Digital Commons Network^™

La Viuda Del Panamá -- A Sixteenth-Century Novel, Maria Cecilia Herrera Astua

Open Access Theses & Dissertations

La Viuda del Panamá es una novela histórica acerca de Sir Francis Drake y su amante, María Isabel Domínguez--una viuda mestiza de quien él se enamora cuando ella lo salva de una muerte segura. Isabel oculta su ascendencia india porque, en el pueblito Nombre de Dios, esa circunstancia es un pecado social. Mas al corregidor don Pedro—un viudo quien ha tenido un matrimonio infernal—no le interesa la pureza de sangre. Nacido en un hogar judeo-musulmán, don Pedro se enamora de Isabel desde el día en que ella lo atiende en la posada La Costeña y decide ofrecerle un futuro impensable …

Establishment Of A Novel Prairie Vole (Microtus Ochrogaster) Sars-Cov-2 Infection And Transmission Model, Stephanie Rebecca Kehl

Open Access Theses & Dissertations

Considering that the number of SARS-CoV-2 cases and deaths continues to increase three years after the onset of the pandemic, the need for animal models to study disease pathology and test antiviral effectiveness remains paramount. Prairie voles offer unique advantages as an infection model, such as mirroring human social behavior, including pair bonding and biparental offspring rearing, having inducible estrus and ovulation cycles, and not being overly domesticated. Based on the sequence homology of the vole ACE2 receptor to that of other species that are susceptible to SARS-CoV-2, such as the ferret and hamster, we hypothesized that the vole ACE2 …

Integrating Machine Learning And Simulation For Resource Planning Of Hospital Systems Based On Predicted Length Of Stay, S M Atikur Rahman

Open Access Theses & Dissertations

Recently Hospital Systems faced a high invasion of patients generated by several events such as health crisis related epidemic (COVID, FLU) or seasonal flows. Hence, managing hospital bed availability and efficiency with proper care is obligatory for addressing the challenges associated with the overburden of patients. However, the Length of stay (LOS) is often increased due to the high patient influx and overcrowding problem occurs within the Hospital. It resolves these issues, it is essential for hospital authority to predict the Patients LOS which is the crucial indicator for the use of medical resources (allocation, utilization of providers and resource) …

Design Of Engineered Nanomaterials For Pfas Adsorption And Catalytic Degradation From Relevant Environmental Conditions, Sheng Yin

Open Access Theses & Dissertations

Poly- and per-fluoroalkyl substances (PFAS) are a class of artificially made chemicals whose carbon chains are fully or partially fluorinated. Due to their persistent and pervasive distribution and their adverse effects on human health, the removal of PFAS from the environment has been the focus of current research. This project explores the use of engineered nanomaterials for the effective removal of PFAS through various adsorption and catalytic degradation methods. First, a comprehensive review of recent studies highlights the significant potential of various nanomaterials, including carbon-based, non-metal, single-metal, and multi-metal nanomaterials, for PFAS remediation. These materials are evaluated for their performance, …

Computational Models That Exploit Spatial, Temporal, And Voltage-Current Relationships In The Electrochemical Generation-Collection Of Redox-Active Molecules, Miguel Angel Abrego Tello

Graduate Theses and Dissertations

The numerical studies in this dissertation explore the application of redox cycling, an advanced electrochemical technique, for analyzing bioelectrochemical systems with a particular focus on small-volume samples and involves electrodes that can be activated to oxidize and reduce, separated by varying distances and featuring different geometries. The redox cycling approach facilitates the spatio-temporal interrogation of kinetics, mass transport, and the quantification and identification of chemical systems. We optimize a previously fabricated neural probe design on an SU-8 substrate, featuring coplanar arrays of nine microband electrodes suited for in vivo applications. Through comprehensive in situ and in silico redox cycling studies …

The Riddle Of Religious Language, Luke Hillman

Graduate Theses and Dissertations

The following project analyzes religious life through the lens of religious language. Motivated by ideas of Wittgenstein and Wittgensteinians, religious language is shown to be nonsensical, and yet significant. Wittgenstein connects how we understand language with how we understand life, and this connection extends to religious life. This project offers an answer to how religious language is unique by comparing religious language to riddles and the process of answering riddles. In addition, religious language becomes understandable with imagination, a relationship with the transcendent, and an understanding of the kinds of language present in religious discourse. These ideas are solidified with …

Rural-Urban Migration And The Extent Of Urbanization: A Case Study Of Rural Migrants From Northern Ghana To Accra, Daniel Kissi-Somuah

Graduate Theses and Dissertations

This study delves into the dynamics of rural-to-urban migration, emphasizing its impact on urbanization in the unique context of Ghana. As migration patterns evolve globally, understanding the motivations and challenges of internal migration is crucial for informed policy-making. The case study focuses on migrants from Northern Ghana to Accra, exploring factors propelling urbanization, challenges in urban job searches, and proposing strategies for managing urbanization. The research uses a comprehensive methodology to draw on extensive data from the 2021 Population and Housing Census. Utilizing thematic reports on migration, economic activities, background characteristics, and education, the study employs descriptive and inferential statistical …

Cancer Heterogeneity And Mitochondrial-Targeted Therapies In Cancer Cachexia, Francielly Morena Clark

Graduate Theses and Dissertations

Cancer Cachexia (CC) is a multifactorial and complex syndrome affecting up to 80% of cancer patients and contributing to approximately 40% of cancer-related deaths. Given its relationship with patients' quality of life and prognosis, there has been increasing emphasis on understanding the underlying mechanisms of CC using pre-clinical models. However, the mechanisms of cachexia vary depending on several factors, including tumor type, model, and biological variables such as sex. RNA-sequencing technology is a crucial tool for investigating CC heterogeneity, enabling the analysis of the transcriptome across different models, conditions, and sexes using publicly available data. Aim 1 of this dissertation …

Alternative Methods For Finishing Beef Cattle: Effects On Performance, Carcass Quality, And Meat Characteristics, Michelle Johnson

Graduate Theses and Dissertations

The objective of these studies was to evaluate the effects of alternative finishing methods on the live performance, carcass quality, and meat characteristics of beef steers. In study 1, treatments consisted of a conventional feedlot finishing diet with roughage included in the ration (FDLT); a high starch diet fed at 2-2.25% of BW with ad libitum access to bermudagrass pastures (STCH); or a high by-product diet fed at 2-2.25% of BW with ad libitum access to bermudagrass pastures (BYPD). Steers were fed their respective diets once daily and weighed every 28 days until deemed finished. Cattle were then transported and …

Neutrophil Cells And Tnf-Α Evaluation On Rat Inflammation Pulp After Application Haruan Fish Extract (Channa Striata) Combined With Calcium Hydroxide, Juni J. Nugroho, Dewi Krisyanti, Hafsah Katu, Aries C. Trilaksana, Wahyuni S. Dwiandhany, Afniati Rachmuddin

Journal of Dentomaxillofacial Science

ABSTRACT

Background: The pulp has a defense system against inflammation involving the immune system. When the surface becomes inflamed, leukocyte accumulation occurs followed by proinflammatory cytokines released. Neutrophils, the largest part of leukocytes, work surround infected areas, and phagocytize pathogens. Tumor Necrosis Factor-alpha (TNF-α), the main cytokine proinflammatory agent, provides a rapid response to infection. Application of calcium hydroxide (CH) in reversible pulpitis releases hydroxyl groups with an alkaline pH and has the potential effect to pulpal irritation and necrosis. So that a combination of medication was developed to reduce the inflammatory effect of CH. Several studies reported that haruan …

E-Cigarettes Theory To Alternative To Smoking And Associated Emerging Health Concerns, Utsav Pokharel

Master's Projects and Capstones

E-cigarettes have emerged as a popular alternative to traditional smoking, with proponents advocating for their potential role in smoking cessation. However, the health implications of e-cigarettes remain a contentious issue within public health discourse. This paper conducts a comprehensive review of the current literature to evaluate the efficacy of e-cigarettes as a smoking cessation tool and to assess their associated health risks. The study finds that while e-cigarettes may produce fewer toxicants than combustible cigarettes, their long-term health effects are still largely unknown. Evidence suggests that e-cigarette use can lead to adverse health outcomes, including lung and cardiovascular diseases, driven …

Connecting Representations And Ways Of Thinking About Slope From Algebra To Calculus, Deborah Moore-Russo, Courtney Nagle

The Mathematics Enthusiast

While slope is a topic in the algebra curriculum, having a robust understanding of slope is needed for students to truly understand several single and multivariable calculus topics with any depth. We begin with a review of the topic of slope and present what is known from its existing corpus of literature. We then outline the tenets of APOS theory. Building from there, we suggest what a robust, flexible understanding of slope involves, as well as how slope is used, with the APOS-slope framework acting as a theoretical lens. This is followed by the cases of two hypothetical students built …

Understanding The Role Of The Microbiome In Infectious Disease, Developing Surveillance Tools, And Engineering Direct Fed Microbials To Improve Animal Health, Alison Clare (Bartenslager) Neujahr

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

With the ever-increasing demand for animal protein and the continual need for the assurance of proper animal welfare, investigations of preventative strategies for diseases is greatly needed. Specifically in the cattle industry, infectious bovine keratoconjunctivitis (IBK), commonly known as pinkeye, causes a large economic loss to the producer. However, effective mitigation strategies are lacking. Partly, this is due to the lack of studies investigating the ocular microbiome. Therefore, studies investigating the bovine ocular microbiome are greatly needed to better understand IBK disease etiology. To this end, we investigated the changes in the ocular microbiome in animals before, during and after …

Service Dog Knowledge And Utilization In Occupational Therapy Practice, Lauren E. Garcia, Sierra P. Mcnicol

Graduate Student Scholarship

The assumed efficacy behind service dog intervention is based on the well-known potential for the development of a strong, emotional bond between humans and dogs. Occupational therapists can use knowledge of their specific scope of practice to aid in the referral process, and the assessment process, and to help assist clients with training and comfortability throughout the service dog placement process. Existing literature on service dog use and implementation within occupational therapy (OT) practice is limited and lacking in rigor, internal and external validity, and reliability. The aims of the current study include evaluating the level of education occupational therapy …

The Impact Of Ectopic Expression Of A Plant Elicitor Peptide In Bacillus Subtilis On Nematode Resistance In Soybean Through Seed Treatment, Abeer Alnasrawi

Graduate Theses and Dissertations

Soybean (Glycine max) is the most beneficial legume crop because it is a source of protein as well as oil for humans and livestock. Soybean is the second most planted crop in the United States following corn and it is also the fourth planted crop worldwide. However, the soybean cyst nematode (Heterodera glycines, SCN) is the most damaging pest of soybean in the United States, accounting for more than twice as much yield loss as the following cause of yield loss in soybean. Therefore, there is a pressing need to develop alternative management strategies to control SCN infection in soybeans. …

On Counter-Memes: A Rhetorical Study Of Allyship In Social Media Memetics From 2015-2024, Kaitlyn Samons

All Dissertations

This dissertation examines the importance of Online allyship through a newly coined term in Memetics and Mis- and Disinformation: “Counter-Memeship.” This work combines previous contributing works on “memes,” “counter-memes,” “counter-stories,” and “allyship” through the lens of feminist, white, and communication theories. Internet memes and studies are explored by looking at how Online participants in internet spaces interact with each other in modern-day protests in memetic ways. The researcher utilizes descriptive and exploratory methods to articulate better how internet memes work between 2015 and 2024. The primary purpose of this research is to see whether Online protests can be considered non-performative …

The Role Of Kinases Signaling In Organogenesis, Fatemeh Nasehi

All Dissertations

Kinases are crucial regulators of organ development and differentiation. This thesis investi- gates the roles of TAK1, TGFbeta-Activate Kinase 1 (TAK1/Map3K7), and Akt3 kinases in skeletal, cardiac muscle, and cartilage. TAK1 is pivotal for the differentiation of various organ systems, including sinoatrial node and cartilage, and is responsible for phosphorylat- ing a diverse array of downstream kinases. We identified several novel proteins, including phospho-Akts, that are upregulated in response to TAK1 activation. We discovered severe Dilated Cardiomyopathy (DCM) and cartilage defects in Akt3 mutant mice. Although this mouse mutant has been studied for over two decades, we are the first …

Exploring The Use Of Social Media Among Theme Park Guests: A Uses And Gratification Theory Approach, William J. Henderson

All Dissertations

Theme parks have provided billions of dollars to the local economies of tourist destinations (Blair & Rush, 1998; Warden, 2019). In the digital age, the theme park experience is shared with vast online audiences and so there is a need to understand how theme parks are presented on social media from the guest perspective. Specifically, it is vital to understand the uses and gratifications of social media use and content creation from guests and influencers within a theme park context.

The Uses and Gratifications Theory serves as a foundational theory for this research to understand the psychological gratifications found through …

Pelvic Sucker Form And Function In Waterfall Climbing Gobies: Variation In Morphology And Adhesive Performance Can Inspire Biomimetic Innovation, Amanda Palecek Mcclung

All Dissertations

Adhesive systems have evolved in many animal lineages and have appeared multiple times among the fishes. Bioadhesion in the gobies, a group found around the world, plays a role in both station-holding and even climbing. Among the Hawaiian streams, we find four species of amphidromous gobies which must face predators as juveniles and climb streams up to hundreds of feet tall to reach adult habitats. These gobies exhibit a range of climbing and adhesive abilities that result in an elevation-dependent species stratification, in which increasingly proficient climbing species are found in streams at increasingly higher elevations. This group is therefore …

The Development Of A Novel Cartilage Analog Scaffold For Chondral Regeneration, Vishal Thomas

All Dissertations

Focal Chondral Defects (FCDs) are cartilage injuries that affect about 900,000 Americans every year. Left untreated, these may lead to osteoarthritis and eventually necessitate painful knee replacements. Current treatment options are limited in terms of durability, cost, and availability of grafts. Tissue engineering, using natural scaffolds, are a highly attractive alternative promising cost efficiency, abundance, and long-term benefits. However, their low mechanical strength and dense matrices are impediments that could lead to sub-optimal repair.

In this work, a natural biomaterial, the bovine nucleus pulposus (bNP), derived from intervertebral disc tissue, was identified as a candidate scaffold for cartilage regeneration. Mechanical …

Virtually Coached Nature-Based Activities For Perceived Stress In Rural-Dwelling Families With A Teenager With Autism Spectrum Disorder, Deborah R. Logan

All Dissertations

Families with teenagers with autism spectrum disorder (ASD) can experience more stress than families without teenagers with ASD due to individuals with ASD often exhibiting social behaviors that differ from social norms, and parents having to adjust their expectations and future goals for their child with ASD. Rural-dwelling families of teenagers with ASD may experience additional stress due to their having to travel to access therapeutic services. Research focused on family-based services aimed at decreasing stress among rural-dwelling families of teenagers with ASD is lacking. The purpose of this convergent mixed methods study was to explore the feasibility of an …

Building Resilience To Contagious Diseases In High Contact Services: An Investigation Of Customers’ Willingness To Dine-In At Restaurants In The Era Of Covid, Hongli Ye

All Dissertations

High customer contact services play a crucial role in our economy, providing essential interactions and experiences that drive numerous industries. However, the COVID-19 pandemic has posed significant challenges to these sectors due to their inherent characteristics, requiring close and frequent interactions. To rebound from the disruptions caused by such a contagious disease, service providers must adopt innovative strategies. Thus, this dissertation addresses the dynamic nature of building resilience strategies in high-contact services, which are affected by contagious diseases. In doing so, we propose an integrative framework that outlines essential new service resilience components, based on the CDC guidelines, to conventional …

Opioid Overdose Epidemic Modeling, Chelsea Spence

All Dissertations

The opioid overdose crisis in the United States has led to thousands of lost lives and thousands more people struggling with opioid dependence. Disease modeling allows researchers to examine the course that the disease may take and to investigate policies to determine the effects they may have. Disease models can be used to model non-communicable diseases and have been used to study opioid use disorder. Many types of disease models exist with their own inherent benefits and drawbacks.

In this dissertation, we provide a scoping review of the disease models that have been used to study the opioid overdose epidemic. …

Essays On The Effects Of Resource Wealth And Us Influence On Employment, Education And Export Structure, Lyndrison Garthfield Lincoln

Dissertations

Although several studies have sought to identify the determinants of export diversity and sophistication, few have examined the role of historical events in shaping or reshaping them. In my first chapter I use data on CIA interventions during the Cold War period. I show that such interventions had a negative impact on the range of goods exported by affected countries. I provide evidence that this effect persisted in the long run. In my second chapter, I study the local impact of trade union strength on employment during resource booms. I use unionization and coverage rates along with the presence of …

Gustav Mahler’S Naturlaut In The Anthropocene: A Musical Landscape Of Early Environmentalism, Alexis Rose

Arts & Sciences Graduate Student Theses and Dissertations

This thesis is an exploration of the perceived roles and potential functions of music and art in environmental movements. I focus on Gustav Mahler, a composer historically associated with nature, as a case study of the relationship between nature and art in Austro-German Romanticism and early environmentalism. In the first chapter, I connect Mahler’s idea of nature as influenced by Friedrich Nietzsche, Richard Wagner, and Arthur Schopenhauer to the ideas and rhetoric of nineteenth-century environmentalists in Austria and Germany. This context serves as the background for my second chapter, in which I analyze Mahler’s Seventh Symphony through an ecocritical lens. …

Bridging The Gap: Ai And The Hidden Structure Of Consciousness, Emily Barnes, James Hutson

Faculty Scholarship

The quest to develop Artificial Intelligence (AI) systems that possess human-like consciousness necessitates a deep dive into both theoretical and practical aspects underpinning this ambitious goal. This article builds on initial philosophical explorations of AI consciousness by examining the intricate and often hidden structures that may facilitate conscious experiences in AI. Drawing from concepts in cognitive science and neuroscience, the article elucidates how AI systems can be designed to replicate the structural and functional aspects of human consciousness. The discussion includes the Hierarchy of Spatial Belongings proposed by Forti (2024), frameworks like the Integrated Information Theory (IIT), and models linking …

Diet Modification Reduces Pain And Improves Function In Adults With Osteoarthritis: A Systematic Review, Karen Stanfar, Corey Hawes, Mina Ghajar, Laura Byham-Gray, Diane R. Radler

Health & Biomedical Sciences Faculty Publications

Background

The effect of dietary modifications on pain and joint function in adults with osteoarthritis (OA) is an emerging area of study. This systematic review aimed to evaluate if adults with OA who consume diets with a higher proportion of plant phenols and omega-3 fatty acids would have less pain and improved joint function than those with a higher proportion of saturated fatty acids, omega-6 fatty acids and refined carbohydrates.

Methods

Database searches of CINAHL (EBSCO), Clinical Trials (NIH-NLM), Cochrane Library (Wiley), Dissertation & Thesis Global (ProQuest), Embase (Elsevier), Medline (OVID), PubMed (NLM), Scopus (Elsevier), Web of Sciences (Clarivate) for …

Genetic Variance Present In Toll-Like Receptor 2 Of Gopherus Polyphemus, Hannah Varghese

Harriet L Wilkes Honors College Theses 2020 - Present

Gopher tortoises (Gopherus polyphemus), a keystone species of the Abacoa Greenway Preserve, face many health risks, like Upper Respiratory Tract Disease (URTD), caused by Mycoplasma agassizii infection. While URTD’s effects differ among tortoise populations, Abacoa’s tortoises display lower fatality rates with unclear causes. This study explores genetic variance in Toll-like Receptor 2 (TLR2) as a possible contributor to lower fatality rates from URTD infection. TLR2 initiates the immune response to Gram-positive bacteria in other tortoise species but is not currently sequenced in Gopherus polyphemus. Genetic sequencing targeted TLR2 through blood genomic DNA extraction, PCR fragment amplification with newly designed primers, …

How Anthropocentrism Shaped Florida, Olivia Benson

Harriet L Wilkes Honors College Theses 2020 - Present

Anthropocentrism, the belief that humankind is central to existence and has priority over all other living beings and systems, is embedded in Western philosophy and motivates environmental degradation. The history of Florida provides some of the most egregious examples, compiled with instances of large-scale transformation and destruction for the sake of tourist, residential, commercial, and industrial developments. Florida’s rapid development and natural resource use in the twentieth century changed its unique landscape by using ruinous methods to reclaim land and synthesize a paradise for humans alone. The loss of over half of the Everglades—the unique wetland system with incredible biodiversity—is …

Hue And Orientation Pinwheels In Macaque Area V4, Arun Parajuli, Daniel J Felleman

Faculty, Staff and Student Publications

Area V4 is an intermediate-level area of the macaque visual cortical hierarchy that serves key functions in visual processing by integrating inputs from lower areas such as V1 and V2 and providing feedforward inputs to many higher cortical areas. Previous V4 imaging studies have focused on differential responses to color, orientation, disparity, and motion stimuli, but many details of the spatial organization of significant hue and orientation tuning have not been fully described. We used support vector machine (SVM) decoding of intrinsic cortical single-condition responses to generate high-resolution maps of hue and orientation tuning and to describe the organization of …