Digital Commons Network^™

Return To Eden: God’S Design For Human Sexuality In The Song Of Songs, Richard M. Davidson

Faculty Publications

No abstract provided.

Navigating Ethical Challenges In Online Wildlife Trade Research, Thais Q. Morcatty, Shan Su, Penthai Siriwat, Astrid Alex Andersson, Sadek Atoussi, Kim Feddema, Sergio Henriques, Jordi Janssen, Anushri Karve, Jennifer Pytka, Ruth M. Thompson, Vincent Nijman, Joss Wright, David L. Roberts

Research outputs 2022 to 2026

The surge in internet accessibility has transformed wildlife trade by facilitating the acquisition of wildlife through online platforms. This scenario presents unique ethical challenges for researchers, as traditional ethical frameworks for in-person research cannot be readily applied to the online realm. Currently, there is a lack of clearly defined guidelines for appropriate ethical procedures when conducting online wildlife trade (OWT) research. In response to this, we consulted the scientific literature on ethical considerations in online research and examined existing guidelines established by professional societies and ethical boards. Based on these documents, we present a set of recommendations that can inform …

Leptospirosis In The Platypus (Ornithorhynchus Anatinus) In Australia: Who Is Infecting Whom?, Richard J. Whittington, Thomas R. Grant, Jarrad Mckercher, Monica Suann, Keith Hart, Kathrine A. Handasyde, James Macgregor, Mark E. Westman, Joanne H. Connolly

Research outputs 2022 to 2026

The platypus (Ornithorhynchus anatinus) is an amphibious, egg-laying mammal of high conservation value that is found only in Australia. The zoonotic bacterium Leptospira interrogans serovar Hardjo was discovered in platypuses in prior studies, but little is known about its epidemiology. Samples in the Platypus Serum Bank were tested in 2023 and the results were combined with historical records. Antibodies against L. interrogans serovar Hardjo were found in 50% of 464 serum samples from 411 platypuses collected from 14 river basins in southeastern Australia between 1981 and 2012; prevalence remained high over three decades in the Shoalhaven River population. Seroprevalence increased …

Beat-It : Beat-Synchronized Multi-Condition 3d Dance Generation, Zikai Huang, Xuemiao Xu, Cheng Xu, Huaidong Zhang, Chenxi Zheng, Jing Qin, Shengfeng He

Research Collection School Of Computing and Information Systems

Dance, as an art form, fundamentally hinges on the precise synchronization with musical beats. However, achieving aesthetically pleasing dance sequences from music is challenging, with existing methods often falling short in controllability and beat alignment. To address these shortcomings, this paper introduces Beat-It, a novel framework for beat-specific, key pose-guided dance generation. Unlike prior approaches, Beat-It uniquely integrates explicit beat awareness and key pose guidance, effectively resolving two main issues: the misalignment of generated dance motions with musical beats, and the inability to map key poses to specific beats, critical for practical choreography. Our approach disentangles beat conditions from music …

Audio Description Customization, Rosiana Natalie, Ruei-Che Chang, Sheshadri Smitha, Anhong Guo, Kotaro Hara

Research Collection School Of Computing and Information Systems

Blind and low-vision (BLV) people use audio descriptions (ADs) to access videos. However, current ADs are unalterable by end users, thus are incapable of supporting BLV individuals’ potentially diverse needs and preferences. This research investigates if customizing AD could improve how BLV individuals consume videos. We conducted an interview study (Study 1) with fifteen BLV participants, which revealed desires for customizing properties like length, emphasis, speed, voice, format, tone, and language. At the same time, concerns like interruptions and increased interaction load due to customization emerged. To examine AD customization’s effectiveness and tradeoffs, we designed CustomAD, a prototype that enables …

The Middle Domain Of Hsp104 Can Ensure Substrates Are Functional After Processing, Hannah Buchholz, Jane E. Dorweiler, Sam Guereca, Brett T. Wisniewski, James Shorter, Anita L. Manogaran

Biological Sciences Faculty Research and Publications

Molecular chaperones play a central role in protein disaggregation. However, the molecular determinants that regulate this process are poorly understood. Hsp104 is an AAA+ ATPase that disassembles stress granules and amyloids in yeast through collaboration with Hsp70 and Hsp40. In vitro studies show that Hsp104 processes different types of protein aggregates by partially translocating or threading polypeptides through the central pore of the hexamer. However, it is unclear how Hsp104 processing influences client protein function in vivo. The middle domain (MD) of Hsp104 regulates ATPase activity and interactions with Hsp70. Here, we tested how MD variants, Hsp104^A503S and …

Adherence To A Healthful Plant-Based Diet And Risk Of Mortality Among Individuals With Chronic Kidney Disease: A Prospective Cohort Study, Alysha S. Thompson, Martina Gaggl, Nicola P. Bondonno, Amy Jennings, Joshua K. O'Neill, Claire Hill, Nena Karavasiloglou, Sabine Rohrmann, Aedín Cassidy, Tilman Kühn

Research outputs 2022 to 2026

Background: Plant-rich dietary patterns may protect against negative health outcomes among individuals with chronic kidney disease (CKD), although aspects of plant-based diet quality have not been studied. This study aimed to examine associations between healthful and unhealthful plant-based dietary patterns with risk of all-cause mortality among CKD patients for the first time.

Methods: This prospective analysis included 4807 UK Biobank participants with CKD at baseline. We examined associations of adherence to both the healthful plant-based diet index (hPDI) and unhealthful plant-based diet index (uPDI), calculated from repeated 24-h dietary assessments, with risk of all-cause mortality using multivariable Cox proportional hazard …

The Use Of Puffed Rice Biomaterial As An Insulation Layer: Characterization And Simulation Study, Nicolas Monje Mejia

Theses

Upon close examination in this study, the feasibility of utilizing puffed rice as an insulation layer for construction is explored. Regions that are warm and receive direct sunlight experience heightened temperatures, which can lead to structures trapping excessive heat, resulting in increased cooling demands, energy consumption, and higher costs all around. As revealed via findings from research conducted over time, puffed rice showcases immense prospects when employed as insulation considering its high level of percolation coupled with low thermal conductivity rates. Conversely, conventional materials tend to have better-quality properties like greater compressive strength than what one sees here, along with …

Painting A Clearer Picture: Introducing New Federal Rule Of Evidence 107 Regulating Illustrative Aids, Daniel J. Capra, Liesa L. Richter

Vanderbilt Law Review

They say a picture is worth a thousand words—and charts, drawings, diagrams, computer animations, and even tangible items are utilized at trial in virtually every case tried in the federal and state court systems. Litigants have come to depend heavily upon such aids to engage visual learners in the jury box and to present a compelling narrative. And the creative use of trial aids has only increased with the rapid technological advancements of recent decades. The ubiquity of such aids notwithstanding, there is no written standard governing their use, no agreed-upon lexicon for describing them, and no set of uniform …

Taking The Law Into Their (Virtual) Hands: Facebook And Digital Vigilantism, Christine Anne R. Cox

Department of Communication Faculty Publications

Digital vigilantism is an emerging phenomenon whereby netizens engage in forms of targeted surveillance, naming and shaming through new media, supposedly for social justice ends. The multi-layered case of Christine Dacera, the Filipina flight attendant who was found dead on New Years Day 2021, is one such case that warrants the critical investigation of the role of Facebook in vigilant behaviors of Filipino users. Using netnographic data and an affordances approach, this study asks the following: What are the dominant affordances associated with the use of Facebook for digital vigilantism, and how does surveillance enable the new normal of community …

Metabolic Crossroads: Gaba Synthesis In Trichomonas Vaginalis Infection, Yesha Dhruv

Biochemistry and Molecular Biology

This study examines the gamma-aminobutyric acid (GABA) synthesis pathway in Trichomonas vaginalis infection of human HCT-8 cells, focusing on key enzymatic processes in glutamate conversion to GABA and metabolic adaptations. The hypothesis tested was that T. vaginalis modulates GABA metabolism to enhance host cell invasion and adaptation. Infection time-point studies, RNA sequencing, and aldehyde dehydrogenase (ALDH) assays were conducted. Comparisons between T. vaginalis strains Casu 2 and Casu 2/MOZ 2 revealed distinct infection dynamics. Casu 2 rapidly attached and replicated within an hour, peaking at 24 hours, while Casu 2/MOZ 2 exhibited delayed replication, peaking at 48 to 72 hours, …

Stable Isotope Analysis Of Antipatharian Diets From The Northwestern Gulf Of Mexico, Keir J. Macartney, Victoria Salinas, Zachary Rivera, David Hicks

School of Earth, Environmental, & Marine Sciences Faculty Publications

Antipatharians, or black corals, form a key component of the benthic fauna found throughout the Gulf of Mexico (GOM). In the northwestern GOM, they are a common member of the communities found on the natural relic coral—algal banks known as the South Texas Banks as well as on artificial reefs. They are known to provide important habitat for many ecologically and economically important species in the area but are relatively understudied. Here we present a study on their trophic ecology using stable isotope analysis of carbon and nitrogen from 2 species, Antipathes atlantica and Stichopathes luetkeni from a mesophotic artificial …

An Efficient Fourier Caching Algorithm For Walk On Spheres, Zihong Zhou

Dartmouth College Master’s Theses

Walk on Spheres (WoS) is a grid-free Monte Carlo method for solving elliptic partial differential equations (PDEs).
Rather than discretizing the domain, WoS leverages the mean-value principle to obtain Monte Carlo estimates by recursively averaging the solution over the largest contained sphere, terminating upon reaching the boundary.
Unfortunately, WoS requires many independent estimates to achieve noise-free results.

We propose an acceleration technique for WoS, inspired by irradiance caching methods, that computes the solution at a sparse set of locations, and extrapolates these cached values to local neighborhoods. A key insight is that WoS can be extended to compute not only …

Sigma Gamma Epsilon Student Research Poster Session, Geological Society Of America Annual Meeting 2023, Pittsburgh, Pennsylvania, Usa, Scott Beason

The Compass: Earth Science Journal of Sigma Gamma Epsilon

The Society of Sigma Gamma Epsilon sponsors an annual poster session at every Annual Meeting of the Geological Society of America. The 35th Sigma Gamma Epsilon undergraduate research poster session took place during the 2023 Geological Society of America Annual Meeting in Pittsburgh, Pennsylvania, USA, on Monday, October 16, 2022. Sixty-three (63) posters were presented in Exhibit Hall B at the David L. Lawrence Convention Center between 8:00 AM and 5:30 PM at the poster session. Titles, authors (italics for the presenting author), affiliations, and abstracts for each poster are listed in this report.

Charles. W Bolen Faculty Recital: October 1, 2024, Jillian Kouzel, Angelo Favis, Lu Witzig

School of Music Programs

Kemp Recital Hall

October 1, 2024

Tuesday Evening

7:30 p.m.

Regulation Of Fibrinogen Synthesis, Dre'von A Dobson, Richard J Fish, Paul S De Vries, Alanna C Morrison, Marguerite Neerman-Arbez, Alisa S Wolberg

Faculty, Staff and Student Publications

The plasma protein fibrinogen is encoded by 3 structural genes (FGA, FGB, and FGG) that are transcribed to mRNA, spliced, and translated to 3 polypeptide chains (Aα, Bβ, and γ, respectively). These chains are targeted for secretion, decorated with post-translational modifications, and assembled into a hexameric “dimer of trimers” (AαBβγ)2. Fully assembled fibrinogen is secreted into the blood as a 340 kDa glycoprotein. Fibrinogen is one of the most prevalent coagulation proteins in blood, and its expression is induced by inflammatory cytokines, wherein circulating fibrinogen levels may increase up to 3-fold during acute inflammatory events. Abnormal …

Ficture: Scalable Segmentation-Free Analysis Of Submicron-Resolution Spatial Transcriptomics, Yichen Si, Changhee Lee, Yongha Hwang, Jeong H Yun, Weiqiu Cheng, Chun-Seok Cho, Miguel Quiros, Asma Nusrat, Weizhou Zhang, Goo Jun, Sebastian Zöllner, Jun Hee Lee, Hyun Min Kang

Faculty, Staff and Student Publications

Spatial transcriptomics (ST) technologies have advanced to enable transcriptome-wide gene expression analysis at submicron resolution over large areas. However, analysis of high-resolution ST is often challenged by complex tissue structure, where existing cell segmentation methods struggle due to the irregular cell sizes and shapes, and by the absence of segmentation-free methods scalable to whole-transcriptome analysis. Here we present FICTURE (Factor Inference of Cartographic Transcriptome at Ultra-high REsolution), a segmentation-free spatial factorization method that can handle transcriptome-wide data labeled with billions of submicron-resolution spatial coordinates and is compatible with both sequencing-based and imaging-based ST data. FICTURE uses the multilayered Dirichlet model …

Lps-Induced Whole-Blood Cytokine Production And Depressive Symptoms In Dementia Spousal Caregivers: The Moderating Effect Of Childhood Trauma, Daniel L Argueta, Kelly N Brice, E Lydia Wu-Chung, Michelle A Chen, Vincent D Lai, Jensine Paoletti-Hatcher, Bryan T Denny, Charles Green, Luis D Medina, Paul Schulz, Jennifer Stinson, Cobi Heijnen, Christopher P Fagundes

Faculty, Staff and Student Publications

Dementia spousal caregivers are at risk for adverse mental and physical health outcomes. Caregiver burden, anticipatory grief, and proinflammatory cytokine production may contribute to depressive symptoms among caregivers. People who report childhood trauma are more likely to have exaggerated stress responses that may also contribute to depressive symptoms in adulthood. This study aimed to test whether the relationship between whole-blood cytokine production and depressive symptoms is strongest in caregivers who report high levels of childhood trauma.

Methods: A sample of 103 dementia spousal caregivers provided self-report data on demographics, health information, caregiver burden, anticipatory grief, and depressive symptoms. We also …

Hippocampal Gray Matter Volume In Young Adulthood Varies With Adolescent Alcohol Use, Juliann B Purcell, Nathaniel G Harnett, Sylvie Mrug, Marc N Elliott, Susan Tortolero Emery, Mark A Schuster, David C Knight

Faculty, Staff and Student Publications

Adolescent substance use is linked with negative future outcomes (e.g., depression, anxiety, substance use disorder). Given that the brain undergoes significant maturation during adolescence, this developmental period may represent a time of particular vulnerability to substance use. Neuroimaging research has largely focused on heavy or binge patterns of substance use; thus, relatively less is known about the neural impact of a broader range of adolescent substance use. Characterizing the neural impact of a broader range of adolescent substance use may inform prevention and treatment efforts. The present study investigated relationships between adolescent substance use trajectories (i.e., alcohol, tobacco, and cannabis) …

Pparγ/Etv2 Axis Regulates Endothelial-To-Mesenchymal Transition In Pulmonary Hypertension, Dong Hun Lee, Minseong Kim, Sarah S Chang, Raham Lee, Andrew J Jang, Juyoung Kim, Jing Ma, Michael J Passineau, Raymond L Benza, Harry Karmouty-Quintana, Wilbur A Lam, Benjamin T Kopp, Roy L Sutliff, C Michael Hart, Changwon Park, Bum-Yong Kang

Faculty, Staff and Student Publications

Endothelial-to-mesenchymal transition (EndoMT) plays an important role in pulmonary hypertension (PH) but the molecular mechanisms regulating EndoMT remain to be defined. We demonstrate that the axis of the transcription factors PPARγ (Peroxisome Proliferator-Activated Receptor gamma) and ETV2 (ETS variant 2) play important roles in the pathogenesis of PH. Decreased levels of the expression of PPARγ and ETV2 along with reduced endothelial and increased EndoMT markers are consistently observed in lungs and pulmonary artery endothelial cells (PAECs) of idiopathic pulmonary arterial hypertension patients, in hypoxia-exposed mouse lungs, human PAECs, and in induced-EndoMT cells. Etv2 +/- mice spontaneously developed PH and right …

The Five Homologous Ciar-Controlled Ccn Srnas Of Streptococcus Pneumoniae Modulate Zn-Resistance, Nicholas R De Lay, Nidhi Verma, Dhriti Sinha, Abigail Garrett, Maximillian K Osterberg, Daisy Porter, Spencer Reiling, David P Giedroc, Malcolm E Winkler

Faculty, Staff and Student Publications

Zinc is a vital transition metal for all bacteria; however, elevated intracellular free Zn levels can result in mis-metalation of Mn-dependent enzymes. For Mn-centric bacteria such as Streptococcus pneumoniae that primarily use Mn instead of Fe as an enzyme cofactor, Zn is particularly toxic at high concentrations. Here, we report our identification and characterization of the function of the five homologous, CiaRH-regulated Ccn sRNAs in controlling S. pneumoniae virulence and metal homeostasis. We show that deletion of all five ccn genes (ccnA, ccnB, ccnC, ccnD, and ccnE) from S. pneumoniae strains D39 (serotype 2) and TIGR4 (serotype 4) causes Zn …

Psychological And Social Well-Being Of Bony Fishes In Zoos And Aquariums, Ronald G. Oldfield, Patrick Bonano

Animal Sentience

Research on the behaviour of animals in zoos has been conducted for decades, and observations have provided information that has improved the psychological and social well-being of animals. However, research on fishes in zoos and aquariums seems to be lacking. Here, we assess the current state of research on fishes in zoos and aquariums by surveying the peer-reviewed literature. Our assessment differs from previous surveys in that we examine the taxonomic classes Chondrichthyes (sharks and rays) and Osteichthyes (bony fishes) separately. Our survey finds that bony fishes have been drastically underrepresented in zoo journals, more drastically than chondrichthyans, revealing an …

Social Emotional Learning (Sel) Instruction: The Effects On Students With Learning Disabilities (Ld), Courtney Schulte

Master's Theses & Capstone Projects

Social Emotional Learning (SEL) has been researched for over 20 years, yet it has become the focus of policy makers over the last several years. SEL competency has proven to increase student relationship building skills, emotional control, academic success and overall self-esteem. Research has shown SEL instruction benefits all students, even students in special education when taught in an explicit and direct manner.

Classifying Open Access Business Models, Tasha Mellins-Cohen

Copyright, Fair Use, Scholarly Communication, etc.

The proliferation of open access (OA) business models has been rapid, presenting challenges for stakeholders in communicating and working effectively with one another. This article aims to clarify terminologies and address the inconsistencies and gaps in previous attempts to categorize OA models, supporting informed decision-making. It presents five core types, each with distinct characteristics and implications for funding, equity, and implementation. Operating at the level of individual pieces of content, transactional models expose authors to the financial implications of their decisions to make content OA; they often must pay out of their own funds. Driven by negotiations between libraries or …

Course Schedule 2024-2025, William & Mary Law School

Course Information

No abstract provided.

The Accurate Conversion Of Biological Experiments From Cesium Irradiation To X-Ray Irradiation: The Significance, Problems, And The Future Of Experimental Radiation Research, Gretchen Carpenter

Dartmouth College Master’s Theses

Preclinical small animal irradiation studies, once conducted on Cesium irradiators, are increasingly being performed with X-ray-based irradiators. The transition stems from concerns regarding national security risks, making X-ray irradiators which are compact and easy to operate an enticing alternative. However, questions regarding the relative biological effectiveness between the two sources have revealed a lack of adequate dosimetric characterization of X-ray beams, standardized protocol for dose calibration, and thorough understanding of experimental biological parameters. A literature review conducted on orthovoltage irradiators has revealed that there are over 54 different types of beam structures used, a dramatic departure from the one uniform …

Valid And Accepted Novel Bacterial Taxa Isolated From Non-Domestic Animals And Taxonomic Revisions Published In 2023, Erik Munson, Claire R. Burbick, Sara D. Lawhon, Trinity Krueger, Elena Ruiz-Reyes

Clinical Lab Sciences Faculty Research and Publications

Continued investigation into the bacteria associated with non-domestic animals provides important information for recognizing normal flora, assessing the health status of these unique species of animals, and identifying new or emerging pathogens of concern. In this summary of novel taxa and taxonomic revisions, considerable additions have been made toward understanding fecal and mucosal flora in multiple wild animal species. In addition, novel pathogenic bacteria are discussed, including multiple Chlamydia spp. causing disease in a hawk and crocodile, two Corynebacterium spp. causing oral lesions in penguins and a lesser-known genus, Mergibacter within Family Pasteurellaceae, causing disease in multiple wild bird …

News From Uab Libraries, 10 2024, Uab Libraries

UAB Libraries News

No abstract provided.

October 2024, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

Breast Cancer Awareness Month

This month was named Breast Cancer Awareness Month to create awareness and/or remind you to get screened. Don’t be one of the 42,000 women in the U.S. who die each year from this disease.

Stress, Obesity, Depression, And Codependency As Predictors Of Unmitigated Communion In African American Pastors, Troy Tyrone Johnson

Walden Dissertations and Doctoral Studies

Many pastors spend significant time tending to their congregants’ needs while disregarding their own needs. They may not know how to ask for or receive help and may look to others for self-worth and value. Inappropriate self-sacrificing behaviors could result in pastors' compromised emotional and physical health. The purpose of this study was to determine whether stress, obesity, depression, and codependency, individually or in a linear combination, were adequate predictors of unmitigated (UC) among African American senior pastors who pastor congregationally led churches without the benefit of paid support staff. The social cognitive learning theory was the theoretical framework in …