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Articles 53221 - 53250 of 733206
Full-Text Articles in Entire DC Network
Unraveling Etc Complex I Function In Ferroptosis Reveals A Potential Ferroptosis-Inducing Therapeutic Strategy For Lkb1-Deficient Cancers, Chao Mao, Guang Lei, Amber Horbath, Min Wang, Zhengze Lu, Yuelong Yan, Xiaoguang Liu, Lavanya Kondiparthi, Xiong Chen, Jun Cheng, Qidong Li, Zhihao Xu, Li Zhuang, Bingliang Fang, Joseph R Marszalek, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Unraveling Etc Complex I Function In Ferroptosis Reveals A Potential Ferroptosis-Inducing Therapeutic Strategy For Lkb1-Deficient Cancers, Chao Mao, Guang Lei, Amber Horbath, Min Wang, Zhengze Lu, Yuelong Yan, Xiaoguang Liu, Lavanya Kondiparthi, Xiong Chen, Jun Cheng, Qidong Li, Zhihao Xu, Li Zhuang, Bingliang Fang, Joseph R Marszalek, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan
Faculty, Staff and Student Publications
The role of the mitochondrial electron transport chain (ETC) in regulating ferroptosis is not fully elucidated. Here, we reveal that pharmacological inhibition of the ETC complex I reduces ubiquinol levels while decreasing ATP levels and activating AMP-activated protein kinase (AMPK), the two effects known for their roles in promoting and suppressing ferroptosis, respectively. Consequently, the impact of complex I inhibitors on ferroptosis induced by glutathione peroxidase 4 (GPX4) inhibition is limited. The pharmacological inhibition of complex I in LKB1-AMPK-inactivated cells, or genetic ablation of complex I (which does not trigger apparent AMPK activation), abrogates the AMPK-mediated ferroptosis-suppressive effect and sensitizes …
Enhancer Switching In Cell Lineage Priming Is Linked To Erna, Brg1’S At-Hook, And Swi/Snf Recruitment, Dhurjhoti Saha, Srinivas Animireddy, Junwoo Lee, Anna Thommen, Mckenzie M Murvin, Yue Lu, J Mauro Calabrese, Blaine Bartholomew
Enhancer Switching In Cell Lineage Priming Is Linked To Erna, Brg1’S At-Hook, And Swi/Snf Recruitment, Dhurjhoti Saha, Srinivas Animireddy, Junwoo Lee, Anna Thommen, Mckenzie M Murvin, Yue Lu, J Mauro Calabrese, Blaine Bartholomew
Faculty, Staff and Student Publications
RNA transcribed from enhancers, i.e., eRNA, has been suggested to directly activate transcription by recruiting transcription factors and co-activators. Although there have been specific examples of eRNA functioning in this way, it is not clear how general this may be. We find that the AT-hook of SWI/SNF preferentially binds RNA and, as part of the esBAF complex, associates with eRNA transcribed from intronic and intergenic regions. Our data suggest that SWI/SNF is globally recruited in cis by eRNA to cell-type-specific enhancers, representative of two distinct stages that mimic early mammalian development, and not at enhancers that are shared between the …
Modern Critiques Of The Kalam Cosmological Argument, Colby D. Crawford
Modern Critiques Of The Kalam Cosmological Argument, Colby D. Crawford
Masters Theses
The Kalam Cosmological Argument (KCA), like all other arguments for the existence of God, is constantly under a microscope. Individuals are continuously struggling to undermine its validity, and until recently they have generally failed in demonstrating that the KCA is irrelevant. Since William Lane Craig revitalized the Kalam in 1979, scientists and philosophers have offered objections against it from all perspectives. However, due to the KCA’s modesty and simplicity it has stood the test of time against its critics. That is, it has until now.
Bridging Faith And Restoration: A Phenomenological Study Exploring Evangelical Pastors’ Experiences Ministering To Congregants With Trauma In The Greater Toronto Area, Lindsay Knox Mcvety
Bridging Faith And Restoration: A Phenomenological Study Exploring Evangelical Pastors’ Experiences Ministering To Congregants With Trauma In The Greater Toronto Area, Lindsay Knox Mcvety
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to understand how evangelical pastors in the Greater Toronto Area describe their experiences with discussing trauma with congregants and their experiences with trauma-informed care in the church. The theory guiding this research is Transformative Learning Theory (TLT). As discussed by Mezirow (1991), TLT explains transformation occurs by increasing knowledge by learning about topics where outdated or misinformed concepts previously existed. The main research question is, how do evangelical pastors in the Greater Toronto Area describe their experiences ministering to congregants who have experienced trauma? Further sub-questions ask, how do evangelical pastors in …
The Essence Of Christian Paideia For Career Classical Christian Educators: A Hermeneutic Phenomenology, Binnie J. King
The Essence Of Christian Paideia For Career Classical Christian Educators: A Hermeneutic Phenomenology, Binnie J. King
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenology was to discover the essence of Christian paideia for career classical Christian educators who make daily curricular decisions at a classical Christian online academy that serves a 2nd-12th grade international student body. A qualitative research design was used to gather data on the experiences of classical Christian educational practitioners when making curricular decisions. The theory that guided this study was Mezirow’s transformational learning theory (TLT), as all manner of teaching and learning attempts transformation to a higher ideal. A hermeneutic phenomenology was employed through the interpretive framework of critical realism to discover the essence …
Physical Aggression And Self-Injurious Behaviors Towards Self Or Others By Non-Verbal/Minimally Verbal Secondary Special Education Students With Autism In A Self-Contained Classroom: A Qualitative Case Study, Rodney Keith Jackson
Doctoral Dissertations and Projects
The purpose of this single intrinsic case study was to describe the experiences of using multiple forms of non-verbal interventions to decrease physical aggression and self-injurious behaviors for special education staff members in self-contained classrooms in Behaviorville ISD. The theory guiding this study was B. F. Skinner’s theory on behaviorism. It explains how non-verbal interventions affect an individual’s environment, how reinforcers influence their behaviors, and how all actions are interconnected. Participants were 10 people who are full-time employees of BISD and have worked with or volunteered with non-verbal/minimally verbal secondary special education students with physical aggression, self-injurious behaviors, and autism …
Applying Stewardship Leadership That Impacts Employee Work Attitudes To Reduce Voluntary Turnover, H. Dea Dietrick Wood
Applying Stewardship Leadership That Impacts Employee Work Attitudes To Reduce Voluntary Turnover, H. Dea Dietrick Wood
Doctoral Dissertations and Projects
At a time when leadership corruption threatens a hazard to sustainable organization development, a new brand of leadership governance is in demand. Therefore, the importance of this quantitative study was to examine a unique, newly proposed theory—stewardship leadership (SSL). SSL theory, based on a biblical worldview, was hypothesized to influence subordinates perceived organizational support (POS), subordinate affective commitment (AC), and subordinate organizational identification (OI) that, in turn, reinforces job embeddedness (JE) and reduces voluntary turnover intentions (TI) in comparison to servant (SL), transformational (TL), and leader-member exchange (LMX) leadership styles on work attitudes. SSL also appeared to be a composite …
Investigating The Effects Of Male Size And Pronotal Glowspots On Female Courtship Behaviour Of The Glowspot Cockroach (Lucihormetica Verrucosa), Ella X. Whitaker, Jane Akerman, Alexander D.M. Wilson
Investigating The Effects Of Male Size And Pronotal Glowspots On Female Courtship Behaviour Of The Glowspot Cockroach (Lucihormetica Verrucosa), Ella X. Whitaker, Jane Akerman, Alexander D.M. Wilson
School of Biological and Marine Sciences
Lucihormetica verrucosa (Blattodea, Blaberidae) are highly sexually dimorphic cockroaches, with the males having two symmetrically organised ‘glowspots’ on their pronotum. The spots can range in colour from whitish-yellow to red, depending on the quantity of carotenoids in their diet. These spots auto-fluoresce when exposed to UV wavelengths, with the amount of fluorescence inversely related to the carotenoid content. The diet-dependent aspect of the pronotal spots insinuates that they are a fitness-dependent trait and thus inform sexual selection, but existing studies have not directly investigated the role of the pronotal spots in courtship behaviour. Invertebrate sexual selection is commonly informed by …
Crisis Of Conscience In Post-Roe America, Elizabeth Sepper
Crisis Of Conscience In Post-Roe America, Elizabeth Sepper
The Journal of Contemporary Legal Issues
This essay proceeds in four parts. Summarizing my previous writing, Part II explains that since Roe, the law has systematically favored refusing individuals and institutions. This asymmetry was unjustified, because “[c]onscience equally may compel a doctor or nurse to deliver a controversial treatment to a patient in need.” After Dobbs v. Jackson Women’s Health Organization, the asymmetry may deepen. In restrictive states, Part III contends, the crisis of conscience for willing providers will increase, even as rights to refusal expand. Part IV identifies several possible complications for the legal framework governing conscience in medicine. It suggests that as …
Environmentally Relevant Concentrations Of Triphenyl Phosphate (Tphp) Impact Development In Zebrafish, Benjamin Schmandt, Mfon Diduff, Gabrielle Smart, Larissa M. Williams
Environmentally Relevant Concentrations Of Triphenyl Phosphate (Tphp) Impact Development In Zebrafish, Benjamin Schmandt, Mfon Diduff, Gabrielle Smart, Larissa M. Williams
All Faculty Scholarship
A common flame-retardant and plasticizer, triphenyl phosphate (TPhP) is an aryl phosphate ester found in many aquatic environments at nM concentrations. Yet, most studies interrogating its toxicity have used µM concentrations. In this study, we used the model organism zebrafish (Danio rerio) to uncover the developmental impact of nM exposures to TPhP at the phenotypic and molecular levels. At concentrations of 1.5–15 nM (0.5 µg/L–5 µg/L), chronically dosed 5dpf larvae were shorter in length and had pericardial edema phenotypes that had been previously reported for exposures in the µM range. Cardiotoxicity was observed but did not present as cardiac looping …
Magpie Naheševehe: An Autoethnographic Study Of A Chief’S Son Reclaiming His Language, Quinn A. Magpie
Magpie Naheševehe: An Autoethnographic Study Of A Chief’S Son Reclaiming His Language, Quinn A. Magpie
Master's Theses
This paper is an autoethnographic study covering my journey to learn my heritage languages, Cheyenne and Arapaho. The purpose of this study is to give a personalized account of what studying my languages means to my Indigenous identity. Between the months of January and April of 2024, I studied my languages daily and documented the process. I then used Brayboy’s TribalCrit as my theoretical framework to elicit themes from my experience, many of which became a personal reflection on how my languages have become a new part of my life. This study also frames my father’s knowledge as essential towards …
A Basis For Removal Or Retention Of Black Folk Songs In Music Education According To Black Americans In The Music Community, Ashley Yarbrough
A Basis For Removal Or Retention Of Black Folk Songs In Music Education According To Black Americans In The Music Community, Ashley Yarbrough
Doctoral Dissertations and Projects
Despite the contribution of a large body of musical literature by Black Americans from the late nineteenth century forward, few musical contributions of Black American slaves have been properly attributed from the centuries prior, and many were credited to White Americans. In recent years, cultural sensitivities and misinterpretations toward the early music of Black Americans have created a movement to remove many of these songs from circulation and in particular, music education repertoire. In this study, the folk music created by Black Americans from the seventeenth through the nineteenth century was explored in order to determine the motivational factors according …
Barriers To Mental Health Treatment Among U.S. Army Aviation Personnel, Aric James Raus
Barriers To Mental Health Treatment Among U.S. Army Aviation Personnel, Aric James Raus
Doctoral Dissertations and Projects
Safe and effective Army aviation operations require a clear focus from all involved. Yet, after more than two decades of U.S. combat aviation operations, little is known about the barriers experienced by aviators when considering mental health evaluation and treatment. An extensive literature review found no published studies examining mental health treatment hesitance among Army Aviation personnel or the perceived acceptability of self-help treatment options. This study identifies the relationships between age, gender, and aviation career specialty on the self-disclosed instrumental, attitudinal, and stigma-based barriers to care among U.S. Army aviation personnel. Additionally, the research determines relationships between the population’s …
Multiple Perspectives Examining How A High School Junior Reserve Officer Training Corps (Jrotc) Program Affects Student Development: A Case Study, Kurt Duane Barry
Multiple Perspectives Examining How A High School Junior Reserve Officer Training Corps (Jrotc) Program Affects Student Development: A Case Study, Kurt Duane Barry
Doctoral Dissertations and Projects
The purpose of this case study was to examine how a high school’s Junior Reserve Officer Training Corps (JROTC) program affects student development of their personal responsibility and a sense of accomplishment by fusing the perspectives of the school administrators, JROTC instructors, and school guidance counselors for a more holistic view. The theories guiding this study are Abraham Maslow’s theory of motivation and Albert Bandura’s theory of self-efficacy, which relate to secondary student development for cadets in the JROTC program. The central research question focused on the benefits of a school’s JROTC program to the cadets enrolled. The research setting …
The Canonical Significance Of Mindset In Romans 8:5–14 (Φρονέω And Its Cognates): Implications For Biblical Interpretation, Application, And Evangelism, Denise Anne Pass
The Canonical Significance Of Mindset In Romans 8:5–14 (Φρονέω And Its Cognates): Implications For Biblical Interpretation, Application, And Evangelism, Denise Anne Pass
Doctoral Dissertations and Projects
The term mindset is common in today’s vernacular, but its significance in the canon has scarcely been explored. Cultures throughout time have viewed mindsets as something that human volition alone can affect. Yet the inability to maintain the mindset God requires of his people has prevented them from faithfully keeping the covenant and rightly interpreting Scripture. Mindsets are habitual or innate mental attitudes that determine how one will interpret life situations and the Word of God, impacting relationships with others and one’s ability to love God and walk in obedience to His Word. Paul’s extensive use of φρονέω echoes back …
Women In The Leadership Of Church Worship Upholding And Manifesting Biblical Principles Of Their God-Given Design, Joyce Ann Walter
Women In The Leadership Of Church Worship Upholding And Manifesting Biblical Principles Of Their God-Given Design, Joyce Ann Walter
Doctoral Dissertations and Projects
Despite the existing literature and changes in church governments that promote women in leadership roles of church worship, there remains a gap that specifies the biblical feminine qualities of women in worship leadership. These specifics should clarify the manifested characteristics of those women in leadership who exhibit the biblical distinctness of their gender from that of the male gender. Historical study shows in past generations that many denominations have banned women from such leading roles because of the interpretation of Scripture pertaining to the man being the head over the woman. This stance has been changing in the 21st century …
Phenomenological Analysis Of Training Effectiveness For Multiracial Ministry Received By Black Pastors Graduating From Southern Baptist Seminaries, Timothy D. Griffin
Phenomenological Analysis Of Training Effectiveness For Multiracial Ministry Received By Black Pastors Graduating From Southern Baptist Seminaries, Timothy D. Griffin
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to understand the perception of preparedness for multicultural ministry of current black senior pastors who earned a Master of Divinity or Doctorate at one of the six Southern Baptist Seminaries, each of which can also be classified as predominantly white institutions (PWIs). The theory guiding this study was Racial Formation Theory (Omi & Winant, 2014). This theory suggests race as being a socially constructed paradigm that is manipulated by political, social, and economic forces. The researcher convened an expert panel of black ministers who are part of a conservative Baptist organization. This panel …
An Exegetical Analysis On Zechariah 11, Jian Wu
An Exegetical Analysis On Zechariah 11, Jian Wu
Doctoral Dissertations and Projects
The prophetic book of Zechariah, the longest one of the Twelve Prophets, contains many interpretive challenges. This dissertation focuses on Zechariah 11 while acknowledging textual issues and heavy influence from the Major Prophets and offers a harmonized holistic interpretation of the two sign-acts, the shepherds and staffs, and other relevant issues such as the thirty pieces of silver through applying five research methodologies. This dissertation argues that Zechariah 11 provides a retrospective of what Israel experienced to raise an alarm for them to obey God’s command. This partly explains the abrupt shift in tone from hope and promise in Zechariah …
Ethics As A Stand-Alone Course For Ph.D. In Public Administration, Daniel Scott
Ethics As A Stand-Alone Course For Ph.D. In Public Administration, Daniel Scott
Doctoral Dissertations and Projects
Ethics is an essential aspect of society and public administration (PA). Despite being an essential aspect of PA, ethics courses are not universally integrated into higher education programs. Few higher education institutions have adopted a comprehensive approach to ethics, and ethics courses are not required for most doctor of philosophy (Ph.D.) graduates in PA. The purpose of this qualitative case study is to understand the ramifications of not having a stand-alone ethics course in PA Ph.D. programs. The research questions that guided this study are: What are the ramifications of not having a stand-alone ethics course in PA Ph.D. programs? …
Brg1/Brm Inhibitor Targets Aml Stem Cells And Exerts Superior Preclinical Efficacy Combined With Bet Or Menin Inhibitor, Warren Fiskus, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christopher P Mill, Christine E Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren B Flores, Courtney D Dinardo, Kapil N Bhalla
Brg1/Brm Inhibitor Targets Aml Stem Cells And Exerts Superior Preclinical Efficacy Combined With Bet Or Menin Inhibitor, Warren Fiskus, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christopher P Mill, Christine E Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren B Flores, Courtney D Dinardo, Kapil N Bhalla
Faculty, Staff and Student Publications
BRG1 (SMARCA4) and BRM (SMARCA2) are the mutually exclusive core ATPases of the chromatin remodeling BAF (BRG1/BRM-associated factor) complexes. They enable transcription factors/cofactors to access enhancers/promoter and modulate gene expressions responsible for cell growth and differentiation of acute myeloid leukemia (AML) stem/progenitor cells. In AML with MLL1 rearrangement (MLL1r) or mutant NPM1 (mtNPM1), although menin inhibitor (MI) treatment induces clinical remissions, most patients either fail to respond or relapse, some harboring menin mutations. FHD-286 is an orally bioavailable, selective inhibitor of BRG1/BRM under clinical development in AML. Present studies show that FHD-286 induces differentiation and lethality in AML cells with …
Impacts Of Hematodinium Infection In A Seasonal Population Model Of The Chesapeake Bay Blue Crab, Gwendolyn R. Sargent, Romuald Lipcius, Leah Shaw, Junping Shi, Jeffrey D. Shields
Impacts Of Hematodinium Infection In A Seasonal Population Model Of The Chesapeake Bay Blue Crab, Gwendolyn R. Sargent, Romuald Lipcius, Leah Shaw, Junping Shi, Jeffrey D. Shields
Biology and Medicine Through Mathematics Conference
No abstract provided.
Understanding Cardiovascular Dynamics: Insights From Data Driven Nonlinear Hyperelastic Wall Modeling In Pulmonary Arteries, Md Arifuzzaman, Mette S. Olufsen, Mansoor A. Haider
Understanding Cardiovascular Dynamics: Insights From Data Driven Nonlinear Hyperelastic Wall Modeling In Pulmonary Arteries, Md Arifuzzaman, Mette S. Olufsen, Mansoor A. Haider
Biology and Medicine Through Mathematics Conference
No abstract provided.
Challenging Norms, Creating Art: An Anti-Ableist Lens On Visual Arts Education, Alexis Lino
Challenging Norms, Creating Art: An Anti-Ableist Lens On Visual Arts Education, Alexis Lino
Education | Master's Theses
This research explored the active role of disabled artists in their own descriptions of meaning making through their artistic process, utilizing phenomenological research to examine the lived experiences of intellectually or developmentally disabled and neurodiverse adult artists in the Bay Area. The literary study element of the research strove to understand and employ anti-ableism and constructivism as framing lenses, while also reviewing literature on issues such as access barriers, traditional quality standards in arts education, and the de-emphasis of art within curriculum funding priorities, indicating a need for continued reform toward promoting inclusive and process-oriented art education. With a focus …
Protecting The Environment In Times Of Armed Conflict: The 2023 Elisabeth Haub Award For Environmental Law And Diplomacy Transcript, Nicholas Robinson
Protecting The Environment In Times Of Armed Conflict: The 2023 Elisabeth Haub Award For Environmental Law And Diplomacy Transcript, Nicholas Robinson
Pace Environmental Law Review
2023 Elisabeth Haub Award for Environmental Law and Diplomacy honoring Ambassador Marja Lehto of Finland and Former Ambassador Marie Jacobsson of Sweden for their pivotal roles advancing environmental law and policy to protect the environment in times of armed conflict.
When It Rains, It Pours: Weather Modification Law In The United States And A Proposal For Federal Control, Brendan Woodruff
When It Rains, It Pours: Weather Modification Law In The United States And A Proposal For Federal Control, Brendan Woodruff
Pace Environmental Law Review
Though weather modification has been used as a strategy to address issues such as drought throughout history, there continues to be a lack of federal regulation addressing weather modification. This Note surveys state regulations on weather modification and examines the current status of how the federal government addresses weather modification. Ultimately, this Note makes the case for why the Department of the Interior should take on the federal regulation of weather modification.
How Sustainable Is Your Coal Ash Cover System, Marc Theisen
How Sustainable Is Your Coal Ash Cover System, Marc Theisen
World of Coal Ash Proceedings
How Sustainable is Your Coal Ash Cover System? Authors Mr. Marc Theisen - United States - Profile Products LLC Abstract Robust cover designs are integral for successful coal ash closures to ensure regulatory compliance while minimizing construction, operational and maintenance costs. Moreover, owners, designers and other stakeholders must meet Environmental, Social and Governance (ESG) obligations. With these goals in mind, cover designs should include considerations for reducing greenhouse gas emissions and carbon footprints while offering environmental sustainability and resilience for the life of the project. A vexing issue facing coal ash site restoration is often the lack of available onsite …
Door In The Trees, Greer E H Garver
The Lowest Point, Archer A. Castle
Matrix Training For Expanding The Communication Of Toddlers And Preschoolers With Autism Spectrum Disorder, Jacy Durdel, Maggie Ratcliff
Matrix Training For Expanding The Communication Of Toddlers And Preschoolers With Autism Spectrum Disorder, Jacy Durdel, Maggie Ratcliff
Honors Theses
Children diagnosed with autism spectrum disorder (ASD) commonly display a range of deficits from communication skills to play skills. When the ability to generalize is improved, a greater number of stimuli can be learned without having to be directly taught, which can be done through matrix training. Matrix training provides a framework for actively teaching a singular exemplar of a target, and, through recombination, many more stimuli can be learned. Participant is a 4-year-old boy diagnosed with ASD who was taught noun-verb combinations through tactile movement of figurines. All targets are tested before and after the single stimulus of each …
The Environmental And Social Impacts Of Chinese Fdi On The Peruvian Mining Industry: Shougang And Toromocho, Meicheng Lu
The Environmental And Social Impacts Of Chinese Fdi On The Peruvian Mining Industry: Shougang And Toromocho, Meicheng Lu
CISLA Senior Integrative Projects
My SIP will be on the social and environmental impacts of the mining industry in Peru, specifically Chinese companies’ involvement and the effect Chinese Foreign Direct Investment has on the local communities and the climate. Currently, there are challenges in ensuring that the local communities are satisfied with certain benefits and ethical conducts of operations. Mining is an economic activity that should be well-facilitated to ensure sustainable mining practices that safeguard the environment, workers, and the community are followed. Many mining projects face protests from local communities, which often results in long-term stalemates. Many projects don’t even get to start …