Digital Commons Network^™

Cannabis Exposure During Pregnancy And Neural Mechanisms Of Parenting: Assessing Neural Responses To Infant Cues And Parenting Outcomes, Shannon Powers

Electronic Theses and Dissertations

As legalization of cannabis and cannabinoids spreads in the United States, access and use of cannabis during the prenatal period has increased. There is limited knowledge on the effects of prenatal cannabis use on the parental brain. One way to identify potential effects of cannabis on parenting is through studying parenting brain functions and behavior. Cannabis use disorder (CUD) has been shown to be associated with lower positive parenting and lower sensitivity to infants, but it is unclear by what mechanisms. The following two studies address this gap in knowledge by examining the association between cannabis use during the prenatal …

Eng 5742-600 Studies In Genre For Writers And Teachers, Christopher Wixson

Summer 2024

No abstract provided.

Evidence Of Climatic Influence On Subsistence Strategies At Sage Hen Springs, Nevada, Andrew Rogers

Electronic Theses and Dissertations

Models of settlement patterns in the northwest Great Basin describe a decrease in residential mobility, intensified use of upland spring ecozones, and an increase in diet breadth during the Middle and Late Archaic. Here, I present data collected from the Sage Hen Springs site in northwestern Nevada during a Phase II testing project conducted by the BLM and an analysis of these data focusing on patterns of subsistence and mobility strategies throughout the Archaic. Results of this analysis support existing models of lifeways in the northwest Great Basin at the small scale and point to climatic factors as influences on …

Reconciling Moral Dissonance: A Framework For Re-Integrating Moral Orientation With Life Agency During Warfighters’ Struggles With Military Moral Injury, Jeffrey L. Zust

Electronic Theses and Dissertations

This dissertation uses case studies to critically examine the Three Mirror Model (TMM) as a framework for understanding the formation and healing of Military Moral Injury (MMI). I adapt the work of Stephen Brookfield and Neal Krause to evaluate using the TMM as a methodology for dealing with the complex issues of MMI within a military deployment cycle (training, warfighting, and healing) (Brookfield 2012, 2017; Krause 2022). Specifically, I use theorists, researchers, healers, and warfighters as key stakeholders to identify and critically examine the intersections of disciplines and the subsets of models where warfighters’ moral orientations and moral agency form …

Neuroinflammation In Alzheimer’S Disease Mouse Brain Following Repetitive Mild Traumatic Brain Injury, Lujain Almuhanna

Electronic Theses and Dissertations

Traumatic brain injuries (TBIs) are a common form of head injury, with mild TBIs (mTBIs) making up 75-90% of the TBI severity scale. It’s been suggested that repetitive mild TBIs (rmTBIs) may enhance effects of Alzheimer’s Disease (AD). With dementia linking TBI and AD together, we investigated the memory hub of the brain - the hippocampus. Astrocytes and microglia are two glial cells that respond to neuroinflammation and therefore imaged in hippocampal regions of the 3xTg-AD mouse brain. We hypothesized that AD brain pathology (i.e., neuroinflammation) would be accelerated in 3xTg-AD mice following rmTBIs early in life. Analyses revealed that …

Evaluating The Efficiency Of Low-Cost Air Quality Sensors At A Suburban Field Site, Olivia Wuttke

Undergraduate Theses, Capstones, and Recitals

Science surrounding the use of low-cost sensors (LCS) to monitor air quality is rapidly expanding to satisfy the need to fill in regional air quality data gaps. This project evaluated the suitability of two types of LCS: Modulair-PM and PurpleAir (SD and Flex models) as efficient means to measure airborne particulate matter. The study involved physical installation of nine co-located sensors at a suburban site in Denver, connectivity troubleshooting as necessary, and data analysis/modeling of data over multiple months (19 weeks). PM data was compared between individual sensors of the same type, as well as across the two different sensor …

Investigating The Role Of Ebf3a In Craniofacial Development, Shujan A. Sharafeldeen

Undergraduate Theses, Capstones, and Recitals

Proper craniofacial development requires many genes. Single-cell RNA sequencing (scRNA-seq) allows us to identify genes expressed in precursor cells for craniofacial structures, but the function of many of these genes in craniofacial development has yet to be characterized. In our scRNA-seq of cranial neural crest cells (NCCs), which are precursor cells for the craniofacial skeleton, we found a gene called early B-cell factor 3 (ebf3a) that may be involved in craniofacial development. In our scRNA-seq data, ebf3a expression is restricted to cranial NCCs of the dorsal and ventral domains of pharyngeal arches 1 and 2. In humans, damaging variants in …

Effect Of Oxidation Of Graphene On Agglomeration And The Mechanical Properties Of Thermosetting Resins, Matthew A. Reil

Electronic Theses and Dissertations

Thermosetting resins are used extensively worldwide in applications ranging from adhesives to structural components. However, these resins generally fail in a brittle fracture mode which is undesirable in most situations. Graphene (G) and its derivatives have been considered as additives to epoxy for material property enhancement and varied results have been reported in the literature. In this work, the effects of the oxidation of G to graphene oxide (GO) on polymer interactions and plate agglomeration were studied by classical molecular dynamics (MD). Results from those simulations concluded that agglomerates were likely present in all G-based nanocomposites. The effect of these …

Evaluating The Effect Of Domain-Specific Large Language Models On Question And Response, Phillip D. Crippen

Electronic Theses and Dissertations

Large Language Models have emerged to great fanfare in the Information Technology market. Business and Information Technology leaders are currently exploring ways to apply these models to assist their organizations in executing business processes and generating innovation. Software vendors, consultants, and academics promote various approaches to making Large Language Models work effectively for business. However, little academic literature is available today that quantifies the degree of improvement possible with these domain-specific approaches over the standard capabilities of generalized Large Language Models.

The study seeks to quantify the benefits of one approach, Retrieval Augmented Generation. The study uses a collection of …

Using Historic Glacial Data And Gis To Predict Mount Rainier National Park’S Glacial Future, Daniel Kincaid

Geography and the Environment: Graduate Student Capstones

Will Washington state have glaciers 100 years from now (year 2124)? Due to generally warmer weather glaciers are largely in retreat globally, including the glaciers in Washington state. In Washington state summer glacial meltwater plays a vital role in the survival of wildlife and is needed for human purposes that include recreation, power generation, drinking, agricultural, and industrial. This project looked at the most resilient glaciers in Washington state, the glaciers at Mount Rainier National Park. Historic measurements were used in an exponential growth calculation to project the amount in acres each glacier at Mount Rainer will advance or retreat …

Nebraska Farm Real Estate Market Highlights 2023-2024, Jim Jansen, Jeff Stokes

Nebraska Farm Real Estate Reports

For the fifth consecutive year, the all-land average value in Nebraska rose for the year ending February 1, 2024, averaging approximately 5% higher than the prior year. Figure 2 summarizes these figures and trends along with the percent changes over the preceding year’s all-land average for the eight districts in the state.

The statewide all-land average value for the year ending February 1, 2024, averaged $4,015 per acre, or about a 5% ($180 per acre) increase from the prior year’s value of $3,835 per acre. Rates of increase were the highest in the North and Northeast Districts, as these areas …

Cytotoxicity, Antibacterial And Anti-Inflammatory Properties Of A Synthesized Curcumin Analog And One Of Its Novel Derivatives, Marian Amir

Theses and Dissertations

This research aims to describe the synthesis, characterization, and the biological response via investigating the cytotoxic activity, hypoxic microenvironment response, antibacterial, and anti-inflammatory properties of the novel curcumin analog H-4073 and its succinate derivative (H-4073 SuD) in the context of hepatocellular carcinoma (HCC). The study also aimed to compare the effects of H-4073 and H-4073 SuD to assess their relative efficacy and potential as therapeutic agents. First, the cytotoxic effects of H-4073 and H-4073 SuD were evaluated on HEPG2 cell lines under normal conditions. Results revealed that H-4073 exhibited a significantly better cytotoxic effect than H-4073 SuD in normoxia. However, …

The Effects Of Scenic Pictures And Progressive Time Delay On Intraverbal Responding, Breanna White

USF Tampa Graduate Theses and Dissertations

Researchers have demonstrated the effectiveness of tact prompts to establish single responses to questions about intraverbal categories. Scenic pictures, a visual depiction of multiple exemplars belonging to a stimulus class, may increase the likelihood that individuals will emit multiple responses when answering categorical questions, and promote response variability. The purpose of this study was to extend Glodowski and Rodriguez (2019) by evaluating the effectiveness of a larger array of visual stimuli and progressive time delay on varied intraverbal responding with individuals diagnosed with autism spectrum disorder between the ages of 8 and 17 within a private school for individuals with …

Hepatic Lrp-1 Plays An Important Role In Amyloidosis In Alzheimer's Disease Mice: Potential Role In Chronic Heavy Alcohol Feeding, Devaraj V. Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Urvashi R. Panchal, Adenike Oyegbesan, Oghenetega E. Imiruaye, Hai Zhang, Jerome Garcia, Kamaljit Kaur, Sanda Win, Tin A. Than, Neil Kaplowitz, Moom R. Roosan, Derick Han, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Background

Methods

Foreign Object Debris: A Spatial Analysis Of Wildlife At Seatac Airport, Eli Elias

Geography and the Environment: Graduate Student Capstones

This study investigates the relationship between birds and prey within the airport environment at Seattle-Tacoma International Airport (SEATAC). In 2023, instances of bird and prey activity near Runway 16C/34C were recorded using Foreign Object Debris (FOD) detection radar. The study stems from the importance of safety within the airport environment and analyzing these relationships to better protect people and mitigate aircraft damage. Runway 16C/34C is the runway of focus as it is the only runway equipped with FOD detection radar. Temperature and rainfall averages acquired from the National Weather Service (NWS) were also used to expand this analysis. The results …

Saint Brigit And Her Habits: Exploring Queerness In Early Medieval Ireland, Jacqueline K. Stephenson

Undergraduate Theses, Capstones, and Recitals

Saint Brigit's behavior and reception by society highlight an avenue by which women in the early medieval period could escape societal strictures, exercising agency over their bodies and their romantic choices, and carve out a distinct and unexpected place for themselves in a Christian patriarchal society. In Saint Brigit’s case, this is especially demonstrated by the breadth of her portrayed power as not just a nun but a saint, her extreme resistance to marriage, and her frequent comparisons to men. Indeed, her hagiography, written by Cogitosus in the seventh century, positioned her as one of the three principal and earliest …

Investigating The Regulation Of The Hypothalamic-Pituitary-Interrenal Axis In Atlantic Sturgeon (Acipenser Oxyrinchus) Following An Acute Stressor, Liam Doherty

Undergraduate Theses, Capstones, and Recitals

This study investigated the response to acute stress in Atlantic sturgeon (Acipenser oxyrinchus) and HPI axis regulation of glucocorticoid production during stress by examining the expression of key genes― corticotropin-releasing hormone (crh), corticotropin-releasing hormone receptor (crhr), proopiomelanocortin (pomca/pomcb), melanocortin 2 receptor (mc2r), and steroidogenic acute regulatory protein (star)―that are associated with hypothalamus/pituitary/interrenal (HPI) axis of bony fishes. Additionally, tyrosine hydrogenase (th1 and th2) and phosphoenolpyruvate carboxykinase (pepck), found in catecholamine-producing cells in the head kidney of the sturgeon, were investigated …

Morphological Remodeling Of The Endoplasmic Reticulum During Mitosis And Its Influence On The Integrity Of The Spindle Apparatus, Katie R. Rollins

Electronic Theses and Dissertations

The Endoplasmic Reticulum (ER) is the largest organelle in the cell by surface area and forms contacts with other organelles throughout the cell. In recent work, the ER has been implicated in numerous processes within the cell beyond its canonical roles of protein synthesis and calcium storage. The ER also undergoes a remarkable transition in morphology during cell division, with mitotic divisions requiring a massive remodeling of various membranous organelles such as the nuclear envelope and Golgi. However, whether changes in ER behaviors modulate mitotic events is less clear. The rapid cleavage divisions in the early Drosophila embryo are a …

The Effects Of Wildfire Burn Severity On Bee And Wasp Communities Two Decades Post-Fire, Alaina K. Smith

Electronic Theses and Dissertations

While fire is a natural disturbance in many global ecosystems, anthropogenic changes are affecting fire frequency, severity, and seasonality. Disturbances like wildfire affect bee and wasp communities, but recent meta-analyses are conflicted about whether fire harms or benefits insect pollinators. We investigated the lasting effects of wildfire burn severity on wild bee communities and floral resource availability across different burn severities in two-mixed severity fires that burned >20 years ago. We found that high severity fire has positive effects on bee diversity that are associated with severity-mediated changes to the floral community. We also studied the effects of wildfire burn …

Rhetorical Resonances: An Affective Logic Of Emergence In Space And Time, Craig R. Weathers

Electronic Theses and Dissertations

This project explores the affective circulation of controversy in contemporary public discourse through a rhetorical ecological approach. It addresses the problem of how flattened conceptions of power and social movements cast in binary opposition prevent effective deliberation around public controversies. The research method involves analyzing three case studies through a new framework for rhetorical studies, called a logic of emergence, to consider the resonance and trajectories of actants (individuals, groups, and institutions) in conflict. The first case study examines the Unite the Right rally in Charlottesville and the discursive equating of antifa and the Alt-Right. The second case analyzes the …

In-Silico Analysis Of Tmem2 As A Pancreatic Adenocarcinoma And Cancer-Associated Fibroblast Biomarker, And Functional Characterization Of Nsc777201, For Targeted Drug Development, Prateeti Srivastava, Vijesh Kumar Yadav, Tzu-Hao Chang, Emily Chia-Yu Su, Bashir Lawal, Alexander Th Wu, Hsu-Shan Huang

Faculty, Staff and Student Publications

Pancreatic adenocarcinoma (PAAD), known as one of the deadliest cancers, is characterized by a complex tumor microenvironment, primarily comprised of cancer-associated fibroblasts (CAFs) in the extracellular matrix. These CAFs significantly alter the matrix by interacting with hyaluronic acid (HA) and the enzyme hyaluronidase, which degrades HA - an essential process for cancer progression and spread. Despite the critical role of this interaction, the specific functions of CAFs and hyaluronidase in PAAD development are not fully understood. Our study investigates this interaction and assesses NSC777201, a new anti-cancer compound targeting hyaluronidase. This research utilized computational methods to analyze gene expression data …

Melancholic Revolution And The Natural Love As Reflected In The Selected Poems Of Sergei Yesenin, Widad Allawi Saddam

Alustath Journal for Human and Social Sciences

Sergei Yesenin is one of the most famed Russian poets of the early 20th century. Most of his poems were about nostalgia for the countryside. On the other hand he opposed urbanization, and cursed it in his poems. He is regarded as a master of landscape represntation , an evocative poet who can relate to intense emotions. For two centuries readers have been captivated by the poetry of Sergei Yesenin. This paper explores the themes of melancholic revolution and natural love in the poetry of Through the analysis of selected poems, this paper delves into the ways in which Yesenin …

A Longitudinal Mri And Tspo Pet-Based Investigation Of Brain Region-Specific Neuroprotection By Diazepam Versus Midazolam Following Organophosphate-Induced Seizures, Brad A Hobson, Douglas J Rowland, Yimeng Dou, Naomi Saito, Zachary T Harmany, Donald A Bruun, Danielle J Harvey, Abhijit J Chaudhari, Joel R Garbow, Pamela J Lein

2020-Current year OA Pubs

Acute poisoning with organophosphorus cholinesterase inhibitors (OPs), such as OP nerve agents and pesticides, can cause life threatening cholinergic crisis and status epilepticus (SE). Survivors often experience significant morbidity, including brain injury, acquired epilepsy, and cognitive deficits. Current medical countermeasures for acute OP poisoning include a benzodiazepine to mitigate seizures. Diazepam was long the benzodiazepine included in autoinjectors used to treat OP-induced seizures, but it is now being replaced in many guidelines by midazolam, which terminates seizures more quickly, particularly when administered intramuscularly. While a direct correlation between seizure duration and the extent of brain injury has been widely reported, …

Prevalence Of Anti-Myelin Oligodendrocyte Glycoprotein Antibodies Across Neuroinflammatory And Neurodegenerative Diseases, Ritu R Trivedi, Angela S Archambault, Clarice Pavlak, Matteo Gastaldi, Claudia Cantoni, Laura Ghezzi, Anne H Cross, Timothy M Miller, Gregory F Wu

2020-Current year OA Pubs

Inflammatory central nervous system (CNS) diseases, such as multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), are characterized by humoral immune abnormalities. Anti-MOG antibodies are not specific to MOGAD, with their presence described in MS. Autoantibodies may also be present and play a role in various neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease driven by motor neuron dysfunction. While immune involvement in ALS has been recognized, the presence of antibodies targeting CNS myelin antigens has not been established. We aimed to establish a live cell-based assay for quantification of serum anti-MOG IgG1 in …

Reduced Sensitivity To Future Consequences Underlies Gambling Decision In Cerebellar Ataxia, Ruo-Yah Lai, Eli Levy, Christian J Amlang, Ihika Rampalli, Rory Mahabir, Ming-Kai Pan, Chi-Ying R Lin, Sheng-Han Kuo

Faculty, Staff and Students Publications

Introduction: Previous research has identified that people with cerebellar ataxia (CA) showed impaired reward-related decision-making in the Iowa Gambling Task (IGT). To investigate the mechanisms underlying this impairment, we examined CA participants' combination of performance in the IGT, which predominantly tests reward seeking, and the modified IGT (mIGT), which mainly assesses punishment avoidance.

Methods: Fifty participants with CA and one hundred controls completed the IGT and mIGT. Task performance in each of the five twenty-trial blocks was compared between groups and the learning rates were assessed with simple linear regressions. Each participant's IGT score and mIGT score were compared.

Results: …

A Dysphemistic Approach To The Study Of Textual Cyberbullying In Social Media, Duaa Ali Hassan

Alustath Journal for Human and Social Sciences

Abstract

The current study is a dysphemistic approach to the study of textual cyberbullying in social media. Cyberbullying became, to an extent, widespread in social media interaction. The study aims at analyzing a sample of 6oo facebook comments taken from different news agencies and websites. The study believes that cyberbullying is used in order to reach certain end. The sample of the study consists of comments for six different topics. And 100 comments were taken for each of the six topics. The model of the study is Allan and Burridge's (1991) which classifies dysphemism into eight types. The process of …

Gamification And Game-Based Learning Tools: A Review And Utility For School Libraries, Sarwesh Pareek

Library Philosophy and Practice (e-journal)

This study presents a comprehensive analysis of gamification tools in school libraries, focusing on a web-based survey that identified 29 games related to digital literacy and library services. These games, categorized as free and paid, span various subjects and topics, including math, science, language arts, and information literacy. The research examines the specific uses of these games, assessing their effectiveness in enhancing student engagement and learning outcomes. By analyzing the features, design elements, and user interactions of these games, the study aims to provide insights into their impact on student motivation and educational achievement. The findings highlight the potential of …

Censorship In The Video Game Industry: Government Intervention Or Parental Controls, Richard J. Hunter Jr., Hector R. Lozada, Ann Mayo

Denver Sports & Entertainment Law Journal

No abstract provided.

When Holding On Means Letting Go: Why Fair Use Should Extend To Fan-Based Activities, Nathaniel T. Noda

Denver Sports & Entertainment Law Journal

No abstract provided.

Law & Economics Of The Adult Entertainment Industry Today: An Inside View From The Industry's Leading Trade Publisher, Clay Calvert, Robert D. Richards

Denver Sports & Entertainment Law Journal

No abstract provided.