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Effects Of Comprehensive Exercise Therapy On Knee Joint Function Among Older Adults With Knee Osteoarthritis, Peixin Shen, Qipeng Song, Xiaoxue Zhu, Dewei Mao

ISBS Proceedings Archive

This study investigated the effects of comprehensive exercise therapy on knee joint function for older adults with knee osteoarthritis (KOA). Sixty-six older adults with KOA were randomly assigned to either the exercise group (EG), the heat and electrotherapy group (HG), or the control group (CG) to receive an 8-week intervention. Two-way repeated measures ANOVA was used to analyze the data of knee pain, proprioception, angle, moment, and strength. At week8, the EG had decreased pain scores, proprioception threshold, and knee abduction moment, increased flexion angle and extensor strength; the EG showed lower pain scores and greater strength than the HG …

Differences In Muscle Demand Across Take-Off Techniques In The Back Handspring Step Out In Women’S Gymnastics, Gabriella H. Small, Richard R. Neptune

ISBS Proceedings Archive

The back handspring step out (BHS) is a foundational skill in balance beam routines that can be performed using three different take-off techniques (Simultaneous Flexion, Sequential Flexion, Double-Bounce). However, it is unclear if the different techniques require different levels of muscle demand. The purpose of this study was to use modelling and simulation to quantify muscle demand across the three techniques. While there were no differences in total average muscle demand between techniques, the Sequential Flexion technique required more demand from the knee and hip flexors, while the Simultaneous Flexion and Double-Bounce techniques required more demand from the knee and …

The Influence Of Stature On Human Vertical Jumping Performance, Sam Allen

ISBS Proceedings Archive

Humans become relatively weaker as they increase in size. Despite this, simulations have shown that increased size is of benefit in vertical jumping when isometric scaling is employed due to beneficial effects on the shortening velocity of muscles. Human body mass scales allometrically with the square of stature and it is shown that, assuming constant body composition, strength scales as a function of stature and independently of width and depth. A four-segment planar torque-driven computer model was used to simulate squat jump performance. Body dimensions were scaled allometrically to stature ±3 standard deviations from the mean stature of a young …

Influence Of Inertial Measurement Unit Placement On Knee Flexion Angle Measurement During Cycling, Tjorven Schnack, Arnold Baca, Philipp Neumeister

ISBS Proceedings Archive

Inertial measurement units (IMUs) enable measurements of joint kinematics during sports in the field. The purpose of this study was to investigate the use of IMUs for measuring the knee flexion angle during cycling. To expand the limited research on optimal placement of IMUs on body segments, three different IMU placement setups were tested. Joint angles were calculated from the IMU orientations via OpenSim. Kinematics were captured from six experienced cyclists and compared to optical motion capture. Apart from an amplitude offset between the angle courses measured by IMUs and optical motion capture, no significant differences were observed between measurement …

An Overview Of Environmental Themes In The Video Game Industry, Michael A. Davis

The Geographical Bulletin

Video games of the early 1990s have an appreciable depth of environmental tones that seem prophetic by today’s standards as climate change and environmental degradation have emerged as significant topics of scientific and geographic inquiry. The political and cultural environment of the late 1980s and early 1990s played a significant role in the development of environmentally-minded video games. Since the 20th century, the depiction of these environmental themes have changed with a greater understanding of environmental science literature, have incorporated educational qualities to game play, and have migrated from large video game developers (e.g., Sega and Nintendo) to independent developers …

Defining Humanity In The Popular Imagination: The Neanderthal And The Early Modern Human In H.G. Wells And Yuval Noah Harari, Laurel Bayless

The Geographical Bulletin

Popular depictions of Neanderthals place them in a liminal position between the human and nonhuman. Examination of how such depictions have changed over time reveals evolving and enduring ideas about humanity and nature. Descriptions of Neanderthals and the prehistoric anatomically modern humans who encountered them in Europe reveal the features their authors see as essential to humanity. Not only do authors project their contemporary ideas onto Neanderthals, but doing so but then naturalizes those ideas. H.G. Wells, one of the f irst popular writers to discuss Neanderthals, depicted Neanderthals as shambling, inhuman brutes, whereas he used colonial ideas about the …

Making Space For Yeast: Toward A Zymurpolitics, Walter W. Furness

The Geographical Bulletin

Geographic scholarship on craft brewing has characteristically fixated on place as a lens through which to understand and valuate ostensibly “local” beer, wherein fermentation acts as an alchemistic shorthand, transmuting far-flung ingredients into a product emphatically rooted in a particular location. However, yeast tends to receive little attention in this literature, even though it is a primary agent (alongside humans) in acting on raw materials to produce beer. Defying the notion of “hyperlocal,” yeast is frequently sourced from distant laboratories, though some breweries maintain their own cultures in-house. This paper draws on existing literature, observation, and interviews with brewers to …

The Transformation Of Greek Grasslands Under The Impact Of Socio-Economic Factors, R Thanopoulos

IGC Proceedings (1977-2023)

The impact of socio-economic factors on the transformation of Greek grasslands is examined. Factors like urbanisation, migration, collapse of traditional way of life, social pressure for land distribution, intensification of agriculture shaped the evolution of grasslands. Thus, these factors should be taken into consideration for the planning of grasslands management.

Drug Clinical Trials Legislation In The European Union, Paola Sangiovanni, Flavio Monfrini, Marco Bertucci

Indian Journal of Law and Technology

The purpose of this article is to illustrate the basic tenets of European Union law on clinical trials. Such body of law has been progressively harmonized in the European Union over the years with the aim of subjecting interventional clinical trials conducted in any of the 27 European Union Member States to identical rules.

The article initially describes the reasons why clinical trials are important to measure the safety, efficacy and cost-effectiveness of innovative medical treatment. It then continues by illustrating the scope and basic principles of the current EU Regulation, as well as its main changes over the previous …

Teaching Fairness In Preschool: Evaluating The Steps In An Anti-Bias Education, Sharon Carnahan, Courtney Trohn, Cora Burkley, Diane Terorde Doyle

Faculty Publications

How do young children learn how to talk about ethical concepts, such as fairness and equity? The current research assesses the effects of philosophy-based anti-bias lessons aimed at three to five -year-olds in a laboratory preschool and explores the relationship between socioemotional skills, language development, and understanding of ethical concepts. The constructivist curriculum was grounded in storybook lessons with corresponding activities. In a pre-post test design, we interviewed children before and after lessons in fairness education that included book reading, related games, and philosophical discussions. We found that children showed a significant increase in comprehension of equity related terms and …

Section V.B Producer Price Index, Bureau Of Labor Statistics

Documentary Appendix to Table 1-B of Professor Thompson’s Book <em>The Trump v. Harris Voter’s Guide to Their Economic Debate</em> (2024)

No abstract provided.

Ang Posibilidad At Hanggahan Ng Ekosalin: Isang Pagbabalangkas At Paglalapat Ng Nababagong Teorya Sa Larangan Ng Pagsasalin, Claudette M. Ulit

Filipino Faculty Publications

Nakatuon ang pag-aaral na ito sa pagbubuo at paglalapat ng dulog pampagsasaling nakasentro sa kalikasan na tatawaging “ekosalin” na salig sa larangan ng eco-translation at ekolingguwistika. Ilalapat ang nabuong dulog o ang ekosalin sa mga pilíng artikulo sa Ingles na arawang lumabas sa pahayagang The Manila Times noong 1986-1989 — ang Halupi, partikular ang mga pumapaksa sa flora at fauna na ituturing sa pag-aaral na ito bílang mga stories-we-live-by o mga-kuwentong nakasanayan-na. Pangunahing hakbang ang paglalantad sa mga padron ng paggamit ng wika sa loob o kabuoan ng teksto, gayundin ang pagtatabi ng mga teksto sa inilatag na ekosopiya ng …

27-Hydroxycholesterol Acts On Estrogen Receptor Α Expressed By Pomc Neurons In The Arcuate Nucleus To Modulate Feeding Behavior, Hui Ye, Xiaohua Yang, Bing Feng, Pei Luo, Valeria C.Torres Irizarry, Leslie Carrillo-Sáenz, Meng Yu, Yongjie Yang, Benjamin P. Eappen, Marcos David Munoz, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Penghua Lai, Xinyue Qi, Yuliang Zhou, Maya Kota, Devin Dixit, Madeline Mun, Chong Wee Liew, Yuwei Jiang, Chunmei Wang, Yanlin He, Pingwen Xu

Division of Basic Science Faculty Publications

Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC binds to the estrogen receptor α (ERα) in the brain to regulate energy balance. Supporting this view, we found that delivering 27HC to the brain reduced food intake and activated proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (POMCARH) in an ERα-dependent manner. In addition, we observed that inhibiting brain ERα, deleting ERα in POMC neurons, or chemogenetic inhibition of …

An International Multidisciplinary Consensus On Pediatric Metabolic Dysfunction-Associated Fatty Liver Disease, Le Zhang, Mortada El-Shabrawi, Louise A. Baur, Christopher D. Byrne, Giovanni Targher, Mohit Kehar, Gilda Porta, Way Seah Lee, Sander Lefere, Serap Turan, Anna Alisi, Ram Weiss, Maria Felicia Faienza, Ambika Ashraf, Shikha S. Sundaram, Anshu Srivastava, Ruth De Bruyne, Yunkoo Kang, Flora Bacopoulou, Yong Hai Zhou, Andy Darma, Monica Lupsor-Platon, Masahide Hamaguchi, Anoop Misra, Nahum Méndez-Sánchez, Nicholas Beng Hui Ng, Claude Marcus, Amanda E. Staiano, Nadia Waheed, Saleh A. Alqahtani, Cosimo Giannini, Ponsiano Ocama, Mindie H. Nguyen, Maria Teresa Arias-Loste

Population and Public Health Science Faculty Publications

Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts. Methods: A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed …

Corrigendum To “Two New Species Of Inocybe (Inocybaceae: Agaricomycetes) From Türkiye Based On Morphological Characteristics And Phylogenetic Evidence [Turkish Journal Of Botany 48 (3) 2024 145-154 ], Oğuzhan Kaygusuz, Ditte Bandini, Henning Knudsen, Meike Piepenbring

Turkish Journal of Botany

This corrigendum is to address an issue regarding the manuscript's previous publication, specifically Fig. 5.Regrettably, the authors have noticed that the Figure 5 is missing among the figures although there is an incite reference within the text. To rectify this oversight and ensure the accuracy of the published work, the Figure 5 is included for your reference.

Link to the original article: https://journals.tubitak.gov.tr/botany/vol48/iss3/3/

Otocolobus Manul (Carnivora: Felidae), Paula Noonan, Zoe Baker, Virginia Hayssen

Biological Sciences: Faculty Publications

Otocolobus manul (Pallas, 1776) is a small, solitary, terrestrial felid commonly called the Manul and is the sole species of its genus. It occurs in Afghanistan, Armenia, Bhutan, China, India, the Islamic Republic of Iran, Kazakhstan, Kyrgyzstan, Mongolia, Nepal, Pakistan, the Russian Federation, and Turkmenistan. Otocolobus manul might still occur in Tajikistan and Uzbekistan but might be extinct in Azerbaijan. As assessed in 2020, O. manul is listed as “Least Concern” (LC) on the International Union for Conservation of Nature and Natural Resources Red List of Threatened Species, with an estimate of 58,000 adults, although the population might be decreasing.

Onesamp 3.0: Estimation Of Effective Population Size Via Snp Data From One Population, Aaron Hong, Rebecca Cheek, Suhashi Nihara De Silva, Kingshuk Mukherjee, Isha Yooseph, Mark Heim, David Tallmon, Christina Boucher

Faculty, Staff, and Students

The genetic effective size (Ne) is arguably one of the most important characteristics of a population as it impacts the rate of loss of genetic diversity. Methods that estimate Ne are important in population and conservation genetic studies as they quantify the risk of a population being inbred or lacking genetic diversity. Yet there are very few methods that can estimate the Ne from data from a single population and without extensive information about the genetics of the population, such as a linkage map, or a reference genome of the species of interest. We present ONeSAMP 3.0, an algorithm for …

A Systematic Review Of Implementation Fidelity Interventions For School-Based Behavior Supports In Special Education Settings, Paige C. Mesui

Theses and Dissertations

Problem behavior has been increasing in classrooms and has significantly contributed to teacher burnout. Students in special education settings have been found to demonstrate problem behaviors more than their general education peers. Schools have a responsibility to implement evidence-based behavioral support to assist students with their behavioral needs, decrease problem behavior, and increase desired behavior in the classroom. There is a relationship between the level of implementation fidelity and the effectiveness of an intervention. If there are not high levels of fidelity, the results are not expected to mimic what has been found in the research. The purpose of this …

Asmrtistry In Immersive Sound: Investigating The Effectiveness Of Immersive Sound Technologies In Eliciting Autonomous Sensory Meridian Response, Scott D. Nelson

LSU Doctoral Dissertations

Despite a wide array of immersive sound technologies available to digital media creators who specialize in making audio-visual content that aims to elicit Autonomous Sensory Meridian Response (ASMR), only a few sound reproduction modalities are widely used: mono/stereo and binaural recording. To date, nearly all research studying ASMR, a bio-sensory phenomenon wherein people feel brain tingles triggered by calming audio-visual cues, has been content to carry out ASMR studies entirely with stereo and binaural sound reproduction methods. Therefore, it stands to reason that more understanding about how diverse immersive sound modalities like wave field synthesis, or three-dimensional spatial audio for …

Chemical And Physical Properties Of Fine Fractions From A Village Proximate To A Uranium Mine: Insights About Soil Health, Mary P. Haley

Nanoscience and Microsystems ETDs

Thousands of abandoned uranium mines (AUM) in Native American tribal lands have not been fully remediated, leaving uranium mine wastes exposed and accessible for potential erosion and transport by wind. Analyzing the metal and organic content of the fine-grained fractions in soils could uncover the impact of mine legacy on the soil health in communities that live in proximity to AUM. This study investigates the physical and chemical properties of the fine-grained fraction (μm) of soils to quantify the effect of heavy metal-bearing particulates on the soil health in the village of Paguate and within the Jackpile-Paguate AUM located on …

Students Exploring Careers In Occupational Therapy, Shayna Kymes, Mary Thelander

InterProfessional Education Research and Scholarship

To engage students from rural and underserved communities, the Occupational Therapy Graduate Program participated in a Students Exploring Careers in Health (SECiH) event. We introduced the students to Occupational Therapy (OT) during the morning and provided three examples of assessments during the afternoon portion. We chose to have them explore one handed baby dressing, name as many animals as they can in 60 seconds per the Animal Naming Test (ANT) and the Minnesota Spatial Relations Test. We chose these assessments as the ANT is an equipment free test that can be given bedside to test for minimal or covert hepatic …

Using Behavioral Skills Training To Promote Online Safety Skills In Individuals With Developmental Disabilities, Robert Lynn

Theses

Abstract

Children are spending more time online, which is putting them at risk of encountering online predators. There have been attempts to minimize the occurrence of these encounters, but most of these involved instructional training and parent supervision. One alternative intervention for addressing safety skills that has been shown to be effective is behavior skills training (BST), which is a procedure based on behavior analytic literature. BST involves instructions, modeling, rehearsal, and feedback. The purpose of this study was to evaluate the effects of BST on the acquisition of online safety skills in adolescents and adults with developmental disabilities. In-situ …

Lymphoid Tissues Contribute To Plasma Viral Clonotypes Early After Antiretroviral Therapy Interruption In Siv-Infected Rhesus Macaques, Antonio Solis-Leal, Nongthombam Boby, Suvadip Mallick, Yilun Cheng, Fei Wu, Grey De La Torre, Jason Dufour, Xavier Alvarez, Vinay Shivanna, Yaozhong Liu, Christine M. Fennessey, Jeffrey D. Lifson, Qingsheng Li, Brandon F. Keele, Binhua Ling

School of Biological Sciences: Faculty Publications

The rebound-competent viral reservoir, composed of a virus that is able to persist during antiretroviral therapy (ART) and mediate reactivation of systemic viral replication and rebound viremia after ART interruption (ATI), remains the biggest obstacle to treating HIV infection. A better understanding of the cellular and tissue origins and the dynamics of viral populations that initiate rebound upon ATI could help develop therapeutic strategies for reducing the rebound-competent viral reservoir. In this study, barcoded simian immunodeficiency virus (SIV), SIVmac239M, was used to infect rhesus macaques to enable monitoring of viral barcode clonotypes contributing to virus detectable in plasma after ATI. …

Learning To Express Reward Prediction Error-Like Dopaminergic Activity Requires Plastic Representations Of Time, Ian Cone, Claudia Clopath, Harel Z Shouval

Faculty, Staff and Student Publications

The dominant theoretical framework to account for reinforcement learning in the brain is temporal difference learning (TD) learning, whereby certain units signal reward prediction errors (RPE). The TD algorithm has been traditionally mapped onto the dopaminergic system, as firing properties of dopamine neurons can resemble RPEs. However, certain predictions of TD learning are inconsistent with experimental results, and previous implementations of the algorithm have made unscalable assumptions regarding stimulus-specific fixed temporal bases. We propose an alternate framework to describe dopamine signaling in the brain, FLEX (Flexibly Learned Errors in Expected Reward). In FLEX, dopamine release is similar, but not identical …

Monoallelic De Novo Ajap1 Loss-Of-Function Variants Disrupt Trans-Synaptic Control Of Neurotransmitter Release, Simon Früh, Sami Boudkkazi, Peter Koppensteiner, Vita Sereikaite, Li-Yuan Chen, Diego Fernandez-Fernandez, Pascal D Rem, Daniel Ulrich, Jochen Schwenk, Ziyang Chen, Elodie Le Monnier, Thorsten Fritzius, Sabrina M Innocenti, Valérie Besseyrias, Luca Trovò, Michal Stawarski, Emanuela Argilli, Elliott H Sherr, Bregje Van Bon, Erik-Jan Kamsteeg, Maria Iascone, Alba Pilotta, Maria R Cutrì, Mahshid S Azamian, Andrés Hernández-García, Seema R Lalani, Jill A Rosenfeld, Xiaonan Zhao, Tiphanie P Vogel, Herda Ona, Daryl A Scott, Peter Scheiffele, Kristian Strømgaard, Mehdi Tafti, Martin Gassmann, Bernd Fakler, Ryuichi Shigemoto, Bernhard Bettler

Faculty, Staff and Students Publications

Adherens junction–associated protein 1 (AJAP1) has been implicated in brain diseases; however, a pathogenic mechanism has not been identified. AJAP1 is widely expressed in neurons and binds to γ-aminobutyric acid type B receptors (GBRs), which inhibit neurotransmitter release at most synapses in the brain. Here, we show that AJAP1 is selectively expressed in dendrites and trans-synaptically recruits GBRs to presynaptic sites of neurons expressing AJAP1. We have identified several monoallelic AJAP1 variants in individuals with epilepsy and/or neurodevelopmental disorders. Specifically, we show that the variant p.(W183C) lacks binding to GBRs, resulting in the inability to recruit them. Ultrastructural analysis revealed …

Pulmonary Osteoclast-Like Cells In Silica Induced Pulmonary Fibrosis, Yoshihiro Hasegawa, Steven L Teitelbaum, Et Al.

2020-Current year OA Pubs

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored mechanisms of silica-induced pulmonary fibrosis in human lung samples collected from patients with occupational exposure to silica and in a longitudinal mouse model of silicosis using multiple modalities including whole-lung single-cell RNA sequencing and histological, biochemical, and physiologic assessments. In addition to pulmonary inflammation and fibrosis, intratracheal silica challenge induced osteoclast-like differentiation of alveolar macrophages and recruited monocytes, driven by induction of the osteoclastogenic cytokine, receptor activator of nuclear factor κΒ ligand (RANKL) in pulmonary lymphocytes, and …

27-Hydroxycholesterol Acts On Estrogen Receptor Α Expressed By Pomc Neurons In The Arcuate Nucleus To Modulate Feeding Behavior, Hui Ye, Xiaohua Yang, Bing Feng, Pei Luo, Valeria C Torres Irizarry, Leslie Carrillo-Sáenz, Meng Yu, Yongjie Yang, Benjamin P Eappen, Marcos David Munoz, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Penghua Lai, Xinyue Qi, Yuliang Zhou, Maya Kota, Devin Dixit, Madeline Mun, Chong Wee Liew, Yuwei Jiang, Chunmei Wang, Yanlin He, Pingwen Xu

Faculty, Staff and Students Publications

Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC binds to the estrogen receptor α (ERα) in the brain to regulate energy balance. Supporting this view, we found that delivering 27HC to the brain reduced food intake and activated proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (POMCARH) in an ERα-dependent manner. In addition, we observed that inhibiting brain ERα, deleting ERα in POMC neurons, or chemogenetic inhibition of …

Giardiasis: A Review Study In Iraq, Sarah Kamal Naser

Al-Ameed Journal for Medical Research and Health Sciences

Background: Giardia lamblia is the parasite that causes giardiasis, small intestine infection can result in severe issues and persistent symptoms, especially in children, giardiasis is a common diarrheal disease that can affect anyone everywhere in the world. It may not show any signs at all or it may result in symptoms like intermittent flatulence or persistent malabsorption, Giardia antigen  test,  molecular test for the presence of parasite DNA in feces, and identification of the organism in fresh stool or duodenal contents are all methods of diagnosis.

Aims: Finding the prevalence of giardiasis among cities is the purpose of this review …

An Epidemiological Study Of Tinea Corporis In Al-Najaf City, Ahmed Rashad Rasool, Amel Mustafa Kamil, Dhakam Mohammed Abbas

Maaen Journal for Medical Sciences

Background: Dermatophytes are humans' and animals' primary causative agents in charge of cutaneous fungal infections. Understanding the epidemic behavior of dermatophytosis, such as Tinea corporis, which specifically affects the trunk, neck, and extremities, might aid in its prevention. Aim of the study: The study aims to determine the proportion of Tinea corporis and dermatophytosis, the clinical type distribution of dermatophytosis, and participant demographics for Tinea corporis. Method: a cross-sectional study focuses on individuals diagnosed with Tinea corporis in the three general hospitals in Al-Najaf City the study takes place from April 1st to July 31st. all cases with tinea corporis …

A Rehabilitation Of The Body As Home: Reconstructing Young’S Feminist Phenomenology, Amanda Nicole C. Collantes

Budhi: A Journal of Ideas and Culture

This essay investigates Iris Marion Young’s account of female bodily experience and reconstructs her feminist phenomenology with the aim of reinterpreting and enriching the tradition of embodiment using feminist critique. It offers a clearer, more cohesive reconstruction of Young’s phenomenology by referencing three essays where she considers a particular aspect of women’s lived bodily experiences. It considers three recurring themes that appear in and are developed in the three main essays by Young referred to throughout the study. It presents personal, lived experience as political, thus encouraging social cooperation and women’s solidarity through collective meaning-making and a recovery of our …