Digital Commons Network^™

Assessment Of Genetic Diversity And Population Structure Of U.S. Polypay Sheep From Breed Origins To Future Genomic Selection, Carrie S. Wilson, Jessica Lynn Petersen, Luiz F. Brito, Brad A. Freking, Sara M. Nilson, J. Bret Taylor, Thomas W. Murphy, Ronald M. Lewis

Department of Animal Science: Faculty Publications

Knowledge of past and present genetic diversity within a breed is critical for the design and optimization of breeding programs as well as the development of strategies for the conservation of genetic resources. The Polypay sheep breed was developed at the U.S. Sheep Experiment Station (USSES) in 1968 with the goal of improving productivity in Western U.S. range flocks. It has since flourished in the more intensively managed production systems throughout the U.S. The genetic diversity of the breed has yet to be documented. Therefore, the primary objective of this study was to perform a comprehensive evaluation of the genetic …

Noramco Llc V. Dishman Usa Inc

2024 Decisions

USDC for the District of Delaware

Effect Of Transcranial Direct Current Stimulation And Narrow-Band Auditory Stimulation On The Intraoperative Electroencephalogram: An Exploratoratory Feasibility Study, Oliver G. Isik, Tuan Z. Cassim, Meah T. Ahmed, Matthias Kreuzer, Alice M. Daramola, Paul S. Garcia

SKMC Student Presentations and Publications

INTRODUCTION: During general anesthesia, frontal electroencephalogram (EEG) activity in the alpha frequency band (8-12 Hz) correlates with the adequacy of analgesia. Transcranial direct current stimulation (tDCS) and auditory stimulation, two noninvasive neuromodulation techniques, can entrain alpha activity in awake or sleeping patients. This study evaluates their effects on alpha oscillations in patients under general anesthesia.

METHODS: 30 patients receiving general anesthesia for surgery were enrolled in this two-by-two randomized clinical trial. Each participant received active or sham tDCS followed by auditory stimulation or silence according to assigned group (TDCS/AUD, TDCS/SIL, SHAM/AUD, SHAM/SIL). Frontal EEG was recorded before and after neuromodulation. …

A Multicenter, Phase 1, Adult Brain Tumor Consortium Trial Of Oral Terameprocol For Patients With Recurrent High-Grade Glioma (Gator), Manmeet Ahluwalia, Ahmad Ozair, Atulya Khosla

All Publications

Recurrent high-grade gliomas (rHGGs) have a dismal prognosis, where the maximum tolerated dose (MTD) of IV terameprocol (5 days/month), a transcriptional inhibitor of specificity protein 1 (Sp1)-regulated proteins, is 1,700 mg/day with median area under the plasma concentration-time curve (AUC) of 31.3 μg∗h/mL. Given potentially increased efficacy with sustained systemic exposure and challenging logistics of daily IV therapy, here we investigate oral terameprocol for rHGGs in a multicenter, phase 1 trial (GATOR). Using a 3 + 3 dose-escalation design, we enroll 20 patients, with median age 60 years (range 31-80), 70% male, and median one relapse (range 1-3). Fasting patients …

The Hydrological Impacts Of Woody Plant Encroachment On Coastal Tallgrass Prairie Of Texas, Zhiwei Guo

LSU Master's Theses

Globally, woody plant encroachment into grassland and savanna ecosystems impacts the hydrological functions of grasslands and associated wetlands. In the coastal tallgrass prairie of Texas, encroachment of woody plants has altered vegetation structure, but the hydrological impacts are poorly understood. In this study, I evaluated and quantified how woody plant encroachment affects hydrological processes on the pimple mounds and inter-mound freshwater marsh, including precipitation partitioning, infiltration in the vadose zone, groundwater recharge, and water volume in the inter-mound marsh. I randomly selected three pimple mounds with woody plants and three pimple mounds with tallgrass w to quantify hydrologic processes. The …

The Role Of Furan Moieties On The Thermal Decomposition And Char Formation Of Intrinsically Fire-Resistant Epoxy Thermosets For Composites, Amy E. Honnig Bassett

Theses and Dissertations

Fire-retardant chemicals added to epoxy thermosets used as coatings, adhesives, and fiber-reinforced polymer composites (FRPCs) negatively impact performance and the environment. This dissertation takes a novel approach to mitigate the flammability of these systems by designing intrinsically fire-resistant epoxies via the incorporation of furan moieties. Glycidyl amines based on furfuryl amine and judiciously selected derivatives of furfuryl amine were synthesized to produce furan-based di-epoxies (FDEs) that were cured by anionic polymerization and with amine curing agents. The furan ring was found to impart additional reactivity for cross-linking and to induce char-forming reactions at higher temperatures. More importantly, the placement of …

Mutant Androgen Receptor Induces Neurite Loss And Senescence Independently Of Are Binding In A Neuronal Model Of Sbma, Jordyn Karliner, Y Liu, Diane Merry

Department of Biochemistry and Molecular Biology Faculty Papers

Spinal and bulbar muscular atrophy (SBMA) is a slowly progressing neuromuscular disease caused by a polyglutamine (polyQ)-encoding CAG trinucleotide repeat expansion in the androgen receptor (AR) gene, leading to AR aggregation, lower motor neuron death, and muscle atrophy. AR is a ligand-activated transcription factor that regulates neuronal architecture and promotes axon regeneration; however, whether AR transcriptional functions contribute to disease pathogenesis is not fully understood. Using a differentiated PC12 cell model of SBMA, we identified dysfunction of polyQ-expanded AR in its regulation of neurite growth and maintenance. Specifically, we found that in the presence of androgens, polyQ-expanded AR inhibited neurite …

Katz, Helen, Sophia Maier Garcia

Bronx Jewish History Project

Summarizer: Sophia Maier

Helen Katz was born to Holocaust survivor parents in the Bronx. The family originally lived in the South Bronx until Katz was one year old, when they moved to the Olinville section of the Bronx. They lived there until Katz was in her 20s, when they moved to Pelham Parkway. Each time, they moved because the neighborhood was deteriorating.

Katz describes the Olinville neighborhood as predominantly Italian, although her own family was Orthodox. Despite the differences, she remembers playing with the Italian Catholic school girls. They attended a Lubavitcher shul, and Katz attend a yeshiva for her …

Biophysics Of Protein-Lipid Interactions, Paula A Bender, Vasanthi Jayaraman

Faculty, Staff and Student Publications

The biological phenomenon of protein-lipid interactions in cell membranes underlies the diversity of peripheral membrane protein function and physical properties of the membrane. To summarize novel findings in the field, this research highlight focuses on recent publications in Biophysical Journal.

Role Of Acute Alcohol Exposure In Klebsiella Pneumoniae-Induced Pneumonia, Prantho Malakar Dipta

LSU Master's Theses

Klebsiella pneumoniae (KP), a Gram-negative bacterium, induces severe pneumonia associated with devastating pathological consequences in the lung, such as substantial parenchymal damage. K. pneumoniae is responsible for causing life-threatening lung infections in patients with alcoholics and diabetics. The need to look for new therapeutic approaches is due to the emergence of Klebsiella pneumoniae strains that are resistant to many drugs. The effects of acute alcohol consumption on the host’s innate immune response to KP during infection remain unclear. Age-matched C57BL/6 female mice were administered 6g/kg of 32% alcohol or same amount of PBS via oral gavage 30 minutes prior to …

Development Of A Hydrogen Peroxide-Inactivated Vaccine That Protects Against Viscerotropic Yellow Fever In A Non-Human Primate Model, Ian J Amanna, Archana Thomas, Flora Engelmann, Erika Hammarlund, Hans-Peter Raué, Adam L Bailey, Elizabeth A Poore, Benjamin K Quintel, Anne D Lewis, Michael K Axthelm, Amanda L Johnson, Lois M A Colgin, Michael S Diamond, Ilhem Messaoudi, Mark K Slifka

2020-Current year OA Pubs

Yellow fever virus (YFV) is endemic in >40 countries and causes viscerotropic disease with up to 20%-60% mortality. Successful live-attenuated yellow fever (YF) vaccines were developed in the mid-1930s, but their use is restricted or formally contraindicated in vulnerable populations including infants, the elderly, and people with compromised immune systems. In these studies, we describe the development of a next-generation hydrogen peroxide-inactivated YF vaccine and determine immune correlates of protection based on log neutralizing index (LNI) and neutralizing titer-50% (NT

Examining Social Anxiety, Generalized Anxiety, And Major Depression’S Symptom Comorbidity In Children And Adolescents: A Longintudinal Test Of The Multiple Pathway Model, Paige Picou

LSU Doctoral Dissertations

Anxiety and depressive disorders are highly prevalent in and impairing for children and adolescents and are highly comorbid. Many theories have been proposed to explain this co- occurrence, with recent models postulating multiple pathways in which specific anxiety disorders and depression may co-occur both concurrently and over time. Unfortunately, little research has evaluated these pathways longitudinally across development in a community sample. The current study tested the multiple pathway model in a sample of 9 to 12-year-old youth (Mage = 9.48, SD= 0.51) at baseline and at two-year follow-up using a subsample of the Adolescent Brain Cognitive Development …

Chimeric Viruses Enable Study Of Antibody Responses To Human Rotaviruses In Mice, Sarah Woodyear, Tawny L Chandler, Takahiro Kawagishi, Tom M Lonergan, Vanshika A Patel, Caitlin A Williams, Sallie R Permar, Siyuan Ding, Sarah L Caddy

2020-Current year OA Pubs

The leading cause of gastroenteritis in children under the age of five is rotavirus infection, accounting for 37% of diarrhoeal deaths in infants and young children globally. Oral rotavirus vaccines have been widely incorporated into national immunisation programs, but whilst these vaccines have excellent efficacy in high-income countries, they protect less than 50% of vaccinated individuals in low- and middle-income countries. In order to facilitate the development of improved vaccine strategies, a greater understanding of the immune response to existing vaccines is urgently needed. However, the use of mouse models to study immune responses to human rotavirus strains is currently …

Exploring Lipin1 As A Promising Therapeutic Target For The Treatment Of Duchenne Muscular Dystrophy, Abdulrahman Jama, Abdullah A Alshudukhi, Steve Burke, Lixin Dong, John Karanja Kamau, Brooklyn Morris, Ibrahim A Alkhomsi, Brian N Finck, Andrew Alvin Voss, Hongmei Ren

2020-Current year OA Pubs

BACKGROUND: Duchenne muscular dystrophy (DMD) is a progressive and devastating muscle disease, resulting from the absence of dystrophin. This leads to cell membrane instability, susceptibility to contraction-induced muscle damage, subsequent muscle degeneration, and eventually disability and early death of patients. Currently, there is no cure for DMD. Our recent studies identified that lipin1 plays a critical role in maintaining myofiber stability and integrity. However, lipin1 gene expression levels are dramatically reduced in the skeletal muscles of DMD patients and mdx mice.

METHODS: To identify whether increased lipin1 expression could prevent dystrophic pathology, we employed unique muscle-specific mdx:lipin1 transgenic (mdx:lipin1

RESULTS: …

Mapping The Contribution Of The C-Linker Domain To Gating Polarity In Cnbd Channels, Jenna L Lin, Yongchang Chang, Debanjan Tewari, John Cowgill, Baron Chanda

2020-Current year OA Pubs

Ion channels of the cyclic nucleotide-binding domain (CNBD) family play a crucial role in the regulation of key biological processes, such as photoreception and pacemaking activity in the heart. These channels exhibit high sequence and structural similarity but differ greatly in their functional responses to membrane potential. The CNBD family includes hyperpolarization-activated ion channels and depolarization-activated ether-à-go-go channels. Structural and functional studies show that the differences in the coupling interface between these two subfamilies' voltage-sensing domain and pore domain may underlie their differential response to membrane polarity. However, other structural components may also contribute to defining the polarity differences in …

Chimeric Antigen Receptor-Induced Antigen Loss Protects Cd5cart Cells From Fratricide Without Compromising On-Target Cytotoxicity, Royce Ma, Mae Woods, Phillip Burkhardt, Noah Crooks, Dayenne G Van Leeuwen, Daniil Shmidt, Jacob Couturier, Alexandre Chaumette, Divya Popat, Laquisa C Hill, Rayne H Rouce, Sachin Thakkar, Aaron F Orozco, Alexandre F Carisey, Malcolm K Brenner, Maksim Mamonkin

Center for Medical Ethics and Health Policy Staff Publications

Chimeric antigen receptor T cells (CART) targeting lymphocyte antigens can induce T cell fratricide and require additional engineering to mitigate self-damage. We demonstrate that the expression of a chimeric antigen receptor (CAR) targeting CD5, a prominent pan-T cell antigen, induces rapid internalization and complete loss of the CD5 protein on T cells, protecting them from self-targeting. Notably, exposure of healthy and malignant T cells to CD5.CART cells induces similar internalization of CD5 on target cells, transiently shielding them from cytotoxicity. However, this protection is short-lived, as sustained activity of CD5.CART cells in patients with T cell malignancies results in full …

Analysis Of The Potential For Enhancing The Efficiency Of A Floating Photovoltaic (Fpv) System, How-Ping Wu, Ching-Yi Tseng, Chuan-Chung Jen, Yuan-Ching Chiang, Sih-Li Chen

Journal of Marine Science and Technology–Taiwan

This study examined the power generation capabilities of FPV systems and the advantages of employing active cooling on floating solar panels. Floating solar panels exhibit improved efficiency due to operating at lower temperatures facilitated by the cooling effect of water evaporation. Additionally, the high availability of water renders the application of the active cooling technique economically viable. This study developed a comprehensive simulation of a floating solar system, integrating a mathematical model to validate experimental findings and a temperature model derived from an energy equation specific to floating solar panels. This model calculates the heat transfer among the three different …

Sustaining America's Non-Jurisdictional Wetlands Post-Sackett Through Conservation, Shawna Bligh

UMKC Law Review

Part I of this Article discusses the functional role of wetlands in meeting the intended purpose of the Clean Water Act (“CWA”). The intended purpose of the CWA is to "restore and maintain the chemical, physical and biological integrity of the Nation's waters." The Court's decision in Sackett undermines the intended purpose of the CWA. Wetlands play an essential role in meeting this objective. Wetlands are hydrologically connected to and an embedded part of the overall aquatic ecosystem. The Sackett decision leaves wetlands subject to further degradation.

Part II of this Article provides an overview of the CWA, how we …

(Hidden) In Plain Sight: Migrant Child Labor And The New Economy Of Exploitation, Shefali Milczarek-Desai

Arkansas Law Review

Oppressive child labor in America is both an age-old problem and one that is relatively new. Part I presents the tumultuous history of child labor regulation in the United States—a history that provides clues as to why contemporary child labor laws fall far short of comprehensively addressing oppressive, migrant child labor. It then pivots to the contemporary child labor crisis by describing the new economy of exploitation and the unaccompanied migrant children upon which it relies. Part II sets forth the current U.S. legal landscape surrounding child labor laws, including these laws’ failure to protect migrant children. Next, Part II …

Lubin Business Magazine Spring 2024

Lubin Business Magazine

No abstract provided.

Effects Of Two Grazing Conditions On The Reproductive Achievement Of Male Alpaca In The Northern Peru Grasslands, C Pinares, E Malpartida, S Cortez

IGC Proceedings (1977-2023)

Alpaca have recently been introduced to the northern Peru grasslands (Jalca). Effects of two systems of grazing management, co-grazing (with sheep) under fair grassland condition (CGFC) versus exclusive grazing under good grassland condition (EGGC), upon the reproductive achievement was examined from the 6th to the 16th month of age. Each system involved 20 Huacaya animals, managed by individual herders. Availability of herbage preferred by alpaca (HMA) and animal measurements (herbage intake, liveweight, testicle size, penis release from preputial attachments, plasma testosterone) were monitored monthly. Puberty, judged by the penis release from the preputial attachments, was achieved by 7 …

Experiences Of Eight Ohio Beef And Sheep Producers With Year Round Grazing, H M. Bartholomew, S L. Boyles, B Carter, E Vollborn, D Miller, R M. Sulc

IGC Proceedings (1977-2023)

Livestock producers participated in a demonstration project to extend the grazing season and evaluate dormant forage quality and yield. Differences were not detected in yields among forage species but yield differences existed among sites. Yield estimates did not change over time across all forage species but some sites were only able to participate for two months. Producers utilizing fescue beyond November had reductions in herbage mass. Crude protein, available crude protein, acid detergent fiber, and neutral detergent fiber content differed among forage species and sites. Energy and lignin content were similar for all forage species and sites. Sodium and copper …

Forage Production Of Irrigated Lecerne- Grass Mixtures Grazed By Sheep, M L. Enrique, D P. Minon

IGC Proceedings (1977-2023)

The forage production and botanical changes of lucerne cultivars in pure stands and in grass mixtures were studied in a split-plot experiment with irrigation and sheep grazing. The non dormant lucerne cultivars (Medicago sativa) CUF 101, Monarca SPINTA, P 30 and common were the main plots, and tall fescue (Festuca arundinacea), canarygrass (Phalaris aquatica), cocksfoot (Dactylis glomerata), tall wheatgrass (Thynopirum ponticum) and prairie grass (Bromus catharticus) were the subplots. The experiment was grazed 3, 6 and 4 times during 3 years. Total yield was similar for all lucerne …

Oat Grazing: Forage Composition And Supplementation Response, A J. Freddi, M J. Arzadun, A A. Pissani, P Sastre

IGC Proceedings (1977-2023)

Oat forage (Avena sativa), which has low soluble carbohydrates (SC) and high soluble protein (SP) content, can reduce liveweight gain of grazing animals; supplementation with grain and low degradability protein may serve to counteract the effect. A grazing trial was carried out on two soils with different nitrogen (NO3 -) availability, from 16 April 1994 to 6 September 1994. Steers were randomly allocated to 3 treatments: low nitrogen (LN), high nitrogen (HN) and high nitrogen with supplementation (HNS). Forage of LN showed lower SP (p<0.05) during the first month of grazing, and higher SC (p<0.05), than HN during the first two months of the trial. Animal liveweight gain was: 892, 909 and 775 g/an/day for LN, HNS and HN, respectively, with animals in HN of significantly lower liveweight gain (p<0.05). Under the conditions of this trial, animals grazing on oat forage with lower SC and higher SP had lower liveweight gain and responded to supplementation.

Native And Introduced Forage Systems For Cow-Calf Production, S W. Coleman, W A. Phillips, J D. Volesky

IGC Proceedings (1977-2023)

The objectives of this study was to compare a highly productive introduced warm-season perennial grass to native range for cowcalf production over two years. Three systems, 1) native range with pelleted soybean or cottonseed meal as winter protein supplement (NC); 2) native range with wheat pasture (NW); and 3) Plains Bluestem with wheat pasture (PB) were compared. Protein supplements were given twice weekly and cows grazing wheat pasture were allowed 6 hrs to graze. Cows on NW were heavier with higher condition at breeding in the spring of 1994 than those on NC and cows on PB were heavier and …

Rotational Stocking And Soil Nutrient Distribution On Hawaiian Grasslands, B W. Mathews, J P. Tritschler, L E. Sollenberger

IGC Proceedings (1977-2023)

A naturalized kikuyu (Pennisetum clandestinum Hochst. ex Chiov.) grassland was grazed by heifers (Bos taurus) for 2 years to determine the effects of two rotational stocking methods (short vs. long grazing periods) on soil N, P, K, Ca, Mg, and S distribution in paddocks with natural shade. Additionally, kikuyugrass-greenleaf desmodium (Desmodium intortum Urb.) paddocks were used to evaluate soil nutrient distribution in rotationally stocked paddocks (long grazing periods) without shade. In the study with shade, soil N, P, and K distribution did not differ between stocking methods. These nutrients accumulated within 15 m of shade, but did not …

Relationship Between Height And Sward Quality In Rotational Dairy Systems, M R. Mosquera-Losada, A Gonzalez-Rodriguez

IGC Proceedings (1977-2023)

Height is a good guide for management in dairy systems.Intake by dairy cows depends on amount offered and quality of pasture and for this reason a relationship between that offered and pasture quality with height should be studied. The experiment was conducted in NW of Spain with three different stocking rates in dairy systems. A lower quality sward was found in the taller offered pasture as indicated by its higher ADF and lower CP percentages. Total sward ADF (kg x ha-a) was higher in taller offered pasture, which indicated a lower pasture quality, however the total CP was positively related …

Non-Destructive Methods For The Estimation Of Sward Production, M R. Mosquera-Losada, A Gonzalez-Rodriguez

IGC Proceedings (1977-2023)

Two non- destructive methods of grass production were compared: grassmeter and sward stick, in order to find an equation for transforming one into the other in dairy rotational systems. Linear, logarithmic and quadratic equations were fitted to the data. Linear equation was preferred by simplicity. General equations which included all the year periods showed no differences between sward stick and grassmeter. A detailed study of the different phenology states showed lower heights with grassmeter than with the sward stick method, which should take into account grazing management height recommendations.

Vol. 61 No. 2 - Whole No. 409, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Pawsitive Purpose: The Impact Of Autism Assistance Dogs On The Occupations Of Autistic Children, Morgan Starkweather, Amie E. Germain, Christine A. Kivlen

The Open Journal of Occupational Therapy

Background. The World Health Organization recognizes that participation is important to individuals’ well being; yet, autistic children participate in fewer activities compared to neurotypical children. This article aims to describe the role of autism assistance dogs (AADs) in promoting participation and engagement in occupations and activities of daily living (ADLs) for autistic children.

Method. A qualitative interpretative phenomenological design was used. Two semi-structured interviews from a narrative perspective were conducted with each participant. Four volunteer parents and primary handlers of their child’s AAD participated in the study. Inductive analysis was used to interpret open-ended questions. Following transcription, Creswell’s …