Digital Commons Network^™

Impacts Of Stream Habitat Restoration On Macroinvertebrate Assemblages: A Systematic Literature Review, Morgan E. Seitzer

University Honors Theses

Globally, river restoration has become a popular tool for improving the health of a watershed and restoring ecosystem services, but still has significant knowledge gaps. In certain areas and scientific communities, special attention has been given to the response of macroinvertebrates as a measure of restoration success. This systematic literature review aims to highlight and discuss the patterns in studies that have comparable before-and-after restoration data on macroinvertebrates after reconnecting stream channels to their floodplains. Macroinvertebrate sampling is a simple if not time-consuming task that can reveal important data about habitat quality. Because they serve as an important food source …

Effects Of Exercise Or Metformin On Myokine Concentrations In Patients With Breast And Colorectal Cancer: A Phase Ii Multi-Centre Factorial Randomized Trial, Justin C. Brown, Guillaume Spielmann, Shengping Yang, Stephanie L.E. Compton, Lee W. Jones, Melinda L. Irwin, Jennifer A. Ligibel, Jeffrey A. Meyerhardt

School of Medicine Faculty Publications

Background: Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations. Methods: This hypothesis-generating analysis used biospecimens collected from a multi-centre 2 × 2 factorial randomized design of 116 patients with stage I–III breast and colorectal cancer who were randomized to 12 weeks of (1) aerobic exercise (moderate intensity titrated to 220 min/week); (2) metformin (850 mg daily for 2 weeks and then titrated to 850 mg twice per day); (3) aerobic exercise and metformin; or (4) control. Fourteen myokines were …

Oregon State Rank Assessment For Black-Backed Woodpecker (Picoides Arcticus), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Black-backed woodpecker (Picoides arcticus) using NatureServe methodology, 2024.

The Cdk9 Inhibitor Enitociclib Overcomes Resistance To Btk Inhibition And Car-T Therapy In Mantle Cell Lymphoma, Vivian Jiang, William Lee, Tianci Zhang, Alexa Jordan, Fangfang Yan, Qingsong Cai, Joseph Mcintosh, Jovanny Vargas, Yang Liu, Michael Wang

Faculty, Staff and Student Publications

Inhibitors of Bruton's tyrosine kinase (BTKi) and chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 are paradigm-shifting advances in treating patients with aggressive mantle cell lymphoma (MCL). However, clinical relapses following BTKi and CD19-directed CAR-T treatments are a fast-growing medical challenge. Development of novel therapies to overcome BTKi resistance (BTKi-R) and BTKi-CAR-T dual resistance (Dual-R) are urgently needed. Our single-cell RNA sequencing data revealed major transcriptomic reprogramming, with great enrichment of MYC-targets evolving as resistance to these therapies developed. Interestingly, cyclin-dependent kinase 9 (CDK9), a critical component of the positive transcription elongation factor-b complex, was among the top upregulated genes …

Neurogranin Modulates The Rate Of Association Between Calmodulin And Target Peptides, John A Putkey, Laurel Hoffman, Vladimir Berka, Xu Wang

Faculty, Staff and Student Publications

The best-known mode of action of calmodulin (CaM) is binding of Ca2+ to its N- and C-domains, followed by binding to target proteins. An underappreciated facet of this process is that CaM is typically bound to proteins at basal levels of free Ca2+, including the small, intrinsically disordered, neuronal IQ-motif proteins called PEP-19 and neurogranin (Ng). PEP-19 and Ng would not be effective competitive inhibitors of high-affinity Ca2+-dependent CaM targets at equilibrium because they bind to CaM with relatively low affinity, but they could influence the time course of CaM signaling by affecting the rate of association of CaM with …

Targeting Il-11r/Ezh2 Signaling Axis As A Therapeutic Strategy For Osteosarcoma Lung Metastases, Eswaran Devarajan, R Eric Davis, Hannah C Beird, Wei-Lien Wang, V Behrana Jensen, Arumugam Jayakumar, Cheuk Hong Leung, Heather Y Lin, Chia-Chin Wu, Stephanie A Ihezie, Jen-Wei Tsai, P Andrew Futreal, Valerae O Lewis

Faculty, Staff and Student Publications

Lung metastases are the primary cause of death for osteosarcoma (OS) patients. We recently validated interleukin-11 receptor α (IL-11Rα) as a molecular target for the inhibition of OS lung metastases. Since there is no clinically approved antibody against this receptor, we sought to identify downstream targets that mediate the effects of IL-11Rα signaling. We used shRNA to deplete IL-11Rα from OS cells; as a complementary approach, we added IL-11 exogenously to OS cells. The resulting changes in gene expression identified EZH2 as a downstream candidate. This was confirmed by knockdown of IL-11Rα in OS cells, which led to increased expression …

Fate-Mapping And Functional Dissection Reveal Perilous Influence Of Type I Interferon Signaling In Mouse Brain Aging, Ethan R Roy, Sanming Li, Sepideh Saroukhani, Yanyu Wang, Wei Cao

Faculty, Staff and Student Publications

Background: Aging significantly elevates the risk of developing neurodegenerative diseases. Neuroinflammation is a universal hallmark of neurodegeneration as well as normal brain aging. Which branches of age-related neuroinflammation, and how they precondition the brain toward pathological progression, remain ill-understood. The presence of elevated type I interferon (IFN-I) has been documented in the aged brain, but its role in promoting degenerative processes, such as the loss of neurons in vulnerable regions, has not been studied in depth.

Methods: To comprehend the scope of IFN-I activity in the aging brain, we surveyed IFN-I-responsive reporter mice at multiple ages. We also examined 5- …

Repeat Controlled Human Plasmodium Falciparum Infections Delay Bloodstream Patency And Reduce Symptoms, Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Faculty, Staff and Student Publications

Resistance to clinical malaria takes years to develop even in hyperendemic regions and sterilizing immunity has rarely been observed. To evaluate the maturation of the host response against controlled repeat exposures to P. falciparum (Pf) NF54 strain-infected mosquitoes, we systematically monitored malaria-naïve participants through an initial exposure to uninfected mosquitoes and 4 subsequent homologous exposures to Pf-infected mosquitoes over 21 months (n = 8 males) (ClinicalTrials.gov# NCT03014258). The primary outcome was to determine whether protective immunity against parasite infection develops following repeat CHMI and the secondary outcomes were to track the clinical signs and symptoms of malaria and anti-Pf antibody …

Elizabeth Street Garden, Inc. V. City Of New York

All Decisions

In a SEQRA challenge regarding proposed senior housing development on city-owned land in Manhattan, the court affirmed HPD's negative declaration. The case hinged on whether HPD adequately considered environmental impacts under SEQRA. The court held HPD's assessment met legal standards by identifying relevant environmental concerns and taking a reasoned approach, including mitigating open space deficiencies. The decision reinforced that judicial review of agency actions under SEQRA is limited to procedural adherence and rationality, emphasizing agencies' discretion in environmental assessments. The ruling clarified that SEQRA does not require agencies to address every potential environmental impact comprehensively.

A Modelled Estimate Of Food Access Within Countries Shows That Inequality Within Countries Has Increased Despite Rising Equality Between Countries, Juan Diego Martinez, Navin Ramankutty, Zia Mehrabi, Tom W. Hertel

Department of Agricultural Economics Faculty Publications

Global food calorie supply per person is more than 2900 kcal per day on average, but we have failed to ensure equitable access to these calories. Yet how uneven food access is within countries has remained poorly understood, as has the progress made over the past five decades on closing the access gap. Using publicly available data, we developed a theoretically-grounded statistical model to estimate the cross-national relationship between average per capita expenditure and per capita food availability and used this to estimate within-country access to food for income deciles in 135 countries. We find that, from 1961 to 2013, …

Oregon State Rank Assessment For Western Toad (Anaxyrus Boreas), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Western toad (Anaxyrus boreas) using NatureServe methodology, 2024.

Oregon State Rank Assessment For Golden Eagle (Aquila Chrysaetos), Misty Nelson, Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Golden Eagle (Aquila chrysaetos) using NatureServe methodology, 2024.

Legend Of Merlin And The Quest For Cardiac Lineage Commitment, Rich Gang Li, James F Martin

Faculty, Staff and Students Publications

No abstract provided.

Remodeling Of Anti-Tumor Immunity With Antibodies Targeting A P53 Mutant, Dafei Chai, Junhao Wang, Chunmei Fan, Jing-Ming Lim, Xu Wang, Praveen Neeli, Xinfang Yu, Ken H Young, Yong Li

Faculty, Staff and Students Publications

BACKGROUND: p53, the most frequently mutated gene in cancer, lacks effective targeted drugs.

METHODS: We developed monoclonal antibodies (mAbs) that target a p53 hotspot mutation E285K without cross-reactivity with wild-type p53. They were delivered using lipid nanoparticles (LNPs) that encapsulate DNA plasmids. Western blot, BLI, flow cytometry, single-cell sequencing (scRNA-seq), and other methods were employed to assess the function of mAbs in vitro and in vivo.

RESULTS: These LNP-pE285K-mAbs in the IgG1 format exhibited a robust anti-tumor effect, facilitating the infiltration of immune cells, including CD8+ T, B, and NK cells. scRNA-seq revealed that IgG1 reduces immune inhibitory signaling, increases …

Structural Basis For Hyperpolarization-Dependent Opening Of Human Hcn1 Channel, Verena Burtscher, Jonathan Mount, Jian Huang, John Cowgill, Yongchang Chang, Kathleen Bickel, Jianhan Chen, Peng Yuan, Baron Chanda

2020-Current year OA Pubs

Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion channels, the HCN and related plant ion channels activate upon membrane hyperpolarization. Although functional studies have identified residues in the interface between the voltage-sensing and pore domain as crucial for inverted electromechanical coupling, the structural mechanisms for this unusual voltage-dependence remain unclear. Here, we present cryo-electron microscopy structures of human HCN1 corresponding to Closed, Open, and a putative Intermediate state. Our structures reveal that the downward motion of the gating …

Protein Restriction Slows The Development And Progression Of Pathology In A Mouse Model Of Alzheimer's Disease, Reji Babygirija, Natalie M Niemi, Et Al.

2020-Current year OA Pubs

Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and dietary protein restriction extends the lifespan and healthspan of mice. In this study, we examined the effect of protein restriction (PR) on metabolic health and the development and progression of Alzheimer's disease (AD) in the 3xTg mouse model of AD. Here, we show that PR promotes leanness and glycemic control in 3xTg mice, specifically rescuing the glucose intolerance of 3xTg females. PR induces sex-specific alterations in circulating and brain metabolites, downregulating sphingolipid subclasses in 3xTg females. PR also …

Creating A Digital Escape Room To Increase Student Engagement In Cultural Literacy, Stacey Diliberto, Debra Luken, Amy Sugar

FDLA Journal

Teaching cultural literacy skills provides students an opportunity to develop capabilities to competently function in our current ever-changing global society. A digital escape room was created for a fully online Latin American Humanities course offered in the fall 2022 semester, after the peak of the COVID-19 pandemic. This asynchronous activity was developed to increase engagement and teach cultural literacy to students who experienced a time of turmoil and upheaval and who might have experienced a lack of engagement in a fully online class. In this paper, we will discuss the pedagogical, content, logistical, technical, and accessibility considerations we applied to …

Variegated Order: Making Space For Neurodiverse Perspectives In Archives, Sophie Penniman

Journal of Contemporary Archival Studies

This article aims to envision how archives could better reflect and represent neurodivergent records creators—people whose brains function in ways that diverge significantly from dominant societal standards of “normal". It discusses how neurodivergent records creators and their recordkeeping behaviors often do not fit within traditional archival paradigms which center verbal, written, and linear documents in specific organizational systems. The article then brings together sources from disability studies, feminist and gender studies, library studies, literary analysis, and archival scholarship to imagine ways in which the principle of provenance could be expanded to fit the archives of neurodiverse creators (and archives that …

Graduate Students' E-Book Awareness And Usage At A Public Research University In The U.S.A., Denise Brush, Daniel G. Kipnis

Libraries Scholarship

Purpose

This study aims to understand the level of graduate students’ awareness and usage of e-books purchased by the authors’ university library since the COVID-19 pandemic.

Design/methodology/approach

The authors created a Qualtrics survey with 13 questions that was sent to the university’s graduate student email list. The survey was sent in the fall of 2023 and was open for one month. The list had 3,318 subscribers; 113 complete responses were received, for a response rate of 3.4%.

Findings

The results found that doctoral students (80%) are more aware than master’s students (64%) of e-book availability through the library, and usage …

Biphasic Burrowing In Atlantic Hagfish (Myxine Limosa), Douglas S. Fudge, Joshua Lee, Kennedy Guillen, Cassandra M. Donatelli, Andrew Lowe, Luke Arnold, Keolani Kahale-Lua, Christian Quinteros, Peter Ly, Larissa Atkins, Noah Bressman, Charlene L. Mccord

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Myxine limosa is a burrowing species of hagfish that occurs in the western North Atlantic in areas with muddy substrate and at depths generally greater than 100 meters. Burrowing of M. limosa has been observed from submersibles, but little is known about the behavior of these animals within the substrate or the biomechanical mechanisms involved. Here, we investigated burrowing in M. limosa by observing individuals as they burrowed through transparent gelatin. A photoelastic setup using crossed polarizers allowed us to visualize stress development in the gelatin as the hagfish moved through it. We found that M. limosa created U-shaped burrows …

Short-Chain Fatty Acid Valerate Reduces Voluntary Alcohol Intake In Male Mice., Suresh C Bokoliya, Jordan Russell, Yair Dorsett, Hunter A Panier, Vijender Singh, Lauren Daddi, Hanshu Yuan, Liv R Dedon, Zhongmao Liu, Yuqi Zhou, Zefang Min, Jessica R Barson, Jonathan Covault, Jason A. Bubier, Yanjiao Zhou

Faculty Research 2024

BACKGROUND: Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. The development of novel therapeutic and preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between the gut microbiome and microbial metabolites with drinking behavior, but druggable targets and their underlying mechanism of action are understudied.

RESULTS: Here, using a drink-in-the-dark mouse model, we identified a microbiome metabolite-based novel treatment (sodium valerate) that can reduce excessive alcohol drinking. Sodium valerate is a sodium salt of valeric acid short-chain fatty acid with a similar structure as γ-aminobutyric acid …

De L’Oral À L’Écrit : Pour Une Traduction Du Statut Social De La Littérature Dans « L’Arbre Anthropophage » De Jean-Luc Raharimanana, Fitahianjanahary Ralaiharinony

Al-Kīmiyā

“In Africa, an old person who dies is like a burning library”, emphasizes Amhadou Ampaté Bâ. This statement highlights the significant role of an elderly person who, in Madagascar, stands as the guardian of the knowledge governing social harmony. It has become a tradition for the youth to gather around the elders or “masters of speech” to benefit from teachings transmitted through legends, proverbs, and stories. In this context, the essence of oral tradition, closely connected to humanity, reveals its worldview while maintaining its ultimate mission: the preservation of culture. Considering this perspective, we will examine Malagasy literature in French …

Measurements In Kautilya’S Arthasastra, In The Domains Of Public Finance And Governance, Saraswathi Murali M

Theses and Dissertations

Ancient Sanskrit literature has rich discussion of measurements by different authorities. Examples from the Vedic Age and the period of Itihāsas can be found in Ṛgveda (c. 1500 BCE), Rāmāyaṇa, and Mahābhārata. A subsequent, and more elaborate, exercise of codification of measurements, relevant to finance and administration, is observed in Arthaśāstra, written by Kauṭilya, also known as Cāṇakya and Viṣṇugupta (c. 350-275 BCE).

The author, a scholar from Takṣaśilā, was the advisor during Cāndragupta Maurya’s reign (c. 321-297 BCE). After millennia of hibernation, Kauṭilya’s Arthaśāstra resurfaced, in the beginning of the twentieth century. Ever since, Arthaśāstra has been a subject …

Decreasing Anxiety During Nursing Skills Evaluation In First-Semester Nursing Students, Terri Davis

Doctor of Nursing Practice Projects

Nursing students experience moderate to severe anxiety related to the rigor of nursing programs. Anxiety often leads to poor performance on exams and skills evaluations. When anxiety is not limited, it can contribute to nursing students being unable to progress in the nursing program and high attrition rates. The National League of Nursing (2021) estimates the attrition rate for nursing students in the United States at 20%. Attrition rates for associate degree programs are even greater and estimated to be around 50% (Kubec, 2017, as cited in Priode et al., 2020). This DNP quality improvement project looks to examine the …

The Flourishing Gut Cookbook, Mackenzie C. Stanley, Brittany Lopez-Itingen

Department of Nutrition Student Projects

Herbs and spices have been used in herbal medicine for thousands of years, and yet these therapeutic approaches used to heal from within are foreign to many Americans. We have decided to create a cookbook utilizing 5 evidence-based gut-healing herbs and spices in hopes to provide tangible recipes to promote gut health. The cookbook will also provide an educational opportunity that will speak to the benefits of each herb or spice in the recipe. Background We have decided to pursue a cookbook as a result of our love of cooking and interest in herbal medicine. We want to learn more …

Fabrication Of Metallo-Pharmaceutical Composite Hydrogel Composed Of Curcumin-Loaded Cmc-Na/Sodium Alginate/Pdcl2: Optimization, Antimicrobial Activity, And Cancer Cell Mortality In Vitro Assessment, Samar A. Salim, Elbadawy A Kamoun, Mariam Emam, Shahira H El-Moslamy, Ayman Elsawaf, Amal Nassar, Nehal Eldeeb

Nanotechnology Research Centre

This work explores the fabrication route of curcumin-loaded carboxymethyl cellulose sodium/sodium alginate/palladium chloride (CMC-Na/SA/PdCl2) composite hydrogel as localized delivery system for cancer treatment. Herein, an approach was established for improving encapsulation capacity and exploiting therapeutic efficiency. CMC-Na/SA/PdCl2 composite hydrogels were prepared by gelation method using ionic crosslinker (PdCl2). Results proved that the optimized formula (CMC-Na:SA (4:1)/PdCl2 0.4%) recorded a gel fraction of 91% with a swelling ratio ~ 3000% after 96 h, while XRD analysis exhibited no remarks of sharp peaks which confirmed an amorphous phase of tested hydrogel. TGA results showed that this recipe is thermostable compared to other …

Antidepressant Effect Of Enzymatic Porcine Placenta Hydrolysate In Repeated Immobilization Stress-Induced Ovariectomized Female Mice, Minsook Ye, Sharon Nguyen, Min Ju Kim, Jee Sun Hwang, Gun Won Bae, Keun-Hang Susan Yang, Insop Shim

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

When postmenopausal women are under stress conditions, this exacerbates mood disorders and issues with neuroimmune systems. The porcine placenta is known to relieve menopausal depression in clinical trials, but its underlying mechanisms for depression and anti-inflammatory functions remain poorly defined. The present study was designed to examine the anti-inflammatory effects of enzymatic porcine placenta hydrolysate (EPPH) on LPS-induced levels of nitric oxide (NO), prostaglandin E2 (PGE2), corticosterone (CORT), and pro-inflammatory cytokine interleukin-1 beta (IL-1β) in RAW 264.7 macrophage cells. In addition, the neurite outgrowth of PC12 cells was evaluated to examine the effects of EPPH on neurite growth. To mimic …

“Safer To Plant Corn And Beans”? Navigating The Challenges And Opportunities Of Agricultural Diversification In The U.S. Corn Belt, Rebecca Traldi, Lauren Asprooth, Emily M. Usher, Kristin Floress, J. Gordon Arbuckle, Megan Baskerville, Sarah P. Church, Ken Genskow, Seth Harden, Elizabeth Maynard, Aaron Thompson, Ariana P. Torres, Linda Stalker Prokopy

Department of Horticulture & Landscape Architecture Faculty Publications

Agricultural diversification in the Midwestern Corn Belt has the potential to improve socioeconomic and environmental outcomes by buffering farmers from environmental and economic shocks and improving soil, water, and air quality. However, complex barriers related to agricultural markets, individual behavior, social norms, and government policy constrain diversification in this region. This study examines farmer perspectives regarding the challenges and opportunities for both corn and soybean production and agricultural diversification strategies. We analyze data from 20 focus groups with 100 participants conducted in Indiana, Illinois, and Iowa through a combined inductive and deductive approach, drawing upon interpretive grounded theory. Our results …

Aquatic Plants Could Help Reduce Water Pollution, Nicholas Gosling

UNH Today Archive

No abstract provided.

Sting Agonist 8803 Reprograms The Immune Microenvironment And Increases Survival In Preclinical Models Of Glioblastoma, Hinda Najem, Spencer T Lea, Shashwat Tripathi, Lisa Hurley, Chao-Hsien Chen, Ivana William, Moloud Sooreshjani, Michelle Bowie, Genevieve Hartley, Corey Dussold, Sebastian Pacheco, Crismita Dmello, Catalina Lee-Chang, Kathleen Mccortney, Alicia Steffens, Jordain Walshon, Martina Ott, Jun Wei, Anantha Marisetty, Irina Balyasnikova, Roger Stupp, Rimas V Lukas, Jian Hu, Charles David James, Craig M Horbinski, Maciej S Lesniak, David M Ashley, Waldemar Priebe, Leonidas C Platanias, Michael A Curran, Amy B Heimberger

Faculty, Staff and Student Publications

STING agonists can reprogram the tumor microenvironment to induce immunological clearance within the central nervous system. Using multiplexed sequential immunofluorescence (SeqIF) and the Ivy Glioblastoma Atlas, STING expression was found in myeloid populations and in the perivascular space. The STING agonist 8803 increased median survival in multiple preclinical models of glioblastoma, including QPP8, an immune checkpoint blockade-resistant model, where 100% of mice were cured. Ex vivo flow cytometry profiling during the therapeutic window demonstrated increases in myeloid tumor trafficking and activation, alongside enhancement of CD8+ T cell and NK effector responses. Treatment with 8803 reprogrammed microglia to express costimulatory CD80/CD86 …