Enhanced In Agricultural Classrooms Using 360-Degree Video Technology, Morgan L. Barba

SACAD: Scholarly Activities

Experiential or “hands-on” learning allows students to self-correct educational missteps and have live examples of core concepts registered in the brain as holistic experiences, which enhances their educational experience overall (Roland, M.A 2017). However, due to financial constraints and logistical barriers, it becomes more difficult for educators to give their students these field-based experiences. Using 360 video technology, educators have the opportunity to address these limitations and provide students with field experience anywhere (Clay, M. A. 2022). This presentation will highlight the opportunities 360 video technology can offer to animal and plant science education and the opportunities it can offer …

Personality Trait Theory And Combat Performance: A Retroactive Study Analyzing Combat Performance And Resilience Among Usaf Eod Veterans Of Iraq And Afghanistan, Michael C. Pasley

PhD in Organizational Leadership

The United States' national security depends upon high-performing leaders within select high-stress and high-risk military functional communities. However, research into the personality traits needed to perform well in these communities is lacking. This quantitative, retrospective, nonexperimental, correlational research aimed to determine whether relationships existed between the personality traits of Air Force EOD Team Leader Veterans of Iraq and Afghanistan and their combat performance and resilience. The theoretical foundation of this study encompassed personality trait theory, theories of human resource management and performance, and criterion measurement theories. The TAKE5 FC, a commercially available forced-choice five-factor model personality assessment, measured personality traits. …

Development Of A Novel Biology Laboratory Course For Incarcerated Students, Elsa H.K. Spencer, Joanna R. Vondrasek

Inquiry: The Journal of the Virginia Community Colleges

Federal second chance Pell grants were recently made widely available to incarcerated students in the United States to fund undergraduate education. Piedmont Virginia Community College was a pilot site for this expansion and began full scale implementation of transfer-oriented associate degrees at three correctional centers in its service area. The college did not have a biology laboratory curriculum that would meet general education requirements and be feasible in a correctional center, where students do not have internet access or even reliable computer (word processing or spreadsheet) access and where materials are restricted for entry. This paper will serve to introduce …

An Integrative Review Of Management Research On Caste: Broadening Our Horizons, Hari Bapuji, Snehanjali Chrispal, Pardeep Singh Attri, Gokhan Ertug, Vivek Soundararajan

Research Collection Lee Kong Chian School Of Business

Even though management research on caste is growing, it is not yet on a clear trajectory to realize its vast potential due to varying terminology and framing of caste, the limited incorporation of directly relevant work from proximate disciplines, and the narrow and selective usage of the attributes of caste. To remove these obstacles, we review 259 scholarly works on caste (216 articles and 43 books and research reports) and develop an integrative framework to i) clarify the contemporary manifestations of caste as being a graded hierarchy, an inherited membership, and a set of socially enforced practices, and ii) summarize …

Cell-Type Specific Molecular Expression Levels By Restricted-Dimensional Cytometry, David Kaplan, Hillard M. Lazarus

Faculty Scholarship

Background: Cytometric analysis has been commonly used to delineate distinct cell subpopulations among peripheral blood mononuclear cells by the differential expression of surface receptors. This capability has reached its apogee with high-dimensional approaches such as mass cytometry and spectral cytometry that include simultaneous assessment of 20–50 analytes. Unfortunately, this approach also engenders significant complexity with analytical and interpretational pitfalls. Methods: Here, we demonstrate a complementary approach with restricted-dimensionality to assess cell-type specific intracellular molecular expression levels at exceptional levels of precision. The expression of five analytes was individually assessed in four mononuclear cell-types from peripheral blood. Results: Distinctions in expression …

Development Of Carf Accreditation Requirements For A Vocational Rehabilitation Program For Individuals Independently Living With Post-Traumatic Brain Injury, Samantha Kowalczyk

Capstone Projects

The purpose of this capstone project was to assist a vocational rehabilitation program at Community Connections in Sterling Heights, Michigan with developing requirements for CARF Accreditation for individuals independently living with post-traumatic brain injury. This work program site is unique in the fact it is primarily run by Occupational Therapists and Certified Occupational Therapy Assistants. Achieving CARF Accreditation, which stands for Commission on Accreditation of Rehabilitation Facilities, demonstrates that standards are being met and provides greater satisfaction and the possibility for reimbursement and funding for a program. The overall aim was to assist in the development of the primary materials …

Reimagining Comfort: Designing For Climate Resilience, Dissinger

Capstone Projects

In a world undergoing constant transformation, driven by factors like extensive CO2 emissions since the Industrial Revolution, the impacts of greenhouse gases are irreversible, necessitating innovative solutions to confront global warming. Adapting to a progressively warmer planet presents unforeseen challenges, from shifting ecosystems to heightened vulnerability to natural disasters, and rising global temperatures.

The solution lies in the creation of a harmonious structure that fuses nature and technology, fostering self-sufficiency and compassion for the climate crisis. This structure aspires to be a paragon of eco-consciousness, adorned with entirely recyclable materials and integrated green systems, promoting sustainability. In a departure from …

Design Of Sustainable & Affordable Housing For Disadvantaged Communities In Nicaragua, Guillermo Terán

Civil, Environmental and Sustainable Engineering Senior Theses

Addressing Nicaragua's urgent housing needs, this project transforms a conventional CMU block design into a sustainable and affordable model using local, structural bamboo and adobe plaster. It includes appropriate member size connections, local-code compliant construction drawings, cost estimation and logistics, offering an eco-friendly, affordable housing solution for local communities. The scope of this project can be emphasized with the three words from the project title which are design, sustainable & affordable. The design aspect of this project involved producing detailed architectural and engineering drawings for the housing model, incorporating structural design to ensure the safety, stability and durability of the …

Say Her Name: A Phenomenological Study On Black Women’S Experiences With Fearful Encounters With The Police, Marilyn Shantey Buford

Dissertations

Police violence is a historical, systemic issue that continues to plague the Black community to this day. Research discussing the systemic oppression of police violence on Black people has seen an increase over the past decade. However, little has been discussed on the effects of police violence on Black people’s health and wellness, particularly their mental health. The research that exists surrounding police violence and mental health is largely concentrated on the experiences of Black men. Little is known about how Black women personally experience police violence or how these experiences impact their mental, emotional, and physical health. Not exploring …