Digital Commons Network^™

Engl 101-045-057-071: English Composition: Introduction To Academic Writing, Shirli Sela-Levavi

Humanities Syllabi

No abstract provided.

Engl 101-061-082: English Composition: Introduction To Academic Writing, Bingyao Xie

Humanities Syllabi

No abstract provided.

Engl 101-072-092: English Composition: Introduction To Academic Writing, Christina Crovetto

Humanities Syllabi

No abstract provided.

Engl 101-083-097: English Composition: Introduction To Academic Writing, Josh English

Humanities Syllabi

No abstract provided.

Engl 101-085-095: English Composition: Introduction To Academic Writing, Dawn Smith-Henry

Humanities Syllabi

No abstract provided.

Engl 101-101: English Composition: Introduction To Academic Writing, David Tress

Humanities Syllabi

No abstract provided.

The Rider (2024-09-03), Natalie Lapsley

The Rider Archives

Vol.10 No.2

Hospital-Associated Functional Status Decline In Pulmonary Patients, Amy C. Shay

Dissertations

Chronic obstructive pulmonary disease (COPD) is a significant worldwide cause of chronic illness and mortality and one of the most common admitting diagnoses in the United States. Persons with COPD are at increased risk for deconditioning during hospitalization, which can lead to decreased functional status at discharge. Disease-related factors and elements of the hospital environment make older adults with COPD vulnerable to hospital-associated functional status decline. The purpose of this dissertation was to identify activity factors that contribute to hospital-associated functional status decline in older adults with COPD by promoting functioning during hospitalization. This predictive correlational study is a secondary …

Calibration Of A Novel Microdosimetry System For In Vitro Applications Of Actinide Radiopharmaceuticals, Lydia J. Wilson, Brian Miller, George Tabatadze, Firas Mourtada

Department of Radiation Oncology Posters

Background

• Alpha-emitting radionuclides show promise for targeted radiopharmaceutical therapy (TRT).
• High linear energy transfer and short range cause highly localized DNA damage for effective cancer cell eradication.
• However, distributions of radioactivity and absorbed dose on the cellular scale remain elusive.
• Progress toward understanding α-TRT radiobiologic response, evaluating novel α-TRT drug efficacy, and optimizing administration for personalized treatments will require knowledge of radioactivity and absorbed dose distributions.
• A novel real-time α camera, the ionizing radiation quantum imaging detector (iQID), has successfully mapped the microdistribution of α-emitting radionuclides in mouse and human tissues [1].

Sustainable Mobility, Shams Tanvir

Mavs Open Press Open Educational Resources - Archive

This textbook and OER material cover tools and basic knowledge required to prepare transportation engineers and planners to contribute towards a carbon-neutral mobility future. The goal of the textbook is to train engineering students on existing tools and policy levers that can be used to incorporate emerging transportation technologies in a sustainable, equitable, and efficient manner.

Flavonoid-Rich Foods, Dementia Risk, And Interactions With Genetic Risk, Hypertension, And Depression, Amy Jennings, Alysha S. Thompson, Anna Tresserra-Rimbau, Joshua K. O'Neill, Claire Hill, Nicola P. Bondonno, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Importance: A composite score of flavonoid-rich foods (flavodiet) may provide a clear public health message regarding the range of foods with the potential to lower dementia risk. Objective: To examine associations of flavodiet score and intakes of flavonoid subclasses with dementia risk according to genetic risk and presence of depression and hypertension. Design, Setting, and Participants: This prospective, population-based cohort study included dietary data from adults aged 40 to 70 years in the UK Biobank, recruited between 2006 and 2010, with a mean (SD) follow-up of 9.2 (1.5) years. The data analyses were conducted from September 1 to 30, 2023. …

Early Preclinical Studies Of Ergosterol Peroxide And Biological Evaluation Of Its Derivatives, Taotao Ling, Luz V. Arroyo-Cruz, William R. Smither, Emily K. Seighman, Michelle M. Martínez-Montemayor, Fatima Rivas

Faculty Publications

Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol peroxide (EP), which is attributed to its anticancer effects. The current study focuses on the in vitro ADME (absorption, distribution, metabolism, and elimination), in vivo efficacy and toxicity of EP, and the synthesis of new EP derivatives to improve aqueous solubility. It was found that EP is metabolically stable in liver microsomes and plasma. In vivo studies showed that EP inhibits tumor growth in murine cancer models, and it is well tolerated by mice. The maximum tolerated dose …

Jingle’ And ‘Jangle’ Fallacies

The International Journal of Ecopsychology (IJE)

Systematic approaches (theories and applications) from early founders of the social sciences and education, even in their early history, paid meticulous attention to the many pitfalls encountered when neglecting to clarify and specify what one means when using words which imply “constructs” and their purported cause and effect dynamics. ‘Jingle’ and ‘jangle’ fallacies, when finally spotted and addressed, turn out to be the naiveté of a person not understanding the terms/words they were using. They failed to notice, according to Thorndike and Woodworth that words are (1901), “… mythological, not real entities. The words do not mean any existing fact …

Chem 243-003: Organic Chemistry I, Pier Champagne

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Targeting Akr1b10 By Drug Repurposing With Epalrestat Overcomes Chemoresistance In Non-Small Cell Lung Cancer Patient-Derived Tumor Organoids, Kanve N Suvilesh, Yariswamy Manjunath, Yulia I Nussbaum, Mohamed Gadelkarim, Murugesan Raju, Akhil Srivastava, Guangfu Li, Wesley C Warren, Chi-Ren Shyu, Feng Gao, Matthew A Ciorba, Jonathan B Mitchem, Satyanarayana Rachagani, Jussuf T Kaifi

2020-Current year OA Pubs

PURPOSE: Systemic treatments given to patients with non-small cell lung cancer (NSCLC) are often ineffective due to drug resistance. In the present study, we investigated patient-derived tumor organoids (PDTO) and matched tumor tissues from surgically treated patients with NSCLC to identify drug repurposing targets to overcome resistance toward standard-of-care platinum-based doublet chemotherapy.

EXPERIMENTAL DESIGN: PDTOs were established from 10 prospectively enrolled patients with non-metastatic NSCLC from resected tumors. PDTOs were compared with matched tumor tissues by histopathology/immunohistochemistry, whole exome sequencing, and transcriptome sequencing. PDTO growths and drug responses were determined by measuring 3D tumoroid volumes, cell viability, and proliferation/apoptosis. Differential …

Hierarchical Tricarboxylic Acid Cycle Regulation By Hepatocyte Arginase 2 Links The Urea Cycle To Oxidative Metabolism, Yiming Zhang, Cassandra B Higgins, Stefani Tica, Joshua A Adams, Jiameng Sun, Shannon C Kelly, Xiaoyu Zong, Dennis J Dietzen, Terri Pietka, Samuel J Ballentine, Leah P Shriver, Gary J Patti, Yin Cao, Brian J Debosch

2020-Current year OA Pubs

Urea cycle impairment and its relationship to obesity and inflammation remained elusive, partly due to the dramatic clinical presentation of classical urea cycle defects. We generated mice with hepatocyte-specific arginase 2 deletion (Arg2

Proteomic Correlates And Prognostic Significance Of Kidney Injury In Heart Failure With Preserved Ejection Fraction, Oday Salman, Ali Javaheri, Douglas L Mann, Et Al.

2020-Current year OA Pubs

BACKGROUND: Kidney disease is common in heart failure with preserved ejection fraction (HFpEF). However, the biologic correlates and prognostic significance of kidney injury (KI), in HFpEF, beyond the estimated glomerular filtration rate (eGFR), are unclear.

METHODS AND RESULTS: Using baseline plasma samples from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) trial, we measured the following KI biomarkers: cystatin-C, fatty acid-binding protein-3, Beta-2 microglobulin, neutrophil gelatinase-associated lipocalin, and kidney-injury molecule-1. Factor analysis was used to extract the common variability underlying these biomarkers. We assessed the relationship between the KI-factor score and the risk of death …

Minutes From September 3 2024, University Senate

University Senate Minutes

Minutes from September 3 2024 University Senate Meeting

Physiological Role For S-Nitrosylation Of Ryr1 In Skeletal Muscle Function And Development, Qi-An Sun, Zachary W. Grimmett, Douglas T. Hess, Zhaoxia Qian, Ruchi Chaube, Nicholas M. Venetos, Bradley N. Plummer, Kenneth R. Laurita, Richard T. Premont, Jonathan S. Stamler

Faculty Scholarship

Excitation-contraction coupling in skeletal muscle myofibers depends upon Ca2+ release from the sarcoplasmic reticulum through the ryanodine receptor/Ca2+-release channel RyR1. The RyR1 contains ∼100 Cys thiols of which ∼30 comprise an allosteric network subject to posttranslational modification by S-nitrosylation, S-palmitoylation and S-oxidation. However, the role and function of these modifications is not understood. Although aberrant S-nitrosylation of multiple unidentified sites has been associated with dystrophic diseases, malignant hyperthermia and other myopathic syndromes, S-nitrosylation in physiological situations is reportedly specific to a single (1 of ∼100) Cys in RyR1, Cys3636 in a manner gated by pO2. Using mice expressing a form …

Book Review: The Evolved Nest: Nature’S Way Of Raising Children And Creating Connected Communities

The International Journal of Ecopsychology (IJE)

No abstract provided.

An Ecopsychological Reading Of Susan Fennimore Cooper’S “Rural Hours”

The International Journal of Ecopsychology (IJE)

Ecopsychology explores the relationships between the mind (psyche) and the surrounding environment. As Andy Fisher puts it in Radical Ecopsychology (2013), ecopsychology, “would approach the psyche in relation to its earthly or natural home, its native abode” as well as the “the basic shifts in our patterns of identity and relationship that occur when we include our connection to the web of life around us as essential to human well-being.” Fisher considers ecopsychology as a project that paves the ground for changing the role of humans from exploiters to members in the biotic community. If eco or ‘oikos’ refers to …

Artist Interview: Viken Peltekian

The International Journal of Ecopsychology (IJE)

No abstract provided.

Vol 9(1) Editorial: Dr. Matthew Jamnik, Matthew Jamnik

The International Journal of Ecopsychology (IJE)

No abstract provided.

Rad21 Promotes Oncogenesis And Lethal Progression Of Prostate Cancer, Xiaofeng A Su, Konrad H Stopsack, Daniel R Schmidt, Duanduan Ma, Zhe Li, Paul A Scheet, Kathryn L Penney, Tamara L Lotan, Wassim Abida, Elise G Dearment, Kate Lu, Thomas Janas, Sofia Hu, Matthew G Vander Heiden, Massimo Loda, Monica Boselli, Angelika Amon, Lorelei A Mucci

Faculty, Staff and Student Publications

Higher levels of aneuploidy, characterized by imbalanced chromosome numbers, are associated with lethal progression in prostate cancer. However, how aneuploidy contributes to prostate cancer aggressiveness remains poorly understood. In this study, we assessed in patients which genes on chromosome 8q, one of the most frequently gained chromosome arms in prostate tumors, were most strongly associated with long-term risk of cancer progression to metastases and death from prostate cancer (lethal disease) in 403 patients and found the strongest candidate was cohesin subunit gene,

Pancreatic Epithelial Il17/Il17ra Signaling Drives B7-H4 Expression To Promote Tumorigenesis, Susana Castro-Pando, Rian M Howell, Le Li, Marilina Mascaro, Erika Y Faraoni, Olivereen Le Roux, David Romanin, Virginia Tahan, Erick Riquelme, Yu Zhang, Jay K Kolls, James P Allison, Guillermina Lozano, Seyed J Moghaddam, Florencia Mcallister

Faculty, Staff and Student Publications

IL17 is required for the initiation and progression of pancreatic cancer, particularly in the context of inflammation, as previously shown by genetic and pharmacological approaches. However, the cellular compartment and downstream molecular mediators of IL17-mediated pancreatic tumorigenesis have not been fully identified. This study examined the cellular compartment required by generating transgenic animals with IL17 receptor A (IL17RA), which was genetically deleted from either the pancreatic epithelial compartment or the hematopoietic compartment via generation of IL17RA-deficient (IL17-RA-/-) bone marrow chimeras, in the context of embryonically activated or inducible Kras. Deletion of IL17RA from the pancreatic epithelial compartment, but not from …

Effects Of Intensity On Emotion Regulation Strategy Preferences Are Emotion-Specific, Bram Van Bockstaele, Patrick J.F. Clarke, Jemma Todd, Frances Meeten, Julie L. Ji, Julian Basanovic, Nigel T.M. Chen, Daniel Rudaizky, Lies Notebaert

School of Psychology

Adaptive emotion regulation is characterized by the ability to flexibly select and switch between different strategies, depending on individual and contextual factors. Previous studies have shown that people prefer disengagement strategies to regulate more intense emotions, while they prefer engagement strategies to regulate less intense emotions. In this study, we investigated whether – in addition to the intensity of emotions – the discrete emotion type (disgust versus fear) also affects emotion regulation strategy preferences. A total of 401 students from three different universities completed an emotion regulation choice task in which they could choose between distraction and reappraisal to regulate …

A Study Of Inhibition Development In Young Children, Ai Thi Thanh Hoang

Theses and Dissertations from DePaul University

Child inhibition can be learned consciously and unconsciously, and it is highly dependent on the quality of interaction with adults (i.e., parents and teachers). However, little is known about the impact of teachers’ emotional management and sensitivity on the development of inhibition skills among students in early childhood classrooms. This dissertation takes an integrative approach to explore whether teacher-child relationship and teacher self-efficacy have a bidirectional connection and how they work to impact child inhibition, directly and indirectly. The present research utilizes the large nationally represented Early Childhood Longitudinal Study 2010-2011, sponsored by the National Center for Education Statistics in …

The Cancer-Associated Secretory Phenotype: A New Frontier In Targeted Therapeutics, Xiaochao Tan, Guan-Yu Xiao, Priyam Banerjee, Shike Wang, Jonathan M Kurie

Faculty, Staff and Student Publications

No abstract provided.

Angiotensin-(1-9) Retro-Enantiomer Peptide With Cardioprotective Activity, Yvo Flores, Gerald Zapata-Torres, Agustín Nuñez, Douglas J Matthies, Larissa Alemán, Carolina Hernández-Fuentes, Gina Sánchez, Eyleen Araya, Fanny Guzman, Zully Pedrozo, Salvador Guardiola, Mónica Varese, Ernest Giralt, Ivan Maslov, Mark Del Borgo, Robert E Widdop, Silvana Valdebenito, Eliseo A Eugenin, Mario Chiong, Joseph A Hill, María Paz Ocaranza, Marcelo J Kogan, Sergio Lavandero

Faculty, Staff and Student Publications

No abstract provided.

Assessing The Impact Of A College Service-Learning Course Focused On The United Nations Sustainable Development Goals, Anna L. Krift, Antonella Regueiro, Patrick J. Cooper, Alanna L. Lecher

Faculty and Staff Publications & Presentations

Liberal arts education in the United States seeks not only to prepare students for a specific career but also to develop well-rounded citizens. As part of the core liberal arts curriculum at Lynn University, all students must complete a service-learning course known as the Citizenship Project. A core component of the course is a student-designed service-learning project executed each year. In 2019, the Citizenship Project was revised to align with the United Nations Sustainable Development Goals (SDGs), ensuring that each project would seek to contribute to one of these goals. The purpose of this study is to examine which SDGs …