Digital Commons Network^™

Neurocognitive Outcome Following Tuberculous Meningitis Treatment: A Systematic Review, Muhammad Ilham Dhiya Rakasiwi, Erlina Burhan, Afid Brilliana Putra, Ihya Fakhrurizal Amin, Nadhif Wiratara

Pakistan Journal of Neurological Sciences (PJNS)

Background and objective: Tuberculous meningitis (TBM) is an infectious disease of the central nervous system that remains to be a global health challenge. Patients who survive after experiencing TBM have a risk of developing functional, cognitive and psychological disorders that can affect daily activities. The objective of this study is to present a comprehensive review of data on cognitive outcome after TBM infection.

Method: We conducted a systematic literature search to identify studies addressing cognitive outcomes in adult TBM patients. Following a systematic literature search (PubMed, Scopus, EBSCO), studies were reviewed by independent reviewers to assess eligibility for inclusion. Three …

A Mouse Model Of The Protease-Activated Receptor 4 Pro310leu Variant Has Reduced Platelet Reactivity, Xu Han, Elizabeth A. Knauss, Maria De La Fuente, Ronald A. Conlon, David F. Lepage, Weihong Jiang, Marvin T. Nieman

Faculty Scholarship

Background: Protease-activated receptor 4 (PAR4) mediates thrombin signaling on platelets and other cells. Our recent structural studies demonstrated that a single nucleotide polymorphism in extracellular loop 3 and PAR4-P310L (rs2227376) leads to a hyporeactive receptor. Objectives: The goal of this study was to determine how the hyporeactive PAR4 variant in extracellular loop 3 impacts platelet function in vivo using a novel knock-in mouse model (PAR4-322L). Methods: A point mutation was introduced into the PAR4 gene F2rl3 via CRISPR/Cas9 to create PAR4-P322L, the mouse homolog to human PAR4-P310L. Platelet response to PAR4 activation peptide (AYPGKF), thrombin, ADP, and convulxin was monitored …

Autism Spectrum Disorder And Menstruation Research Guide, Emily Roberts, Keely Lundy

Projects

Autism Spectrum Disorder (ASD), which is often called autism, can make it hard for people to communicate and interact with others and can cause repetitive behaviors and interests1. Girls, women, and other people who were assigned female at birth are commonly misdiagnosed, not diagnosed, or may be diagnosed later in life with autism because healthcare providers don’t know enough about how they show symptoms or how they “mask”, or hide their differences2 3 4 5. Because of this, many autistic people’s needs are unmet and unexamined.

One important need that isn't always met for autistic people who have periods, also …

Un Auto Interior: La Vida Es Sueño De [Los Números Imaginarios] Para La Cntc, Sergio Adillo Rufo

Teatro: Revista de Estudios Escénicos / A Journal of Theater Studies

En este artículo reivindico la necesidad del trabajo dramatúrgico para fomentar el diálogo contemporáneo con un texto clásico (el auto sacramental de La vida es sueño de Calderón de la Barca) a través de un dispositivo inmersivo o relacional que tiene conexiones con la vuelta al rito de Artaud y Grotowski.

In this article I claim the need for dramaturgical work to promote contemporary dialogue with a classic text (the auto sacramental of Life is a Dream by Calderón de la Barca) through an immersive or relational device connected with the return to the rite of Artaud and Grotowski.

Present Case Studies Highlighting Practical Implications Of Architectural Design Choices, Emily Barnes, James Hutson

Faculty Scholarship

The interpretability of deep neural networks (DNNs) has become a crucial focus within artificial intelligence and machine learning, particularly as these models are increasingly used in high-stakes applications such as healthcare, finance, and autonomous driving. This article explores the impact of architectural design choices on the interpretability of DNNs, emphasizing the importance of transparency, trust, and accountability in AI systems. By presenting case studies and experimental results, the article highlights how different architectural elements—such as layer types, network depth, connectivity patterns, and attention mechanisms—affect model interpretability and performance. The discussion is structured into three main sections: real-world applications, architectural trade-offs, …

Application Of Intravenous Laser Irradiation Of Blood (Ilib) In Physical Medicine: A Narrative Review, Ya-Chi Chuang, Yuan-Yang Cheng

Rehabilitation Practice and Science

Intravenous laser irradiation of blood (ILIB) involves a type of intravascular treatment which applies a helium-neon laser possessing a wavelength of 632.8nm. Since its first use in 1981 by Russian scientists, it is now widely applied in the treatment of various diseases, including chronic musculoskeletal pain, wound healing, spinal cord injury, stroke, traumatic brain injury, coronary artery disease, type 2 diabetes mellitus, rheumatoid arthritis and acute kidney injury. The underlying mechanism for ILIB may be associated with its anti-oxidative (through regulating the reactive oxygen species systems) and anti-inflammatory effects (by reducing the production of inflammatory cytokines). Moreover, positive effects on …

Green Gold: The Akkoub’S Settler Ecologies, Irus Braverman

Journal Articles

The akkoub (Gundelia tournefortii) is a thistle-like plant so precious in Palestinian cuisine that it is often referred to as “green gold.” The risks, as well as the mystique, surrounding the akkoub have only intensified since the state of Israel designated this plant as protected under the Nature and Parks Protection Act. The story of the akkoub as depicted in this article illustrates the three tenets of “settler ecologies”: the regime of environmental protections enacted by the settler state that furthers its domination of the natural landscape and its dispossession of local and Indigenous communities. The first and …

Repeated Stimulation Of Feeding Mechanoafferents In Aplysia Generates Responses Consistent With The Release Of Food, Hillel J. Chiel

Faculty Scholarship

How does repeated stimulation of mechanoafferents affect feeding motor neurons? Monosynaptic connections from a mechanoafferent population in the Aplysia buccal ganglia to five motor followers with different functions were examined during repeated stimulus trains. The mechanoafferents produced both fast and slow synaptic outputs, which could be excitatory or inhibitory. In contrast, other Aplysia mechanoafferents produce only fast excitation on their followers. In addition, patterns of synaptic connections were different to the different motor followers. Some followers received both fast excitation and fast inhibition, whereas others received exclusively fast excitation. All followers showed strong decreases in fast postsynaptic potential (PSP) amplitude …

Implementing And Evaluating Social-Emotional Learning Through Inquiry Research And Best Practice, Nada Abid

Dissertations

Previous research has provided insight into the benefits of incorporating social-emotional learning (SEL) into the classroom, such as in the area of academic performance. As Jones et al. (2018) explained, “Children who can effectively manage their thinking, attention, and behavior are also more likely to have better grades and higher standardized test scores” (p. 15). I designed this research to examine the implementation of an SEL program and evaluate its effectiveness. The school’s multi-tiered system of supports(MTSS) team worked to implement the SEL program in the classrooms and chose two classrooms in which to pilot the program. The evaluation involved …

From Pre-Clinical To Translational Brain Metastasis Research: Current Challenges And Emerging Opportunities, Emilija Aleksandrovic, Siyuan Zhang, Dihua Yu

Faculty, Staff and Student Publications

Brain metastasis, characterized by poor clinical outcomes, is a devastating disease. Despite significant mechanistic and therapeutic advances in recent years, pivotal improvements in clinical interventions have remained elusive. The heterogeneous nature of the primary tumor of origin, complications in drug delivery across the blood-brain barrier, and the distinct microenvironment collectively pose formidable clinical challenges in developing new treatments for patients with brain metastasis. Although current preclinical models have deepened our basic understanding of the disease, much of the existing research on brain metastasis has employed a reductionist approach. This approach, which often relies on either in vitro systems or in …

Evaluating Postoperative Prognosis: A Single Surgeon's Experience With Total Mesorectal Excision In Middle And Lower Rectal Cancer Cases In Iraq, Aqeel S Mahmood, Mohammed Ahmed Abbas, Ammar Gany Yassin, Haider A Ahmed, Samer Sabri, Ahmed A Shakir, Hussein Abbas, Mustafa Ismail

Faculty, Staff and Student Publications

INTRODUCTION: Surgical intervention for rectal cancer is widely recognized for its potential to significantly impact quality of life, chiefly due to the high probability of permanent colostomy and the associated postoperative complications.

OBJECTIVE: This study aimed to evaluate the short-term outcomes and morbidity associated with total mesorectal excision for middle and lower rectal cancer within an Iraqi cohort, in a prospective setting.

METHODS: This study prospectively collected and analyzed data from 89 patients who underwent a standardized radical rectal resection, with a follow-up period extending to one month post-surgery.

RESULTS: The mean age of patients was 54.4 ± 12.9 years, …

International Consensus Guidelines For The Definition, Detection, And Interpretation Of Autophagy-Dependent Ferroptosis, Xin Chen, Andrey S Tsvetkov, Han-Ming Shen, Ciro Isidoro, Nicholas T Ktistakis, Andreas Linkermann, Werner J H Koopman, Hans-Uwe Simon, Lorenzo Galluzzi, Shouqing Luo, Daqian Xu, Wei Gu, Olivier Peulen, Qian Cai, David C Rubinsztein, Jen-Tsan Chi, Donna D Zhang, Changfeng Li, Shinya Toyokuni, Jinbao Liu, Jong-Lyel Roh, Enyong Dai, Gabor Juhasz, Wei Liu, Jianhua Zhang, Minghua Yang, Jiao Liu, Ling-Qiang Zhu, Weiping Zou, Mauro Piacentini, Wen-Xing Ding, Zhenyu Yue, Yangchun Xie, Morten Petersen, David A Gewirtz, Michael A Mandell, Charleen T Chu, Debasish Sinha, Eftekhar Eftekharpour, Boris Zhivotovsky, Sébastien Besteiro, Dmitry I Gabrilovich, Do-Hyung Kim, Valerian E Kagan, Hülya Bayir, Guang-Chao Chen, Scott Ayton, Jan D Lünemann, Masaaki Komatsu, Stefan Krautwald, Ben Loos, Eric H Baehrecke, Jiayi Wang, Jon D Lane, Junichi Sadoshima, Wan Seok Yang, Minghui Gao, Christian Münz, Michael Thumm, Martin Kampmann, Di Yu, Marta M Lipinski, Jace W Jones, Xuejun Jiang, Herbert J Zeh, Rui Kang, Daniel J Klionsky, Guido Kroemer, Daolin Tang

Faculty, Staff and Student Publications

Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense …

A Stray Thought On “Happiness”, Yeomin Yoon

KAUPA Letters

No abstract provided.

Kcnk1 Promotes Proliferation And Metastasis Of Breast Cancer Cells By Activating Lactate Dehydrogenase A (Ldha) And Up-Regulating H3k18 Lactylation, Xiangchan Hou, Jiawei Ouyang, Le Tang, Pan Wu, Xiangying Deng, Qijia Yan, Lei Shi, Songqing Fan, Chunmei Fan, Can Guo, Qianjin Liao, Yong Li, Wei Xiong, Guiyuan Li, Zhaoyang Zeng, Fuyan Wang

Faculty, Staff and Students Publications

Breast cancer is the most prevalent malignancy and the most significant contributor to mortality in female oncology patients. Potassium Two Pore Domain Channel Subfamily K Member 1 (KCNK1) is differentially expressed in a variety of tumors, but the mechanism of its function in breast cancer is unknown. In this study, we found for the first time that KCNK1 was significantly up-regulated in human breast cancer and was correlated with poor prognosis in breast cancer patients. KCNK1 promoted breast cancer proliferation, invasion, and metastasis in vitro and vivo. Further studies unexpectedly revealed that KCNK1 increased the glycolysis and lactate production in …

Multidisciplinary Training In Dermatology: Exploring The Spectrum Of Board Certifications Among Physicians Practicing Dermatology In Texas, Rebecca H Lee, Jason Lee, Jonny Hatch, Lilian Zhan, Braden Van Alfen, Mark Conley, Tracy Zhao, Carlos Gomez-Meade

Faculty, Staff and Students Publications

Dermatology, a medical specialty focused on skin, hair, and nail conditions, often overlaps with various medical specialties. Although most physicians practicing dermatology are board-certified in dermatology, there are physicians practicing dermatology who are board-certified in a variety of different medical specialties. This cross-sectional study examines the board certifications of physicians who reported practicing dermatology in Texas. Data were sourced from the Texas Medical Board database updated in August 2023. The data showed that out of 1,614 practicing physicians declaring dermatology as a specialty in Texas, 1,080 (66.91%) physicians had one board certification, 200 (12.39%) had two, and 15 (0.93%) had …

Skeletal Abnormalities In Mice With Dnmt3a Missense Mutations, Austin Bell-Hensley, Diana C Beard, Kathryn Feeney, Hongjun Zheng, Yunhao Jiang, Xiyun Zhang, Jin Liu, Harrison Gabel, Audrey Mcalinden

2020-Current year OA Pubs

Overgrowth and intellectual disability disorders in humans are typified by length/height and/or head circumference ≥ 2 standard deviations above the mean as well as intellectual disability and behavioral comorbidities, including autism and anxiety. Tatton-Brown-Rahman Syndrome is one type of overgrowth and intellectual disability disorder caused by heterozygous missense mutations in the DNA methyltransferase 3A (DNMT3A) gene. Numerous DNMT3A mutations have been identified in Tatton-Brown-Rahman Syndrome patients and may be associated with varying phenotype severities of clinical presentation. Two such mutations are the R882H and P904L mutations which result in severe and mild phenotypes, respectively. Mice with paralogous mutations (Dnmt3a

Hyperkinetic Movement Disorder Caused By The Recurrent C892c>T Nacc1 Variant, Jonna Komulainen-Ebrahim, Salla M Kangas, Estrella López-Martín, Timothy Feyma, Fernando Scaglia, Beatriz Martínez-Delgado, Outi Kuismin, Maria Suo-Palosaari, Lucinda Carr, Reetta Hinttala, Manju A Kurian, Johanna Uusimaa

Faculty, Staff and Students Publications

BACKGROUND: Genetic syndromes of hyperkinetic movement disorders associated with epileptic encephalopathy and intellectual disability are becoming increasingly recognized. Recently, a de novo heterozygous NACC1 (nucleus accumbens-associated 1) missense variant was described in a patient cohort including one patient with a combined mitochondrial oxidative phosphorylation (OXPHOS) deficiency.

OBJECTIVES: The objective is to characterize the movement disorder in affected patients with the recurrent c.892C>T NACC1 variant and study the NACC1 protein and mitochondrial function at the cellular level.

METHODS: The movement disorder was analyzed on four patients with the NACC1 c.892C>T (p.Arg298Trp) variant. Studies on NACC1 protein and mitochondrial function …

Advances In Bone And Orthopedics 2024 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet

Publications and Research

We are delighted to present the latest edition of ”Advances in Bone and Orthopedics,” a comprehensive compilation of pioneering research and innovative developments in the field. This volume brings together a selection of peer-reviewed abstracts from BONITOS 2024, the Fourth Season of the Bone and Orthopedics Interdisciplinary Symposium, held on May 31st, 2024, at the College of Staten Island in New York. This symposium, a hallmark event in the calendar of professionals dedicated to bone health and orthopedic excellence. The contributions within this volume reflect the breadth and depth of research presented at BONITOS 2024. These abstracts represent cutting-edge studies …

Redistributing Justice, Benjamin Levin, Kate Levine

Articles

This Essay surfaces an obstacle to decarceration hiding in plain sight: progressives’ continued support for the carceral system. Despite progressives’ increasingly prevalent critiques of criminal law, there is hardly a consensus on the left in opposition to the carceral state. Many left-leaning academics and activists who may critique the criminal system writ large remain enthusiastic about criminal law in certain areas— often areas in which defendants are imagined as powerful and victims as particularly vulnerable.

In this Essay, we offer a novel theory for what animates the seemingly conflicted attitude among progressives toward criminal punishment—the hope that the criminal system …

The Effect Of Nuciferine On The Renal Dysfunction Following Ischemia/Reperfusion Injury, Sundus Farag Sallabi

Theses

Renal Ischemia-Reperfusion Injury (IRI) is an inevitable consequence of some surgical procedures and clinical conditions such as renal transplantation and aortic cross-clamping. The pathophysiology of renal IRI includes oxidative stress, an aggravated inflammatory response, apoptotic cell death, and fibrogenesis. These pathophysiological processes underlying renal IRI lead to the development of Acute Kidney Injury (AKI). Therefore, there is a need for effective and affordable therapeutic agents, such as phytochemical compounds to mitigate this injury. Nuciferine (NF), is a phytochemical compound extracted from the plant Nelumbo nucifera Gaertn and has been selected for its antioxidant and anti-inflammatory properties as demonstrated in the …

Cellular Automata Modeling Approach Of Addiction, Ruba Hameed

Theses

The purpose of this thesis includes the application of a mathematical model, as well as cell automata simulation, to shed light on the behavior of addiction spread in a population. The model describes the key determinants of drug addiction which includes peer influence, availability of substances, support networks, and awareness campaigns. The research aims to gain insights into the underlying mechanisms and patterns of addiction spread to develop effective prevention and intervention strategies.

The study begins by creating a discrete dynamical system that captures the transitions between 4 different states of substance use, including non-users (N), experimental users (E), recreational …

Studies On The Corrosion Of Bronze Artifacts From Sarouq Al-Hadid And Al-Qusais Archeological Sites In Dubai, Uae, Zainab Ali Salmin

Theses

This thesis compares the status of bronze artefacts from two archaeological sites in Dubai (UAE): the Sarouq Al-Hadid site (Stone Age to Early Islamic Period) and the Al- Qusais site (Late Bronze Age to Early Iron Age). The main objective of this research is to understand the two sites' environment and their influence on the corrosion of archaeological bronze artifacts found at the sites. This study uses mCed methods to comprehensively understand the corrosion behavior of bronze objects, depending on their burial environment. The two different sites presented different soil types and rates of corrosivity on the buried bronze artifacts, …

Using Bayesian Multispecies Models To Evaluate Fish And Invertebrate Detection Probability And Distribution In The Hypersaline Bahia Grande Tidal Basin, Roy M. Ulibarri, Catherine M. Eckert, David Hicks, David Montagne, Brandon Jones, David R. Stewart

School of Earth, Environmental, & Marine Sciences Faculty Publications

Objective

In 2000, the Laguna Atascosa National Wildlife Refuge acquired the Bahia Grande (Texas) management unit, a space that had lain barren and arid for 70 years. A large cooperative partnership launched a restoration project to replenish the basin and recover its original tidal hydrology. In 2005, the construction of a pilot channel successfully restored water throughout the basin, and plans to eventually widen the channel were developed. Our study aims to evaluate an estuarine habitat restoration by assessing ecological drivers and the impacts on species diversity.

Methods

We evaluated species richness, detection/occupancy rates, and species–habitat relationships, and we estimated …

Historikong Pagbagtas Ng Mgabanyagang Impluwensiyasa Kontemporanyong P-Pop, Kirsten Louise G. Velasco

Katipunan

Maaring makita ang kontemporanyong industriya ng P-pop na umusbong sa mga nagdaang taon bilang bahagyang produkto ng mga katumbas nitong genreng banyaga, partikular na ang J-pop at K-pop ng mga bansang Japan at South Korea. Maraming aspekto ng industriya ng P-pop, tulad na lamang ng konsepto nito ng “idol,” sistema nito sa pagbubuo ng mga idolo, at pamamaraan nito ng pagmarket sa mga idolo, ang pare-parehong nakuha sa nabanggit na mga banyagang industriya. Ito ay ginawa sa pagnanais na makabuo at makapamahala ang bansa ng sarili nitong “idol industry.” Sa katunayan din, ang pagsisimula ng P-pop ay maaring maiugat sa …

Species Diversity And Extinction Risk Of Vertebrate Pollinators In India, Ratheesh Kallivalappil, Florencia Grattarola, Dilkushi De Alwis Pitts, Sheena C. Cotter, Daniel Pincheira-Donoso

All Works

Animal pollinators underpin the functioning and persistence of ecosystems globally. However, the vital role of pollination is being progressively eroded by the worldwide decline of pollinator species caused by human-induced environmental degradation, resulting in rising costs to biodiversity, agriculture, and economy. Most studies quantifying pollinator diversity and declines have focused on insects, whereas vertebrate pollinators remain comparatively neglected. Here, we present the first comprehensive study quantifying the macroecological patterns of species richness and extinction risk of bird and mammal pollinators in India, a region of extremely high biodiversity and increasing anthropogenic pressure. Our results reveal that hotspots of mammal pollinator …

Economic Impacts Of Industry Shifts: Evaluating The Decline Of The Coal Industry In Indonesia's Transition To Renewable Energy, Sebastian Ming Lopez

University Honors Theses

Worldwide usage of coal in energy production is declining. Agreements on carbon reduction and decreasing reliance on non-renewable energy systems are occurring at differing rates. Developed countries are quick to adapt and switch to renewable energy systems using their greater resources, technological advances, and government support. Developing countries however are at a disadvantage due to a lack of resources and prior investments in older, polluting, technology. This study aims to look at the potential effects of the decline of the coal industry within Indonesia, a fast-growing developing country that relies heavily on its coal sector. Indonesia as a country is …

Determining Factors For Improved Uptake Of Harm Reduction Services In The United States: A Study Of Inclusive, Culturally Sensitive Messaging, Lauretta Ekanem Omale

Dissertations

Harm reduction refers to public health policies and programs aimed at decreasing the adverse consequences associated with drug use. While harm reduction services (e.g., syringe exchange programs) can mitigate health risks, marginalized groups face barriers to service access and utilization, partially due to ineffective messaging approaches that fail to align with cultural values and experiences. A one-size-fits-all approach to messaging can negatively impact service utilization, health outcomes, and health disparities. Ineffective communication can lead to poor adherence to treatment, poorer health outcomes, and increased adverse events.

Culturally insensitive communication contributes to stigma, mistrust, and lack of perceived relevance, discouraging service …

The Utilisation Of Mushroom Leftovers, Oats, And Lactose-Free Milk Powder For The Development Of Geriatric Formulation, Snigdha Paul, Ravinder Kaushik, Shuchi Upadhyay, Ansab Akhtar, Prince Chawla, Naveen Kumar, Saurabh Sharma, Pooja Rani

School of Medicine Faculty Publications

This study aims to focus on developing a food supplement for the geriatric population using disposal mushrooms, oats, and lactose-free milk powder. Lactose intolerance is most common in older adults, raising the demand for lactose-free foods. One of the major global challenges currently faced by humankind is food waste (FW). Most of the food that is produced for human consumption has not been utilized completely (1/3rd-1/2 unutilized), resulting in agricultural food waste. Mushrooms are highly valuable in terms of their nutritional value and medicinal properties; however, a significant percentage of mushroom leftovers are produced during mushroom production that do not …

Comprehensive Pluralist, Political Liberal: Rosenfeld And Rawls, Frank I. Michelman

Cardozo Law Review

A main plot in A Pluralist Theory of Constitutional Justice starts out from a supposition of political common cause between the author and his readers. Together, we are to be concerned with the upkeep and the fate of a certain high form of politics to which we're presumed attached, named by the book's first words as "liberal constitutional democracy" (LCD). The idea is that we want that form of politics to be in actual implementation going forward the best that it can be.

Tumor Necrosis Factor And Interleukin Modulators For Pathologic Pain States: A Narrative Review, Alan D. Kaye, Dominique M. Perilloux, Alison M. Hawkins, Grace C. Wester, Amanda R. Ragaland, Sage V. Hebert, Julian Kim, Michael Heisler, Rucha A. Kelkar, Azem A. Chami, Sahar Shekoohi, Adam M. Kaye

Pacific Faculty Work

Chronic pain, a complex and debilitating condition, involves intricate interactions between central and peripheral inflammatory processes. Cytokines, specifically tumor necrosis factor (TNF) and interleukins (IL), are key mediators in the initiation and maintenance of chronic pain states. Sensory neurons expressing receptors for cytokines like TNF, IL-1, and IL-6 are implicated in peripheral sensitization, contributing to increased signaling of painful sensations. The potential of targeting TNF and IL for therapeutic intervention in chronic pain states is the focus of this review, with preclinical and clinical evidence supporting the use of TNF and IL modulators for pain management. The physiological and pathological …