Digital Commons Network^™

Historical Trends In Macro-Jurisprudence: A Language Model Assessment, 1870–2023, Edward H. Stiglitz, Rosamond Thalken

Maryland Law Review

No abstract provided.

The Costs Of Ecosystem Disturbances, E. Wesley F. Peterson

Cornhusker Economics

Presents an illustration of the interdependencies inherent in natural ecosystems. An ecosystem may be defined as: “… a single environment and every living (biotic) organism and non-living (abiotic) factor that is contained within it or characterizes it. An ecosystem embodies every aspect of a single habitat, including all interactions between its different elements” (Knapp 2020). In such interdependent systems, removal of one or more of the essential “elements” can severely disrupt the functioning of the system and such disruptions can give rise to negative impacts on the environment and human health and well-being.

Skn-1 Activation During Infection Of Caenorhabditis Elegans Requires Cdc-48 And Endoplasmic Reticulum Proteostasis, Carolaing Gabaldón, Ozgur Karakuzu, Danielle A Garsin

Faculty, Staff and Student Publications

During challenge of Caenorhabditis elegans with human bacterial pathogens such as Pseudomonas aeruginosa and Enterococcus faecalis, the elicited host response can be damaging if not properly controlled. The activation of Nrf (nuclear factor erythroid-related factor)/CNC (Cap-n-collar) transcriptional regulators modulates the response by upregulating genes that neutralize damaging molecules and promote repair processes. Activation of the C. elegans Nrf ortholog, SKN-1, is tightly controlled by a myriad of regulatory mechanisms, but a central feature is an activating phosphorylation accomplished by the p38 mitogen-activated kinase (MAPK) cascade. In this work, loss of CDC-48, an AAA+ ATPase, was observed to severely compromise SKN-1 …

A Distributed Secure System For Threads Detection In Crowded Environments Based On Biometric Facial Expression, Nourhan Zayed, Hassan I. Sayed, Ghada F. El-Kabbany

Mechanical Engineering

Ensuring security in crowded areas poses a significant problem due to the dense population and the intricate task of monitoring their behaviors. This research presents a real-time security system that utilizes facial expression analysis to identify potential threats. The technology utilizes sophisticated facial recognition and emotion detection techniques to accurately recognize emotions such as wrath, fear, and anxiety. These feelings can serve as indicators of suspicious activities or potential security risks. The system utilizes a Convolutional Neural Network (CNN) to classify facial expressions and recognize objects. In addition, it integrates an SVM classifier trained on features derived from the combined …

Induction Of A Distinct Macrophage Population And Protection From Lung Injury And Fibrosis By Notch2 Blockade, Mayra Cruz Tleugabulova, Meizi Liu, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Macrophages are pleiotropic and diverse cells that populate all tissues of the body. Besides tissue-specific resident macrophages such as alveolar macrophages, Kupffer cells, and microglia, multiple organs harbor at least two subtypes of other resident macrophages at steady state. During certain circumstances, like tissue insult, additional subtypes of macrophages are recruited to the tissue from the monocyte pool. Previously, a recruited macrophage population marked by expression of Spp1, Cd9, Gpnmb, Fabp5, and Trem2, has been described in several models of organ injury and cancer, and has been linked to fibrosis in mice and humans. Here, we show that Notch2 blockade, …

Failure In A Population: Tauopathy Disrupts Homeostatic Set-Points In Emergent Dynamics Despite Stability In The Constituent Neurons, James N Mcgregor, Clayton A Farris, Sahara Ensley, Aidan Schneider, Leandro J Fosque, Chao Wang, Elizabeth I Tilden, Yuqi Liu, Jianhong Tu, Halla Elmore, Keenan D Ronayne, Ralf Wessel, Kiran Bhaskaran-Nair, David M Holtzman, Keith B Hengen, Et Al.

2020-Current year OA Pubs

Homeostatic regulation of neuronal activity is essential for robust computation; set-points, such as firing rate, are actively stabilized to compensate for perturbations. The disruption of brain function central to neurodegenerative disease likely arises from impairments of computationally essential set-points. Here, we systematically investigated the effects of tau-mediated neurodegeneration on all known set-points in neuronal activity. We continuously tracked hippocampal neuronal activity across the lifetime of a mouse model of tauopathy. We were unable to detect effects of disease in measures of single-neuron firing activity. By contrast, as tauopathy progressed, there was disruption of network-level neuronal activity, quantified by measuring neuronal …

Engineered Self-Regulating Macrophages For Targeted Anti-Inflammatory Drug Delivery, Molly Klimak, Amanda Cimino, Kristin L Lenz, Luke E Springer, Kelsey H Collins, Natalia S Harasymowicz, Nathan Xu, Christine T N Pham, Farshid Guilak

2020-Current year OA Pubs

BACKGROUND: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by increased levels of inflammation that primarily manifests in the joints. Macrophages act as key drivers for the progression of RA, contributing to the perpetuation of chronic inflammation and dysregulation of pro-inflammatory cytokines such as interleukin 1 (IL-1). The goal of this study was to develop a macrophage-based cell therapy for biologic drug delivery in an autoregulated manner.

METHODS: For proof-of-concept, we developed "smart" macrophages to mitigate the effects of IL-1 by delivering its inhibitor, IL-1 receptor antagonist (IL-1Ra). Bone marrow-derived macrophages were lentivirally transduced with a synthetic gene circuit …

Quantifying And Reducing The Cost Of Tagging: Combining Computational Fluid Dynamics And Diving Experiments To Reduce Impact From Animal-Borne Tags, J. Chris Mcknight, Chris Pass, Dave Thompson, Steve Balfour, Sophie M.J.M. Brasseur, Clare Embling, Gordon Hastie, Ryan Milne, Adam Kyte, Simon E.W. Moss, Richard Pemberton, Debbie J.F. Russell

School of Engineering, Computing and Mathematics

Animal-borne instruments are essential research tools for ecologists and physiologists. An increasing number of studies have shown impacts of carrying a tag on behaviour and energetics, which can have implications for animal welfare and data validity. Such impacts are a result of the additional mass and/or drag loads, with the latter requiring empirical measurements or computational fluid dynamics (CFD) to estimate. To quantify and effectively minimize tag impacts from drag, a novel combined empirical and CFD approach is required. Here, we demonstrate such an approach using captive phocid seals and the widely used Sea Mammal Research Unit (SMRU) Instrumentation Group …

Evolution And Biogeographic Analysis Of The Dyssodia Genus, Serena Jeannine Blais

Electronic Theses and Dissertations Archive

Modern phylogenetics, or the study of organismal evolutionary relationships, establishes the basis of understanding needed to explore the evolution and ecology of biological systems. Knowing the past of how species arrived where they are today allows us to make inferences about what might occur in the future under different climate and geological conditions by combining geologic knowledge with phylogenetic discoveries. Dyssodia is a small, understudied genus of plants from the marigold (Tageteae) tribe of the sunflower (Asteraceae) family. The goal of this project is to use next generation sequencing techniques to better understand the relationships within the Dyssodia genus. By …

Functional Recovery In Volumetric Muscle Loss After Receiving A Minced Muscle Transplant, Zachary Rasmussen, Jake Sorensen Facsm

International Journal of Exercise Science: Conference Proceedings

Volumetric muscle loss (VML) refers to the traumatic or surgical loss of a substantial portion of skeletal muscle, which lacks the ability to regenerate naturally, leading to chronic functional deficits. Current therapeutic interventions have shown limited success in restoring both muscle structure and function, highlighting the need for novel regenerative approaches. Purpose: This study aimed to enhance muscle regeneration and functional recovery following VML injury through the use of a minced muscle transplant (MMT), designed to restore the structural and cellular components lost during the injury. Methods: Eight rats received a full-thickness, 6 mm VML injury in the left tibialis …

Body Mass & Muscle Weight Following Volumetric Muscle Loss Injuries, Kyndal Jones, Jj Payne, Matt Mangus, Jake Sorensen

International Journal of Exercise Science: Conference Proceedings

Volumetric muscle loss (VML) is the traumatic or surgical loss of a significant amount of skeletal muscle, resulting in decreased function and regenerative abilities. Despite the decrease in function, when one muscle is injured or removed, there is typically a compensatory response in the surrounding muscles that promote hypertrophic adaptations. PURPOSE: The purpose of this study was to observe how surgery impacts body mass and the weight of certain muscle groups 6 weeks after a VML injury to the tibialis anterior (TA) muscle, with particular interest in determining if a hypertrophy response occurs in surrounding muscle groups. METHODS: …

Effect Of Intranasal Insulin On Neurovascular Coupling In Healthy Young Adults, Brian Shariffi, Neil Mcmillan, Anna Gonsalves, Camila Manrique-Acevedo, Jaume Padilla, Jacqueline Limberg

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

Emerging evidence supports an essential role for insulin signaling in neurovascular coupling (NVC) – the link between neuronal activity and cerebral blood flow. In preclinical animal models, impaired insulin signaling is associated with reduced NVC, highlighting the neurogenic role of insulin. However, it remains unclear whether brain insulin stimulation can enhance NVC in humans. PURPOSE: To examine the acute effect of intranasal insulin delivery on NVC. We hypothesized intranasal insulin would augment NVC in healthy young adults. METHODS: Carotid artery blood flow (CBF, Doppler ultrasound) and middle cerebral artery blood velocity (MCAv, transcranial Doppler ultrasound) were measured during …

Destructive Plasticity, “Surplus Of Consciousness,” And The “Monster” In True Detective, Courtney Patrick-Weber

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

The first season of HBO's cult hit True Detective introduced viewers to a southern gothic murder mystery that many will not easily forget. Since many of us focused primarily on the whodunit narrative, we may have missed the narrative of trauma simmering under the surface of the story. This narrative of trauma reveals a deeper layer to the story between Detective Rust Cohle and serial killer Errol Childress, one that also reveals our own fears regarding trauma in our lives. By applying first the nihilist philosophies of Peter Zapffe with Cohle and Catherine Malabou's concept on destructive plasticity in Childress, …

Vol. 19, No. 10 - Whole No. 29, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 19, No. 8 - Whole No. 27, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 19, No. 2 - Whole No. 21, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

The Race To Embrace Zoom, Olivia Moore

Marriott Student Review

There was a 2,900% increase in Zoom meeting participants at the beginning of the COVID-19 pandemic. Even though employees have started to head back into the office, Zoom has retained these participants and continues to grow. The retention of Zoom, along with other video-conferencing platforms, for over 18 months suggests that it was not just a tool for the pandemic. If employees are going to be using Zoom for an extended period of time, they will become familiar with the platform.

Exceptional Experiences Equal Content Customers, Brenna Black

Marriott Student Review

Would you rather spend money on a designer bag or on a trip to Hawaii? According to University of Texas marketing and psychology professor Amit Kumar, “People derive more satisfaction from experiential purchases than material purchases.” Experiences carry meaning. In today’s society, people are willing to pay a significant amount of money to have a better experience. Customers are no longer satisfied with simply receiving a product or service; the process involved in receiving a product or service matters more than ever.

More Than A Cashier: Making Space For Neurodivergent Individuals In The Workplace, Abby Ebert

Marriott Student Review

Most people know someone – a friend, a sibling, a schoolmate, or otherwise – who has autism, down-syndrome, Asperger’s, or is otherwise on the spectrum. These individuals likely function mostly normal, but have an especially hard time in social situations coming off as awkward, uncomfortable, or nervous. Thinking of a friend of yours in this situation, what future do you see for them? Knowing them as individuals had you thinking of cool careers that would fit their personality – an engineer, programmer, or lawyer. However, people belonging to this demographic find themselves unemployed or in low entry-level positions, such as …

Embrace: Full Issue

Marriott Student Review

No abstract provided.

Popular Culture Pedagogy: Theory And Application In Academia [Dialogue, Volume 3, Issue 1 (Spring 2016)], Lynnea Chapman King, Anna S. Cohenmiller

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Popular Culture Pedagogy: Theory and Application in Academia [Dialogue, Volume 3, Issue 1 (Spring 2016)]

Editorial, Lynnea Chapman King and A. S. CohenMiller

Articles

(Re)learning about Learning: Using Cases from Popular Media to Extend and Complicate our Understandings of What It Means to Learn and Teach, Kelli Bippert, Dennis Davis, Margaret Rose Hilburn, Jennifer D. Hooper, Deepti Kharod, Cinthia Rodriguez, and Rebecca Stortz

Building a Popular Writing Course, Emily Howson, Chris Massenburg, and Cecilia Shelton

Lady Gaga Meets Ritzer: Using Music to Teach Sociological Theory, Kenneth Culton and José A. Muñoz

A Framework for Using Popular Music Videos to Teach …

Applications In The Classroom: Pop Culture And Ed Psychology: What I Learned From Larry David, Rick Grimes, And Hank Hill, Melissa Vosen Callens

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

In teacher education courses, it is common to teach educational psychology concepts using case studies. Many publishers provide these case studies in textbooks and/or in ancillary materials, and there are many advantages to using them. For example, an instructor does not have to spend extra time finding or writing the case studies, both of which can be very time consuming. In addition, if students have the textbook, they have immediate access. One major disadvantage, however, is that students may find themselves uninterested and disengaged with the cases, depending on the students’ interests and the cases. This paper argues that studying …

A Framework For Using Popular Music Videos To Teach Media Literacy, Jordan M. Mcclain

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This article discusses the use of popular music videos as a tool for teaching media literacy. First, the article addresses the importance of music videos as popular culture, what other music video research has examined, and what features make music videos a good fit for in-class work investigating media and popular culture. Then the article details a single-class activity for introducing and teaching media literacy through the use of music videos. To achieve this objective, the article also proposes a set of original music video-specific discussion questions. Finally, a particular music video is considered to illustrate possible results of this …

(Re)Learning About Learning: Using Cases From Popular Media To Extend And Complicate Our Understandings Of What It Means To Learn And Teach, Kelli Bippert, Dennis Davis, Margaret Rose Hilburn, Jennifer D. Hooper, Deepti Kharod, Cinthia Rodriguez, Rebecca Stortz

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This article utilizes sociocultural and socio-constructivist learning theories to analyze incidents of learning, and by extension teaching, in six different popular media selections. The authors describe their shared theoretical framework and the nature of the original analyses, which were completed as part of a doctoral course assignment. Each of the six excerpts is then described and discussed employing unique theoretical perspectives. The use of popular culture as the context for examining learning and teaching provides a space untethered from traditional notions of schooling through which typically accepted assumptions about pedagogy are revealed, re-examined, and reframed.

The Peaks We Climbed, Kyle Swann

Night Flight: Online Literary Journal

A short story of a young man who has been caught up in the never-ending race of adulthood. He recalls a time in his life that was filled with adventure and purpose.

Avian Index Of Biotic Integrity: Evaluating Wetland Health In The Red River Basin, Texas/Louisiana, Elexis M. Anderson

Biology Theses

Wetlands play a vital role in maintaining environmental health by filtering pollutants, controlling floods, and providing habitat for diverse species. These ecosystems are essential for sustaining biodiversity and regulating hydrological and biogeochemical cycles. The Red River Basin (The Red River of the South), spanning Texas, Oklahoma, and Louisiana, is home to various types of wetlands, which provide essential habitats to an array of wildlife. However, anthropogenic pressures such as agriculture and urbanization have led to the degradation and loss of these valuable ecosystems. To counter this loss, federal programs such as the Agricultural Conservation Easement Program - Wetland Reserve Easement …

Born High, Born Fast: Does Highland Birth Confer A Pulmonary Advantage For Sea Level Endurance?, Hunter L. Paris, Marissa N. Baranauskas, Keren Constantini, Ren Jay Shei, Peyton E. Allen, John R. Jadovitz, Chad C. Wiggins, Cooker Perkins Storm

All Faculty Open Access Publications

Less than 7% of the world's population live at an altitude above 1500 m. Yet, as many as 67% of medalists in the 2020 men's and women's Olympic marathon, and 100% of medalists in the 2020 men's and women's Olympic 5000 m track race may have been born or raised above this otherwise rare threshold. As a possible explanation, research spanning nearly a quarter of a century demonstrates that indigenous highlanders exhibit pulmonary adaptations distinct from their lowland counterparts. These adaptations may then promote endurance performance. Indeed, healthy indigenous highlanders often exhibit a larger aerobic exercise capacity compared to sea-level …

Forecasting The Promotion Rate For Women In The U.S. Senior Foreign Service, Jodi Wynn Erickson

Walden Dissertations and Doctoral Studies

Despite efforts worldwide to increase diversity, women continue to be underrepresented in the most senior leadership and management positions. The aim of this study was to provide insight into whether specific variables increased female representation at the most senior levels of the U.S. Foreign Service. A quantitative correlational study was completed using an autoregressive integrated moving average model in SPSS. Following that, time series forecasts were run in SPSS and AI generated in Google Gemini and Microsoft Copilot, to create a forecast for the female promotion rate in the Senior Foreign Service (the equivalent of the Senior Executive Service) within …

Forecasting The Promotion Rate For Women In The U.S. Senior Foreign Service, Jodi Wynn Erickson

Walden Dissertations and Doctoral Studies

Despite efforts worldwide to increase diversity, women continue to be underrepresented in the most senior leadership and management positions. The aim of this study was to provide insight into whether specific variables increased female representation at the most senior levels of the U.S. Foreign Service. A quantitative correlational study was completed using an autoregressive integrated moving average model in SPSS. Following that, time series forecasts were run in SPSS and AI generated in Google Gemini and Microsoft Copilot, to create a forecast for the female promotion rate in the Senior Foreign Service (the equivalent of the Senior Executive Service) within …

Patterns Of Government In Onondaga County: Structure And Services Of County, City, Town, And Village Governments (2024), Focus Greater Syracuse, Syracuse University, Maxwell School, Community Benchmarks Program

Community Benchmarks Program

The 2024 revised Patterns of Government is an important resource for elected and public officials, citizens, students, businesses, nonprofit organizations, educational institutions, and the general public. Patterns of Government also serves as the textbook for Citizens Academy, co- sponsored by FOCUS Greater Syracuse and Syracuse University Community Engagement. Local government courses at Maxwell School of Syracuse University and Newhouse School of Public Communications also use Patterns of Government as an educational tool. This book contains vital information that ordinarily can be found only when one researches multiple sources. This informational book will help you understand how local governments are organized, …