Digital Commons Network^™

The Impact Of Lactobacillus Supplementation On Gut Microbiome Composition And Phage Induction In Mice, Kimia Boreiri

Dissertations

The mammalian gastrointestinal (GI) tract harbors a dense and dynamic community of microbes known as the gut microbiota, which plays vital roles in digestion, immunity, and overall health. Among these, probiotic bacteria such as Lactobacillus strains have garnered attention for their ability to influence microbial community structure and host physiology. This study investigated the effects of five Lactobacillus strains, Lactobacillus casei R1A482, Lactobacillus casei O3, Lactobacillus rhamnosus GG, Lactobacillus gasseri ATCC 33323, and Lactobacillus paragasseri UMB1065, on the gut microbiome of Swiss Webster mice over a six-week feeding period. To reduce stress, mice were fed Lactobacillus strains using gelatin pellets …

Role Of Coronavirus Envelope Protein On Infectivity, Garrett E. Zaagman

Dissertations

Coronaviruses infect a wide range of hosts and have caused recent human pandemics. While much has been learned, gaps remain in understanding viral assembly and egress, particularly the role of the envelope (E) protein in specific infectivity. To study this, recombinant MHV viruses were created with E gene deletions and HiBiT-tagged spike (S) proteins to monitor virion release. In mouse cells, MHV∆E S-HiBiT secreted less spike and fewer infectious particles, indicating reduced specific infectivity. Comparisons between human HeLa-CEACAM and mouse DBT cells showed species-specific support for virus production. TMED10, a host membrane protein, was tested as a potential E-interacting partner …

Anti-Inflamatory Mechansim Of Bacillus Subtilis Derirved Exopolysaccharide, Adrian Taylor Ibarra

Dissertations

Exopolysaccharides (EPS) secreted by the commensal bacterium Bacillus subtilis exhibit potent anti-inflammatory properties, yet the underlying molecular mechanisms remain incompletely understood. We hypothesized that EPS reprograms antigen-presenting cells toward a tolerogenic state by modulating TLR4–MyD88 signaling. To test this, we began using a chemically defined, high-yield EPS production and purification protocol that largely eliminates protein and DNA contaminants, thus improving functional reproducibility across experiments using this new method. In vitro, EPS engaged TLR4 on murine dendritic cells (DC2.4) without inducing classical NF-κB activation, seen by LPS stimulation. Rather, EPS treatment upregulated inhibitory molecules, PD-L1 and PD-L2 while leaving activation markers, …

Developing Chemically Defined Serum-Free Medium For Leukemic Blast And Stem Cell Expansion, Carmen Eva Finley

Dissertations

The relapse and chemotherapy resistance are the major challenges of acute myeloid leukemia (AML) treatment, driven by a rare population of leukemia stem cells (LSCs). LSCs are unique types of cells which evade standard chemotherapies and can regenerate AML post-treatment. Targeting LSC therapy remains limited, in part due to the lack of reliable in vitro AML culture systems to grow LSCs for drug discovery. This study aimed to engineer a chemically defined, serum-free 2D in vitro culture condition that supports either the expansion of leukemic blasts (LBs) or primary human LSCs by optimizing current protocols for hematopoietic stem cells (HSCs) …

“What’S Happening In The Gulf Of Maine?”: Middle School Students’ Engagement In Climate Science Through Data Visual Representation And Reflections, Grace Ocular

Dissertations

This study examined how middle school students engaged with science concepts while working with data visualizations during a field trip learning experience. Fifty-one teams of 2–4 students from 35 schools participating in the LabVenture program were video- and audio-recorded. Students completed two activities: one using a frequency table of marine species illustrating threats to Maine’s lobster population, and another using maps depicting changes in Gulf of Maine sea surface temperature. After each activity, students annotated the visualization, discussed their claims, and recorded short reflections. Transcripts were coded for science-related talk, and annotations and gestures were also analyzed. Findings indicate that …

The Bacterial Sensing Nuclear-Oligomerization Domain 2 Receptor In The Brain: Location And Potential Function, Julia Smyth

Dissertations

Nucleotide-binding oligomerization domain-2 (NOD2) is a cytosolic receptor, activated by bacterial peptides that initiates innate immune responses through nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and Caspase-1 pathways. While the role of NOD2 in inflammation outside the central nervous system (CNS) is well-established, especially in the gastrointestinal system, its expression and function in the brain remain poorly defined. Previous genetic studies suggest a link between NOD2 and neurological and psychiatric conditions, including stroke, Parkinson’s disease, and schizophrenia. However, information regarding NOD2 expression, localization, and function in the CNS is limited. In this work, we investigated NOD2 expression, localization, and regulation …

Effects Of Nitrogen, Phosphorus And The Fungicide Azoxystrobin Additions On Larval And Post-Metamorphic Fitness Of American Toads (Anaxyrus Americanus), Michael Vosburgh

Dissertations

Since European settlement, vast areas of U.S. land have been modified by humans. In the Midwest, an estimated 99% of native grasslands have been replaced by agriculture and urban development. Such alternations have replaced native habitat, redefined hydrology and introduced a wide array of chemicals into aquatic ecosystems. Modern agricultural practices utilize fertilizers and pesticides to maximize crop production. These chemicals frequently runoff into surrounding waters, potentially effecting aquatic organisms. One group of organism thought to be susceptible to agricultural contaminants are amphibians. Amphibians are vulnerable to pollution due, in part, to their permeable skin and biphasic life history. Global …

The Forced Sterilization Of Quechua-Speaking Women In Peru: The Role Of Epistemic Injustice In The Perpetration Of Genocide, Geraldine Diaz

Dissertations

The forced sterilization of Quechua-speaking women in Peru from 1996 to 2000 represents a case of genocide in which the state as an epistemic agent has a fundamental role. Although the systematic sterilization was carried out under the guise of a family planning program, the targeting of these women provides strong circumstantial evidence of genocidal intent. According to the testimonies of these women, medical staff, acting on behalf of the government, performed tubal ligation procedures through coercion, threats, lies, bribery, manipulation, and other tactics where the state intentionally withheld information, misinformed women, and failed to obtain proper consent. This research …

Response Of Benthic Macroinvertebrate Community Structure And Aquatic Insect Secondary Production To Coarse Woody Debris Addition In Peri-Urban To Urban Golf Course Ponds, Ryan Johnson

Dissertations

Golf courses represent 29% and 26% of all greenspace areas in the U.S. urban regions and the Chicago metropolitan region, respectively; however, they are often overlooked among urban greenspaces as a tool to mitigate the impacts of increased urbanization on ecological communities. The primary aim of this research was to assess whether manipulating golf course pond habitats by adding coarse woody debris (CWD) would enhance aquatic invertebrate community structure and secondary production, with the potential to increase local biodiversity. One pond in each of six golf courses was selected for this study and sampled in summer 2020 before wood addition …

Urban Coyotes As A Source Of Conflict With Humans: An Evaluation Of Common Management Practices, Paul D. Curtis, David L. Bergman, Angeline Barker, Daniel Bogan, Mary Ann Bonnell, Pierre Canac-Marquis, David Drake, Dave Kay, Brian F. Wakeling, H. Bryant White

Human–Wildlife Interactions Monographs

Wildlife often serves as a catalyst for conflict among stakeholders. Management actions that are intended to address sources of disagreement may initiate additional conflict. The Association of Fish and Wildlife Agencies Human–Wildlife Conflict Working Group initiated an effort to identify management actions commonly used to address unwanted coyote (Canis latrans) interactions within urban environments and identify the benefits and challenges associated with each action. Challenges with coyotes in urban environments include aggressive behavior toward humans and pets, attacks, disease exposure, and domestic livestock damage. Although elimination of all attractants would prove preventative in most instances, in practice this …

Cultivating Community-University Partnerships Within The Chicago Region Food System, Hanan Abdillahi, Vivian Cossey, Tania Schusler, Kevin Erickson, Karen Schauwecker, Sarah Ku, Ray Dybzinski

School of Environmental Sustainability: Faculty Publications and Other Works

We interviewed 22 organizations in the Chicago Regional Food System to gain insights on their current initiatives, assets, challenges, future visions, and perceived roles of universities in advancing their work. We analyzed themes to report on strong consensus or varied perspectives related to this work. This report aims to advise Loyola’s School of Environmental Sustainability's future work and collaboration activities with Chicago Food System organizations.

The Effect Of Social Hierarchy And Captivity On Behavior In Cercopithecus Petaurista, Haley Bombard

Undergraduate Scholarship and Creative Works

The social hierarchy within three Cercopithecus petaurista individuals was studied to determine how the influence of captivity affects behavior. The three individuals were monitored from August-November, and the data retained was focused on aggression and allogrooming behaviors. The group consisted of one dominant male and two females in the Central Florida Zoo, and behavioral observations were recorded at 10-minute intervals. Results showed that the dominant male infrequently engaged in allogrooming behavior but more often received it from the less dominant females. The hierarchy and social status of the females was shown and influenced by the allogrooming given and received between …

Innovative Bird Strike Mitigation Strategies: Integrating Drones And Cutting-Edge Technologies To Enhance Airport Safety, Abdellah Hanine, Abdellah Elbarkany

International Journal of Aviation, Aeronautics, and Aerospace

Notwithstanding significant efforts to reduce the risk of bird strikes at and around airports, as well as advancements in technology, aviation safety continues to be threatened by this hazard. Our study of recent data shows a clear historical increase in accidents, therefore underscoring the flaws in present technologies. Although among the technologies in common use are radar, drones, cameras, and acoustic approaches, they are not always able to completely meet the challenging needs of bird strike risk mitigation. This approach creatively blends these four fundamental technologies by means of enhanced real-time data processing and targeted drone deployment. While providing more …

“Assessing The Feasibility And Acceptability Of Blood Flow Sensing Technology In Kidney Transplant Surveillance”., M Malik

School of Nursing and Midwifery Theses

AbstractIntroductionVascular thrombosis is a disastrous postoperative complication resulting in the loss of 3.5% to 5.7% of all kidney transplants. The use of novel blood flow-sensing technology in the early postoperative period may allow loss of vascular patency or thrombosis to be detected immediately, which is critical in reducing thrombosis-related graft loss. An implantable Doppler probe utilises blood flow sensing technology to provide continuous feedback on blood flow when connected to a vascular anastomosis. This clinical research aimed to assess the theoretical basis and feasibility of an implantable Doppler probe as a blood flow-monitoring device in kidney transplant recipients and to …

Natural Allies: A Qualitative Exploration Of The Impact Of Nature Immersion For Wellbeing And Its Relevance To Nursing: Challenges And Opportunities On The Journey Towards Interconnected Human And Planetary Health, Sarah Howes

School of Nursing and Midwifery Theses

Human beings have evolved in direct relationship with the natural world, our health and survival inextricably connected to that of the planet. In recent years, an expanding evidence base has extolled the benefits of time in green and blue space for restoration from busy and stressful lives, yet limited literature explores the impact of time in nature from a nursing perspective. Through three study phases, this reflexive qualitative ethnographic study examines the complex, multifaceted and perpetually shifting contexts which influence nature connection and sustainability concepts in nursing, highlighting a shared vulnerability between people and planet. Through a critical interpretive synthesis …

Lipid Biomarkers For Marine Fungi, Emily Cooper

School of Geography, Earth and Environmental Sciences Theses

Marine fungi play key roles as parasites and saprotrophs in marine ecosystems and are important degraders of organic matter. They likely facilitate the remineralisation of marine carbon, thus have a profound impact on marine biogeochemical cycles. However, as little is known about their global abundance and biomass, fungi are yet to be included in biogeochemical models. Lipid biomarkers can be used to assess microbial abundance and biomass due to their specificity and may be utilised to explore the viability and trophic dynamics of marine microbial communities. Although lipid biomarkers for fungi have been used in terrestrial environments, such as soils, …

Dred Scott, Military Enslavement, And The Case For Reparations, Hugh Barrett Mcclean

All Faculty Scholarship

For more than a decade, Dred Scott was enslaved by a U.S. Army officer in a military system that perpetuated the institution of slavery in the free states and Northern territories of the antebellum period. Scott’s life, his lawsuit for freedom, and the U.S. Supreme Court case holding that Black people have “no rights which the white man was bound to respect” became infamous. But the history of the Dred Scott case and the military’s use of enslaved persons is largely unknown. Drawing on reparations advocacy in the Rosewood and Tulsa race massacre cases and other historical precedent for reparations, …

Bioaccumulation Of Legacy And Novel Pfas In The Environment, Hesham Taher, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

The bioaccumulation of per- and polyfluoroalkyl substances (PFAS), both legacy and novel, in the environment presents significant ecological and health risks. PFAS are a diverse group of synthetic chemicals known for their persistence and bioaccumulation, which can cause widespread environmental contamination and health risks. Strong carbon-fluorine bonds give these compounds unparalleled stability, preventing them from degrading and enabling them to endure in a range of environmental matrices, including water, soil, and biota. Legacy PFAS, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), have been extensively studied and regulated, resulting in lower concentrations in some environmental media. However, novel PFAS, …

Final Cruise Report: Tn401, Roxanne A. Beinart, Shawn Arellano, Craig Young

Graduate School of Oceanography Faculty Publications

No abstract provided.

Unh/Noaa Joint Hydrographic Center 2025 Performance And Progress Report Executive Summary, Larry A. Mayer

Center for Coastal and Ocean Mapping

No abstract provided.

Unh/Noaa Joint Hydrographic Center 2025 Performance And Progress Report Executive Summary, Larry A. Mayer

Center for Coastal and Ocean Mapping

Reporting Period: 01/01/2025–12/31/2025

No Neutral Ground: Sports Political Ideology In The 1936 Olympic Games, Lea Zeitler

Electronic Theses and Dissertations

By using literary and cinematic narratives to explore changing cultural and ideological positions, my thesis demonstrates how the 1936 Berlin Olympics became a defining event of the intersection of sports and politics. Through analyzing Leni Riefenstahl’s Olympia, Richard Mandell’s The Nazi Olympics, and Elise Hooper’s Fast Girls, I show how distinct historical circumstances inform understandings of race, gender, and nationalism. The Berlin Games, used by the Third Reich as a platform for Nazi propaganda, stand as an example of how international sporting events become battlegrounds for ideological struggles and political messaging. This thesis argues that these narratives are not just …

Exploring A Modern Deep Learning Technique For Wetland Mapping And Monitoring Using Worldview-2 Satellite Products, Mizanur Rahman

Electronic Theses and Dissertations

Wetlands play a significant role in the world’s hydrology, climate, and biodiversity. Even with the benefits and values wetlands provide to the environment, they have been undergoing loss and degradation due to natural and anthropogenic processes. To protect wetlands from loss and degradation and to restore their function, it is essential to develop a sustainable wetland monitoring system. One of the key elements of a wetland monitoring system is wetland mapping. This dissertation research developed an object-based deep learning protocol for mapping heterogeneous wetlands with many communities from a high-resolution WV-2 satellite image. To test this developed protocol, an object-based …

Embodied Liminality: The Ritual-Drama Nexus In Pan-Tribal Native American Dance And Theatrical Performances, Oscar Pereira

Electronic Theses and Dissertations

This study examines the intersection of ritual, drama, and liminality in pantribal Native American dance performances, emphasizing embodied liminality as a performative process shaping cultural continuity, identity transformation, and communal reinforcement.

Using an interdisciplinary methodology that integrates archival research, visual anthropology, and qualitative analysis, this study investigates three case studies: (1) the Ghost Dance movement as a liminal ritual of resistance and cultural revitalization; (2) pan-tribal powwows as sites of embodied liminality and cultural revitalization, and (3) contemporary Native American theater, analyzing theatrical plays through the lens of liminality, visual anthropology, theater and performance methodologies.

Examining embodied liminality in historical …

Mblac1 Knockout Mice: Behavioral Modeling Of A Novel Risk Factor In Alzheimer's Disease, Cara Melillo

Electronic Theses and Dissertations

Alzheimer’s disease (AD) involves progressive cognitive decline, with mitochondrial dysfunction, oxidative stress, and copper (Cu) imbalance implicated in its pathogenesis. MBLAC1 has been identified as a risk factor for AD in individuals with comorbid cardiovascular disease (AD-CVD). Its C. elegans ortholog, swip-10, regulates Cu ion homeostasis and mitochondrial function. To investigate MBLAC1’s role, we examined behavioral phenotypes in Mblac1 knockout (KO) mice and tested the efficacy of the Cu chaperone elesclomol (ES). Male KO mice exhibited deficits in novel object recognition (NOR), which were rescued by ES treatment. Female KOs showed increased anxiety-like behavior in the Elevated Plus …

Whispers From The Islands Preserving And Reinterpreting Caribbean Myths Through Augmented Narratives, Tatyanna Gay

Electronic Theses and Dissertations

This thesis explores the role of design as a contemporary medium for preserving, reinterpreting, and disseminating Caribbean cultural myths through visual storytelling. Focusing on using Augmented Reality (AR) and paper sculpture, this research examines how immersive technologies can bridge the gap between oral traditions and digital innovation to safeguard intangible heritage. Centering Caribbean folklore, specifically myths such as the Chickcharney, the Lusca, and the La Diablesse, this work analyzes these stories' historical, symbolic, and social functions within Caribbean identity formation and collective memories.

Drawing on interdisciplinary frameworks from mythology studies, design history, and visual culture, the project investigates how AR …

Applications Of Deep Learning And Signal Processing In Acoustics, Oceanography, And Biometrics, Ali Abdulmajeed Altaher

Electronic Theses and Dissertations

This dissertation examines multidisciplinary methods in marine research, computational modeling, and artificial intelligence. This dissertation tackles significant issues in ecological monitoring, ocean dynamics forecasting, and assistive technology via three independent but interrelated research streams.

The first study examines the localization and distribution of marine organisms along Florida’s East Coast via passive acoustic monitoring methods. The research analyzed more than 65,000 audio recordings to delineate the geographical distribution of several marine creatures, such as black drum, toadfish, Sei whales, North Atlantic right whales, dolphins, and false killer whales. A novel automated detection and localization model was developed, using an adaptive matching …

Exploiting Undulating Fin Kinematics For Multi-Directional Swimming Control, Omar S. Odeh

Electronic Theses and Dissertations

The Black Ghost Knifefish achieves remarkable swimming gait transition by leveraging the distinctive morphology and kinematics of a single, elongated undular fin. Alongside bi-directional swimming, complex maneuvers incorporating vertical movement and pitch control can also be attained. Inspired by the Knifefish, we explore a novel propulsive and directional control method for an undulating membrane affixed to a robotic vessel utilizing counter-propagating waveforms in tandem with a sigmoidal spatiotemporal pattern to control forward, backward, and turning of the vessel. The proposed actuation supplied the propulsion necessary for the robotic vessel to swim bi-directionally with heading control under varying flow speed conditions. …

Materia Non Medica: Reading Disability And Medical Narratives In The Daughter Of Doctor Moreau, Jessica Elizabeth Young

Electronic Theses and Dissertations

This thesis presents a close reading of The Daughter of Doctor Moreau by Silvia Moreno-Garcia, engaging Indigenous studies and disability studies to illuminate how the novel interrogates embodiment, medical authority, and human difference. By situating the text within historical frameworks of medicine and corporeality in Mexico, and alongside speculative modes that seek to recuperate non-Western epistemologies, the analysis reveals how Moreno-Garcia reimagines the body as mutable, relational, and politically charged. The narrative’s hybrid characters and transgressive identities offer a generative lens through which to explore bodily variance, not as deviation, but as a site of possibility. Ultimately, this thesis argues …

Phosphorus Removal Using Novel Carbon Adsorbents Derived From Waste Algae: An Industrial Ecology Approach To Mitigate Algal Blooms, Vithulan Suthakaran

Electronic Theses and Dissertations

High phosphate levels and warm temperatures in surface waters can stimulate the overgrowth of certain alga types, causing harmful algal blooms (HABs). HABs may adversely affect public health and have negative economic impacts due to associated healthcare costs, required clean-up activities, and tourism revenue loss. The overarching objective of this study was to utilize an industrial ecology approach and convert algal biomass into chemically modified activated carbon adsorbent materials for phosphate removal. Cyanobacterial biomass was collected from Lake Okeechobee in Florida and processed before activation using fast and energy-efficient microwave heating. To improve phosphate removal, the surface of the adsorbents …