Digital Commons Network^™

The Primate Gut Microbiota Contributes To Interspecific Differences In Host Metabolism., Elizabeth K Mallott, Sahana Kuthyar, Won Lee, Derek Reiman, Hongmei Jiang, Sriram Chitta, E Alexandria Waters, Brian T Layden, Ronen Sumagin, Laura D Manzanares, Guan-Yu Yang, Maria Luisa Savo Sardaro, Stanton Gray, Lawrence E Williams, Yang Dai, James P Curley, Chad R Haney, Emma R Liechty, Christopher W Kuzawa, Katherine R Amato

Faculty Research 2024

Because large brains are energetically expensive, they are associated with metabolic traits that facilitate energy availability across vertebrates. However, the biological underpinnings driving these traits are not known. Given its role in regulating host metabolism in disease studies, we hypothesized that the gut microbiome contributes to variation in normal cross-vertebrate species differences in metabolism, including those associated with the brain's energetic requirements. By inoculating germ-free mice with the gut microbiota (GM) of three primate species - two with relatively larger brains and one with a smaller brain - we demonstrated that the GM of larger-brained primates shifts host metabolism towards …

Lessons Learned From 20 Years Of Preclinical Testing In Pediatric Cancers., Malcolm A Smith, Peter J Houghton, Richard B Lock, John M Maris, Richard Gorlick, Raushan T Kurmasheva, Xiao-Nan Li, Beverly A Teicher, Jeffrey Chuang, Filemon S Dela Cruz, Michael A Dyer, Andrew L Kung, Michael W Lloyd, Yael P Mossé, Timothy M Stearns, Elizabeth A Stewart, Carol J Bult, Stephen W Erickson

Faculty Research 2024

Programs for preclinical testing of targeted cancer agents in murine models of childhood cancers have been supported by the National Cancer Institute (NCI) since 2004. These programs were established to work collaboratively with industry partners to address the paucity of targeted agents for pediatric cancers compared with the large number of agents developed and approved for malignancies primarily affecting adults. The distinctive biology of pediatric cancers and the relatively small numbers of pediatric cancer patients are major challenges for pediatric oncology drug development. These factors are exacerbated by the division of cancers into multiple subtypes that are further sub-classified by …

Interruption Of Glucagon Signaling Augments Islet Non-Alpha Cell Proliferation In Slc7a2- And Mtor-Dependent Manners., Katie C Coate, Chunhua Dai, Ajay Singh, Jade Stanley, Brittney A Covington, Amber Bradley, Favour Oladipupo, Yulong Gong, Scott Wisniewski, Katelyn Sellick, Erick Spears, Greg Poffenberger, Anna Marie R Schornack, Alexandria Bustabad, Tyler Rodgers, Nandita Dey, Leonard D. Shultz, Dale L Greiner, Hai Yan, Alvin C Powers, Wenbiao Chen, E Danielle Dean

Faculty Research 2024

OBJECTIVE: Dysregulated glucagon secretion and inadequate functional beta cell mass are hallmark features of diabetes. While glucagon receptor (GCGR) antagonism ameliorates hyperglycemia and elicits beta cell regeneration in pre-clinical models of diabetes, it also promotes alpha and delta cell hyperplasia. We sought to investigate the mechanism by which loss of glucagon action impacts pancreatic islet non-alpha cells, and the relevance of these observations in a human islet context.

METHODS: We used zebrafish, rodents, and transplanted human islets comprising six different models of interrupted glucagon signaling to examine their impact on delta and beta cell proliferation and mass. We also used …

The Interplay Of Covid 19, Organized Religion, And Social Media: “How Can I Be The Person I Feel I Need To Be?”, White Dove Bryant Beethoven Keith Short

All-Inclusive List of Electronic Theses and Dissertations

Young adults are disaffiliating themselves from organized religion (Hout & Fischer, 2014). This study investigates the impact of social media use on religious identity, teaching, and learning. Social media use is changing young adults as individuals in worldview and perspective, spirituality, religion, and personal lifestyle (Schaeffer, 2019). Messages devised for young adults by Christian ministers for discipleship in teaching and instruction are inharmonious with young adults and their personal views of the world, how to live, and religion (Pew Research Center, 2019). The continued existence of religious teaching, congregant replenishment, and practice of the organized institutional Christian church within society …

Time For A Copyright Remix: Learning From Djs’ Problematic Pandemic Livestreams & Reimagining A More Productive Framework For Music On Social Media, Aaron Thompson

Chicago-Kent Law Review

No abstract provided.

Pack Your Bags…We’Re Moving To The Public Domain: The Expiration Of Copyright Terms And Its Implications On Future Protection, Sophie Ganion

UC Law SF Communications and Entertainment Journal

The following Note addresses the expiration of copyright terms for a multitude of creative works and the various implications of that expiration for their future IP protection. It explores the conflicting perspectives of stakeholders, from the excitement of artists and everyday creatives versus the concerns of industry leaders about the potential erosion of their copyright monopolies. Drawing from landmark cases like Baker v. Selden and Dastar Corporation v. Twentieth Century Fox Film Corp., this Note highlights the complex questions surrounding copyright expiration and the strategic use of trademark protection. The Note emphasizes the necessity for coherent legal frameworks to ensure …

The Right To Inequality: Conservative Politics And Precedent Collide, Jonathan P. Feingold

Connecticut Law Review

The “end of affirmative action” is the beginning of this story. In Students for Fair Admissions v. Harvard (SFFA), the Supreme Court struck a near fatal blow to race-consciousness. Many institutions have since pivoted to “race neutral alternatives.” This is a natural turn. But one that faces immediate headwinds.

The same entities that demanded Harvard pursue racial diversity through colorblind means have sued public high schools for doing just that. These litigants assert a “right to inequality”—a theory that would pit the Equal Protection Clause against equality itself. Even if normatively jarring, a right to inequality might seem a natural …

Library News December 2024, Research Medical Library

Library News 2024

• Authorship Considerations for Biomedical Research Papers
• The Significance and Innovation Sections of NIH Research Grant Applications
• Why Does My Editor Leave Some Abbreviations but Recommend Spelling Out Others?
• Top 10 Tool Time Tuesday Videos
• Best and Worst Reads of 2024

The Mayfly Newsletter, Donna Giberson

The Mayfly Newsletter

The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.

Investigating Challenges Of Converting Cad Models To Game Ready Assets, Vathsa Pawar

All Theses

This thesis explores the challenges associated with converting detailed CAD models into game-ready assets optimized for use in virtual reality (VR) environments using game engines, focusing on enhancing using mechanical engineering models. The primary goal is to establish a toolchain that allows the integration of CAD models into game engines for immersive applications, enabling engineers and stakeholders to interact with 3D models in a synthetic environment. The study employs several test cases ranging from simple door models to complex automotive vehicle prototypes, elaborating the process of exporting CAD models through intermediate formats (such as STEP, STL, GLB) using tools like …

Environmental Storytelling In Video Games Through The Lens Of Film Noir, Samuel Hagen

All Theses

My project is an interactable video game experience showcased through the lens of film noir, that focuses on the capabilities and benefits of environmental storytelling in video games. With a heavy focus on immersion, my project forces the player to explore a murder scene and encourages them to formulate their own narrative about what has transpired. My project fuels the player’s ability for self-reflection and self-acceptance through the player’s personalized and unique interpretations experienced while exploring the scene I have created. In my paper, I discuss the aspects of environmental storytelling and immersion in video games and how they have …

The Effect Of Packaging On The Acceptance Of Natural Peanut Butter, Perian M. Reese

All Theses

The aim was to determine the effect of packaging on the acceptance of natural peanut butter, especially concerning the acceptance of the undesirable oil layer. The jars of peanut butter differed by color, label size, and inclusion of qualifying statements. 119 participants across two groups completed this study. Both groups completed an eye-tracking study in a mock grocery setting. The first group rated all five jars in appearance, expected quality, and overall rating. They were given one sample cup of peanut butter and gave hedonic liking values for color, oiliness, peanut flavor, smoothness, sweetness, and overall liking. The second group …

On Humans, Hogs, And Habitat: How Landscape Features And Vegetation Influence Wild Hog (Sus Scrofa) Detection On Private Lands And Using Existing Wild Hog Outreach Websites To Create An Effective Website For South Carolina, Andrew Jamison

All Theses

Invasive species are a source of human conflict with wildlife on a global scale and exist to the detriment of native wildlife species. Invasive species often possess the ability to respond rapidly to change and they often exist alongside humans. Wild hogs (Sus scrofa) are perhaps one of the most infamous examples of an invasive species. The spread of wild hogs necessitates effective communication with the public being impacted by them, as well as a continuation of research to learn more about wild hog behavior to promote effective management. Chapter 1 focuses on how we created a website …

Enrollment Of Females In Randomized Trials For Glucagon-Like Peptide 1 Receptor Agonists: A Systematic Review, Frederick Berro Rivera, Mc John Caro Ybañez, John Vincent Magalong, Mario Prado, Eloise Arias Aguirre, Ana Patricia Ting Cañares, Janos Marc Rubia, Allyn Ralph Hiyas, Polyn Luz S. Pine, Kyla Lara-Breitinger, Francisco Lopez-Jimenez, Martha Gulati

Ateneo School of Medicine and Public Health Publications

Background

Randomized controlled trials (RCTs) of glucagon-like peptide 1 receptor agonists (GLP-1RAs) form the basis for therapeutic recommendations for both males and females. Historically, females have been significantly underrepresented in RCTs.

Objectives

The authors sought to determine the trends of representation of females in GLP-1RA RCTs from 2007 to 2024.

Methods

We reviewed eligible studies and extracted important variables. The proportion of females among the total participants was obtained per study. This was compared over time (year) of publication and over mean age of participants. This proportion was also compared between specific types of GLP-1RA received, diabetes status, indication of …

Removing Methane Via Soil Amendments: The Legal Framework, Korey Silverman-Roati, Romany M. Webb

Sabin Center for Climate Change Law

Rapid and sustained reductions in human-driven methane emissions are critical to limiting warming in line with the 2015 Paris Agreement. Reductions in certain methane emissions, particularly from the fossil fuel sector, can be implemented cheaply and efficiently. Other forms of methane emissions, like those from agricultural sources, are more difficult to control. This fact, coupled with concerns that climate change could unlock significant additional natural emissions from tropical wetlands and melting permafrost, has increased interest in atmospheric methane removal (“AMR”).

AMR refers to human interventions to accelerate the conversion of methane in the atmosphere to a form that causes less …

Design, Manufacturing, And Assembly Of Modular Snake-Like Robotic Arm, Alongside Design And Implementation Of System’S Digital-Twin, Scott Brown

Master's Theses

A unique modular snake-like robotic arm, also referred to as MA\RS – the Modular Arm \ Robotic System - was designed, manufactured, assembled, simulated, and programmed to create a modular robot which could move to a desired end position given the number of links, the position of the end link and the duration of motion. This robotic arm serves as the start of research into a modular space robotic system to be used in low-gravity environments. As such, this project focused on developing the initial design of the robot and its digital twin. The system’s modularity allows for changes to …

Quantifying The Mechanisms Behind Carbon Sequestration And Soil Health Following Compost Application In A Rangeland Chronosequence, Grace Damaschino

Master's Theses

Compost application to rangelands has the potential to sequester carbon (C) and add essential plant nutrients to the soil. The California Department of Food and Agriculture's (CDFA) Healthy Soils Project (HSP) provides financial support to farmers and landowners to implement innovative practices that promote soil health. The CDFA is currently recommending compost application rates of 6-10 tons per acre; however, previous research suggests that degraded soils may require a larger dose of compost to overcome limitations, therefore this recommendation might not meet soil health or soil carbon sequestration objectives. This study examines the compost rate effects on soil health, while …

Effects Of Fast And Slow-Wilting Soybean Genotypes On Plant-Herbivore Interactions, Jessica Ayala

Graduate Theses and Dissertations

Soybean [Glycine max (L.) Merr.] is one of the most important food crops in the world due to its multiple uses in agriculture sector. A major limiting factor in soybean production system is drought stress, causing up to 80% reduction in yield. Due to climate change and associated rise in ambient temperatures, water scarcity is a major concern in crop production, and consequently researchers are turning to soybean accessions that demonstrate better water use efficiency (WUE) traits. However, field grown soybean is also under severe pressure from insect herbivores, often accounting for a 30% reduction in yield. Among these, …

Perceived Barriers And Facilitators Of Behavioral-Health Modality Change Adoption During The Covid-19 Pandemic: A Systematic Review, Nicholas Sims-Rhodes, Hannah E. Cornwell, Emily Barena, Vandy C. Dubre, Kimberly S. Elliott, Eman H. Nabulsi, Nelly Yuen, Sarah Sass, Anastasia Miller, Yordanos M. Tiruneh, Karan P. Singh

Presentations and Publications

Introduction: During the Coronavirus Disease 2019 pandemic, there was a surge in demand for mental health services worldwide, presenting challenges for healthcare institutions as they navigated changes in policy and safety regulations. In the United States, this resulted in many behavioral health modality changes to remain in compliance with the Center for Disease Control guidelines. A growing body of literature has documented these, yet few explored barriers and facilitators affecting the adoption of these modality delivery changes. The researchers conducted a systematic review using the PRISMA method, focusing on service delivery changes across healthcare systems in the United States from …

Boise State Magazine, Anna Webb (Editor)

FOCUS on Boise State

No abstract provided.

Nourishing Nations: A Comparative Analysis Of American Food Production Laws & Regulations, Morgan Flood

Honors Theses

Food manufacturing, distribution, and consumption have a significant influence on equity, sustainability of the environment, and public health. Food regulations control these factors, but there are substantial variations in how European countries and America balance safety, innovation, and economic interests. With a focus on finding flaws in the American regulatory system, this thesis compares the rules and regulations overseeing food production in the US and Europe. It examines how these inequalities fuel environmental deterioration, economic inequality, and public health issues. For example, dangerous chemicals like titanium dioxide, potassium bromate, and Red Dye 40 have been restricted in the European Union …

Aged 539- Internship In Agriculture Education - Waterford High School, Jennifer Pierce

Agricultural Education: Graduate Internship Reports

This report explores the development and implementation of an agricultural education program plan aimed at enhancing student engagement, community involvement, and career readiness. Drawing from established models of program planning and needs assessment, the report focuses on the integration of instructional strategies, supervised agricultural experiences (SAEs) and FFA involvement to foster comprehensive student development. The plan outlines key goals such as increasing student enrollment, improving curriculum alignment with industry standards, and expanding partnerships with local agricultural stakeholders. Strategies include curriculum enhancement, teacher professional development, and the use of data-driven decision-making. The report also emphasizes the importance of evaluation and continuous …

Video Game Development 3.0: Ai-Driven Collaborative Co-Creation, Jay Ratican, James Hutson

Faculty Scholarship

The evolution of game development has transitioned from manual coding (Software 1.0) to data-driven Artificial Intelligence (AI) (Software 2.0), and now to a more advanced stage—video game development 3.0. This phase is characterized by AI-driven processes leveraging large language models (LLMs), neural networks, and other AI techniques that autonomously generate code, content, and narratives. This paper explores the foundational technologies underpinning this paradigm shift, including customizable AI modules, dynamic asset creation, and intelligent non player characters (NPCs) that adapt to player interactions. It also highlights the integration of AI with emerging technologies like Virtual Reality (VR), Augmented Reality (AR), and …

International Society Of Sports Nutrition Position Stand: Β-Hydroxy-Β-Methylbutyrate (Hmb), John A. Rathmacher, Lisa M. Pitchford, Jeffrey R. Stout, Jeremy R. Townsend, Ralf Jägerg, Richard B. Kreider, Bill I. Campbell, Chad M. Kerksick, Patrick S. Harty, Darren G. Candow, Brandon M. Roberts, Shawn M. Arent, Douglas S. Kalman, Jose Antonio

Faculty Scholarship

Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on an analysis of the literature regarding the effects of β-Hydroxy-β-Methylbutyrate (HMB). The following 12 points have been approved by the Research Committee of the Society: 1. HMB is a metabolite of the amino acid leucine that is naturally produced in both humans and other animals. Two forms of HMB have been studied: Calcium HMB (HMB-Ca) and a free acid form of HMB (HMB-FA). HMB-FA appears to lead to increased appearance of HMB in the bloodstream when compared to HMB-Ca, though recent results are mixed. 2. …

Dileucine Ingestion, But Not Leucine, Increases Lower Body Strength And Performance Following Resistance Training: A Double-Blind, Randomized, Placebo-Controlled Trial, Anthony M. Hagele, Joesi M. Krieger, Connor J. Gaige, Kevin F. Holley, Kristen N. Gross, Joshua M. Ianotti, Leah E. Allen, Paige J. Sutton, Logan S. Orr, Petey W. Mumford, Martin Pupura, Ralf Jager, Chad M. Kerksick

Faculty Scholarship

Background

The essential amino acid leucine (LEU) plays a crucial role in promoting resistance-training adaptations. Dileucine (DILEU), a LEU-LEU dipeptide, increases MPS rates, however its impact on resistance training outcomes remains unexplored. This study assessed the effects of DILEU supplementation on resistance training adaptations.

Methods

Using a randomized, double-blind, placebo-controlled approach, 34 resistance-trained males (age: 28.3 ± 5.9 years) consumed 2 grams of either DILEU monohydrate (RAMPS™, Ingenious Ingredients, L.P.), LEU, or placebo (PLA) while following a 4-day per week resistance training program for 10 weeks. Changes in body composition, 1-repetition maximum (1RM) and repetitions to failure (RTF) for leg …

Shape Between Intimacy, Mackenzie Serwa

Theses

This thesis examines the parallel exploration of raw tactile materials and relationships to develop a personal dialogue of intimacy. It breaks down the materiality of glass, clay, and the impulse of collecting, aiming to communicate the human connections shared between each. By engaging with materials in this way, this study aims to foster a deeper understanding of the existence, influence, and expression of intimate relationships.

The Mythical Nexus: Illuminating The Rich Tapestry Of Global Folklore, Trishala Parmar

Theses

There is a lack of accessibility and exposure to global folklore for a wider audience. Despite the richness and diversity of folktales worldwide, many people may not have access to them due to limited resources, language barriers, cultural isolation, and a lack of exposure. I saw a need to preserve and celebrate cultural heritage through stories and make it fun. I created an interactive website called The Mythical Nexus which allows an audience to interact with different stories and cultures through a series of rotating cubes. This website connects stories and folklore from around the globe through the power of …

Robust And Efficient Active Inference For Perception, Action, And Learning, Zhizhuo Yang

Theses

Active Inference (AIF) is an emerging framework rooted in neuroscience aimed at elucidating human perception, action, and cognitive processes. Recent advances in machine learning have facilitated the non-invasive study of human cognition through the lens of this framework. This dissertation expands upon this theoretical foundation to address practical challenges in robotic control and human cognitive behavior analysis. We initiate our exploration with a review of the eye-tracking studies that underpin the motivation for AIF research. This provides a background for understanding how AIF can model cognitive processes. First, we present a minimal AIF model within a discrete state space, framed …

Estereotipos Sexistas En La Representación De La Mujer En El Videoclip De Animación Y De Imagen Generada Por Ordenador, Julia Sainz Cortés

Capítulos de libros

La representación de la feminidad en los medios audiovisuales ha sido históricamente caracterizada por una destacada exposición de los atributos físicos de la mujer, relegándola a la posición de objeto de deseo pasivo, cosificado y sexualizado en multitud de ocasiones. Dentro de un género audiovisual intermodal e intermedial como es el vídeo musical, y por su afán hipermoderno y de adalid de los avances técnicos, esta representación de la mujer se ha resuelto en ocasiones desde un enfoque tecnológico mediante distintas técnicas digitales que han ido evolucionando a lo largo de su corta historia. Inspirado en diversas formas de expresión …

Recast, Reform, Reshape: Surreal Figurative Painting, Keely Wu

Theses

This thesis explores the use of surreal imagery and the reimagining of historical subjects as a means to discuss complex ideas of identity. In this exploration, I chose to use the human figure as a vessel for expressing my own intimate viewpoints and experiences. Through a series of paintings, I investigate how the juxtaposition of human forms with non-human elements challenges conventional notions of gender and sexuality to empower marginalized perspectives. My Master’s degree started with my transition from commercial illustration to fine art. The study examines my evolution of thematic and stylistic choices, emphasizing the creation of new works …