Digital Commons Network^™

Revitalizing The Urban Riverfront: Redesigning The West End Bridge In Pittsburgh,Pa For Sustainable Multi-Use Connectivity And Public Space Creation., Mina Kargari Rezapour

Graduate Theses, Dissertations, and Problem Reports (ETD)

Urban waterfronts are critical assets for cities, offering opportunities for ecological restoration, public engagement, and multi-modal transportation. However, many riverfronts remain underutilized due to infrastructure barriers and lack of accessibility.

Pittsburgh’s riverfront is dynamic asset that supports recreation, cultural expression, and community interaction. The Three River Heritage Trail Loop, a visionary project led by River Life over the past 20 years, seeks to connect diverse neighborhoods and natural assets along the city’s rivers. At the heart of this initiative is the West End Bridge, serving as the bookend and a pivotal gateway to complete the loop and critical link for …

Evaluation And Identification Of Novel Viruses In Wild Fishes Using Varied Molecular Biology Techniques, Clayton Douglas Raines

Graduate Theses, Dissertations, and Problem Reports (ETD)

Viruses are among the most abundant biological entities on Earth, yet their diversity and ecological roles in aquatic vertebrates, particularly fishes, remain poorly characterized. This dissertation advances fish virology through integrative approaches that combine historical context, molecular diagnostics, and genomic discovery. A novel hepadnavirus (ApHBV) was identified in asymptomatic Alosa pseudoharengus, emphasizing the prevalence of subclinical infections in migratory forage species. In Catostomus commersonii, transcriptomic profiling revealed sexually dimorphic immune responses to hepatitis B and C-like viruses, highlighting complex host-pathogen dynamics. In Micropterus nigricans, next-generation sequencing uncovered a novel nackednavirus and multiple adomaviruses within hyperpigmented lesions, expanding …

Neurobiological Variables Mediating The Relationship Between Breast Cancer And Sleep Disruption, Brittany Domenique Elliott

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neurobiological Variables Mediating the Relationship between

Breast Cancer and Sleep Disruption

Brittany D. Elliott, MS

Breast cancer is the most commonly diagnosed malignancy in women, with more than two million new cases diagnosed world-wide each year. Improvements in screening technology and diagnostics have increased survival rates, but cancer-associated sleep disruptions persist for the majority of breast cancer survivors well beyond the treatment period. In addition to reducing quality of life, reduced sleep quality is associated with greater incidences of affective dysfunction, reduced treatment efficiency, aggressive cancer progression, increased symptom severity, and increased mortality by all causes. Thus, identifying the variables …

Non-Lethal Sampling Methods For Fish Health Assessments Using Smallmouth Bass Micropterus Dolomieu, Lindsey Nicole Hartzell

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the early 2000s, fish kills of different species, including smallmouth bass Micropterus dolomieu, were reported in areas of the Potomac River drainage, including the Shenandoah River in Virginia. Since the first reports of fish kills and lesions affecting smallmouth bass, they have continued to show signs of adverse health effects. Additionally, in some areas of the Potomac River drainage, population declines have occurred, and lethal sampling is discouraged. To develop a holistic, integrative approach to assess fish health, Smallmouth Bass were collected and sampled using non-lethal techniques at three sites within the Shenandoah River drainage, VA and one …

Longitudinal And Ensemble Modeling Of Beef Cattle Feed And Water Intakes, Nathan El Blake

Graduate Theses, Dissertations, and Problem Reports (ETD)

Beef cattle production remains a cornerstone of global food systems, providing highly bioavailable protein and essential micronutrients that are difficult to secure from plant-based foods alone. Yet this production is also resource-intensive, requiring substantial land, feed, and water inputs while contributing significantly to greenhouse gas emissions. Efficiency of dry matter intake (DMI) and water intake (WI) is central to both productivity and sustainability, but accurate measurement of these traits—particularly in grazing systems—remains a major limitation. National WI standards continue to rely on pen-level data collected in the 1950s, while most existing DMI prediction equations perform poorly when applied beyond the …

Microbial And Plant Biodiversity In Appalachian Agroecosystems And Their Implications For Soil Health, Kinsey Reed Close

Graduate Theses, Dissertations, and Problem Reports (ETD)

The sustainability of agricultural landscapes depends on understanding the complex interactions between plants, soil, and microbes. In Appalachia, a region shaped by complex terrain and long histories of human and ecological interaction, small family farms produce hay, livestock, and row crops. These agroecosystems, though often treated as “artificial” by many ecologists, have the potential to support both food production and biodiversity conservation if managed with an understanding of ecological complexity. This dissertation examines how plant and microbial diversity interact with soil and management to influence nutrient cycling, soil health, and long-term resilience in Appalachian agricultural systems. A literature review revealed …

Dynamic Force Feedback Controller Improves Metrics Of Stepping In A Biomimetic Robot Leg, Isabella Mae Kudyba

Graduate Theses, Dissertations, and Problem Reports (ETD)

Force feedback is a type of robotic control where forces are measured, fed back into the control system, and actuation is adjusted to compensate for environmental forces, with the goal of quick and precise limb positioning in walking. Robots of today use single force sensors (e.g. pressure sensitive pads, load cells) per leg which are often bulky, expensive, and susceptible to crosstalk. Walking robots often employ model predictive controllers or policy controllers trained through reinforcement learning (RL) to actuate their limbs, but these methods are time and energy consuming. Biomimetic robots offer an alternative approach, investigating biological theories with the …

Replicating The Functionality Of Ghost Knifefish Cerebellar Feedback Using Synthetic Nervous Systems, Sheldon Paul Cj Johnson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sensory inputs allow animals to perceive, react, and adapt to an environment. However, the sensory information received by the body, such as visual, auditory, and proprioceptive information, could become overwhelming, thus overloading the brain. Yet, animals can process all this information by canceling redundant signals from their surroundings, allowing them to be more sensitive to novel or unexpected signals in their environment. Each species (i.e., birds, fish, mammals) has its own way of using and filtering sensory information, from auditory to locomotion adaptivity. Cerebellar circuits contribute to sensory filtering in a variety of systems. In particular, research on Ghost knifefish …

Rational Design Of Small Molecules Targeting Mitochondrial Redox Proteins, Matheus Barbosa Belchior

Graduate Theses, Dissertations, and Problem Reports (ETD)

Reactive oxygen species play a crucial role in many cellular processes. Despite being a natural byproduct of cellular metabolism, overexpression of these species causes damage to the cell, leading to cell dysfunction. Central to the regulation of these highly reactive molecule is the mitochondria. Impairment in its function has been associated with oxidative stress within the cell. Herein, a ligand-based and structure-based approach to design new small molecules to inhibit mitochondrial redox proteins associated with oxidative stress and reactive oxygen species. In the first project two molecules were synthesized and characterized as potential monoamine oxidase B inhibitors. Results showed two …

Identifying The Role And Influence Of Interleukin-27 On The Neonatal Immune Response, Jordan Kane Vance

Graduate Theses, Dissertations, and Problem Reports (ETD)

The first month of life is a critical and vulnerable developmental stage, characterized by a heightened risk of life-threatening infections. Each year, 1.3 million newborns succumb to neonatal bacterial sepsis. The immune system during the neonatal period has unique features that lead to inefficiencies at clearing infection. Early life immunity is characterized by a Th2-biased profile with decreased IL‑12, IFN-γ, and TNF-α, along with increased IL‑6 and IL‑23. Additionally, IL‑27, an immunosuppressive cytokine, is also elevated during this period and further contributes to susceptibility to infection. Early diagnosis and intervention are critical in administering effective care in newborns and there …

Exploring The Ruminal Microbiome And Its Impacts On Feed Efficiency In Beef Cattle, Taylor Simone Sidney

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ability for beef cattle to utilize feed efficiently is a critical determinant for both economic and environmental sustainability in livestock production. However, despite extensive research, the complex microbial ecosystem within the rumen and its relationship to feed efficiency remain incompletely understood. This dissertation explores the physiological and microbial foundations of feed efficiency by characterizing how rumen microbial communities and their functions differ among beef cattle with divergent residual feed intake (RFI) phenotypes and how the RFI status of beef cattle influenced their response to dietary interventions such as supplementation with a Bacillus-based feed additive. In the first study, …

Survival And Spatial Ecology Of North American River Otters (Lontra Canadensis) In West Virginia, Laurel Marie Glover

Graduate Theses, Dissertations, and Problem Reports (ETD)

Wildlife reintroductions function to regain wildlife populations in areas where they have been extirpated or greatly diminished. One such species that has been reintroduced to several states is the North American river otter (Lontra canadensis). The West Virginia Division of Natural Resources (WVDNR) conducted a river otter reintroduction effort between 1984-1997, releasing 245 individuals into the state. The reintroduction was deemed a success with the WVDNR opening a regulated trapping season for river otters in 2011, allowing trappers to take one river otter per season. As the population has reestablished in West Virginia, several management challenges have arisen …

2024-2025 Annual Report, Tennessee. Wildlife Resources Agency

Annual Reports

This annual report presents an overview of the Tennessee Wildlife Resources Agency programs and management.

Effects Of Environmental And Anthropogenic Gradients On Fish Beta Diversity In Central Appalachian Streams, Alanna Kaylee Lowther Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding the environmental and spatial drivers of community composition is essential for conserving freshwater biodiversity. We examined how environmental gradients, land cover, and spatial structure influence fish beta diversity in wadeable streams across West Virginia, USA. We quantified total beta diversity and partitioned it into species replacement and richness difference components and used local contributions to beta diversity (LCBD) to identify compositionally unique sites. Community–environment relationships were evaluated with distance-based redundancy analysis (dbRDA), and a beta regression GLMM was used to test how elevation, slope, land cover, and stream order (factor) predicted LCBD while accounting for spatial structure (dbMEMs) and …

Watershed-Level Survey Of Antimicrobial Resistance From Onsite Wastewater Systems, Trey Franklin Clark

Graduate Theses, Dissertations, and Problem Reports (ETD)

The emergence of antimicrobial resistance (AMR) has quickly become one of the largest global health and development threats. Research related to environmental modes of transmission of AMR has accelerated in recent years, and the US Environmental Protection Agency is particularly interested in this emerging contaminant. Knowledge of how onsite (decentralized) wastewater treatment systems contribute to this issue is lacking, so this research serves to analyze and quantify the environmental dissemination of AMR and fecal contamination from these sources at a watershed level while using statistical analysis to assess relationships between physiochemical, spatial, and sampling parameters. This research surveyed four watersheds …

Development Of Novel Carbohydrate-Based Nanoparticles For Precision Drug Delivery, Krystal Ann Hughes

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nanoparticle-based drug delivery has made tremendous advancements in the last decade. However, several critical factors, including precision drug delivery at the site of interest, long-term storage stability, and controlling release profiles of drugs in the systemic circulation, need to be addressed for successful clinical translation of nanomedicine. This dissertation presents novel carbohydrate-based nanoparticles that achieve precise intracellular delivery and therapeutic release at the disease site. We present the formulation and optimization of polymeric and polymer-lipid hybrid nanoparticles that enable precision intracellular delivery and passive accumulation of therapeutics in the bone marrow. Intracellular delivery is highly impactful and sought after. One …

Extinction Bursts Reexamined: The Role Of Consummatory Time And Response Reallocation, Braden Toler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Two experiments were conducted to examine how the removal of the opportunity to consume reinforcement and the reallocation of that time might account for extinction bursts during within-session transitions from FR 1 to extinction. In Experiment 1, rats and pigeons were trained under FR 1 schedules and subsequently exposed to within-session extinction. Total counts of responses suggested that extinction bursts occurred for each subject, but when adjusted to exclude responses that would have overlapped with food consumption, no bursts were observed. In Experiment 2, pigeons experienced four extinction arrangements: conventional extinction, response-independent reinforcement, conditioned reinforcement, and differential reinforcement of alternative …

Copula-Based Bayesian Model For Detecting Differential Gene Expression, Prasansha Liyanaarachchi, N. Rao Chaganty

Mathematics & Statistics Faculty Publications

Deoxyribonucleic acid, more commonly known as DNA, is a fundamental genetic material in all living organisms, containing thousands of genes, but only a subset exhibit differential expression and play a crucial role in diseases. Microarray technology has revolutionized the study of gene expression, with two primary types available for expression analysis: spotted cDNA arrays and oligonucleotide arrays. This research focuses on the statistical analysis of data from spotted cDNA microarrays. Numerous models have been developed to identify differentially expressed genes based on the red and green fluorescence intensities measured using these arrays. We propose a novel approach using a Gaussian …

The New Game Theory, Cortelyou C. Kenney

Georgia Law Review

Game theory and the legal system it models are deeply indebted to the idea of efficiency and efficient outcomes. A great many scholars use game theory to rationalize approaches based on efficiency not only to commercial transactions but also to the legal system writ large, including the tort law system and the criminal justice system.

Efficiency and efficient outcomes have a storied history dating back to Vilfredo Pareto, Ronald Coase, and even before that to Adam Smith. But the person who truly popularized the idea of efficiency was John Nash, who won the Nobel Prize for his work on noncooperative …

Conservation Benefits Of A Large Marine Protected Area Network That Spans Multiple Ecosystems, Joshua G. Smith, Cori Lopazanski, Christopher M. Free, Julien Brun, Clarissa Anderson, Mark H. Carr, Joachim Claudet, Jenifer E. Dugan, Jacob G. Eurich, Tessa B. Francis, David A. Gill, Scott L. Hamilton, Kristin Kaschner, David Mouillot, Peter T. Raimondi, Richard M. Starr, Shelby L. Ziegler, Daniel Malone, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Marine protected areas (MPAs) are widely implemented tools for long-term ocean conservation and resource management. Assessments of MPA performance have largely focused on specific ecosystems individually and have rarely evaluated performance across multiple ecosystems either in an individual MPA or across an MPA network. We evaluated the conservation performance of 59 MPAs in California's large MPA network, which encompasses 4 primary ecosystems (surf zone, kelp forest, shallow reef, deep reef) and 4 bioregions, and identified MPA attributes that best explain performance. Using a meta-analytic framework, we evaluated the ability of MPAs to conserve fish biomass, richness, and diversity. At the …

Physiological Effects Of Research Handling On The Northern Elephant Seal (Mirounga Angustirostris), Lauren A. Cooley, Allyson G. Hindle, Cassondra L. Williams, Paul J. Ponganis, Shawn M. Hannah, Holger Klinck, Markus Horning, Daniel P. Costa, Rachel R. Holser, Daniel E. Crocker, Birgitte I. Mcdonald

Faculty Research, Scholarly, and Creative Activity

Wildlife researchers must balance the need to safely capture and handle their study animals to sample tissues, collect morphological measurements, and attach dataloggers while ensuring their results are not confounded by stress artifacts caused by handling. To determine the physiological effects of research activities including chemical immobilization, transport, instrumentation with biologgers, and overnight holding on a model marine mammal species, we collected hormone, blood chemistry, hematology, and heart rate data from 19 juvenile northern elephant seals (Mirounga angustirostris) throughout a translocation experiment. Across our six sampling timepoints, cortisol and aldosterone data revealed a moderate hormonal stress response to handling accompanied …

A Unifying Double-Reference Approach To Semantic Paradoxes: From The White-Horse-Not-Horse Paradox And The Ultimate-Unspeakable Paradox To The Liar Paradox In View Of The Principle Of Noncontradiction, Bo Mou

Faculty Research, Scholarly, and Creative Activity

The purpose of this study is to suggest and explain an engaging approach to three distinct types of (alleged or genuine) semantic paradoxes, the White-Horse-Not-Horse Paradox, the Ultimate-Unspeakable Paradox, and the Liar Paradox, in a unifying way that is sensitive to distinct features of them. Although the three types of semantic paradoxes address distinct types of objects, and although their seemingly paradoxical features are different (alleged or genuine), their distinct structures and contents can be understood and treated on the same common ground, which is jointly conceived in people's pretheoretic understandings of truth and of the double-reference feature of people's …

RaˉMaˉNuja's Cosmopsychist-Panentheistic Solution To The Hard Problem Of Consciousness, Anand Jayprakash Vaidya, S. Siddharth

Faculty Research, Scholarly, and Creative Activity

Recent decades have seen a renewal of interest in panpsychism as a solution to the hard problem of consciousness. This has, in part, also driven an increase in interest in classical Indian philosophical traditions among analytic philosophers of mind. Many of these cross-cultural studies pertaining to panpsychism (and cosmopsychism) have focused on one particularly influential school of Indian philosophy, Advaita (non-dual) Veda nta, the most famous proponent of which is sankara. In this work, we would like to consider the view of another influential philosopher and the school that developed based on his view - Rama nuja (eleventh century CE) …

Gender-Sexuality Alliance Advisors’ Covid-19 Strategies Inform Future Responses To Sociopolitical Crises, Robert A. Marx, Michael O’Brien, Megan K. Yang, Diana Smith, V. Paul Poteat

Faculty Research, Scholarly, and Creative Activity

In the spring of 2020, the COVID-19 pandemic necessitated a sudden shift to remote learning in schools across the United States, profoundly impacting marginalized communities, including LGBTQ+ students. This qualitative study explores the experiences of Gender and Sexuality Alliance (GSA) advisors during this period. Drawing on interviews with 10 GSA advisors, the research highlights the structural and logistical challenges faced, such as limited access to technology and virtual-meeting fatigue, as well as the innovative solutions and adaptations made to continue supporting LGBTQ+ youth. The study reveals how GSAs leveraged existing resources, maintained group cohesion, and adjusted meeting structures to navigate …

Unseen Connections: A Storymap Exploring Case Studies In Water-Energy Transitions And Environmental Justice, Alida Cantor, Elizabeth Bartholomew, Kate Berry, James Blair, Dustin Mulvaney, Nancee Hunter

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Evaluating Seasonal Vs. Spatial Extrapolation For Cetacean Distribution Models In The California Current, Elizabeth A. Becker, Karin A. Forney, Bruce J. Thayre, Katherine Whitaker, Ryan Hoopes, Joshua M. Jones, John A. Hildebrand, Jeff Moore

Faculty Research, Scholarly, and Creative Activity

Species distribution models (SDMs) have been developed for multiple cetacean species within the California Current Ecosystem (CCE) from shipboard survey data collected by the Southwest Fisheries Science Center (SWFSC) in summer and fall, thus limiting the ability to inform management decisions in cool seasons when abundance and distribution patterns are substantially different. Winter and spring SDMs have been developed for a few species using California Cooperative Oceanic Fisheries Investigations (CalCOFI) shipboard survey data, but model predictions are limited to the waters off southern and central California. In this study, winter and spring density estimates for the entire CCE study area …

Optogenetic Methods To Stimulate Gamma Motor Neuron Axons Ex Vivo, Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson

Faculty Research, Scholarly, and Creative Activity

It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons. Here, we test the feasibility of stimulating gamma motor neuron axons using optogenetics in two transgenic mouse lines. We used an ex vivo muscle–nerve preparation in adult mice to monitor muscle spindle afferent firing, which should increase in response to gamma motor neuron-induced lengthening of the sensory region of the muscle spindle. A force transducer measured alpha motor neuron-mediated twitch contractions. Blue LED light (470 nm; 1–5 mW) was delivered via a light guide to the sciatic …

Using Advanced Machine Learning To Evaluate The Spatial And Temporal Patterns Of Human–Bear Interactions In Maryland, Usa, Katherine A. Kurth, Jonathan K. Trudeau

Human–Wildlife Interactions

American black bears (Ursus americanus) are highly adaptable to human-dominated areas, which can lead to interactions with humans. Managing these interactions is a priority for many wildlife agencies in North America. Climate-induced shortages in natural food can exacerbate human–bear interactions, as bears are driven to seek alternative food sources in human-dominated areas. However, few studies have investigated the impact of climate or weather on the frequency and severity of human–bear interactions. In Maryland, USA, no research has examined the anthropogenic or environmental factors contributing to human–bear interactions, even though reported interactions have consistently increased since the 1990s. Our …

Annual Report, Fiscal Year 2025, Tennessee. Department Of Correction

Annual Reports

This document is the annual report for the Tennessee Department of Correction during the fiscal year.

Recdreamer: Consistent Text-To-3d Generation Via Uniform Score Distillation, Chenxi Zheng, Yihong Lin, Bangzhen Liu, Xuemiao Xu, Yongwei Nie, Shengfeng He

Research Collection School Of Computing and Information Systems

Current text-to-3D generation methods based on score distillation often suffer from geometric inconsistencies, leading to repeated patterns across different poses of 3D assets. This issue, known as the Multi-Face Janus problem, arises because existing methods struggle to maintain consistency across varying poses and are biased toward a canonical pose. While recent work has improved pose control and approximation, these efforts are still limited by this inherent bias, which skews the guidance during generation. To address this, we propose a solution called RecDreamer, which reshapes the underlying data distribution to achieve more consistent pose representation. The core idea behind our method …