Digital Commons Network^™

Hyperpolarized Magnetic Resonance Imaging, Nuclear Magnetic Resonance Metabolomics, And Artificial Intelligence To Interrogate The Metabolic Evolution Of Glioblastoma, Kang Lin Hsieh, Qing Chen, Travis C. Salzillo, Jian Zhang, Xiaoqian Jiang, Pratip K. Bhattacharya, Shyan Shams

Faculty Publications

Glioblastoma (GBM) is a malignant Grade VI cancer type with a median survival duration of only 8–16 months. Earlier detection of GBM could enable more effective treatment. Hyperpolarized magnetic resonance spectroscopy (HPMRS) could detect GBM earlier than conventional anatomical MRI in glioblastoma murine models. We further investigated whether artificial intelligence (A.I.) could detect GBM earlier than HPMRS. We developed a deep learning model that combines multiple modalities of cancer data to predict tumor progression, assess treatment effects, and to reconstruct in vivo metabolomic information from ex vivo data. Our model can detect GBM progression two weeks earlier than conventional MRIs …

Lessons Learned Over A Growing Development Cycle In Medical Simulation, Alex Pacheco-San Martin

Master of Fine Arts in Digital Media Culminating Experience

For the last five years, East Tennessee State University’s Department of Digital Media has partnered with the East Tennessee Children’s Hospital in downtown Knoxville to create a collection of training modules for their nursing staff. Dozens of students have devoted thousands of hours both inside and outside of the department’s various production courses to build the eleven modules currently in use today. However, development has not been without its hurdles, particularly in moving from one project to the next. Poor documentation and miscommunications compounded with faults in the projects’ design philosophies to repeatedly delay production. While each deliverable was playable …

Policing, Power, And Protests: Landscapes Of Surveillance In Private And Public Spaces In Lower Manhattan, Kelly Britt

Publications and Research

No abstract provided.

Elucidating The Roles Of Septin Proteins In Thermotolerance And Cell Wall Integrity In Cryptococcus Neoformans, Stephani S. Martinez Barrera

All Dissertations

Cryptococcus neoformans is a globally distributed fungal pathogen responsible for causing cryptococcal meningitis in immunocompromised individuals. This pathogenic yeast must adapt to changes in temperature upon entering the human host. Septin proteins are conserved filament-forming GTPases that assemble as higher-order complexes at the cell cortex to support cytokinesis and morphogenesis in fungal and animal cells. In C. neoformans, four septin homologs (Cdc3, Cdc10, Cdc11, and Cdc12) assemble at the mother-bud neck, contributing to cytokinesis through poorly understood mechanisms. C. neoformans strains lacking the septins Cdc3 or Cdc12 are viable at 25°C, but fail to proliferate at 37°C, and are …

Student Handbook 2024-2025, Saint Mary's College Of California

Student Handbook

No abstract provided.

Modeling, Simulation, And Experimental Testing Of A Single-Legged Hopper, John Anthony Bennett

Master's Theses

Legged robots are well-suited for navigating unstructured terrain due to their ability to perform agile dynamic motions. Building on the efforts of Cal Poly's Legged Robotics Group, this project focuses on achieving stable forward hopping with a single legged robot.

A comprehensive model of leg hopping is formulated, with leg dynamics during flight and stance phases derived using Euler-Lagrange equations. During the stance phase, a spring-mass system models the leg-ground interaction. The touchdown and lift-off conditions are formulated mathematically, and state mappings between phases are determined via momentum conservation. A two-phase hybrid controller is designed, incorporating trajectory planning during flight …

The Impact Of Lutein-Loaded Poly(Lactic-Coglycolic Acid) Nanoparticles Following Topical Application: An In Vitro And In Vivo Study, Renee T. Carter, Sean Swetledge, Sara Navarro, Chin C. Liu, Nikole Ineck, Andrew C. Lewin, Fabrizio Donnarumma, Ede Bodoki, Rhett W. Stout, Carlos Astete, Jangwook P. Jung, Cristina M. Sabliov

Faculty Publications

Antioxidant therapies are of interest in the prevention and management of ocular disorders such as cataracts. Although an active area of interest, topical therapy with antioxidants for the treatment of cataracts is complicated by multiple ocular anatomical barriers, product stability, and solubility. Entrapment and delivery of antioxidants with poly(lactic-co-glycolic acid) nanoparticles is a possible solution to these challenges, however, little is known regarding their effects in vitro or in vivo. Our first aim was to investigate the impact of blank and lutein loaded PLGA nanoparticles on viability and development of reactive oxygen species in lens epithelial cells in vitro. Photo-oxidative …

Investigating The Adaptive Potential Of Leaf Variegation In Two Dimorphic Hexastylis Species, Cierra N. Sullivan

All Dissertations

Variegated leaves with disjointed, patterned coloration of the leaf blade are often hypothesized to have decreased photosynthetic capacity in comparison to uniformly colored leaves. Yet, many forest understory plants in tropical, subtropical, and temperate climates possess leaf variegation. Moreover, mixed findings from previous research on the physiological impacts of leaf variegation suggest variegation is adaptative under certain environmental conditions despite decreased photosynthetic tissue area. I take an eco-physiological approach to investigate agents of selection maintaining a leaf variegation polymorphism in Hexastylis, which has both quantitative and qualitative variation in variegation. First, I conduct field surveys of morph frequencies, quantitative …

Barriers To Telemedicine: Factors Influencing The Adoption Of Telemedicine, Carleton T. Brown

All Dissertations

Telemedicine is a rapidly evolving health treatment capability that offers an efficient and cost-effective alternative to conventional medical care. Providing access to alternative medical treatment may mitigate the population’s stress on the medical infrastructure in the upcoming decades. This study investigated the factors influencing patient adoption of telemedicine, including patient experiences and economic considerations. A quantitative survey explored patient population’s intention to utilize telemedicine, focusing on factors influencing the patients’ decision-making processes. Analyzing the survey results, the researcher focused on five main variables: exposure to telemedicine, age, loss of income, trust in doctors, and time lost. The research findings offer …

The Effects Of An Acute Dose Of Cannabidiol On Health And Two-Mile Time Trial Performance, Elyssa Bell

Master's Theses

As more studies exploring the therapeutic effects of cannabidiol (CBD) in both clinical and non-clinical populations continue to increase, there is a renewed interest in the ability of CBD to affect performance. In fact, many anecdotal reports in the media and online suggest that CBD may improve performance. Unfortunately, very few studies support these claims and research in the area is limited. Purpose: The purpose of this study is to explore the effects of an acute dose of CBD on anxiety symptoms, GI distress, heart rate variability (HRV), heart rate (HR), blood pressure (BP), blood lactate (BL) rate of perceived …

Contrast As A Governing Principle: Topic Deployment In Selected Sonatas Of Johann Christian Bach, Morgan Hall

Master's Theses

Between the end of the Baroque era and the end of the Classical era, there was a shift in the way music was composed. This shift allowed composers to employ multiple topics in one work as opposed to the single-affect-per-movement that was standard under the Doctrine of Affections. Despite plenty of scholarship about both of the eras, the transition from one to the other has been relatively unexplored. Early musicologist Charles Burney noted in a volume of his General History of Music that there was a composer who was the first to employ “contrast as a governing principle”, and this …

Determining Spatiotemporal Regulation Of Actin Dynamics In Choroid Fissure Closure, Cristal Gonzalez

Master's Theses

There are several stages of development necessary for proper vision. During vertebrate eye development, early eye morphology progresses in three stages: optic cup morphogenesis, basement membrane breakdown, and tissue fusion. Eye development is an intricate collaboration between many cells and requires tissues to migrate and bridge together. The following research investigates the Danio Rerio eye development to understand the molecular regulation of choroid fissure closure (CFC). It is hypothesized that CFC requires temporal and spatial regulation of actin dynamics. We investigate this question using chemical inhibitors, cytochalasin D, an actin treadmilling inhibitor, and NSC23766, a Rac-GEF inhibitor of the actin …

Bioaffinity Analysis Of Aptamer-Target Interactions, Pooja Karunanithi

Honors Theses

This study explores the bioaffinity of aptamer-target interactions through a comprehensive analysis. Aptamers, oligonucleotides that can bind to target molecules, have emerged as powerful tools in various fields, including diagnostics and therapeutics. The primary objective of this research was to assess the binding affinity and specificity of selected aptamers to their respective targets using a combination of experimental techniques and computational models. The binding affinity of 10 different complexes were measured through surface plasmon resonance (SPR) followed by molecular simulations. The results showed that the 6th complex had the best binding affinity. The data suggest that these aptamers could be …

Integrating Building Information Modelling And Extended Reality In The Transportation Infrastructure Industry, Yosra El Maghraby, Shady Salem, Ahmed Alhady, Yasser Khodeir

Civil Engineering

No abstract provided.

Animal Science News (August 6, 2024), Department Of Animal Science

Animal Science Newsletters

No abstract provided.

Functional Contribution Of Epithelial To Mesenchymal Transition Program On Krasg12d Targeting Efficacy In Pancreatic Cancer, Ana S. Maldonado

Dissertations and Theses (Open Access)

Functional contribution of epithelial to mesenchymal transition program on KRAS^G12D targeting efficacy in pancreatic cancer

Ana S. Maldonado, BS

Advisory Professor: Raghu Kalluri, M.D., Ph.D.

Pancreatic Ductal Adenocarcinoma (PDAC), a highly aggressive, metastatic, and therapeutically resistant form of pancreatic cancer has been projected to become the second-leading cause of cancer related mortality in the United States. This is driven by its detection difficulty, treatment efficacy, and asymptomatic nature, among other factors. PDAC is driven predominantly by KRAS^G12D mutations, which are responsible for the initial development of pancreatic intraepithelial neoplasia (Pan-IN) lesions, that are further maintained and progressed until …

The Role Of The Circadian Clock In The Paraventricular Nucleus Of The Hypothalamus In Diurnal Energy Balance, Rachel Van Drunen

Dissertations and Theses (Open Access)

Circadian rhythms are internal biological rhythms that drive oscillations in physiology and metabolism. Maintained at the level of individual cells throughout the body, the circadian clock is necessary for driving tissue-specific temporal programs of energy balance. Though loss of the circadian transcription factor, BMAL1, in the paraventricular nucleus (PVN) of the hypothalamus has revealed its importance in driving rhythms in energy intake and metabolism, its transcriptional functions across time and in individual cell types in the PVN are not well understood. In this study, we show that loss of BMAL1 in the PVN not only results in arrhythmicity in processes …

Antibacterial Efficacy Of 940 Nm Diode Laser Against Cariogenic Bacteria (Tooth Decay-Causing Bacteria), Noha M. Jameel, Hanan J. Taher

Baghdad Science Journal

Dental caries is an extremely prevalent infectious disease caused by gram-positive bacteria mainly streptococcus mutans which is considered the major etiological factor causing dental caries. In recent years, there has been an enormous increase in the use of laser technology in medicine and dentistry and it has been demonstrated to have a considerable antibacterial action with no harm to the oral tissues. The study goal was to assess a diode laser's effectiveness as an antibacterial agent against the bacterium species S. mutans at various doses. The study was performed on streptococcus mutans microorganism at 106 CFU/ml concentration which received irradiation …

On The Right Track? Energy Use, Carbon Emissions, And Intensities Of World Rail Transportation, 1840–2020, Bernardo Tostes, Sofia T. Henriques, Paul E. Brockway, Matthew Kuperus Heun, Tiago Domingos, Tânia Sousa

University Faculty Publications and Creative Works

The history of rail transport can offer valuable insights for future energy transitions due to its importance in promoting clean mobility. There is a complex interplay between the evolution of the railway network, fuel consumption, efficiency, energy service, and CO2 emissions that requires further exploration. We developed a dataset that covers energy use in all stages of rail transportation, as well as the length of track, energy service, and CO2 emissions at the world scale. To deal with missing data we utilized machine learning techniques for the first time in a historical energy reconstruction study. Our analysis reveals that …

The Athero-Af Study: A Need To Optimize Af Management In An Environment Of Medical Advancement, Michael D. Ezekowitz, Ibrahim Alameh, Mohammed Kamareddine

Department of Medicine Faculty Papers

No abstract provided.

Promoting Cultural Humility, Belonging, And Inclusion To Improve Well-Being Among Direct Care Staff In Oregon Assisted Living, Residential Care, And Memory Care Communities, 2024, Jacklyn Kohon, Dani Himes, Laura Rodriguez, Sarah Dys, Paula Carder, Diana Jacoby, Madeline Fox

Institute on Aging Publications

The voices and experiences of those working and living in assisted living, residential care, and memory care (AL/RC) settings in Oregon are highlighted in this study to understand cultural humility, belonging, inclusion, and intersectional experiences related to sustaining the workforce and promoting quality care. This qualitative study collected data through individual and focus group interviews with a total of 68 people, including 25 direct care staff, voice memos or interviews with 9 former direct care staff, interviews with 9 administrators, interviews with 7 management representatives (owner/operators, human resources specialists, directors of operations, among other titles), and interviews with 18 current …

Psychophysiological Insights Into Child-Centered Play Therapy For Trauma: A Case Study, Kristi L. Perryman, Samantha Robinson, Timothy J. Schoonover, Julia Conroy

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

Existing literature thoroughly reviews the detrimental consequences that adverse childhood experiences (ACEs) have physically, emotionally, neurobiologically, and financially. It is imperative to develop effective treatments that offer a sense of hope to children who have been impacted. The established relationship between high ACE scores and physiological hyperarousal due to emotional dysregulation is clear in the literature. This relationship indicates that taking psychophysiological measures may be an effective method of gauging the effectiveness of trauma treatments. This study measured the heart rate of a child who had experienced multiple ACEs, during 16 child-centered play therapy (CCPT) sessions, using the Empatica (E4) …

Avian Communities Monitored Along A Successional Chronosequence In Bottomland Hardwood Forests In The Lower Mississippi Alluvial Valley, Eamonn Alasdair Thurmond

Electronic Theses and Dissertations

Bottomland hardwood forests in the Lower Mississippi Alluvial Valley have been extensively reduced due to agriculture conversion and altered hydrology. Remnant forests have undergone further degradation from sources such as a lack of forest management, invasive species, and reduced regeneration of oaks (Quercus spp.). Recent restoration efforts of bottomland hardwood forests have focused on implementing wildlife forestry practices that prioritize restoring wildlife habitat while retaining profitable timber harvests. In this study I surveyed bird communities in bottomland hardwood forests in the Lower Mississippi Alluvial Valley along a successional chronosequence. Birds were sampled using automated recording units over 10 days …

Biological Sex Influences Daily Locomotor Rhythms In Mice Held Under Different Housing Conditions, Amanda Pastrick, Matthew Diaz, Griffin Adaya, Victoria Montinola, Madeline Arzbecker, Deborah A. M. Joye, Jennifer A. Evans

Biomedical Sciences Faculty Research and Publications

Daily rhythms are programmed by a central circadian clock that is modulated by photoperiod. Here, we recorded locomotor activity rhythms in C57Bl/6 or mPer2^Luc mice of both sexes held under different housing conditions. First, we confirm that the structure of locomotor activity rhythms differs between male and female mice in both genetic backgrounds. Male mice exhibit a nightly “siesta,” whereas female mice fluctuate between nights with and without a nightly siesta, which corresponds with changes in locomotor activity levels, circadian period, and vaginal cytology. The nightly siesta is modulated by the presence of a running wheel in both sexes …

Epilogue: Uc Law Journal – Rice Symposium, Ming Hsu Chen

UC Law Journal

No abstract provided.

Mental Models Of Translational Scientists, Rasnia Tabpla, Antonie J. Jetter

Engineering and Technology Management Faculty Publications and Presentations

Translational science aims to bridge the gap between scientific discoveries and practical application yet faces challenges in achieving high success rates. This study examines the effective engagement of translational scientists, who play a key role in the translation process. It uses Fuzzy Cognitive Maps (FCMs) to analyze the scientists' mental models and identify common concepts related to success factors, such as ability, resources, opportunity, and entrepreneurial competencies. It then compares the mental models of the scientists and finds that mental models exhibit similarities, yet variations exist such as density and connectedness. Scenario analysis with FCM is then used to identify …

Engineered Nucleic-Acid Binding Intrinsically Disordered Proteins For Biomedical Applications, Telmo Diez Perez

Biomedical Engineering ETDs

This dissertation explores the use of intrinsically disorder proteins (IDPs) in biomedical applications related to the detection and biosensing of nucleic-acid species. We engineer several low critical solution temperature (LCST) nucleic-acid binding elastin-like polypeptides (ELPs) as model IDPs and study their potential in biomedical application via interactions with short single-stranded (ss) DNA, tRNA and viral RNAs. First, we engineer a simple polycationic ELP capable of recruiting DNA on demand in a DNA-protein-rich condensate via LLPS. Moreover, we develop a modified Flory-Huggins theory to quantify the partitioning of DNA and protein upon coacervate formation with and without salts. We then design …

Linking Risk Preference, Women’S Empowerment, Farm Investment And Household Well-Being, Samuel Olusesi Olumide

Department of Agricultural Economics: Dissertations, Theses, and Student Research

A nuanced understanding of intra-household dynamics can inform the design of more effective empowerment and agricultural investment policies. By integrating household risk preferences and empowerment dynamics, this work offers valuable insights into the complex mechanisms driving household welfare and provides a framework for future interventions to promote gender equality and economic development in rural settings. This thesis addresses three core hypotheses: first, that the spouses of risk-seeking male heads are more likely to be disempowered compared to those of risk-averse male heads; second, that households with risk-seeking male heads and disempowered spouses are likely to invest more in farming activities; …

Investigating Associations Between Activity And Performance Traits Across Three Breeds Of Swine Using NuTrack, Dalton R. Obermier

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Feed costs are the largest contributor towards the variable costs of pork production. To decrease feed cost while not sacrificing output requires an improvement in feed efficiency (FE). A potential approach to expand available phenotypes associated with FE is with activity tracking, yet the relationship between activity and performance is not well defined in swine. Therefore, the objective of this study was to quantify associations between activity and feed intake traits. Average daily feed intake (ADFI) was collected on 1,766 purebred boars of three genetic lines (Duroc, Landrace, and Yorkshire) using FIRE (Osborne Industries, Inc., Osborne, Kansas) at a testing …

Experimental Investigation Of The Suitability Of Soybean-Derived Surfactant (Sods) In Gas Well Deliquification, Abiodun Gbadegesin Adeyemi

Theses and Dissertations

Gas well deliquification is a crucial process in the oil and gas industry, focused on maintaining or restoring production rates by removing liquids that impede gas flow. This is a recurring challenge that is prominent in many gas wells across North Dakota. Surfactants play a vital role in this process by altering the interfacial tension between gas and liquid phases, alleviating liquid accumulation in these wells. However, due to their high production costs, non-biodegradability, and toxicity, the use of synthetic surfactants has raised environmental concerns. The pursuit of sustainable and environmentally friendly alternatives has led to the exploration of natural …