Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 57061 - 57090 of 733928

Full-Text Articles in Entire DC Network

The Duality Of Neurons: Co-Transmission Of Serotonin And A Neuropeptide, Nlp-3, In The Caenorhabditis Elegans Egg-Laying Circuit, Allison Butt Apr 2024

The Duality Of Neurons: Co-Transmission Of Serotonin And A Neuropeptide, Nlp-3, In The Caenorhabditis Elegans Egg-Laying Circuit, Allison Butt

Yale Graduate School of Arts and Sciences Dissertations

Neurons typically release both a neurotransmitter and one or more neuropeptides in a process known as co-transmission. While this process is a widely observed phenomenon, the logic of why a neuron releases these two or more different types of signals to accomplish its myriad of functions remains largely unclear. In this dissertation, I studied how two serotonergic neurons in the C. elegans egg-laying circuit—known as the Hermaphrodite Specific Neurons (HSNs)—release both the neurotransmitter serotonin and the neuropeptide NLP-3 to activate egg laying. Egg laying typically occurs in a temporal pattern with two-minute active phases, during which the HSNs are highly …

Go to article

How Molecular Chaperones Promote Pathogen Survival, Carissa Chan Apr 2024

How Molecular Chaperones Promote Pathogen Survival, Carissa Chan

Yale Graduate School of Arts and Sciences Dissertations

All organisms require metal ions to help carry out biological processes. Mg2+ is the most abundant divalent cation in all living cells, where it neutralizes negative charges on DNA and RNA, acts as a cofactor for enzymatic reactions, stabilizes macromolecular complexes, and fulfills numerous other essential roles. Due to the critical nature of Mg2+ in all cellular compartments, cells have developed intricate mechanisms of sensing and responding to changes in intracellular and extracellular Mg2+. Inside the cell, Mg2+ concentration in the cytoplasm impacts the synthesis, maintenance, and degradation of proteins, which perform the vast majority of biochemical functions. First, because …

Go to article

Microbial Controls On Globally Significant Methane Cycling In Wetlands And Forests, Wyatt Arnold Apr 2024

Microbial Controls On Globally Significant Methane Cycling In Wetlands And Forests, Wyatt Arnold

Yale Graduate School of Arts and Sciences Dissertations

Methane (CH4), like carbon dioxide (CO2), is a potent greenhouse gas that has played a critical role in the warming of the planet. Yet unlike CO2, virtually all of the methane emitted into the atmosphere is the product of biological activity. Specifically, it is the metabolic byproduct of a group of archaea that are collectively referred to as methanogens. These methanogens thrive in a diversity of habitats—from landfills, to ruminant guts, to the wood of trees—and excel at converting carbon into methane. Their vast presence and activity in natural environments, like wetlands and inland waters, accounts for more than half …

Go to article

Nanopatterned Electrochemical Biosensor Electrodes With Enhanced Signal And Sensitivity, Emily R. Kinser Apr 2024

Nanopatterned Electrochemical Biosensor Electrodes With Enhanced Signal And Sensitivity, Emily R. Kinser

Yale Graduate School of Arts and Sciences Dissertations

Innovations in materials and process development in recent decades have enabled surface engineering at the nanoscale, which provides a pathway to improvement in the performance and longevity of biomedical implants and biosensors. One such novel class of materials is bulk metallic glass. As an amorphous metal, bulk metallic glass can be molded with after initial casting to produce high-precision features by elevating the material above the glass transition temperature, Tg, via the process of thermoplastic forming (TPF). Thus, BMGs enable a unique pathway to molding nano-scale structures in air at comparably low processing temperatures. Platinum-base BMG alloys (Pt-BMGs) are of …

Go to article

Impact Of Medical Drugs On Microbiome Dynamics, Andrew Albert Verdegaal Apr 2024

Impact Of Medical Drugs On Microbiome Dynamics, Andrew Albert Verdegaal

Yale Graduate School of Arts and Sciences Dissertations

Medical drugs, especially orally delivered medical drugs, remain one of the most w¬idely used methods for treating diseases and ameliorating disease symptoms. Furthermore, all humans are colonized with a diverse representation of bacteria in their gastrointestinal tracts. As such, medical drugs administered to patients will encounter the gut microbiome. This dissertation describes some possible interactions occurring between host, drug, and the gut microbiome, and how these interactions can affect hos¬¬t health. The first example I present describes the intertwining of Parkinson’s disease (PD) drug-based therapies with the gut microbiome through a complex network of interactions. One group of PD drugs, …

Go to article

“The Geopoetics Of An Undiscovered Continent: Eurasianism As A Writing Practice”, John Anthony Stachelski Apr 2024

“The Geopoetics Of An Undiscovered Continent: Eurasianism As A Writing Practice”, John Anthony Stachelski

Yale Graduate School of Arts and Sciences Dissertations

Drawing on extensive archival research and a comprehensive body of scholarship, this dissertation offers a critical reimagining of early 20th-century Eurasianism through the prism of literature and art. Beginning with the proto-Eurasianist schema introduced by Konstantin Leontiev in the 19th century, I argue that the influence of his deeply aestheticized combination of politics and religious thought is essential to understanding the work of Eurasianism’s founders Petr Savitsky and Petr Suvchinsky, the figures around whom the ideology’s major split occurred. This dissertation challenges the way Eurasianism has often been understood and portrayed in scholarship, and simultaneously presents an original argument about …

Go to article

Spatial Multi-Omics Mapping Of The Human Brain Hippocampus, Graham Su Apr 2024

Spatial Multi-Omics Mapping Of The Human Brain Hippocampus, Graham Su

Yale Graduate School of Arts and Sciences Dissertations

With the introduction of next-generation high-throughput DNA sequencing, “Omics” has become staple in biological and biomedical research. Currently, single-cell omics has enabled a wide range of biomolecular assays at single cell level including proteomics, transcriptomics, epigenomics, metabolomics, and more. These techniques have the power to interrogate the different dimensional states of single cells and in parallel with one another. Extensive and rich datasets have been produced with these methods ranging from normal to developing to diseased cells, especially informative in delineating heterogeneous populations. However, the trade-off for high-throughput single-cell Omics is the loss of cellular phenotypic and positional information. When …

Go to article

Regulation Of Hepatic Mitochondrial Oxidation And Gluconeogenesis, Traci Ellen Lamoia Apr 2024

Regulation Of Hepatic Mitochondrial Oxidation And Gluconeogenesis, Traci Ellen Lamoia

Yale Graduate School of Arts and Sciences Dissertations

Type 2 diabetes (T2D) is one of the most common metabolic disorders worldwide and is characterized by defective insulin secretion, peripheral insulin resistance, and dysregulated whole-body glucose homeostasis. In Chapter 1 I review the etiology of T2D and describe the well-established link between T2D and metabolic dysfunction associated steatotic liver disease (MASLD). I also describe several pharmaceutical interventions for the treatment of T2D, including metformin, the first-line treatment for T2D, and glucagon-like peptide-1 receptor (GLP-1R)/glucagon receptor (gcgR) dual agonists, a class of recently developed and highly effective treatments for T2D. This sets up the major goal of the work presented …

Go to article

The Black Spirit: Theorizing Black Political Theology In The Long Civil Rights Movement, Da'von Anthony Boyd Apr 2024

The Black Spirit: Theorizing Black Political Theology In The Long Civil Rights Movement, Da'von Anthony Boyd

Yale Graduate School of Arts and Sciences Dissertations

This dissertation investigates how Black political theology constructed the philosophical, ethical, and political architecture of the long civil rights movement. By recovering the radicalism of Black political theology in the Black Freedom Struggle, I seek to assess how religion animates the normative theorizing and political mobilization of liberation movements. I closely examine the political theories of its preeminent organizations, including the Southern Christian Leadership Conference (SCLC), Student Nonviolent Coordinating Committee (SNCC), and the Nation of Islam (NOI). I offer a theory of Black political theology in defining civil rights praxis by tapping into the cultural synergy of theism with the …

Go to article

Uncovering Transkingdom Connectivity Through Mapping Host-Microbiota Interactions, Nicole Sonnert Apr 2024

Uncovering Transkingdom Connectivity Through Mapping Host-Microbiota Interactions, Nicole Sonnert

Yale Graduate School of Arts and Sciences Dissertations

Our microbiota, the trillions of microbes that constitutively colonize every outward-facing surface of our bodies, have diverse impacts on human physiology, yet the molecular bases for these effects remain mostly unknown. Classical pathogens often invade host tissues and modulate immune responses through interactions with human extracellular and secreted proteins (the ‘exoproteome’). Commensal microbes may also facilitate niche colonization and shape host biology by engaging host exoproteins; however, direct microbiota-exoproteome interactions remain largely unexplored. We developed and validated a novel technology, BActerial Selection to Elucidate Host-microbe Interactions in high Throughput (BASEHIT), that enables proteome-scale assessment of human exoproteome-microbiome interactions. Using BASEHIT, …

Go to article

Exploring Function And Mechanism Through Intuitions, Explanations, & Learning, Amanda Mccarthy Apr 2024

Exploring Function And Mechanism Through Intuitions, Explanations, & Learning, Amanda Mccarthy

Yale Graduate School of Arts and Sciences Dissertations

Imagine learning about a car engine for the first time. You might expect that the person explaining to you how a car engine works would first explain the role that the car engine has within the car (functional information) before diving into how the camshaft, pistons, spark plugs, cylinders, and crankshaft all work together to make the car engine work (mechanistic information). Where might this intuition that functional information should come before mechanistic information come from? Is mechanistic information too convoluted to be understood without function as a cognitive scaffold? This thesis considers the strength of this intuition of explanatory …

Go to article

The Ambivalence Of Salvation: On Sentimentality, Suffering, And Redemption, Amanda Griffin Apr 2024

The Ambivalence Of Salvation: On Sentimentality, Suffering, And Redemption, Amanda Griffin

Yale Graduate School of Arts and Sciences Dissertations

For many contemporary theologians and theorists, the Christian doctrine of salvation is a problem. This is clearly elucidated for today’s context in the anti-social turn in queer theory, or queer negativity. This dissertation develops a Christian soteriology that takes queer negativity’s critiques seriously, without abandoning salvation altogether. Instead, I argue that honesty about the ambivalence that virtually always attends soteriology can allow it to mean and function differently. My attention to queer negativity focuses on the work of Lee Edelman, Leo Bersani, and Stephen Best. All three, in different ways, argue that Christian redemptive logics shapes common-sense thinking in the …

Go to article

Identifying Mechanisms Of Pathogenicity In Familial Cardiomyopathy-Linked Alpha-Tropomyosin Mutations, Saiti Srabonti Halder Apr 2024

Identifying Mechanisms Of Pathogenicity In Familial Cardiomyopathy-Linked Alpha-Tropomyosin Mutations, Saiti Srabonti Halder

Yale Graduate School of Arts and Sciences Dissertations

Hypertrophic Cardiomyopathy (HCM) and Dilated Cardiomyopathy (DCM) are two very divergent diseases which often have poor prognosis and are major causes of sudden cardiac death. In HCM, the left ventricular wall stiffens and thickens, making it difficult for the heart to pump blood efficiently. In DCM, the left ventricular chamber becomes enlarged while the walls become thinner and weaker, being unable to pump blood. When HCM or DCM happens as a result of an inherited mutation, it is said to be familial and can be passed down from one generation to the next. Missense mutations in alpha-tropomyosin (TPM1), a regulatory …

Go to article

A “Spicy” Molecular Mechanism Of Trpa1 Hyperactivation Conferred By A Disease Mutant And Insights Into C-Terminal Regulatory Components, Avnika Prasad Bali Apr 2024

A “Spicy” Molecular Mechanism Of Trpa1 Hyperactivation Conferred By A Disease Mutant And Insights Into C-Terminal Regulatory Components, Avnika Prasad Bali

Yale Graduate School of Arts and Sciences Dissertations

Roughly one third of Americans suffer from chronic pain and inflammation, yet so far little progress has been made to develop new pain remedies beyond non-steroidal anti-inflammatory agents and opioids, which often harbor deleterious side-effects. The identification and mechanistic analysis of pain-initiating receptors in peripheral nociceptor neurons is therefore an attractive approach to develop new analgesic and anti-inflammatory therapeutics. Transient receptor potential (TRP) ion channels are the largest group of receptors expressed in nociceptor neurons and are capable of transducing noxious thermal and chemical stimuli into cation influx that triggers pain signaling. My thesis work focuses on one such TRP …

Go to article

Dissecting The Role Of Neuromodulators In Value-Based Decision Making, Heather Ortega Apr 2024

Dissecting The Role Of Neuromodulators In Value-Based Decision Making, Heather Ortega

Yale Graduate School of Arts and Sciences Dissertations

Neuromodulators such as acetylcholine (ACh) and norepinephrine (NE) play diverse roles in the central nervous system. Structurally they are organized to exert a coordinating force over many brain regions as their nuclei project widely. Functionally both neuromodulators serve basic functions including arousal and attention as well as more complex roles such as learning and reinforcement. More interestingly, new evidence points to a distinct cognitive utility where ACh may influence learning and NE promotes stochastic choice. Evidence for these roles comes primarily from pharmacological depletion studies, recording from nuclei, and Pavlovian or sensory-cue guided tasks. However, the computational roles of NE …

Go to article

Models For Interrogating The Role Of Glutathione Biosynthesis In Pancreatic Islet Development And Function, Emily Ann Davidson Apr 2024

Models For Interrogating The Role Of Glutathione Biosynthesis In Pancreatic Islet Development And Function, Emily Ann Davidson

Yale Graduate School of Arts and Sciences Dissertations

Currently, over 537 million people worldwide have diabetes, a disease characterized by impaired insulin synthesis, and/or utilization. Of diabetics, roughly 90% have type 2 diabetes and develop high blood glucose caused by pancreatic islet dysfunction. The islet is composed of five different endocrine cell types. Sixty - 80% (varies by species) of islet cells are insulin-producing β cells. A hallmark characteristic of dysfunctional β cells is impaired insulin secretion. Among the many factors implicated in islet cell dysfunction is oxidative stress. Oxidative stress is defined as the imbalance between reactive oxygen species (ROS) and cellular antioxidant capacity. During oxidative stress, …

Go to article

Single-Cell Perturbation Of Human Accelerated Regions In Neural Stem Cells, Mark Alan Noble Apr 2024

Single-Cell Perturbation Of Human Accelerated Regions In Neural Stem Cells, Mark Alan Noble

Yale Graduate School of Arts and Sciences Dissertations

The evolutionary emergence of the uniquely large and complex human brain isunderpinned by the alteration and expansion of the neural stem and progenitor cell (NSC) pool during development. These modifications are the manifestation of numerous regulatory and genetic changes, many of which have yet to be described. One salient set of candidates consists of ~1500 Human Accelerated Regions (HARs), which are noncoding regions of the genome that have been highly constrained throughout evolution until the human lineage, where a significant number of substitutions occur, indicating divergent functions. I designed a direct-capture Perturb-seq screen repressing 180 HARs with evidence of neurodevelopmental …

Go to article

Bronze Age Prone Burials Of The Mongolian Gobi Desert: An Anthropological Study Of Mortuary Traditions, Bukhchuluun Dashzeveg Apr 2024

Bronze Age Prone Burials Of The Mongolian Gobi Desert: An Anthropological Study Of Mortuary Traditions, Bukhchuluun Dashzeveg

Yale Graduate School of Arts and Sciences Dissertations

The Late Bronze Age (LBA) and Early Iron Age (EIA) in Mongolia witnessed significant changes in mortuary practices, particularly the transition from prone burials to the slab grave tradition. This dissertation investigates the complex interplay between socio-cultural, political, and ideological factors that shaped these transformations, focusing on the reuse of burial spaces at the Shiriin Chuluu site in the Gobi Desert. In attempting to better understand the prone burial tradition of the Gobi and eastern Mongolia, I focus specifically on the history and utility of the prone concept as a category; the emergence and spread of these practices as a …

Go to article

Genetic Background’S Influence On The Pathogenesis Of Spinocerebellar Ataxia Type 1 (Sca1), Victor Hipolito Olmos Apr 2024

Genetic Background’S Influence On The Pathogenesis Of Spinocerebellar Ataxia Type 1 (Sca1), Victor Hipolito Olmos

Yale Graduate School of Arts and Sciences Dissertations

Spinocerebellar ataxia type 1 (SCA1) is a rare, dominantly inherited monogenic neurodegenerative disease that primarily affects the Purkinje cells (PCs) of the cerebellum. Our lab utilizes SCA1 as a model to unravel the complexity that is neurodegeneration. Neurodegeneration has long been a challenge due to the interactions of multiple cell types, various disease-causing genes, and degeneration beyond a single brain region. We utilized the SCA1 82Q B05 transgenic model (B05) which expresses the disease-causing gene, ATAXIN-1 (ATXN1), only in the PCs of the cerebellum. This mouse model recapitulates the disease phenotypes seen in human patients and allows us to investigate …

Go to article

Neutrophil Heterogeneity And Transmigration: Decoding Molecular Profiles Through Multi-Omic Analysis And In Vitro Mimicry Of The Venular Wall, Laura C. Morales Apr 2024

Neutrophil Heterogeneity And Transmigration: Decoding Molecular Profiles Through Multi-Omic Analysis And In Vitro Mimicry Of The Venular Wall, Laura C. Morales

Yale Graduate School of Arts and Sciences Dissertations

Neutrophils are crucial innate immune cells that comprise about 50-70% of the white blood cell population in the human peripheral circulation. These polymorphonuclear leukocytes play a pivotal role in the innate immune system, acting as the primary line of defense against pathogens and facilitating tissue repair. Neutrophils exhibit a diverse repertoire of cytotoxic mechanisms to eliminate offending pathogenic agents and promote the resolution of inflammation. These include phagocytosis, degranulation, generating reactive oxygen species, and forming neutrophil extracellular traps, underscoring their versatility in host defense. A critical aspect of neutrophil functionality is their capacity to infiltrate sites of injury or infection, …

Go to article

Investigations Of Bacteroides Thetaiotaomicron Population Dynamics, Anna P. Zagieboylo Apr 2024

Investigations Of Bacteroides Thetaiotaomicron Population Dynamics, Anna P. Zagieboylo

Yale Graduate School of Arts and Sciences Dissertations

The human intestine contains a large, complex, and dynamic community of microbes termed the microbiota, which is made up of hundreds of individual species populations. Certain community compositions are linked to health or disease in the human host, and substantial effort has been directed towards identifying methods of modulating the microbiota composition for therapeutic purposes. While many studies assess which species are present or fluctuate within the community, little is known about fluctuations within individual isogenic populations over time. These types of high-resolution changes could reasonably be expected to have profound impacts on a commensal’s ability to colonize the gut …

Go to article

Engineering Polymeric Nanoparticles For Intra-Amniotic And Intravenous In Utero Delivery, Anna Lynn Apr 2024

Engineering Polymeric Nanoparticles For Intra-Amniotic And Intravenous In Utero Delivery, Anna Lynn

Yale Graduate School of Arts and Sciences Dissertations

Fetal therapy is a rapidly expanding field that provides opportunities to treat or prevent congenital diseases early in the process of fetal development. Prior studies suggest that polymeric nanoparticles (NPs) are a safe, tunable, and effective vehicle for in utero delivery of therapeutic agents via administration into the amniotic fluid space. Previous work has focused on the feasibility of using poly(lactic-co-glycolic acid) (PLGA) NPs, as well as viral vectors and lipid NPs, for in utero delivery. Modifications to the core polymer and surface chemistry of NPs are known to be key in modulating the performance of NPs in various biological …

Go to article

Mechanisms And Functions Of Lipodystrophy In Dermal Fibrosis, Elizabeth Ann Caves Apr 2024

Mechanisms And Functions Of Lipodystrophy In Dermal Fibrosis, Elizabeth Ann Caves

Yale Graduate School of Arts and Sciences Dissertations

The skin is the largest organ in the human body and acts as a barrier between the inside and outside environments. A significant function of the skin is to maintain its structural integrity through extracellular matrix protein (ECM) homeostasis. Tissue fibrosis is characterized by a failure of ECM homeostasis, resulting in the accumulation of ECM proteins in healthy tissue. Systemic sclerosis is an autoimmune disease in which fibrosis develops throughout the body in organs such as the heart, lungs, and skin. Interestingly, during skin fibrosis, resident lipid-filled, mature adipocytes are depleted in humans and mice concomitant with ECM expansion. However, …

Go to article

Uncovering A Critical Role For Calmodulin In Calcium-Dependent Regulation Of The Nociceptor Trpa1, Justin Sanders Apr 2024

Uncovering A Critical Role For Calmodulin In Calcium-Dependent Regulation Of The Nociceptor Trpa1, Justin Sanders

Yale Graduate School of Arts and Sciences Dissertations

Transient receptor potential (TRP) channels are sensory receptors expressed throughout the peripheral nervous system that help shape how we respond to our environment. TRPA1 has been identified as a key component in the transition from acute to chronic pain and inflammation making it a prime target for development of novel analgesics. Calcium has been shown to regulate TRPA1 by rapidly potentiating channel activity followed by rapid desensitization. While the effects of calcium on TRPA1 activity have been well-described, the mechanisms governing these calcium effects have been difficult to elucidate. Work described within this thesis details the discovery of a novel …

Go to article

An Epigenetic Timer Regulates The Transition From Cell Division To Cell Expansion During Arabidopsis Petal Organogenesis, Ruirui Huang Apr 2024

An Epigenetic Timer Regulates The Transition From Cell Division To Cell Expansion During Arabidopsis Petal Organogenesis, Ruirui Huang

Yale Graduate School of Arts and Sciences Dissertations

Epigenetic changes, such as histone modifications or DNA methylation, can modify gene expression without affecting the genetic code. Such alterations can persist for many cell generations, and often are induced by various environmental inputs in both plants and animals. A number of studies have demonstrated that epigenetic factors regulate plant developmental timing in response to environmental changes. However, we still have an incomplete view of how epigenetic factors can regulate developmental events such as organogenesis, and the transition from cell division to cell expansion, in plants. The small number of cell types and the relatively simple developmental progression required to …

Go to article

Diverse Models Of Immunoediting: Exploring Tumor-T Cell Interactions In Developing Cancers, Julie F. Cheung Apr 2024

Diverse Models Of Immunoediting: Exploring Tumor-T Cell Interactions In Developing Cancers, Julie F. Cheung

Yale Graduate School of Arts and Sciences Dissertations

Cancer's complexity is characterized by its genetic diversity, adaptability to environmental changes, and the extent of immunoediting that results from interactions with the immune system. T cells, tasked with eliminating mutated cells, have entered the cancer research spotlight due to their therapeutic potential to restore the natural host immune response against established tumors. However, their effectiveness is limited to a subset of cancers, and their inability to eradicate all tumors from the outset has perplexed researchers. Consequently, immunoediting, which encapsulates the interplay between T cells and developing tumor cells within their specific microenvironment, is a linchpin in determining cancer fate. …

Go to article

Developing Metabolism-Targeting Adjuvants To Immunotherapy In Murine Melanoma, Xinyi Zhang Apr 2024

Developing Metabolism-Targeting Adjuvants To Immunotherapy In Murine Melanoma, Xinyi Zhang

Yale Graduate School of Arts and Sciences Dissertations

Melanoma is the deadliest skin cancer type, causing 8000 deaths per year in the United States. The development of immunotherapy significantly prolongs the survival of cancer patients, including patients with melanoma. By impairing the inhibitory signaling pathway, immunotherapy, for example anti-PD-1 monoclonal antibody, reinforces the anti-tumor effector function of T cells that recognize cancer cells and therefore suppresses tumor progression. However, the problem of low responsiveness and development of resistance significantly prevents a large proportion of patients from benefiting from immunotherapy. Therefore, it is of great importance to develop adjuvants to increase the efficacy of immunotherapy. Metabolic alterations have long …

Go to article

Character In Conflict: Soldiers And Eighteenth-Century English Literary Character, Adam C. Keller Apr 2024

Character In Conflict: Soldiers And Eighteenth-Century English Literary Character, Adam C. Keller

Yale Graduate School of Arts and Sciences Dissertations

“Character in Conflict” explores the function of the soldier as a literary character in multiple genres of literature across the long eighteenth century. It constructs a series of literary case studies drawn from multiple genres, supplemented at times by soldier memoirs, drill manuals, political pamphlets, and other historical materials, to argue that soldiers make an ideal test case for literary characterization. To that end, this project examines soldier-characters that appear in Theophrastan character books, early eighteenth-century comedy, and the mid eighteenth-century novel. “Character in Conflict” uses these character case studies to explore the transhistorical properties of martial form and situates …

Go to article

Secrets Of Inheritance: Modernism And The Afterlives Of Jewish Literature, Evan Goldstein Apr 2024

Secrets Of Inheritance: Modernism And The Afterlives Of Jewish Literature, Evan Goldstein

Yale Graduate School of Arts and Sciences Dissertations

This dissertation offers a new theory of the relationship between Jewish literature and Jewish identity in European modernity. Taking up the perennially troubling case of literary modernism, I argue that Jewish writers reject the reproductive logics of Jewish identity politics by theorizing a literary mode of relationality. I term this mode of relationality aesthetic afterlife. This concept refuses the figures of blood, descent, and race that dominate Jewish identity discourse in the twentieth and twenty-first centuries. Amid a biopolitical imaginary that privileges the legibility of Jewish bodies as the sign of Jewish collective vitality and continuity, Jewish modernists celebrate the …

Go to article

Transcriptional Regulation Of Fate Specification In Human Megakaryocytic-Erythroid Progenitors, Nayoung Kwon Apr 2024

Transcriptional Regulation Of Fate Specification In Human Megakaryocytic-Erythroid Progenitors, Nayoung Kwon

Yale Graduate School of Arts and Sciences Dissertations

Megakaryocytic-erythroid progenitors (MEP) are a population of bipotent hematopoietic progenitors that give rise to the megakaryocytic (Mk) or erythroid (E) lineages. The Mk lineage produces platelets, and the E lineage produces RBCs, that govern coagulation and oxygen transport, respectively. Both are critical components of the blood system, and maintaining an adequate and balanced pool of platelets and red blood cells is essential for life. As MEP stand as a final branchpoint before committing to Mk or E lineages, understanding the fate specification mechanism of MEP may provide insight into treating conditions that involve platelets and/or red blood cells.This thesis focuses …

Go to article

First Prev Next Last