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Carbon Dioxide Dynamics In The Carbonate Critical Zone, Savoy Experimental Watershed, Arkansas, Usa, Michael Darvin Jones Dec 2024

Carbon Dioxide Dynamics In The Carbonate Critical Zone, Savoy Experimental Watershed, Arkansas, Usa, Michael Darvin Jones

Graduate Theses and Dissertations

The dynamics of carbon dioxide (CO2) within the Earth’s critical zone (CZ) are essential for driving spatial and temporal variations of carbonate dissolution and precipitation, which are fundamental to subsurface porosity and permeability development. However, there is still a significant knowledge gap regarding the patterns of CO2 transport and production within the carbonate critical zone (CCZ). In this study, we investigated these dynamics within a mantled karst terrain at the Savoy Experimental Watershed (SEW) in Northwest Arkansas.

Previous monitoring of partial pressure of CO2 (PCO2) and dissolution rates at karst springs in …


Primary Industries Education Foundation Australia (Piefa) Storm And Flood Industry Recovery Program: Evaluation Report, Tamara Van Der Zant, Katherine Dix Dec 2024

Primary Industries Education Foundation Australia (Piefa) Storm And Flood Industry Recovery Program: Evaluation Report, Tamara Van Der Zant, Katherine Dix

Program monitoring and evaluation

Despite the growing diversity of careers in Primary Industries, young peoples’ pursuit of agricultural careers is often hampered by outdated perceptions of the sector and its opportunities. As Primary Industries adapt to the threat of natural disasters by turning to scientific and technological solutions, a diverse, highly skilled workforce will be required. In the wake of the devastating impacts of storm and floods in early 2021 across New South Wales, the Storm and Flood Industry Recovery Program (SFIRP): Creating resilience through empowering school curriculums about primary industries careers project was developed. To aid the long-term recovery and resilience of the …


Use Of Hatchery-Raised Fish In Validation Of Daily Age Estimates For Juvenile Common Snook, Philip W. Stevens, Kyle L. Williams, Meredith B. Pfennig, Ryan W. Schloesser, Alexis A. Trotter, Derek P. Crane Dec 2024

Use Of Hatchery-Raised Fish In Validation Of Daily Age Estimates For Juvenile Common Snook, Philip W. Stevens, Kyle L. Williams, Meredith B. Pfennig, Ryan W. Schloesser, Alexis A. Trotter, Derek P. Crane

Biology

Objective: We investigated the validity of daily age estimates for juvenile Common Snook Centropomus undecimalis by using sectioned and sanded sagittal otoliths. Methods: Common Snook have a protracted spawning season, which is problematic for validation of daily ages because a hatch date—needed to calculate age—cannot be reasonably assigned like it can for species with a short spawning period (<30 days). To help overcome this, two readers independently counted presumed daily increments in otoliths collected from hatchery-reared Common Snook of known age (100–240 days; n = 91). Result: Differences between known ages and those estimated from otoliths were small (mean absolute difference = 3.4 days) for individuals aged 100 days, but these differences increased after 100 days, mainly due to the crowding of increments along the otolith margin. Underestimation of ages was 8% at 120 days, 29% at 180 days, and 36% at 240 days. Conclusion: Ideally, analyses based on counts of daily increments in Common Snook otoliths should be limited to fish with an age of 100 days or younger.


Recreational Fishing For Western Rock Lobster: Estimates Of Participation, Effort And Catch In 2023/24, Claire B. Smallwood, Karina L. Ryan, Alissa C. Tate Dec 2024

Recreational Fishing For Western Rock Lobster: Estimates Of Participation, Effort And Catch In 2023/24, Claire B. Smallwood, Karina L. Ryan, Alissa C. Tate

Fisheries Research Reports

The Western Rock Lobster (WRL) (Panulirus cygnus) is the most commonly caught Rock Lobster (RL) species in Western Australia. Catches from the commercial and recreational sectors are required to determine and monitor Total Allowable Commercial Catch (TACC), Total Allowable Recreational Catch (TARC) and the proportion of Allowable Harvest Level (AHL) achieved. The TARC is set at 5% of the AHL and evaluated in the harvest strategy based on a 5-year average.

Data for the recreational sector are obtained using phone-recall surveys to provide annual estimates of participation, fishing effort and retained catch (by numbers) from recreational fishers who hold a …


Training In Ecological Thinking: Narrative Practices For Educational Professional, Cristina Trovato Dec 2024

Training In Ecological Thinking: Narrative Practices For Educational Professional, Cristina Trovato

University of South Florida (USF) M3 Publishing

Since the 1970s, the issue of environmental education has assumed relevance in the context of a theory of training towards new forms of sustainability education. Literary ecology, a discipline born from the contamination of ecology and literature, proposes itself as a critical response to environmental distress, enhancing the implicit dialogue and interconnections between the text and the circumstances of the environment. The literary heritage constitutes a precious resource for promoting, in educational contexts from early childhood, dimensions that range from the cognitive to the emotional and for activating sustainable processes, through ecological paths that develop a civic conscience, capable of …


Fostering Ecological Awareness And Inclusion Through Narrative Pedagogy: Insights From The ‘Eco-Narrations’ Projects, Giambattista Bufalino, Gabriella D’Aprile Dec 2024

Fostering Ecological Awareness And Inclusion Through Narrative Pedagogy: Insights From The ‘Eco-Narrations’ Projects, Giambattista Bufalino, Gabriella D’Aprile

University of South Florida (USF) M3 Publishing

The paper presents The Eco-Narrations: Educational Care Atelier, an innovative collaborative initiative between the University of Catania and the Municipality of Ragusa. The project integrates narrative pedagogy into education to advance ecological awareness and social inclusion. From June to December 2023, the initiative offered a comprehensive training program to over 100 educators across kindergarten, primary, and lower secondary schools, blending theoretical sessions with practical workshops. Central to the program were eco-narrations, which employed ecological storytelling to deepen knowledge, foster emotional engagement, and promote inclusion. The project enhanced teachers’ abilities to address ecological and social issues while cultivating a collaborative …


2024 Indigenous Child Language Research Center Handbook, Tamera C. Yazzie, Bethany G. Lycan, Ryan D. Smith, Cormac League, Melvatha R. Chee Dec 2024

2024 Indigenous Child Language Research Center Handbook, Tamera C. Yazzie, Bethany G. Lycan, Ryan D. Smith, Cormac League, Melvatha R. Chee

Indigenous Child Language Research Center

This handbook is continuously being developed by the Indigenous Child Language Research Center at UNM to provide Indigenous communities with a description of our organization and our research methodologies to aid in their own child language research endeavors.


Understanding And Intervening In Children's Tick Risk Perceptions And Protective Behaviors: A Grounded Theory, Ariel Dawdy Dec 2024

Understanding And Intervening In Children's Tick Risk Perceptions And Protective Behaviors: A Grounded Theory, Ariel Dawdy

Department of Entomology: Dissertations, Theses, and Student Research

Children, ages 8 years and younger, are at a particularly high risk of contracting a tick-borne disease. This is partially due to the misconceptions spread about tick protective behavior and a poor understanding of how antibiotic treatment can help. Because most communities and families believe that tick control is the individual’s responsibility, looking at the interaction between ticks and human children is essential to understanding the individual’s motivations to protect themselves. To help alleviate the number of individuals contracting tick-borne diseases, misconceptions must be addressed, intervention programs implemented, and a behavioral change must occur. This study used a qualitative research …


Soybean Cyst Nematode (Heterodera Glycines Ichinohe) Virulence Assay Against Resistance Sources In Nebraska, Pratibha Karki Dec 2024

Soybean Cyst Nematode (Heterodera Glycines Ichinohe) Virulence Assay Against Resistance Sources In Nebraska, Pratibha Karki

Department of Plant Pathology: Dissertations, Theses, and Student Research

Soybean cyst nematode (SCN, Heterodera glycines Ichinohe), one of the major yield-limiting pathogens of soybean, is currently found in 60 counties of Nebraska that produce more than 90% of the state’s soybean. Often, yield loss occurs without any above-ground symptoms, which makes it difficult to manage. The primary management option is the use of SCN-resistant varieties. Several soybean plant introductions serve as resistance sources against SCN. Unfortunately, the single source, PI 88788, is used in approximately 90% of resistant varieties and its prolonged use has increased the virulence status of SCN in the U.S. A study was conducted to assess …


Analysis Of Impulsive Differential Equation Models Of Cell Populations Undergoing Radiation Therapy, Abigail D'Ovidio Long Dec 2024

Analysis Of Impulsive Differential Equation Models Of Cell Populations Undergoing Radiation Therapy, Abigail D'Ovidio Long

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Radiation therapy is a mode of treatment which is implemented for approximately 50% of cancer patients. Treatment needs to be able to kill cancer cells, but also do minimal damage to surrounding healthy tissue. We propose two main impulsive differential equation models of radiation therapy to capture the periodic nature of the treatment. These models build off of previous studies using clinical data to ensure biological relevance. The first model incorporates only cancer cell populations, and we provide parameter relationships which theoretically ensure treatment outcomes of cancer eradication, cancer approaching a carrying capacity, and cancer approaching a periodic solution. We …


Local Rural Knowledge And Early Childhood Informal Science Education In Rural Nebraska, Sarah Michelle Paulos Dec 2024

Local Rural Knowledge And Early Childhood Informal Science Education In Rural Nebraska, Sarah Michelle Paulos

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This study aims to discover the existing experiences that lead to local rural knowledge (LRK) of specific rural Northeast Nebraska communities. This information will assist in understanding the impact that LRK has on young children’s science knowledge in rural communities. By engaging in hands-on experiences and interactions, science learning goals for children may be achieved and developed through science outreach programs. During Phase 1 of this study, adults in the selected rural communities participated in an online survey indicating their knowledge of various common rural phrases with the option to share personal stories of experiences and family history. This information …


Characterization Of The Final Enzyme In The Coenzyme M Biosynthesis Pathway In Methanosarcina, Connor John Hines Dec 2024

Characterization Of The Final Enzyme In The Coenzyme M Biosynthesis Pathway In Methanosarcina, Connor John Hines

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Methanogenesis is known to be one of the oldest forms of energy generation on our planet. Methanogens rely on this method of energy conservation and have evolved to metabolize a variety of substrates, including the waste products of other organisms. This feature has made methanogens beneficial to both wastewater treatment and landfill-to-energy projects. Methane itself is a greenhouse gas twenty times more potent than carbon dioxide, viewed as a particularly influential contributor to global greenhouse emissions. Climate change was known to be on the horizon throughout the 20th century but has made itself known vocally during this 21st …


Investigating The Impact Of An Elaborative Conversation Strategies (Ecs) Intervention On Parent-Child Interactions And Preschool Children's Science Learning Using A Single-Case Experimental Design, Yao Yao Dec 2024

Investigating The Impact Of An Elaborative Conversation Strategies (Ecs) Intervention On Parent-Child Interactions And Preschool Children's Science Learning Using A Single-Case Experimental Design, Yao Yao

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The primary purpose of this study was to examine the efficacy of the elaborative conversation strategies (ECS) intervention in improving the quality of parents' science talk during everyday home learning interactions using a single-case experimental design. Specifically, the study explored whether training parents in ECS could increase their use of these high-quality conversation strategies and enhance the quality of their science talk when engaging their children in science activities. The study also investigated how the ECS intervention impacted children's science knowledge, skills, and interest, as well as parents' attitudes toward supporting their children's science learning.

Participants included five typically developing …


Novel Mouse Models To Study The Role Of T Cells In Cardiac Autoimmunity, Meghna Sur Dec 2024

Novel Mouse Models To Study The Role Of T Cells In Cardiac Autoimmunity, Meghna Sur

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Myocarditis patients can chronically develop dilated cardiomyopathy and autoreactive T cells could contribute to the disease pathogenesis, but defining their antigen specificity remains a major challenge. To fill this gap, we generated T cell receptor (TCR) transgenic (Tg) mice specific to cardiac myosin heavy chain (Myhc)-α 334–352 and made a few observations. First, we unexpectedly noted both CD4 and CD8 T cells expressing TCRs specific to Myhc-α 334–352. Second, while Tg T cells from myocarditis-resistant C57BL/6J mice did not respond to Myhc-α 334–352, those from immunized mice responded, indicating that in vivo priming is necessary to break tolerance. Third, upon …


Performance Of Acoustic Telemetry And Space Use Of Pallid Sturgeon In The Lower Platte River, Nebraska, Christopher F. Pullano Dec 2024

Performance Of Acoustic Telemetry And Space Use Of Pallid Sturgeon In The Lower Platte River, Nebraska, Christopher F. Pullano

School of Natural Resources: Dissertations, Theses, and Student Research

Pallid Sturgeon (Scaphirhynchus albus) are centenarian, potamodromous, rheophiles that historically occupied the Missouri River and Mississippi River basins. Listed on the U.S. Endangered Species Act in 1990, population declines are attributed to habitat fragmentation and degradation, as well as overharvest, and hybridization. A knowledge gap exists regarding the extent to which tributaries facilitate key life stages for Pallid Sturgeon. This study evaluated the capacity of acoustic telemetry to monitor the movements of Pallid Sturgeon in a shallow, braided tributary to the Missouri River. The specific objectives were to (1) evaluate the environmental variables influencing the performance of acoustic …


Occupancy Of Fish Species Of Greatest Conservation Need And Temporal Patterns Of Assemblage Occurrence In Sandhills Ecoregion, Nebraska Streams, Braxton M. Newkirk Dec 2024

Occupancy Of Fish Species Of Greatest Conservation Need And Temporal Patterns Of Assemblage Occurrence In Sandhills Ecoregion, Nebraska Streams, Braxton M. Newkirk

School of Natural Resources: Dissertations, Theses, and Student Research

Fish species’ occurrence is influenced by environmental conditions across multiple spatial and temporal scales. Alteration to stream systems has the potential to affect occurrence patterns of fish species. Stream systems of the North American Great Plains face threats originating from climate change and anthropogenic activities resulting in negative implications for many fish species. The Sandhills Ecoregion, Nebraska is considered one of the largest intact grasslands in North America, and thus may experience fewer threats than surrounding areas. Stream systems of the Sandhills Ecoregion are home to 12 fish species of greatest conservation need (SGCN). Little context exists regarding the environmental …


Spatial Ecology Of American Bison On Vermejo Park Ranch, New Mexico, Kate Ann Asmus Dec 2024

Spatial Ecology Of American Bison On Vermejo Park Ranch, New Mexico, Kate Ann Asmus

School of Natural Resources: Dissertations, Theses, and Student Research

American bison (Bison bison) are a keystone species that impact grassland productivity, plant diversity, and landscape heterogeneity. We used GPS telemetry and a replicate herbivore grazing experiment on Vermejo Park Ranch in northeastern New Mexico to advance understanding of bison spatial ecology and grazing dynamics. First, we evaluated the potentially disparate influences of forage productivity and site fidelity on the size and selection of home ranges of bison. Home range size was strongly negatively influenced by forage productivity. However, home range selection was influenced more strongly by site fidelity than spatial variation in forage, as bison selected home …


The Genomic Basis Of Adaptation In Salt-Marsh-Breeding Sparrows, Jonathan David Clark Dec 2024

The Genomic Basis Of Adaptation In Salt-Marsh-Breeding Sparrows, Jonathan David Clark

Doctoral Dissertations

Salt marshes are an ecotone between terrestrial and marine environments characterized byshort, graminoid vegetation and periodic tidal inundation with saline water. Despite the generally inhospitable conditions salt marshes present for terrestrial vertebrate life—principally, exposure to heat, salinity, and flooding—several terrestrial vertebrate species have adapted to, or are capable of inhabiting salt marshes. Notably, species of passerine birds that have adapted to salt marshes have repeatedly evolved a similar suite of adaptations, which has been named the “saltmarsh syndrome,” including larger bills, darker plumage, and an increased tolerance of salt.

The myriad species of New World sparrows (Passerellidae) that breed in …


Functional Characterization Of Copper Tolerance In The Atypical Microsymbiont Pseudofrankia Inefficax, Megan Paige Garcia Dec 2024

Functional Characterization Of Copper Tolerance In The Atypical Microsymbiont Pseudofrankia Inefficax, Megan Paige Garcia

Doctoral Dissertations

Bacterial species in the family Frankiaceae are soil-dwelling microsymbionts that form a mutualistic symbiosis, termed the actinorhizal symbiosis, with over 220 species of woody dicots. In this relationship, frankia fix atmospheric nitrogen to ammonia, a form usable by plants, while the bacteria benefit from the carbon sources exuded by their actinorhizal hosts. Since nitrogen is typically a limiting nutrient for growth in degraded and contaminated soils, actinorhizal plants establish at these sites as pioneer plant species, initiating a path for phytoremediation. Likely due to their association with plant hosts in contaminated soils, most frankia strains have evolved above average tolerances …


Breaking The Grid: Metamorphosis And Materiality In Meret Oppenheim’S An Evening In The Year 1910, Jacklyn Meyer Dec 2024

Breaking The Grid: Metamorphosis And Materiality In Meret Oppenheim’S An Evening In The Year 1910, Jacklyn Meyer

Theses

This paper analyzes Meret Oppenheim’s painting An Evening in the Year 1910 from 1972 and its exploration of the theme of metamorphosis and materiality. Looking at certain biographical information about the artist’s crisis period and time spent with the Surrealist group is crucial in understanding what can be discerned from viewing this work. Other works with the theme of metamorphosis within her oeuvre are studied as they provide further context for Oppenheim’s artistic philosophy and her penchant for revisiting themes repeatedly. Other works with the theme of metamorphosis are studied as they provide further context for Oppenheim’s artistic philosophy and …


Troubling Paradise: Exploring The Experiences Of National Student Exchange Participants To The University Of HawaiʻI At Mānoa, Allison Yap Dec 2024

Troubling Paradise: Exploring The Experiences Of National Student Exchange Participants To The University Of HawaiʻI At Mānoa, Allison Yap

Journal of Comparative & International Higher Education

No abstract provided.


Global South Sisterhood In A Virtual Exchange: A Critical Autoethnography, Bhavika Sicka, Arzu Atajanova Dec 2024

Global South Sisterhood In A Virtual Exchange: A Critical Autoethnography, Bhavika Sicka, Arzu Atajanova

Journal of Comparative & International Higher Education

No abstract provided.


Factors Influencing Colostrum Avoidance In Developing Countries: Insights From A Literature Review, Muhammad Zeeshan Aslam, Jonathan Johnson, Marina Baig, Abeer Musaddique Dec 2024

Factors Influencing Colostrum Avoidance In Developing Countries: Insights From A Literature Review, Muhammad Zeeshan Aslam, Jonathan Johnson, Marina Baig, Abeer Musaddique

Journal of Asian Midwives (JAM)

Introduction: Colostrum is a thick, sticky, clear and yellowish-coloured milk produced after the first few hours of birth until day 3. It consists of vitamin A, proteins, lipids, potassium, and maternal antibodies, including lactoferrin, immunoglobulin, growth factors and antimicrobial factors. Colostrum avoidance is the practice of squeezing out, pumping, and discarding the first milk. Various studies have reported colostrum avoidance worldwide, but its prevalence is higher in developing countries. Every day, approximately 3000 to 4000 infants die due to diarrhea and respiratory infections in developing countries, and one of the leading causes is colostrum avoidance. Infants are unable to take …


Induced Systemic Resistance Against Nematodes By Plant Growth-Promoting Microbes In Potatoes, Cole Grannan Dec 2024

Induced Systemic Resistance Against Nematodes By Plant Growth-Promoting Microbes In Potatoes, Cole Grannan

Master's Theses

Biofertilizers consist of plant growth-promoting microorganisms that establish symbiotic relationships with plant roots and stems. These beneficial microbes play a crucial role in enhancing plant defenses against various threats including insects, nematodes, and microbial pathogens. The purpose of this study was to investigate the effectiveness of two fungal biofertilizers (an endophytic strain of Beauveria bassiana (BA) and a mixture of arbuscular mycorrhizal (AM) fungi), specifically their ability to induce systemic resistance against plant- parasitic nematodes (PPNs) in potatoes (Solanum tuberosum cv. Masquerade) under controlled greenhouse conditions. The study utilized soil collected from Colorado State University’s San Luis Valley (SLV) Research …


Cultural Memory And The Search For Identity In Victorian Fantasy Fiction, Sadie Boggs Dec 2024

Cultural Memory And The Search For Identity In Victorian Fantasy Fiction, Sadie Boggs

Honors College Theses

Fantasy literature's origins can be traced through myths and folktales, medieval romances, enlightenment fairy tale fantasy, and Romanticism, before finally taking firmer root in the Victorian period and blooming into its own genre in 20th century modern fantasy. Victorian thinkers reacted to the Enlightenment’s realism and technological innovation by “rediscovering” the Middle Ages as a time of beauty, simplicity, and moral virtue. Simultaneously, Psychology developed as a recognized field of study, and theories emerged about the psychological process of memory formation and retrieval, as well as its reliability and relation to identity.

Considering these psychological theories, Victorian fantasy's cultural memory …


International Pcos Guideline Clinical Research Priorities Roadmap: A Co-Designed Approach Aligned With End-User Priorities In A Neglected Women's Health Condition, H. J. Teede, M. Gibson, J. Laven, A. Dokras, L. J. Moran, T. Piltonin, M. Costello, A. Mousa, A. E. Joham, C. T. Tay, Wiebke Arlt, Ricardo Azziz, Adam Balen, Lisa Bedson, Lorna Berry, Jacky Boivin, Jacqueline Boyle, Leah Brennan, Wendy Brown, Tania Burgert, Maureen Busby, Carolyn Ee, Rhonda M. Garad, Cheryce Harrison, Roger Hart, Marie Misso, Rachel Morman, Angelica Lindén Hirschberg, Tuong Ho, Kathleen Hoeger, Sonia Jitpiriyaroj, Cailin Jordan, Richard S. Legro, Rong Li Dec 2024

International Pcos Guideline Clinical Research Priorities Roadmap: A Co-Designed Approach Aligned With End-User Priorities In A Neglected Women's Health Condition, H. J. Teede, M. Gibson, J. Laven, A. Dokras, L. J. Moran, T. Piltonin, M. Costello, A. Mousa, A. E. Joham, C. T. Tay, Wiebke Arlt, Ricardo Azziz, Adam Balen, Lisa Bedson, Lorna Berry, Jacky Boivin, Jacqueline Boyle, Leah Brennan, Wendy Brown, Tania Burgert, Maureen Busby, Carolyn Ee, Rhonda M. Garad, Cheryce Harrison, Roger Hart, Marie Misso, Rachel Morman, Angelica Lindén Hirschberg, Tuong Ho, Kathleen Hoeger, Sonia Jitpiriyaroj, Cailin Jordan, Richard S. Legro, Rong Li

Clinical Research Faculty Publications

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy with significant reproductive, metabolic, and psychological complications. Consensus on PCOS clinical research priorities across end-users is fundamental and necessitates a robust co-development of a clinical research roadmap to guide international research efforts. Methods: A multistage process included: i) international surveys of women and healthcare providers to identify research priorities and unmet needs; ii) interrogation of systematic reviews conducted for the International PCOS Guideline to identify research gaps; iii) International PCOS Guideline Network consensus generated clinical research roadmap; and iv) international peer review for external validation. Findings: A codesigned survey engaging 1278 …


Supplementary Data For "Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2024, Christina Tzikas, Kamaladdin Saei, Anne Schweighardt, Fang Zhao Dec 2024

Supplementary Data For "Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2024, Christina Tzikas, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

No abstract provided.


Bad Plants, Heather I. Sullivan Dec 2024

Bad Plants, Heather I. Sullivan

Modern Languages and Literatures Faculty Research

“Bad plants” represent the seemingly unexpected and startling forms of plant power overlooked by many modern, industrialized societies that treat vegetal beings as mere resources instead of animate, world-shaping forces. Since science fiction and fairy tales often explore more openly animistic visions of non-human life, such texts provide ample possibilities for reconsideration by critical plant studies of our human-plant relations both cultural and ecological. For example, both Jack McDevitt’s 2001 science fiction novel, Deepsix, and Ludwig Tieck’s 1799 fairy tale, “Faithful Eckart and Tannhäuser”, feature “bad plants” that bring human beings violently back into the plant cycles they assume they …


Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster Dec 2024

Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster

All Dissertations

This dissertation investigates the development and optimization of pathology-responsive polymersomes for simultaneous enhanced magnetic resonance imaging (MRI) and enzyme replacement therapy (ERT) in the treatment of GM1 gangliosidosis (GM1). While therapeutic strategies exist for similar, non-neuropathic lysosomal storage disorders, implementation towards GM1 faces significant challenges due to the blood-brain barrier.

Herein, we developed and characterized a range of low molecular weight hyaluronic acid-b-polylactic acid (HA-PLA) polymersomes (PSs) capable of encapsulating therapeutic enzymes in their hydrophilic core. These polymersomes exhibit pathophysiology-triggered responsiveness, degrading in the presence of acidic conditions, which is characteristic of lysosomes, and enzymes such as hexosaminidase A, which …


Hypoalbuminemia In Children With Acute Lymphoblastic Leukemia: Relation To Asparaginase Therapy And Impact On High Dose Methotrexate Elimination., Sophie Rex Christensen, Christina Friis Jensen, Jesper Heldrup, Zachary Taylor, Laura Ramsey, Steen Rosthøj Dec 2024

Hypoalbuminemia In Children With Acute Lymphoblastic Leukemia: Relation To Asparaginase Therapy And Impact On High Dose Methotrexate Elimination., Sophie Rex Christensen, Christina Friis Jensen, Jesper Heldrup, Zachary Taylor, Laura Ramsey, Steen Rosthøj

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: High-dose methotrexate (HDMTX) therapy is an important component in treatment regimens for acute lymphoblastic leukemia (ALL). Courses are associated with a risk of renal injury, delayed elimination, and increased systemic toxicity. Recently hypoalbuminemia has been recognized as yet another risk factor.

METHODS: To examine the impact of serum albumin we reviewed 325 HDMTX 5 g/m2 courses in a cohort of 51 children treated on the NOPHO ALL 2008 protocol, dividing the courses into four groups with different levels of baseline albumin (A < 25 g/L, B 25-29 g/L, C 30-34 g/L and D ≥ 35 g/L).

RESULTS: Hypoalbuminemia was present in 51% of the courses, mostly in the early phases of chemotherapy while …