Digital Commons Network^™

Large-Scale Annotated Dataset For Cochlear Hair Cell Detection And Classification., Christopher J Buswinka, David B Rosenberg, Rubina G Simikyan, Richard T Osgood, Katharine Fernandez, Hidetomi Nitta, Yushi Hayashi, Leslie W Liberman, Emily Nguyen, Erdem Yildiz, Jinkyung Kim, Amandine Jarysta, Justine Renauld, Ella Wesson, Haobing Wang, Punam Thapa, Pierrick Bordiga, Noah Mcmurtry, Juan Llamas, Siân R Kitcher, Ana I López-Porras, Runjia Cui, Ghazaleh Behnammanesh, Jonathan E Bird, Angela Ballesteros, A Catalina Vélez-Ortega, Albert S B Edge, Michael R Deans, Ksenia Gnedeva, Brikha R Shrestha, Uri Manor, Bo Zhao, Anthony J Ricci, Basile Tarchini, Martín L Basch, Ruben Stepanyan, Lukas D Landegger, Mark A Rutherford, M Charles Liberman, Bradley J Walters, Corné J Kros, Guy P Richardson, Lisa L Cunningham, Artur A Indzhykulian

Faculty Research 2024

Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5-15 thousand terminally differentiated hair cells, and their survival is essential for hearing as they do not regenerate after insult. It is often desirable in hearing research to quantify the number of hair cells within cochlear samples, in both pathological conditions, and in response to treatment. Machine learning can be used to automate the quantification process but requires a vast and diverse dataset for effective training. …

Dopamine Release Neuroenergetics In Mouse Striatal Slices, Msema Msackyi, Yuanxin Chen, Wangchen Tsering, Ninghan Wang, Hui Zhang

Department of Neuroscience Faculty Papers

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Dopamine (DA) neurons in the substantia nigra pars compacta, which have axonal projections to the dorsal striatum (dSTR), degenerate in PD. In contrast, DA neurons in the ventral tegmental area, with axonal projections to the ventral striatum, including the nucleus accumbens (NAcc) shell, are largely spared. This study aims to uncover the relative contributions of glycolysis and oxidative phosphorylation (OxPhos) to DA release in the striatum. We measured evoked DA release in mouse striatal brain slices using fast-scan cyclic voltammetry applied every two minutes. Blocking OxPhos resulted in a greater …

Assessment Of Thermal Preferences And Critical Temperature Tolerance Polygons On Mangrove Fish And Invertebrates From South Florida, Jailynn Konkler

All HCAS Student Capstones, Theses, and Dissertations

Mangroves serve as important nursery habitats for several species of subtropical fishes and invertebrates. Southeastern Florida mangrove environments have experienced an increasing frequency of strong hot and cold weather front systems, but little information is known about the temperature thresholds for mangrove-associated prey species that lethally disrupts homeostasis. To assess the vulnerability of mangrove-associated prey species to these short-duration temperature fluctuations, critical thermal methodology (CTM) was used to determine thermal tolerances for two fishes and two invertebrates, using loss of equilibrium (LOE) as the endpoint to determine CTmax and CTmin values as a survivable proxy for death. Physiological tolerances were …

Genetic Diversity Of United States Rambouillet, Katahdin And Dorper Sheep, Gabrielle M. Becker, Jacob W. Thorne, Joan M. Burke, Ronald M. Lewis, David R. Notter, James L. M. Morgan, Christopher S. Schauer, Whit C. Stewart, R. R. Redden, Brenda M. Murdoch

Department of Animal Science: Faculty Publications

Background Managing genetic diversity is critically important for maintaining species fitness. Excessive homozygosity caused by the loss of genetic diversity can have detrimental effects on the reproduction and production performance of a breed. Analysis of genetic diversity can facilitate the identification of signatures of selection which may contribute to the specific characteristics regarding the health, production and physical appearance of a breed or population. In this study, breeds with well-characterized traits such as fine wool production (Rambouillet, N = 745), parasite resistance (Katahdin, N = 581) and environmental hardiness (Dorper, N = 265) were evaluated for inbreeding, effective population size …

Sudden Acquired Retinal Degeneration Syndrome In Canine Patients, Morgan Powell

Honors College Theses

Sudden Acquired Retinal Degeneration Syndrome (SARDS) is a perplexing and debilitating ocular condition that affects canine patients primarily in the form of the sudden onset of total vision loss. Veterinary literature will be reviewed to discuss the basic anatomy of the canine eye and retina, as well as to investigate various diagnostic techniques to evaluate ophthalmic function and hypotheses of the pathogenesis of SARDS. The complexity of this disease and the absence of research leads to veterinarians and clients grappling with unanswered questions. This research surveys veterinarians to gain a perspective of the rareness of the disease, the most frequent …

For Dairy, Focusing On The Essentials, Maeve Gifford

UNH Today Archive

No abstract provided.

Spatial Distribution Of Soil Nutrients And Properties As A Function Of Vegetation Distribution, Fire, And Rodent Activity, Nathan O. Jones

Theses and Dissertations

Fires are becoming larger and more frequent in the deserts of North America, driven largely by the expansion of invasive annual grasses. Rodent consumers can curb invasive grass expansion through plant herbivory, but the top-down effects of this pressure on soil resources are understudied. In shrub dominated deserts, islands of fertility under shrub canopies are surrounded by nutrient poor interspace soils that dictate patterns of vegetative growth. Little is known of how top-down controls from rodents and fire may interact with fertile island topography. These studies explore the effects of fire, rodent activity, and fertile island topography on plant available …

Evolution Of Chromosome-Arm Aberrations In Breast Cancer Through Genetic Network Rewiring, Elena Kuzmin, Toby M Baker, Tom Lesluyes, Jean Monlong, Kento T Abe, Paula P Coelho, Michael Schwartz, Joseph Del Corpo, Dongmei Zou, Genevieve Morin, Alain Pacis, Yang Yang, Constanza Martinez, Jarrett Barber, Hellen Kuasne, Rui Li, Mathieu Bourgey, Anne-Marie Fortier, Peter G Davison, Atilla Omeroglu, Marie-Christine Guiot, Quaid Morris, Claudia L Kleinman, Sidong Huang, Anne-Claude Gingras, Jiannis Ragoussis, Guillaume Bourque, Peter Van Loo, Morag Park

Faculty, Staff and Student Publications

The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a panel of 23 primary tumor/patient-derived xenograft basal breast cancers reveals early evolution of chr4p deletion. Mechanistically we show that chr4p loss is associated with enhanced proliferation. Gene function studies identify an unknown gene, C4orf19, within chr4p, which suppresses proliferation when overexpressed-a member of the PDCD10-GCKIII kinase module …

A Conceptual Model Of Organizational Compassion In Healthcare, Rachel Thienprayoon, Eli Awtrey, Teresa Pestian, Beth A. Lown, Naomi Winick, Jason Kanov

Journal of Wellness

Introduction: In healthcare, while the suffering of patients is often evident, the suffering of clinicians receives less focus. Some sources of clinician distress are directly related to constant exposure to patient suffering, but others are caused by the health care system, and thus potentially preventable. Looking at clinician suffering through the lens of compassion fosters a new paradigm of individual, team, and organizational capabilities, and moves the responsibility to alleviate this suffering from the individual onto the organization and team. Yet research into the impact of organizational compassion in healthcare has been extremely limited.

Approach: Our conceptual model of organizational …

Lipoprotein(A) Blood Levels And Cardiovascular Risk Reduction With Icosapent Ethyl, Michael Szarek, Deepak L Bhatt, Michael Miller, Eliot A Brinton, Terry A Jacobson, Jean-Claude Tardif, Christie M Ballantyne, R Preston Mason, Steven B Ketchum, Armando Lira Pineda, Ralph T Doyle, Ph Gabriel Steg, Reduce-It Investigators

Faculty, Staff and Students Publications

Background: Elevated lipoprotein(a) (Lp[a]) concentrations are associated with increased cardiovascular event risk even in the presence of well-controlled low-density lipoprotein cholesterol levels, but few treatments are documented to reduce this residual risk.

Objectives: The aim of this post hoc analysis of REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial) was to explore the cardiovascular benefit of icosapent ethyl (IPE) across a range of Lp(a) levels.

Methods: A total of 8,179 participants receiving statin therapy with established cardiovascular disease or age ≥50 years with diabetes and ≥1 additional risk factor, fasting triglyceride 1.69 to 5.63 mmol/L, and low-density lipoprotein cholesterol …

An Investigation Of Bone Preservation As A Result Of Environmental And Cultural Variables In Mortuary Contexts, Adyn Hallahan

Honors Theses

Stable isotope analysis in bioarchaeology of human bone is generally used to reconstruct diet or migratory patterns of certain populations. Although this type of analysis is now standard practice, little research has been done regarding how cultural and mortuary practices may affect chemical composition of bone. This study aims to determine whether different simulated mortuary contexts have an effect on stable isotope levels in bone, using seven pig rib bone samples as proxy for human bone. In addition, macroscopic and microscopic observations are used to assess preservation and taphonomic processes. One of the samples served as a control, not being …

Xpo1 Blockade With Kpt-330 Promotes Apoptosis In Cutaneous T-Cell Lymphoma By Activating The P53-P21 And P27 Pathways, Nitin Chakravarti, Amy Boles, Rachel Burzinski, Paola Sindaco, Colleen Isabelle, Kathleen Mcconnell, Anjali Mishra, Pierluigi Porcu

Kimmel Cancer Center Faculty Papers

Dysregulated nuclear-cytoplasmic trafficking has been shown to play a role in oncogenesis in several types of solid tumors and hematological malignancies. Exportin 1 (XPO1) is responsible for the nuclear export of several proteins and RNA species, mainly tumor suppressors. KPT-330, a small molecule inhibitor of XPO1, is approved for treating relapsed multiple myeloma and diffuse large B-cell lymphoma. Cutaneous T-cell lymphoma (CTCL) is an extranodal non-Hodgkin lymphoma with an adverse prognosis and limited treatment options in advanced stages. The effect of therapeutically targeting XPO1 with KPT-330 in CTCL has not been established. We report that XPO1 expression is upregulated in …

Aerodynamic Design And Analysis Of A Modified 2006 Mazda Miata, William N. Recher

Honors College Theses

Aerodynamic forces developed by automobiles have destabilizing effects at high speed. These forces tend to skew toward a vehicle’s rear which can present safety concerns, especially for rear-wheel-drive automobiles like the Mazda Miata. To address oversteer and high-speed instability, a vehicle’s design can be tailored to bring about aerodynamic balance and improve traction. LiDAR was used to bring the physical automobile into the digital space. Then, a splitter and diffuser were added to reduce the magnitude of the destabilizing forces. Next, the size and shape of the rear-wing required to balance the vehicle was calculated using a combination of parameters …

Ccr2+ Monocytes Replenish Border-Associated Macrophages In The Diseased Mouse Brain, Lingxiao Wang, Jiaying Zheng, Shunyi Zhao, Yushan Wan, Meijie Wang, Dale B Bosco, Chia-Yi Kuan, Jason R Richardson, Long-Jun Wu

Faculty, Staff and Student Publications

Border-associated macrophages (BAMs) are tissue-resident macrophages that reside at the border of the central nervous system (CNS). Since BAMs originate from yolk sac progenitors that do not persist after birth, the means by which this population of cells is maintained is not well understood. Using two-photon microscopy and multiple lineage-tracing strategies, we determine that CCR2+ monocytes are significant contributors to BAM populations following disruptions of CNS homeostasis in adult mice. After BAM depletion, while the residual BAMs possess partial self-repopulation capability, the CCR2+ monocytes are a critical source of the repopulated BAMs. In addition, we demonstrate the existence of CCR2+ …

Topographical And Cell Type-Specific Connectivity Of Rostral And Caudal Forelimb Corticospinal Neuron Populations, Lina Marcela Carmona, Eric D Thomas, Kimberly Smith, Bosiljka Tasic, Rui M Costa, Anders Nelson

Faculty, Staff and Student Publications

Corticospinal neurons (CSNs) synapse directly on spinal neurons, a diverse assortment of cells with unique structural and functional properties necessary for body movements. CSNs modulating forelimb behavior fractionate into caudal forelimb area (CFA) and rostral forelimb area (RFA) motor cortical populations. Despite their prominence, the full diversity of spinal neurons targeted by CFA and RFA CSNs is uncharted. Here, we use anatomical and RNA sequencing methods to show that CSNs synapse onto a remarkably selective group of spinal cell types, favoring inhibitory populations that regulate motoneuron activity and gate sensory feedback. CFA and RFA CSNs target similar spinal neuron types, …

Lipoprotein(A) And Long-Term Cardiovascular Risk In A Multi-Ethnic Pooled Prospective Cohort, Nathan D Wong, Wenjun Fan, Xingdi Hu, Christie Ballantyne, Ron C Hoodgeveen, Michael Y Tsai, Auris Browne, Matthew J Budoff

Faculty, Staff and Students Publications

Background: Lipoprotein(a) (Lp[a]) is a causal genetic risk factor for atherosclerotic cardiovascular disease (ASCVD). There are limited long-term follow-up data from large U.S. population cohorts.

Objectives: This study examined the relationship of Lp(a) with ASCVD outcomes in a large, pooled, multi-ethnic U.S.

Methods: The study included data on Lp(a) and ASCVD outcomes from 5 U.S.

Prospective studies: MESA (Multi-Ethnic Study of Atherosclerosis), CARDIA (Coronary Artery Risk Development in Young Adults), JHS (Jackson Heart Study), FHS-OS (Framingham Heart Study-Offspring), and ARIC (Atherosclerosis Risk In Communities). Lp(a) levels were classified on the basis of cohort-specific percentiles. Multivariable Cox regression related Lp(a) with …

Dual Functional Magnetic Nanoparticles Conjugated With Carbon Quantum Dots For Hyperthermia And Photodynamic Therapy For Cancer, Mounika Choppadandi, Kondi Soumya, Sumanta Ghosh, Aishwarya Balu, Tanvi Shingote, Srivalliputtur Sarath Babu, Vani Sai Prasanna, Somasundaram Arumugam, Ravichandiran Velyutham, Murali M. Yallapu, Govinda Kapusetti

School of Medicine Publications

The global incidence of cancer continues to rise, posing a significant public health concern. Although numerous cancer therapies exist, each has limitations and complications. The present study explores alternative cancer treatment approaches, combining hyperthermia and photodynamic therapy (PDT). Magnetic nanoparticles (MNPs) and amine-functionalized carbon quantum dots (A-CQDs) were synthesized separately and then covalently conjugated to form a single nanosystem for combinational therapy (M-CQDs). The successful conjugation was confirmed using zeta potential, Fourier transform infrared spectroscopy (FT-IR), and UV-visible spectroscopy. Morphological examination in transmission electron microscopy (TEM) further verified the conjugation of CQDs with MNPs. Energy dispersive X-ray spectroscopy (EDX) revealed …

Functional Organization Of Posterior Parietal Cortex Circuitry Based On Inferred Information Flow, Jung Uk Kang, Eric Mooshagian, Lawrence H Snyder

2020-Current year OA Pubs

Many studies infer the role of neurons by asking what information can be decoded from their activity or by observing the consequences of perturbing their activity. An alternative approach is to consider information flow between neurons. We applied this approach to the parietal reach region (PRR) and the lateral intraparietal area (LIP) in posterior parietal cortex. Two complementary methods imply that across a range of reaching tasks, information flows primarily from PRR to LIP. This indicates that during a coordinated reach task, LIP has minimal influence on PRR and rules out the idea that LIP forms a general purpose spatial …

Large-Scale Annotated Dataset For Cochlear Hair Cell Detection And Classification, Christopher J Buswinka, Jinkyung Kim, Anthony J Ricci, Mark A Rutherford, Et Al.

2020-Current year OA Pubs

Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5-15 thousand terminally differentiated hair cells, and their survival is essential for hearing as they do not regenerate after insult. It is often desirable in hearing research to quantify the number of hair cells within cochlear samples, in both pathological conditions, and in response to treatment. Machine learning can be used to automate the quantification process but requires a vast and diverse dataset for effective training. …

Full Issue

The Thetean: A Student Journal for Scholarly Historical Writing

No abstract provided.

Karl May's Amerika: German Intellectual Imperialism, Seth Cannon

The Thetean: A Student Journal for Scholarly Historical Writing

What is America? European misconceptions with regard to the Americas can be traced back to the beginning of transoceanic contact in 1492. From Columbus to the Spaghetti Westerns of the 20th century, Europeans have taken America, their "West," and manipulated and sculpted ic. A plethora of contradictory voices have contributed to the construction of a complicated and paradoxical Western mych. Each voice offered a different vision of the West. The versions are grounded in a shared Western setting, but the stories are dramatically different, even foreign. Such transnational perceptions of the American West have attracted the attention of several contemporary …

Elmer: The Shepherd Statesman, Cathy Hulse

The Thetean: A Student Journal for Scholarly Historical Writing

Plato quoted Socrates when he said that "The unexamined life is not worth living," He referred to self-examination for the purpose of self-improvement. In a broader sense, it is also important to study the lives of others to identify ways to improve ourselves. Life is a shared experience no matter where or in what era our individual paths lie. Today's society is often fascinated by extreme heroics or infamous people. It gives unbalanced attention to glamorous, athletic, or wealthy celebrities. Despite this trend, valuable wisdom can be learned from the lives of common folks.

Pentecostalism And Current Development In West Africa: Reimagining The Pentecostal Landscape, Politics, And Vision, Fred Cudjoe Adadey, Yisa Barnabas

Spiritus: ORU Journal of Theology

A growing body of literature on African Pentecostals in sub-Saharan Africa is highlighted in this article, highlighting a more defined contribution of African Pentecostals to the development landscape. Until recently, the African Pentecostal development landscape recorded little visibility at the national level, on the assumption that their experience only highlights cultural and theological relevance. However, this emerging visibility has identified, as a conceptual category, an imaginary social space with practical ramification. Based on a critical analytical review of literature, this article examines the shift from traditional Pentecostal theology to a more focused attention on the social transformation created by a …

Forum Response — The Only Constant Is Change: Exploring Grief, Burnout, Ungrading, And Ai In The Basic Communication Course, Kristina Ruiz-Mesa, Ana Terminel Iberri

Basic Communication Course Annual

In the years since the start of the COVID-19 global pandemic, the world of higher education has seen incredible developments in teaching modalities, increased awareness of the socio-political and economic constraints facing many of our students and faculty, and an acute awareness of the rhetorical and material precarity that is facing higher education (Morreale et al., 2022; Ruiz-Mesa, 2022). These precarious conditions have contributed to questions regarding the future of higher education and adaptations needed to serve our diversifying student needs and address the pressing issues facing our world and our campuses. Conversations about well-being in the basic course classroom …

Analyzing The Impact Of Jakarta’S Reclamation On The Distribution Of Tss Using Remote Sensing Technology, Mutia Kamalia Mukhtar

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Jakarta Bay is a bay supporting the economy of thousands of nearby fishermen. Therefore, the reclamation in Jakarta Bay raises many environmental, economic, and social problems. During this reclamation, dredging and stockpiling activities increase the turbidity of the waters. This research aims to determine the changes in the distribution of total suspended solids (TSS) after reclamation using Sentinel 2A satellite imagery from 2016 to 2022. This research implemented the previous algorithm to produce the distribution of TSS in Jakarta Bay for attaining TSS values from Sentinel 2A satellite imagery processed by Google Earth Engine with overlay analysis method in a …

Philoctetes Today: Suffering, Forgiveness, And The Question Of Community, Jason M. Schlude

Languages and Cultures Faculty Publications

No abstract provided.

Faculty Senate Agenda April 29, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

No abstract provided.

The Rider (2024-04-22), Natalie Lapsley

The Rider Archives

Vol.9 No.27

Communication Of Mental Health Diversity To The Early Childhood Age Group: “The Adventures Of Anxious Anderson, Distracted Daniel, And Organized Olive”, Jessica Gower

Honors Projects

In this project, I aim to explore various aspects of communication, cognitive ability, and mental health diversity in early child development. The three research questions guiding this project are: What cognitive and language abilities do children in the early childhood stage of development have? What are the most effective strategies for communicating information about mental health disorders to children ages 4 to 7 through storytelling? And lastly, how do anxiety, attention-deficit/ hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD) manifest, particularly in children? The storybook's purpose is to create a sense of empathy and understanding of mental health diversity in children …

The Decline In Monarch Butterfly, Danaus Plexippus, Populations: An Example Of The Global Threat To Biodiversity, Olivia Sidoti

Honors Projects

Biodiversity encompasses the variety of all life on Earth and how these aspects of nature interact with each other. To have stable and abundant biodiversity, vast amounts of species and organisms are required within an ecosystem. As a result of the increase in negative impacts of human activities and behaviors on the health of nature, biodiversity has been decreasing. An example of the decrease in biodiversity is depicted by the recent decline of the monarch butterfly species. The monarch butterfly is an iconic North American insect that is experiencing a decline in its population due to threats such as deforestation, …