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The Role Of The Transcription Factor Cebpa In Regulating Lung Alveolar Type 2 Cell Fate In Vivo, Dalia Hassan

Dissertations and Theses (Open Access)

Cell plasticity can extend across all possible cell types, yet it naturally diminishes as cells progress through differentiation. This plasticity can be reactivated during injury repair, engaging developmental flexibility. Our investigations reveal the critical role of the transcription factor (TF) CEBPA, specific to lung alveolar type 2 (AT2) cells, in modulating AT2 cell plasticity within the mouse lung. We demonstrate that CEBPA constrains AT2 cell plasticity by promoting the AT2 differentiation program and recruiting the lineage-specific TF NKX2-1. Without CEBPA, AT2 cells, in both neonatal and mature, show a diminished AT2 program; however, only neonatal cells re-activate the SOX9 progenitor …

Uncovering Capillary Endothelial Cells Response During Lung Injury-Repair, Celine Shuet Lin Kong

Dissertations and Theses (Open Access)

Once thought to be a homogenous population, capillary endothelial cells (ECs) have embodied organotypic specialization and heterogenous properties, both during homeostasis and tissue injury. In the lung, capillary ECs consist of two distinct populations, CAP1 and CAP2s; how each population responds to diverse tissue injury is incompletely understood. In this thesis, I report the induction and function of a truncated isoform of Ntrk2, Ntrk2^-tk (lacking the tyrosine kinase domain) in multiple injury models. Using a combinatorial approach of single-cell multiome, mouse genetics and viral infection models, I found that Ntrk2^-tk is broadly induced in CAP1s after the initial …

Bad Water: A Critical Analysis Of Three Municipal Water Crises Through The Lens Of Political Ecology, Noelle Evelyn Schacht

Undergraduate Honors Thesis Collection

In this paper, I analyze the municipal water crises of Flint, Michigan; Toledo, Ohio; and Jackson, Mississippi through the lens of political ecology to determine how history, power, and society have shaped the troubled water system we see in the United States today. In cities around the US, citizens cannot access clean water, violating a basic human right. Policies have been implemented to protect citizens from consuming contaminated water but are poorly enforced. Additionally, despite knowledge of the ongoing problems including insufficient treatment, outdated infrastructure, and overly contaminated source water, little has been done to remedy the situation. The theoretical …

The History Of Gender-Biased Clinical Testing And Its Effects On Pharmaceutical Drug Efficacy, Kathryn E. Olson

Undergraduate Honors Thesis Collection

Concerns about potential risks that clinical research could impose to women of childbearing potential have long dictated pharmaceutical clinical trials. In the United States, women were not allowed to participate in clinical trials for decades, which has had major implications on the pharmaceutical industry today. Due to this oversight, men and women are commonly prescribed drugs at the same dosage despite many sex-specific differences in how male/female bodies respond to drugs during exposure. It is now known that female bodies metabolize drugs much slower than male bodies, which means that women who are prescribed drugs at the same rate as …

The Effects That Dietary Intake And Cardiorespiratory Fitness Has On Insulin Resistance In Adults, Trinady Moore

Honors Theses

Insulin resistance can impair bodily responses to insulin and the uptake of glucose within the human body. This imparity has many consequences and can more commonly cause Type II Diabetes.¹ This study focuses on how different lifestyle modifications can be used to combat the sensitivity to insulin within the body. The sample included forty-one adults whose ages varied from 18 to 35 years old. The participants completed a VO2max test, blood glucose test, and a 31- item food frequency survey. These tests and survey questions revealed the correction between the participants’ age, blood glucose levels, VO2max score, and diet …

Player Exposition: Education And Immersion In Jrpgs, Callan Danenhower

Honors Theses

This thesis examines how the opening segments of Japanese role-playing games use different techniques to educate and immerse the player. Informed by game studies scholarship, I consider how games create exposition differently from other narrative mediums, coining the term “player exposition” as a useful heuristic for game analysis. The thesis will be divided into two sections—education and immersion—to identify the two significant aspects of player exposition. I argue that exposition in Japanese role-playing games draws on concepts from other mediums, specifically film and literature, while using educational and immersive concepts to introduce the player to the game’s fictional world. In …

“Ufo Reports Swamp Mississippi”: Media Coverage Of The 1973 Pascagoula Alien Abduction, Jane Fort

Honors Theses

On October 11, 1973, Charles Hickson and Calvin Parker reported that they were taken aboard an unidentified flying object (UFO) in Pascagoula, Mississippi. Hickson and Parker’s abduction is now known as one of the most famous extraterrestrial encounters in the United States. In 1973, Hickson and Parker’s story captivated the media’s attention, and fifty years later, in 2023, UFOs are still widely reported on. This thesis utilizes the first-hand narratives from Hickson and Parker’s individual books to provide a detailed retelling of what happened on October 11. This thesis then analyzes the media coverage of the Pascagoula alien abduction in …

Exposing The Conflicting Cultural Narratives Of Downtown Springdale, Jennifer Sandoval-Salinas

Interior Design Undergraduate Honors Theses

This capstone project examines the relationship between seen and unseen acts of gentrification, displacement, and cultural preservation during the revitalization of the downtown area of Springdale, Arkansas. Gentrification and displacement are social issues of concern in the Northwest Arkansas region as it is experiencing economic growth and population increase. By means of a creative and artistic inquiry the study uncovers the traditions and identities that continue to shape Springdale’s unique cultural heritage through a multifaceted approach. The study includes a demographic analysis, historical examination, community engagement, and case studies which all collectively inform a comprehensive graphic analysis that interprets current …

How Design Depicted In Film Contributes To The Evolution Of Cultural Narratives, Catherine Vanhoose

Interior Design Undergraduate Honors Theses

Interior Design and its trends have had significant influence on pop culture and the general public through the course of human history. Acting as a universal language, design is a tool often used to help communicate ideas. The different interpretations of these ideas are what help to create cultural narratives. This capstone explores the relationships between film and design as creative arts, how they are affected by the current times and trends throughout the history of women, and as a result how women throughout history are influenced by these relationships. Findings provide insight on how interior design is used to …

Textile-To-Textile Upcycling; A Design Process To Make Hand-Felted Textiles Using Existing Materials By Utilizing The Wet Felting Production Technique, Kristin Rapach

Interior Design Undergraduate Honors Theses

This creative, artistic capstone investigates textile-to-textile upcycling in regards to sustainability, circularity, and adaptive reuse. By synthesizing an understanding of the current data, knowledge gaps, and research needs, this inquiry will explore the process of material manipulation and making. This understanding of textile-to-textile upcycling methods may inform innovative and sustainable modern processes, offering an artisan alternative to the limited existing techniques. This process requires hands-on experimentation in pursuit of a sustainable, circular solution to textile-to-textile upcycling.

Addressing Youth Cannabis Poisonings In Paterson, Nj, Fanny Lauby

Department of Political Science and Law Faculty Scholarship and Creative Works

This report has found that various local stores within the city of Paterson have been packaging and displaying cannabis items in a similar fashion to candies popular with children, thus leading to instances of children purchasing these items and consuming them. This highlights issues surrounding enforcement of various New Jersey statutes regulating the distribution of cannabis items to those under the age of 21. This negligence at the hands of store owners has helped contribute to the increase of cannabis poisonings due to being so easily accessible by children. The increased normalization of cannabis uses with its legalization and the …

Dynamic Path Planning Algorithm For Mobile Robots: Leveraging Reinforcement Learning For Efficient Navigation, Sivayazi Kappagantula, Giriraj Mannayee

Open Access archive

Traversing unfamiliar terrain presents a considerable challenge, particularly concerning the task of locating a viable pathway, regardless of its actual existence. This paper presents a novel navigation algorithm leveraging reinforcement learning, specifically the Markov Decision Process, to address the challenges of navigating dynamic environments. In contrast to traditional methods, this approach offers adaptability and efficiency in scenarios ranging from mobile robot navigation to complex industrial settings. The algorithm integrates an enhanced A* algorithm, showcasing its versatility in handling various tasks, from pathfinding to obstacle avoidance. To evaluate its effectiveness, the algorithm undergoes rigorous testing across multiple scenarios, comparing its performance …

Protecting Protected Characteristics: Statutory Solutions For Employment Discrimination Post-Bostock, Chase Mays

Vanderbilt Law Review

Title VII of the Civil Rights Act of 1964 prohibits employment discrimination on the basis of race, color, religion, sex, or national origin. Significantly, these protected characteristics are undefined, and judicial interpretations of race, sex, and national origin have allowed employers to lawfully discriminate against proxies for these protected characteristics. This Note examines the use of race-based hairstyles, gendered-appearance standards, and citizenship as proxies for race, sex, and national origin, respectively, and how the availability of such proxies inhibits Title VII’s goal of creating equal employment opportunities. The Supreme Court’s dicta in Bostock v. Clayton County offer potential redress to …

Investigating The Demise Of East Bank Ridge Through Local Fishery Perceptions And Fish Population Metrics, Marissa R. Lamb

Theses and Dissertations

East Bank Ridge is a natural reef formation located 18 nautical miles off the coast of South Padre Island, covering an area of over 80 km2, with the southern portion extending into Mexico. There is no previous record of the structural composition or fish community present at the site. The ridge was a well-known fishing site in the local community over the past decades but catch rates have decreased substantially according to personal accounts from local anglers. In this study, areas of reef habitat were identified, and fish presence and abundance metrics were determined at East Bank Ridge. These measures …

Complete Characterization Of Nadh Dehydrogenase Subunit 1 Gene In Human Hydatid Cysts, Sarmad Awad Mozan Al-Asadi, Abdul-Hussien Habash Awad

Baghdad Science Journal

Echinococcus granulosus sensu stricto possesses very similar strains G1 and G3. Mitochondrial genes from NADH dehydrogenase (NAD) family have prominent roles in the identification of very similar strains G1 and G3. Thus, the present study mainly aimed to characterize the whole NAD1 gene (from the start codon to the stop codon) of hydatids isolated from humans. Hydatids were surgically isolated from the livers of patients, who are from Basrah and Maysan provinces, at Al-Sadir Teaching Hospital in Basrah province, Iraq. Protoscoleces were aseptically isolated from hydatid cysts and were used to extract DNA. Specific primers were employed to amplify the …

Modified Meerkat Clan Algorithm For Association Rules Mining, Mohamad Ab. Saleh, Ahmed T. Sadiq

Baghdad Science Journal

Association Rules Mining (ARM) forms one of the important data mining techniques. The classical methods that were previously worked on by researchers have become ineffective to deal with the steady growth of databases, which prompted us to use the mining process for association rules based on metahuristic, and in our work all the correct rules will extracted, and mining is not limited to high-quality rules. Swarm intelligence based is one of these methods. In this paper, Modified Meerkat Clan for Association Rules Mining (MCC-ARM) has been proposed. Basically, the proposed algorithm depends on Meerkat Clan Algorithm (MCA). The greatest benefit …

Vehicle Crashes In Minnesota: Spatial And Temporal Patterns And Contributing Factors To Crash Severity, Bastien Koralalage Pavithra Navodi Rodrigo

Theses and Dissertations

Vehicle crashes represent a critical global issue, resulting in numerous fatalities, injuries, and significant economic and societal impacts. In response, government officials worldwide are developing strategies and policies to enhance road safety and promote sustainable transportation systems, aiming for zero fatalities and injuries. Understanding the causes of crashes is essential for these efforts. This study focuses on identifying spatial and temporal patterns and contributing factors for the crash severity of vehicle crashes in Minnesota. Spatial distribution of crash hotspots is identified and visualized using spatial autocorrelation (global Moran I), hotspot analysis (Getis–Ord Gi*), and kernel density estimation in ArcGIS Pro. …

Implementing A Dairy Industry In Mauritius, Lainey Deitrick

Economics Undergraduate Honors Theses

Over the Summer, I interned at the University of Mauritius and the Ministry of Agro Industry and Food Security from May 18th to July 15th, 2022, researching issues with Mauritius’s food security and helping to create solutions to their economic problems. My project covered all Mauritius’s agricultural imports, but it had an emphasis on their dairy industry. While in Mauritius, I conducted research on food security among Mauritians, and a feasibility study on if residents would be open to drinking more fresh milk, which is a market the country is exploring to replace sugar cane. My data analysis will be …

Surveys Assessing Food Security And Willingness To Buy Dairy Products In Mauritius Conducted Summer 2022, Abigail Burch

Economics Undergraduate Honors Theses

In the summer of 2022, I worked on a team of University of Arkansas and University of Mauritius students to administer surveys regarding the consumption of dairy milk and the impact of COVID-19 on food security in the island nation of Mauritius. This project was created by both universities in conjunction with the Mauritian Ministry of Agro Industry and Food Security.

Reaping What You Subsidize: A Comprehensive Review Of Outcomes From Crop Subsidies In The United States, Sawyer J. Knox

Economics Undergraduate Honors Theses

The motivation for researching this topic comes from an interest in public policy and public health. In this paper, we will examine the impact of farm subsidies on the health of citizens, look at who benefits financially and economically from these subsidies, and examine the environmental impact of these programs. The paper will be structured as follows: Section II, the wealth distribution results from farm subsidies; Section III, the disproportionate impacts on health from farm subsidies; Section IV, the impact on global economies from farm subsidies; Section V, the environmental impact from farm subsidies; and Section VI, conclusions and policy …

Unveiling The Influence: Corporate Lobbying And The American Diet, Annaleigh Mattingly

Economics Undergraduate Honors Theses

The United States has an ongoing health problem. At 41.9%, our obesity rate is one of the highest in the worldi . While there are several factors that contribute to obesity, food is a crucial one. Food plays a key role in our short- and long-term health. This impact spills over into other aspects of life, such as productivity and mental well-being. This begs the question why the United States, as a very wealthy nation, has relatively lower food quality when compared with other high-income nations. This is a multi-faceted problem that is rooted in American culture, government regulation, and …

Personal Green Spaces During The Pandemic - Perceptions Towards Urban Home Gardens During The Covid-19 Pandemic In Bengaluru, India, Varsha Bhaskaran, Charles Nilon

Cities and the Environment (CATE)

The COVID-19 pandemic has brought about unprecedented changes in a short span of time to people’s life and living. Being in a lockdown, especially in urban areas, has led to changes in the way people perceive nature around them and within their homes. Research on this topic in the cities of the global south has been limited with even fewer studies in Indian cities. To begin to address this gap, in this exploratory study we interviewed 30 residents of Bengaluru, India to understand how they perceived the changes they experienced in their home gardens and in the nature around their …

The Impact Of Land Use And Human Population Density On Benthic Macroinvertebrate Diversity In A Highly Urbanized River, Maleha Mahmud, David C. Lahti, Bobby Habig

Cities and the Environment (CATE)

Many studies have documented the detrimental effects of urbanization on aquatic ecosystems. What is less known is how “super urban” centers—areas with unusually high human population densities and immense infrastructures—impact biodiversity. Specifically, freshwater streams and rivers that are situated in highly urbanized metropolitan areas might be more susceptible to anthropogenic disturbance. Here, we evaluated the impacts of land use and human population density on benthic macroinvertebrate diversity along the Bronx River, a freshwater river situated in one of the largest urban centers in the world: the New York metropolitan area. We addressed the following research question: How does (1) high …

Gender Equity In Labor Market Opportunities And Aggregate Technical Efficiency: A Case Of Equity Promoting Efficiency, Gautam Hazarika, Maroula Khraiche, Levent Kutlu

School of Economics and Finance Faculty Publications

This study applies a panel data stochastic frontier analysis to country data towards examining the effect of gender equity in labor market opportunities upon efficiency in the production of GDP. It finds that aggregate technical efficiency is improved by a widening of women’s labor market opportunities as indicated by a rise in their share of employment, but that this effect is dampened by patriarchal cultural norms whose strength is measured by the proportion of the population tracing its ancestry to ethnic groups who adopted the plough as an agricultural implement. That aggregate technical efficiency rises in women’s share of employment …

Application Of Digital Holographic Imaging To Monitor Real-Time Cardiomyocyte Hypertrophy Dynamics In Response To Norepinephrine Stimulation, Wahida Akter, Herman Huang, Jacquelyn Simmons, Alexander Y. Payumo

Faculty Research, Scholarly, and Creative Activity

Cardiomyocyte hypertrophy, characterized by an increase in cell size, is associated with various cardiovascular diseases driven by factors including hypertension, myocardial infarction, and valve dysfunction. In vitro primary cardiomyocyte culture models have yielded numerous insights into the intrinsic and extrinsic mechanisms driving hypertrophic growth. However, due to limitations in current approaches, the dynamics of cardiomyocyte hypertrophic responses remain poorly characterized. In this study, we evaluate the application of the Holomonitor M4 digital holographic imaging microscope to track dynamic changes in cardiomyocyte surface area and volume in response to norepinephrine treatment, a model hypertrophic stimulus. The Holomonitor M4 permits non-invasive, label-free …

Complete Genome Sequences Of 9 Rhodococcus Equi Phages, Randall Dejong, Myles D Radersma, Gabrielle Lathrop, Karena C Moleakunnel, Luke Harlow, Aerin E Baker, Alison J. Chen, Jason G Churu, Carly A Dole, Sophia L Doorn, Ethan M Hill, Anna Howland, Amanda Janvier, Catie M Kramer, Matt J Minasian, Jocelyn R Nieze, Isabella K Perezios, Fiona J Ramsey, Katie L Seinen, Sierra K Swierenga, Michael M Veenstra, Grace E Weaver, Alexandra C White, Esther Yoon

University Faculty Publications and Creative Works

Myles D Radersma, Gabrielle Lathrop, Karena C Moleakunnel, Luke Harlow, Aerin E Baker, Alison J. Chen, Jason G Churu, Carly A Dole, Sophia L Doorn, Ethan M Hill, Anna Howland, Amanda Janvier, Catie M Kramer, Matt J Minasian, Jocelyn R Nieze, Isabella K Perezios, Fiona J Ramsey, Katie L Seinen, Sierra K Swierenga, Michael M Veenstra, Grace E Weaver, Alexandra C White, Esther Yoon, John T Wertz, Randall J DeJong. 2024. Complete genome sequences of 9 Rhodococcus equi phages. Microbiology Resource Announcements. https://doi.org/10.1128/mra.01088-23

Notes For The Stalled, V16n09, May 2024, University Of Northern Iowa. Rod Library.

Rod Library newsletter: Notes for the Stalled

Contents:

--- DeStress Days
--- Congratulations Graduates
--- Extended Hours
--- Did You Know?

Assessing Undergraduate Nonprofit Management Education Programs: Combining Industry And Student Perspectives, Benjamin Walworth

Marketing Undergraduate Honors Theses

Given the role of the nonprofit sector in the U.S. economy, as well as the growth of nonprofit management education (NME) programs, there is a need to specifically assess undergraduate NME programs. This study addresses the current research gap by examining the undergraduate nonprofit studies minor at the University of Arkansas. An assessment of the minor was conducted by surveying three groups: nonprofit professionals, current students pursuing the nonprofit studies minor, and alumni of the minor. These groups were surveyed to understand why students pursue the minor, what students want or gain from the experience, as well as what skills …

Locating, Characterizing, And Comparing Submerged Precontact Site Hubbard Spring To Other Submerged Spring Sites Throughout Florida, Madison Day

USF St. Petersburg campus Honors Program Theses (Undergraduate)

The rise of sea level over the past 20,000 years has led to the submersion of nearly half of Florida’s original land mass, causing freshwater springs hypothesized to have been a gathering spot for prehistoric people to become submerged. As the water rose, humans lost touch with their ancestors’ ways of life and migratory patterns. In recent years, however, interests in the potential significant cultural, archeological, and paleontological resources at submerged spring sites on the West Florida Shelf have spiked among geo-archeologists, historical experts, biologists, and geologists.

The goal of the WF2305 research cruise aboard the R/V Western Flyer was …

Teaching Concept Design Through Structured Practices And Portfolio Projects, Gavin Hadro

USF St. Petersburg campus Honors Program Theses (Undergraduate)

Concept designers serve various roles, but our primary objective is to give workable, inspiring ideas to a development or production team. The greatest difficulty is ensuring designs are visually compelling, intuitively functional, and intellectually stimulating, all at once. This thesis will evaluate what focused practices and strategies best prepare beginning designers to meet all three challenges. Performing industry-relevant tasks that train these skills will, in theory, enable those studying concept design to effectively learn singular skills before attempting to develop a portfolio that showcases an ability to combine them. Potential practices include compositional and storytelling exercises, 3D design studies, reflective …