Digital Commons Network^™

The Relationship Between Diet, Depression, And Alzheimer's Disease: A Narrative Review, Hilal Salim Said Al Shamsi, Stephanie R. Rainey-Smith, Samantha L. Gardener, Hamid R. Sohrabi, Rodrigo Canovas, Ralph N. Martins, Warnakulasuriya Mary Ann Dipika Binosha Fernando

Research outputs 2022 to 2026

Purpose of Review: This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings: AD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, …

Isolation Of Naegleria Lustrarea N. Sp. (Excavata, Discoba, Heterolobosea) From The Feces Of Ambystoma Annulatum (Ringed Salamander) In Northwest Arkansas, Brian M. Becker, Idan Banson, James M. Walker, Anant Deshwal, Matthew W. Brown, Jeffrey D. Silberman

Biological Sciences Faculty Publications and Presentations

The salamander, Ambystoma annulatum, is considered a “species of special concern” in the state of Arkansas, USA, due to its limited geographic range, specialized habitat requirements and low population size. Although metazoan parasites have been documented in this salamander species, neither its native protists nor microbiome have yet been evaluated. This is likely due to the elusive nature and under-sampling of the animal. Here, we initiate the cataloguing of microbial associates with the identification of a new heterlobosean species, Naegleria lustrarea n. sp. (Excavata, Discoba, Heterolobosea), isolated from feces of an adult A. annulatum.

Brome Grass And Its Management In Crops, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Brome grass (Bromus spp.) is one of the most competitive grass weeds in wheat. Over the last 10 years, brome grass has increased in importance to a greater extent than any other weed species in Australia.

Recent changes in crop production systems, increased conservation tillage, a lack of available selective herbicides, and a decline in system diversity have seen an increase in the importance of this weed in Western Australia (WA).

Seed is the main source of brome grass infestation and, as few seeds remain dormant, the most important aspect of management is to reduce its seed bank.

Soxb1 Transcription Factors Are Essential For Initiating And Maintaining Neural Plate Border Gene Expression, Elizabeth Schock, Joshua R. York, Austin P. Li, Ashlyn Y. Tu, Carole Labonne

Markey Cancer Center Faculty Publications

SoxB1 transcription factors (Sox2/3) are well known for their role in early neural fate specification in the embryo, but little is known about functional roles for SoxB1 factors in non-neural ectodermal cell types, such as the neural plate border (NPB). Using Xenopus laevis, we set out to determine whether SoxB1 transcription factors have a regulatory function in NPB formation. Here, we show that SoxB1 factors are necessary for NPB formation, and that prolonged SoxB1 factor activity blocks the transition from a NPB to a neural crest state. Using ChIP-seq, we demonstrate that Sox3 is enriched upstream of NPB genes in …

14-3-3Ζ Suppresses Rankl Signaling By Destabilizing Traf6, R. Ayyasamy, S. Fan, P. Czernik, B. Lecka-Czernik, Somsubhra Chattopadhyay, R. Chakravarti

Markey Cancer Center Faculty Publications

Macrophages are essential regulators of inflammation and bone loss. Receptor activator of nuclear factor-κβ ligand (RANKL), a pro-inflammatory cytokine, is responsible for macrophage differentiation to osteoclasts and bone loss. We recently showed that 14-3-3ζ-knockout (Ywhaz^KO) rats exhibit increased bone loss in the inflammatory arthritis model. 14-3-3ζ is a cytosolic adaptor protein that actively participates in many signaling transductions. However, the role of 14-3-3ζ in RANKL signaling or bone remodeling is unknown. We investigated how 14-3-3ζ affects osteoclast activity by evaluating its role in RANKL signaling. We utilized 14-3-3ζ-deficient primary bone marrow–derived macrophages obtained from wildtype and Ywhaz^{KO …}

Diffuse Reflectance Spectroscopy For Optical Characterizations Of Orthotopic Head And Neck Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu

Markey Cancer Center Faculty Publications

We demonstrated an easy-to-build, portable diffuse reflectance spectroscopy device along with a Monte Carlo inverse model to quantify tissue absorption and scattering-based parameters of orthotopic head and neck cancer models in vivo. Both tissue-mimicking phantom studies and animal studies were conducted to verify the optical spectroscopy system and Monte Carlo inverse model for the accurate extraction of tissue optical properties. For the first time, we reported the tissue absorption and scattering coefficients of mouse normal tongue tissues and tongue tumor tissues. Our in vivo animal studies showed reduced total hemoglobin concentration, lower tissue vascular oxygen saturation, and increased tissue scattering …

Response To Replication Stress And Maintenance Of Genome Stability By Wrn, The Werner Syndrome Protein, David K. Orren, Amrita Machwe

Markey Cancer Center Faculty Publications

Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. WS is a segmental progeroid disease and shows early onset or increased frequency of many characteristics of normal aging. WRN possesses helicase, annealing, strand exchange, and exonuclease activities and acts on a variety of DNA substrates, even complex replication and re- combination intermediates. Here, we review the genetics, biochemistry, and probably physiological functions of the WRN protein. Although its precise role is unclear, evidence suggests WRN plays a role in pathways that respond to replication stress and maintain genome stability particularly in telomeric regions.

Reading Colonial Transitions: Archival Evidence And The Archaeology Of Indigenous Action In Nineteenth-Century California, Lee M. Panich, Gustavo Flores, Michael Wilcox, Monica V. Arellano

Faculty Publications

Archaeologists in North America and elsewhere are increasingly examining long-term Indigenous presence across multiple colonial systems, despite lingering conceptual and methodological challenges. We examine this issue in California, where archaeologists and others have traditionally overlooked Native persistence in the years between the official closing of the region's Franciscan missions in the 1830s and the onset of US settler colonialism in the late 1840s. In particular, we advocate for the judicious use of the documentary record to ask new questions of Indigenous life during this short but critical period, when many Native Californians were freed from the missions and sought new …

Validating An Automated Rodent Ultrasonic Vocalization Data Collator, Devin Mark Kellis

Theses and Dissertations

Rodent ultrasonic vocalizations (USVs) are a key dependent measure within behavioral science that have translational relevance with respect to medical, especially neuropsychiatric, illnesses. In recent years, several programs have been developed to enable the recording, labeling, and parameterization of rodent USVs via conventional, machine learning, or deep learning approaches. However, there remains a need to further automate the downstream process of data collation so that labeled and classified USV parameters can be rapidly formatted and analyzed via statistical approaches based on experimenter preferences. The aim of this thesis was therefore to validate an automated vocalization data collator (AVDC) to expedite …

Executive Function And Feedback In Regulatory Monitoring: Towards An Understanding Of Flexible And Adaptive Emotion Regulation, Gilaine Rui Ng

Dissertations and Theses Collection (Open Access)

Monitoring is a process which involves attending to feedback regarding the efficacy of ongoing regulatory strategies and determining whether to switch or maintain strategies (i.e., strategy switching or maintenance) in order to maximize adaptive outcomes. While conceptual accounts underscore the critical role of monitoring in flexible and adaptive emotion regulation, empirical research remains scarce, and the cognitive factors which subserve the monitoring process remain unclear and poorly understood. To bridge this gap, we investigate how components of executive function (EF)—a set of cognitive control processes necessary for flexible, goal-directed behavior—would differentially support the monitoring process. Additionally, we examine the extent …

Race Against The Clock: A Comparative Analysis Of New York State's And Germany's Ambitious High-Voltage Transmission Sitting Laws And What New York Can Adopt From The German Model, Andrew Leahy

Cardozo International & Comparative Law Review

The note argues that New York should adopt elements of Germany's centralized regulatory model to streamline the approval and construction of high-voltage transmission lines, which are critical for meeting renewable energy goals. While both New York and Germany face similar challenges in expanding their grids, Germany's centralized approach, including federal oversight and coordinated planning, has proven more efficient. The note critiques New York's decentralized and uncoordinated process, suggesting that adopting Germany's methods could help New York meet its ambitious renewable energy targets and reduce reliance on peaker plants.

There Is A Future If There Is Truth: It’S Not A Lesser Evil, Comisión De La Verdad, Angela D. Nichols ,Translator, Andrés Ramírez , Translator, Brooke Zimmerman , Translator, Lina Sofía Vásquez , Translator, Salomé Díaz Gómez , Translator, Isa Marin , Translator, Aura Cuasquer Ordonez , Translator, Sofía Blanco , Translator, Laura Sofia Gallo , Translator, Gabriella Maya , Translator, Maria Gabriela Escobar Valencia , Translator, Juliana Ramírez Restrepo , Translator

Research Books

The volume "It's Not a Lesser Evil: Children and Adolescents in the Armed Conflict" addresses the impacts of the war and the violence directed against the population under eighteen years of age as revealed by the Truth Commission's hearings. The testimonies highlight the experiences of loss and orphanhood, and the attacks on schools and their surroundings, as the most invisible experiences suffered by Colombian children and adolescents, while forced displacement was the most frequent and widespread form of violence.  It also delves into the recruitment of children and adolescents by armed groups as an intentional and systematic phenomenon of the …

Application Of Ncms And Multialism In Indigenous Art Analysis, Allison J. García-Guano, Victoria S. Ruiz-Pinto, Bertha A. Paredes-Calderón, Manuel E. Lanas López

Neutrosophic Sets and Systems

This study utilizes Neutrosophic Cognitive Maps (NCMs) to investigate cultural interactions in Tigua, an indigenous vil-lage in Ecuador known for its rich artistic heritage. The approach evaluates five crucial factors: ancestral traditions (A), external influences (B), cultural synthesis (C), artistic creativity (D), and education and cultural transmission (E). The ac-tivation of cultural synthesis (node C) is crucial for merging traditions with new influences, leading to the development of cultural and artistic breakthroughs. By integrating MultiAlism notions into the discourse, the comprehension of Tigua artworks is heightened since it establishes a correlation between indigenous and postcolonial art. This synthesis not only …

Neutrosophic Hypothesis To Validate The Efficacy And Safety Of Propolis In The Treatment Of External Bacterial Otitis In Canines, Nancy M. Cueva-Salazar

Neutrosophic Sets and Systems

Propolis, known for its antibacterial, antifungal, antioxidant, antiviral, immunomodulatory, and anti-parasitic properties, has been the subject of this study to evaluate its efficacy and safety in the treatment of bacterial external otitis in domestic canines. Through questionnaires administered to veterinary experts and the use of neutrosophic logic for hypothesis test-ing, perceptions based on clinical experiences and scientific literature were analyzed. The results indicate strong agree-ment that propolis is effective and safe, surpassing some aspects of conventional antibiotic treatments and demonstrating high tolerability without serious side effects. This acceptance underscores its potential as a natural alternative in veterinary treatments, particularly valuable …

Proceedings Of The International Conference Called Neutrosophy And Plithogeny: Fundamentals And Applications, 8-9 July 2024, Universidad Cesar Vallejo, Lima, Peru, Florentin Smarandache, Mohamed Abdel-Basset, Maikel Y. Leyva-Vázquez, Said Broumi

Neutrosophic Sets and Systems

We are pleased to present this special issue dedicated to the Neutrosophic approaches in research, on the occasion of the international and multidisciplinary conference Neutrosophy and Plithogeny: Fundamentals and Applications (Spanish) held at the Universidad César Vallejo in Lima, Peru, on July 8 and 9. This event marks a significant milestone, as it is the first time that the Andean region and Latin America host scholars and researchers dedicated to studying various theoretical and applicative issues in the expansive and diverse field of Neutrosophic approaches. Since its conception, Neutrosophic theory has proven to be an interdisciplinary and innovative field, notably …

Cognitive Mapping In The Study Of Agricultural Orality In The Apagua Community, María Florinda Ushco Ayala, Alisson Abigail Criollo Quiroga, Ricardo Francisco Ureña López

Neutrosophic Sets and Systems

This research explores the application of neutrosophy to understand and address the inherent complexity in the oral transmission of knowledge in family agriculture. It leverages its ability to handle contradictions and ambiguities, facilitat-ing a richer analysis of agricultural practices and social interactions. Orality, as the primary form of communication in these communities, is essential for the transmission of agricultural and cultural knowledge. This research highlights how orality acts as a vehicle for the preservation of collective identity and the transmission of ancestral knowledge. The study used Fuzzy Cognitive Maps (FCM) to describe the causal relationships between different variables of interest. …

Development Of An Undergraduate Course On Women In The Design Of The Built Environment, Anahid Behrouzi, Kira Hope Tolman, Paige Van Rossum

Architectural Engineering

The Cal Poly in San Luis Obispo (Cal Poly) Architectural Engineering (ARCE) department has seen significant progress in reaching gender equity as evidenced by recent student enrollment numbers. However, ARCE-affiliated technical and history classes still lack discussion of notable female practitioners or the value of input from women as project stakeholders. This educational shortcoming is likely true at many other civil or structural engineering, construction management, and architecture programs. To address this gap, the authors developed a new 1-credit hour course offered in Spring 2024 to Cal Poly Honors and ARCE students to expose them to the contributions and concerns …

Cultural Tightness-Looseness And Optimal Distinctiveness: Examining The Influence Of Culture On The Need To Belong And The Need To Be Different, Hairong Jiang

Theses and Dissertations

This study investigates the influence of cultural tightness-looseness on optimal distinctiveness motives and group identification, examining the moderating roles of self-construal, global orientation, and tightness/looseness match. Participants (N=465) from the United States and China were randomly assigned to tight or loose conditions and numerically majority or minority group conditions. Experimental manipulation of tightness-looseness did not significantly affect optimal distinctiveness needs. Cultural match, operationalized as alignment of tightness/looseness between participants' own culture and experimental condition, significantly moderated the relationship between culture conditions and need to belong. Individuals with high cultural match showed higher need to belong in tight conditions, while those …

How People Prompt Generative Ai To Create Interactive Vr Scenes, Setareh Aghel Manesh, Tianyi Zhang, Yuki Onishi, Kotaro Hara, Scott Bateman, Jiannan Li, Anthony Tang

Research Collection School Of Computing and Information Systems

Generative AI tools can provide people with the ability to create virtual environments and scenes with natural language prompts. Yet, how people will formulate such prompts is unclear---particularly when they inhabit the environment that they are designing. For instance, it is likely that a person might say, "Put a chair here,'' while pointing at a location. If such linguistic and embodied features are common to people's prompts, we need to tune models to accommodate them. In this work, we present a Wizard of Oz elicitation study with 22 participants, where we studied people's implicit expectations when verbally prompting such programming …

Time-Restricted Feeding Reveals A Role For Neural Respiratory Clocks In Optimizing Daily Ventilatory-Metabolic Coupling In Mice, Aaron A. Jones, Gabriella M. Marino, Deanna M. Arble

Biological Sciences Faculty Research and Publications

The master circadian clock, located in the suprachiasmatic nuclei (SCN), organizes the daily rhythm in minute ventilation (V̇e). However, the extent that the daily rhythm in V̇e is secondary to SCN-imposed O2 and CO2 cycles (i.e., metabolic rate) or driven by other clock mechanisms remains unknown. Here, we experimentally shifted metabolic rate using time-restricted feeding (without affecting light-induced synchronization of the SCN) to determine the influence of metabolic rate in orchestrating the daily V̇e rhythm. Mice eating predominantly at night exhibited robust daily rhythms in O2 consumption (V̇o2), CO2 production (V̇co2), and V̇e with similar peak times (approximately ZT18) that …

Perceptions Of Communities Of Practice And Sense Of Belonging: Focus Groups Of Academic Pediatric Faculty, Margaret P. Huntwork, Myo T. Myint, Emma Simon, Bonnie Desselle, Amy M. Creel

School of Medicine Faculty Publications

BACKGROUND: Providing the opportunity for collaboration around a central purpose to improve skills and exchange knowledge, the Community of Practice model can be useful for faculty development. A sense of belonging enhances the engagement in communities. Yet, the barriers and contributors to academic medicine faculty's sense of belonging in communities are not as well explored. METHODS: Through focus groups with 21 academic pediatric faculty conducted between January and March 2023, this qualitative study examined knowledge of Communities of Practice and the factors that affect sense of belonging and engagement. The authors iteratively coded transcripts to generate themes. RESULTS: Community accessibility; …

Understanding The Genetic Complexity Of Puberty Timing Across The Allele Frequency Spectrum, Katherine A Kentistou, Lena R Kaisinger, Stasa Stankovic, Marc Vaudel, Edson Mendes De Oliveira, Andrea Messina, Robin G Walters, Xiaoxi Liu, Alexander S Busch, Hannes Helgason, Deborah J Thompson, Federico Santoni, Konstantin M Petricek, Yassine Zouaghi, Isabel Huang-Doran, Daniel F Gudbjartsson, Eirik Bratland, Kuang Lin, Eugene J Gardner, Yajie Zhao, Raina Y Jia, Chikashi Terao, Marjorie J Riggan, Manjeet K Bolla, Mojgan Yazdanpanah, Nahid Yazdanpanah, Jonathan P Bradfield, Linda Broer, Archie Campbell, Daniel I Chasman, Diana L Cousminer, Nora Franceschini, Lude H Franke, Giorgia Girotto, Chunyan He, Marjo-Riitta Järvelin, Peter K Joshi, Yoichiro Kamatani, Robert Karlsson, Jian'an Luan, Kathryn L Lunetta, Reedik Mägi, Massimo Mangino, Sarah E Medland, Christa Meisinger, Raymond Noordam, Teresa Nutile, Maria Pina Concas, Ozren Polašek, Eleonora Porcu, Susan M Ring, Cinzia Sala, Albert V Smith, Toshiko Tanaka, Peter J Van Der Most, Veronique Vitart, Carol A Wang, Gonneke Willemsen, Marek Zygmunt, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Paul L Auer, Catriona L K Barnes, Matthias W Beckmann, Amy Berrington De Gonzalez, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Julie E Buring, Federico Canzian, Jenny Chang-Claude, Fergus J Couch, Angela Cox, Laura Crisponi, Kamila Czene, Mary B Daly, Ellen W Demerath, Joe Dennis, Peter Devilee, Immaculata De Vivo, Thilo Dörk, Alison M Dunning, Miriam Dwek, Johan G Eriksson, Peter A Fasching, Lindsay Fernandez-Rhodes, Liana Ferreli, Olivia Fletcher, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Anna González-Neira, Harald Grallert, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Hakon Hakonarson, Roger J Hart, Martha Hickey, Maartje J Hooning, Reiner Hoppe, John L Hopper, Jouke-Jan Hottenga, Frank B Hu, Hanna Huebner, David J Hunter, Helena Jernström, Esther M John, David Karasik, Elza K Khusnutdinova, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Lenore J Launer, Penelope A Lind, Annika Lindblom, Patrik K E Magnusson, Arto Mannermaa, Mark I Mccarthy, Thomas Meitinger, Cristina Menni, Kyriaki Michailidou, Iona Y Millwood, Roger L Milne, Grant W Montgomery, Heli Nevanlinna, Ilja M Nolte, Dale R Nyholt, Nadia Obi, Katie M O'Brien, Kenneth Offit, Albertine J Oldehinkel, Sisse R Ostrowski, Aarno Palotie, Ole B Pedersen, Annette Peters, Giulia Pianigiani, Dijana Plaseska-Karanfilska, Anneli Pouta, Alfred Pozarickij, Paolo Radice, Gad Rennert, Frits R Rosendaal, Daniela Ruggiero, Emmanouil Saloustros, Dale P Sandler, Sabine Schipf, Carsten O Schmidt, Marjanka K Schmidt, Kerrin Small, Beatrice Spedicati, Meir Stampfer, Jennifer Stone, Rulla M Tamimi, Lauren R Teras, Emmi Tikkanen, Constance Turman, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Babette S Zemel, Wei Zheng, Ko W Van Dijk, Behrooz Z Alizadeh, Stefania Bandinelli, Eric Boerwinkle, Dorret I Boomsma, Marina Ciullo, Georgia Chenevix-Trench, Francesco Cucca, Tõnu Esko, Christian Gieger, Struan F A Grant, Vilmundur Gudnason, Caroline Hayward, Ivana Kolčić, Peter Kraft, Deborah A Lawlor, Nicholas G Martin, Ellen A Nøhr, Nancy L Pedersen, Craig E Pennell, Paul M Ridker, Antonietta Robino, Harold Snieder, Ulla Sovio, Tim D Spector, Doris Stöckl, Cathie Sudlow, Nic J Timpson, Daniela Toniolo, André Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J Wareham, Elisabeth Widen, James F Wilson, Lifelines Cohort Study, Danish Blood Donor Study, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, Paul D P Pharoah, Liming Li, Douglas F Easton, Pål R Njølstad, Patrick Sulem, Joanne M Murabito, Anna Murray, Despoina Manousaki, Anders Juul, Christian Erikstrup, Kari Stefansson, Momoko Horikoshi, Zhengming Chen, I Sadaf Farooqi, Nelly Pitteloud, Stefan Johansson, Felix R Day, John R B Perry, Ken K Ong

Faculty, Staff and Student Publications

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, …

Complete Handbook, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

1. Mission, History, General Organization And Governance Of Saint Mary’S College, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

Turtleheads, Iridoids, And Checkerspots, W. John Hayden

Biology Faculty Publications

This article follows the story of how a plant, a molecule, and an herbivore interact with each other. The plant, of course, is White Turtlehead (Chelone glabra), the 2024 VNPS Wild􀏐lower of the Year; the molecule is something called an iridoid glycoside; and the herbivore is the Baltimore Checkerspot Butterfly (Euphydras phaeton).

Course Syllabus - Democracy In Action, Sonalini Sapra

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.

Improving Students’ Sense Of Belonging At School: A School Improvement Plan, Madison Alvarado

Master's Theses & Capstone Projects

Robust research proves the importance of students' sense of belonging at school and its correlation to academic achievement, positive behavior choices, and a student's overall well-being. This school improvement plan was created to implement strategies that will lead to a significant increase in students' sense of belonging at school. The plan includes incorporating professional development that provides educators with a well-rounded understanding of what a sense of belonging entails, along with structures to help increase it in the students they support. The plan also introduces a student program designed to boost students' positive interactions and, thus, increase their sense of …

Lilrb4 On Multiple Myeloma Cells Promotes Bone Lesion By P-Shp2/Nf-Κb/Relt Signal Pathway, Hongying Wang, Lei Wang, Huiwen Luan, Jing Xiao, Zhiling Zhao, Pengfei Yu, Mi Deng, Yifan Liu, Shuhao Ji, Junjie Ma, Yan Zhou, Jiashen Zhang, Xianhui Meng, Juan Zhang, Xinyu Zhao, Chunling Li, Fangmin Li, Dapeng Wang, Shujuan Wei, Lijun Hui, Siman Nie, Changzhu Jin, Zhiqiang An, Ningyan Zhang, Yaopeng Wang, Cheng Cheng Zhang, Zunling Li

The Brown Foundation: Institute of Molecular Medicine

Background: Leukocyte Ig-like receptor B family 4 (LILRB4) as an immune checkpoint on myeloid cells is a potential target for tumor therapy. Extensive osteolytic bone lesion is the most characteristic feature of multiple myeloma. It is unclear whether ectopic LILRB4 on multiple myeloma regulates bone lesion.

Methods: The conditioned medium (CM) from LILRB4-WT and -KO cells was used to analyze the effects of LILRB4 on osteoclasts and osteoblasts. Xenograft, syngeneic and patient derived xenograft models were constructed, and micro-CT, H&E staining were used to observe the bone lesion. RNA-seq, cytokine array, qPCR, the activity of luciferase, Co-IP and western blotting …

New Insights On Hybridization In Potamogeton Floridanus (The Florida Pondweed), Kaitlyn R. Sampson

Graduate Theses and Dissertations (2019 - present)

Freshwater ecosystems are some of the most important and highest threatened habitats in the world, and aquatic plants play an important, but often-overlooked, role in maintaining them. Potamogeton is a diverse and ecologically important aquatic plant genus well known for taxonomic difficulty and rampant hybridization. lbis study aimed to 1) test the hypothesis that Potamogeton jloridanus (Florida pondweed) is a hybrid between P. oakesianus and P. pulcher, and 2) to investigate correlations in ecological conditions for the focal species. This study revealed the discovery of a new population of P. jloridanus in Big Coldwater Creek in Santa Rosa Co., FL, …

Sex Differences In Spontaneous Respiratory Recovery In Chronic Hemisection, Taylor C. Holmes, Nicole M. Popp, Carley F. Hintz, Isabell Dobrzycki, Carolyn J. Schmitz, Kaylyn A. Schwichtenberg, Elisa J. Gonzalez-Rothi, Christopher W. Sundberg, Kristi A. Streeter

Physical Therapy Faculty Research and Publications

Respiratory deficits after C2 hemisection (C2Hx) have been well documented through single-sex investigations. Although ovarian sex hormones enable enhanced respiratory recovery observed in females 2 wk post-C2Hx, it remains unknown if sex impacts spontaneous respiratory recovery at chronic time points. We conducted a longitudinal study to provide a comprehensive sex-based characterization of respiratory neuromuscular recovery for 8 wk after C2Hx. We recorded ventilation and chronic diaphragm electromyography (EMG) output in awake, behaving animals, phrenic motor output in anesthetized animals, and performed diaphragm muscle histology in chronically injured male and female rodents. Our results show that females expressed a greater recovery …