Digital Commons Network^™

Analysing Visitors’ Emotions, Testing The Dramma Model, And Using Reflective Practice For Guided Walk Development, Jane Webb

Plymouth Business School Theses

This thesis examines the relationship between visitor engagement, aura, nostalgia, and emotion in guided walks, demonstrating how these concepts influence the tourism experience. The study advances understanding by offering a pragmatic insight into visitor emotions during co-creation. To achieve the aims, a study of Facebook posts was performed to understand the ties between current and former residents of Torbay. The research's significance stems from its comprehensive examination of visitors' emotional and subjective well-being (DRAMMA) during guided walks. The work assessed contributed to the DRAMMA Model, encompassing detachment, recovery, autonomy, mastery, meaning, and affiliation. The methodological approach follows an interpretative route, …

Synthesis And Characterization Of A High Entropy Alloy By Powder Metallurgy Technique, Aya Fawzy, Mohamed Bhlol, Osama Dawood, Ayman Elsayed

Trends in advanced sciences and technology

Synthesis of CuCoFeNiW alloy has been realized by powder metallurgy. Mechanical alloying was used to prepare a high-entropy alloy consisting of Cu, Co, Fe, Ni with and without 10 wt.% W particles. The mixed samples were compacted by a uniaxial press under pressures ranging from 340 to 840 MPa. Green samples were sintered in a vacuum sintering furnace from 1150 and 1300 C. The results have shown that the proposed synthesis route could be used to obtain the alloy with proper transformation and metallurgical properties. Hot forging has effectively increased the hardness of the alloy at all preparation conditions.

The Possible Protective Effect Of Coenzyme Q10 And Indole-3-Carbinol On Cyclosporine Induced Nephrotoxicity In Rats, Maha A. Ollaek, Gehan S. Georgy, Engy M. El Morsy, Eman M. Raafat

Trends in advanced sciences and technology

Background: Cyclosporine A (CsA) is a potent immunosuppressive drug, with nephrotoxicity being its most frequent adverse effect, primarily due to the involvement of free radicals in inflammatory and fibrotic pathways. Both coenzyme Q10 (CoQ10), a fat-soluble vitamin-like molecule, and indole-3-carbinol (I3C), a natural compound, possess anti-inflammatory and antioxidant properties. Aim: This study aimed to investigate the potential protective effects of CoQ10 and/or I3C against CsA-induced nephrotoxicity in rats. Methods: Male albino rats were randomly assigned to five groups, with six rats in each group. Group (1) served as the normal control group and received corn oil orally by gavage for …

Repair And Regeneration Of Low Dose Ionizing Radiation To Injured Muscles Using Barium Chloride In A Rat Model, Esraa A. Aboelfadl, Hesham Haffez, Soheir S. Koraa, Ahmed E. Abdel Moneim, Ola H. El-Habit, Rasha S. Elbeltagy

Trends in advanced sciences and technology

The biological consequences of low dose ionizing radiation (LDIR) are strongly debated. While most studies confirm its detrimental effects, several studies suggest beneficial (hormetic) effects of LDIR as an anti-inflammatory agent on musculoskeletal injuries. The present study aimed to investigate the bio-stimulatory effects of LDIR (direct and indirect) in healing the musculoskeletal injuries induced by barium chloride (BaCl2). Thirty adult male Albino rats were used in this study and were divided into five groups as follows: control, BaCl2, g-rays (direct), g-rays (indirect), BaCl2 and g (direct), and BaCl2 and g (indirect) group. Muscle injury was induced using 50 ml of …

Evaluation Of Electrical And Piezoresistive Properties Of Carbon Black/Polyurethane Nanocomposite For Strain Sensing Applications, Nihal A. Youssef, Tamer Z. Wafy, O.R Abdelsalam, Nariman E. Elbaly, O.M. Dawood

Trends in advanced sciences and technology

Nanocomposite sensors are gaining importance due to their cost-effectiveness and the ability to modify their properties for various applications. This study investigates the electrical and piezoresistive properties of polyurethane (PU)/carbon black (CB) nanocomposites for strain-sensing applications. Nanocomposite films were prepared by mixing varying weight percentages of CB (3-6 wt %) using a direct method, followed by sonication and screen printing. The characterization of carbon black (CB) particles and nanocomposite microstructure were examined using Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM), while their thermal stability and degradation behavior were assessed by Thermo-Gravimetric Analysis (TGA) under different temperature conditions. The …

Adme Predicted Molecular Intervention Aiming At Assessment Of An Alternative Means Of Phyto-Based Pest Control Of Cotton Leaf Roller, Haritalodes Derogata Using Diluted Ethanolic Extract Of Nux Vomica, Arnob Chakrovorty, Avidipta Hazra, Banani Bhattacharjee, Debarsi Das, Anisur Rahman Khuda-Bukhsh, Asmita Samadder

Trends in advanced sciences and technology

The leaf roller moth, Haritalodes (=Sylepta) derogata (Fabricius, 1775) (Lepidoptera) is a common pest of many economically important plant species including cotton (Gossypium spp.) and okra (Abelmoschus esculentus). This study was designed to investigate mainly the insecticidal/pesticidal efficacy of diluted ethanolic extract from seeds of native deciduous Indian tree, Strychnos nux-vomica Linn. (Nux Vom 2X - prepared by diluting raw extract or mother tincture 100 times in 91% ethanol by following homeopathic procedure) known to contain the main toxic ingredient, Strychnine and to elucidate the toxicity related cellular and physio-chemical effects inflicted by it on larva of H. derogata. Present …

To Explore Potential Targets And Their Natural Inhibitors To Combat Diabetes, Rishita Dey, Sisir Nandi, Asmita Samadder

Trends in advanced sciences and technology

Diabetes is a chronic metabolic disorder that affects millions of people around the globe. Prolonged hyperglycemia, abnormal metabolism of fats and carbohydrates, oxidative damage, and a high incidence of microvascular diseases are the common hallmarks of diabetes and its complications. This condition has been shown to hasten the onset of several other disorders, including peripheral neuropathy, nephropathy, and cardiomyopathy, pulmonary arterial disease, and coronary artery disease, thereby necessitating exploration of different avenues of medicinal regimen to address / delineate the complications. The subject matter for this review has been gathered from a range of research publications, review papers, and book …

Field-Validated Load Modelling And Prediction-Driven Bess Sizing For Oil Drilling Microgrids, Omar H. Abdalla, Alaa A. Afifi, Amr Kassem, Ismail M. Mosaed

Trends in advanced sciences and technology

Diesel-based microgrids serving oil drilling operations are subject to sharp and unpredictable load fluctuations that lead to generator underloading, elevating specific fuel consumption (SFC), and reducing system reliability. Conventional battery energy storage system (BESS) sizing methods typically depend on long-term field measurements and static load assumptions, which fail to capture the real transient nature of drilling processes. This paper develops a framework for BESS sizing that directly integrates a measurement-based machine learning (ML) load prediction model. The adopted model, built using the exponential Gaussian process regression (GPR) technique, has been trained and validated on six months of high-resolution field measurements …

Genetic Mutations Affecting Dentin Formation: Molecular Insights And Therapeutic Strategies, Mohamed Yehia Abdelfattah, Yara Sameh Said, Shimaa A. Elsaady, Shahenda A. Abdallahahmed, Wael Abou-Zeid

Trends in advanced sciences and technology

Writing a comprehensive review on gene mutations affecting dentin mineralization requires thorough research and organization, as each section examines how specific mutations influence this process, supported by relevant findings. Mutations in genes such as DSPP, DMP1, andMEPE impair dentin structure and mineralization by disrupting odontoblast function, dentin matrix integrity, and mineral deposition. These genetic alterations interfere with key biological processes, including odontoblast differentiation and matrix formation, through altered signaling pathways such as Wnt/β- catenin and TGF-β, contributing to dental disorders like Dentinogenesis Imperfecta (DI). Gaining molecular insights into these disruptions enhances our understanding of dentin biology and supports early diagnosis, …

The Development Of A Children’S Book Designed To Use Bibliotherapy And Mindfulness Skills To Promote Interoception In Young Children With Insecure Attachment As A Result Of Adverse Childhood Experiences, Zenaida Agramonte

University of the Pacific Theses and Dissertations

One third of children in the United States have experienced trauma known in the literature as Adverse Childhood Experiences (ACEs). The long-term outcomes of ACEs have a higher likelihood of reducing interoceptive awareness—the ability to sense internal body signals like heart rate, hunger, pain, and emotions. Research suggests that interventions, such as mindfulness and attachment therapies are useful for increasing interoceptive awareness, regulating emotions, and fostering secure attachment in adults. However, apart from attachment, interventions are lacking for young children. Bibliotherapy is one such intervention designed for young children which potentially fosters secure attachment between child and adult storytellers and …

Narrative Inquiry Into The Socio Economic Integration And Resilience Of The Mien Community In The United States, Teresa M. Saefong

University of the Pacific Theses and Dissertations

This qualitative study examined the socioeconomic integration of the Mien community, a refugee minority sometimes overlooked in research and policy discussions, in the United States. Five participants shared their experiences through in-depth interviews and community observations. The study utilizes narrative inquiry and is informed by community cultural wealth and resilience theory. The analysis incorporated restorying, comparative, and performative approaches. The findings suggested that Mien integration depended on intergenerational storytelling, clan-based networks, multilingual skills, and the adaption of traditional practices within U.S. institutions. Community organizations were important for keeping culture alive and filling in the gaps in institutional services by giving …

From Philosophy To Nlu: Evolving Definitions With Research Hypotheses, Jian Wu, Sarah Rajtmajer

Computer Science Faculty Publications

Over the past decades, alongside advancements in natural language processing, significant attention has been paid to training models to automatically extract, understand, test, and generate hypotheses in open and scientific domains. However, interpretations of the term hypothesis for various natural language understanding (NLU) tasks have migrated from traditional definitions in the natural, social, and formal sciences. Even within NLU, we observe differences defining hypotheses across literature. In this paper, we overview and delineate various definitions of hypothesis. Especially, we discern the nuances of definitions across recently published NLU tasks. We highlight the importance of well-structured and well-defined hypotheses, particularly as …

Ocean Acidification Mitigation: Potential Expansion Of Sav Restoration Strategy In The Chesapeake Bay, Cree N. Taylor

UROP Posters

Zostera marina is a species of marine macrophyte that has been largely prioritized in past submerged aquatic vegetation (SAV) restoration initiatives within the Chesapeake Bay because of its 1) previous abundance, 2) demonstrated carbon burial abilities, and 3) observed ability for meadows of Z. marina to ameliorate low pH conditions. Due to the temperature variability and poor water quality associated with anthropogenic disturbances in the Chesapeake Bay, Z. Marina beds have experienced several die-off events with limited capacity for regrowth. This systematic review explored the possible benefits of focusing future SAV recovery initiatives on ensuring a diverse variety of SAV …

Systematic Co-Culture Of Ipsc-Cm And Ipsc-An Promote Co-Maturation In Vitro, William Gregory Terrell Jr.

Graduate Dissertations and Theses

The cardiac microenvironment is a complex system of multicellular interactions that enables proper heart function. In native heart muscle, sympathetic neurons (SN) and parasympathetic neurons (PSN) modulate the beat rate of cardiomyocytes (CM) to maintain homeostasis. Pluripotent stem cells can differentiate into CM, but differentiated CMs are fetal-like, with a high beat rate, and lack organized sarcomeric structure. Recent reports of co-cultured pluripotent CM/SN pairs have reported electrophysiological changes in the SN (increased upstroke velocity). However, interpretation of these results are obscured by the differences in co-culture parameters between studies (stage of development, co-culture duration, etc.). The goal of this …

Analyzing The Benefits Of Artificial Intelligence To Racially Inclusive Democracy, Spencer A. Overton

GW Law Faculty Publications & Other Works

Over the past two decades—as the United States has grown more ethnically diverse—the U.S. Supreme Court has dismantled key voting rights protections, and state legislatures have erected a record number of voting restrictions. Largely oblivious to this growing gap in legal protections, several artificial intelligence (“AI”) optimists have claimed that AI can help usher in a more inclusive, participatory, and unbiased democracy. Such an outcome, however, is far from guaranteed. This Article is the first to comprehensively examine the extent to which AI—and the legal frameworks that regulate it—can advance racially inclusive democracy. It responds to the AI optimism literature …

Feature Comment: Institutional Amnesia And The Neglect Of The Federal Acquisition Workforce, Jessica Tillipman, Steven L. Schooner

GW Law Faculty Publications & Other Works

Public procurement regimes may be constrained by rules, but people - procurement professionals - animate the process. Despite spending over $750 billion last year on federal contracts, the U.S. Government continues to deprioritize the professional capacity of its acquisition workforce. This article bemoans and critiques the persistent failure to recruit, develop, and retain procurement personnel, a failure exacerbated by politically driven downsizing, inadequate investments in workforce development, and misplaced reliance on procedural reform—most recently evidenced by the so-called “Revolutionary FAR Overhaul.” Drawing on historical data, case studies, and recent Government Accountability Office reports, the authors document how decades of underinvestment …

Ai And Doctrinal Collapse, Alicia Solow-Niederman

GW Law Faculty Publications & Other Works

Artificial intelligence runs on data. But the two legal regimes that govern data—information privacy law and copyright law—are under pressure. Formally, each regime demands different things. Functionally, the boundaries between them are blurring, and their distinct rules and logics are becoming illegible.

This Article identifies this phenomenon, which I call “inter-regime doctrinal collapse,” and exposes the individual and institutional consequences. Left unchecked, the data acquisition status quo favors established corporate players and impedes law’s ability to constrain the arbitrary exercise of private power. Through analysis of pending litigation, discovery disputes, and licensing agreements, this Article exposes two dominant exploitation tactics …

Mahmoud V. Taylor: Cause Or Effect Of Disruptions In The Public Schools?, Richard Katskee, Ira C. Lupu

GW Law Faculty Publications & Other Works

Mahmoud v. Taylor represents an extraordinary departure from long-standing constitutional norms about the rights of parents of children in public schools. In Mahmoud, the Supreme Court upheld a Free Exercise Clause claim by parents in Montgomery County, Maryland, who sought to have their children (grades K–5) excused from readings that contain LGBTQ characters and themes. The majority opinion by Justice Alito rests on a highly controversial reading of Wisconsin v. Yoder.

Part I of the paper provides the doctrinal and historical backdrop to Mahmoud, which reflects the acute tension between a once-narrow understanding of Yoder and the post-Obergefell backlash against …

Whose Burden Is It Anyway? A Comprehensive Proposal To Reshape Food Safety Review By Treating Food As Medicine, Katya S. Cronin

GW Law Faculty Publications & Other Works

With more than sixty percent of U.S. adults struggling with at least one diet-related health condition, the relationship between nutrition and public health has never been clearer. Indeed, for the first time in over a century, food has a prominent place on the national political stage and is one of the exceedingly few issues that has garnered bipartisan support. The recent rise in popularity of "Food Is Medicine" initiatives, which seek to provide medically tailored or healthy meals to vulnerable populations, underscores the critical importance of food to public health. Yet, while "Food Is Medicine" is shifting the insurance, business, …

Prima Facie Regulatory Capture: Lessons From Epa’S Regulation Of Glyphosate And Pfas ‘Forever Chemicals’, Jason Maclean

Minnesota Journal of Law, Science & Technology

No abstract provided.

Capacity Building In The Irish Brewing And Distilling Sector For Raw Materials Utilisation, By-Products Management, And Environmental Impact Assessment, Ekene C. Umego

Doctoral

The Irish brewing and distilling sector has shown a consistent increase in number, production output, sales, and export value in the last decade. This has implications for raw materials requirements, assessment, and by-products management for the sustainability of the sector. As a result, the main aim of this research study was to evaluate the status of raw materials use and assessment within the Irish brewing and distilling sector, explore by-products management options and valorisation initiatives, and analyse the environmental impact of Irish whiskey production. The first approach was a survey study to collect data on major raw material inputs use …

Aniela (2025), Blanca Vadillo Sánchez

Grado en Diseño de Moda

Hay cosas que no se dicen, pero permanecen. Una prenda, a veces, es eso: una forma de quedarse, de insistir sin imponerse, de sostener algo que aún no tiene nombre. Este proyecto no propone una respuesta, sino una serie de aproximaciones a través del diseño, el cuerpo y el tiempo. Se parte de una pregunta simple pero insistente: ¿qué significa permanecer cuando todo parece pensado para desaparecer? En un contexto marcado por la velocidad del consumo, por el ritmo acelerado de una industria que produce sin pausa y olvida con rapidez, Aniela propone otra temporalidad. Una más atenta, más situada. …

Land, Labor, Legacy: Historic Family Farms In Licking County Journalistic Analysis Of Rural Heritage Through Historic Family Farms, Delaney Susan Brown

Student Scholarship

No abstract provided.

Reproducibility And Repeatability Of 18f-(2s, 4r)-4-Fluoroglutamine Pet Imaging In Preclinical Oncology Models, Gregory D Ayers, Allison S Cohen, Seong-Woo Bae, Xiaoxia Wen, Alyssa Pollard, Shilpa Sharma, Trey Claus, Adria Payne, Ling Geng, Ping Zhao, Mohammed Noor Tantawy, Seth T Gammon, H Charles Manning

Faculty, Staff and Student Publications

Introduction: Measurement of repeatability and reproducibility (R&R) is necessary to realize the full potential of positron emission tomography (PET). Several studies have evaluated the reproducibility of PET using 18F-FDG, the most common PET tracer used in oncology, but similar studies using other PET tracers are scarce. Even fewer assess agreement and R&R with statistical methods designed explicitly for the task. 18F-(2S, 4R)-4-fluoro-glutamine (18F-Gln) is a PET tracer designed for imaging glutamine uptake and metabolism. This study illustrates high reproducibility and repeatability with 18F-Gln for in vivo research.

Methods: Twenty mice bearing colorectal cancer cell line xenografts were injected with ~9 …

Selective Inhibition Of Canonical Stat3 Signaling Suppresses K-Ras Mutant Lung Tumorigenesis And Reinvigorates Anti-Tumor Immunity, Michael J Clowers, Zahraa Rahal, Sung-Nam Cho, Avantika Krishna, Bo Yuan, Leticia G Hamana Zorrilla, T Kris Eckols, Moses M Kasembeli, Samuel Liu, Stephen Peng, Marco Ramos-Castaneda, Annamarie L Thompson, Carlos Ignacio Rodriguez Reyna, Katherine E Larsen, Maria T Grimaldo, Shanshan Deng, Nastaran Karimi, Cody Chou, Walter V Velasco, Melody Zarghooni, Sayan Alekseev, Luisa M Solis Soto, Edwin J Ostrin, Humam Kadara, Suhendan Ekmekcioglu, David J Tweardy, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

Introduction: K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. One of the lynchpins of chronic inflammation in KM-LUAD is signal transducer and activator of transcription 3 (STAT3).

Methods: Here, we tested the anti-tumor and early immunotherapeutic efficacy of TTI-101, a selective small-molecule inhibitor of canonical STAT3 signaling, in a K-rasG12D mutant lung cancer mouse model (CC-LR).

Results: Treatment of CC-LR mice with TTI-101 resulted in reduced …

Inhibition Of Nitric Oxide Synthase Transforms Carotid Occlusion-Mediated Benign Oligemia Into De Novo Large Cerebral Infarction, Ha Kim, Jinyong Chung, Jeong Wook Kang, Dawid Schellingerhout, Soo Ji Lee, Hee Jeong Jang, Inyeong Park, Taesu Kim, Dong-Seok Gwak, Ji Sung Lee, Sung-Ha Hong, Kang-Hoon Je, Hee-Joon Bae, Joohon Sung, Eng H Lo, James Faber, Cenk Ayata, Dong-Eog Kim

Faculty, Staff and Student Publications

No abstract provided.

The Ethical Theory Of Enrique Dussel: An Investigation Of Violence And Coercion In His Three Foundational Principles, Eric Antonio Del Valle Cruz

Dissertations

Problem

Enrique Dussel's ethics proposes addressing global inequality through legitimate coercion as a means of liberating the poor, contrasting it with the violence of the current system. However, the inclusion of life-threatening acts, such as armed revolution, as coercion raises practical challenges for the Christian community, including ethical-political dialogue, inclusion of opposing parties, and potential dehumanization, which need further exploration in light of Dussel’s use of Scripture in support of his proposals.

Purpose

This dissertation aims to assess Dussel's philosophical principles and their connection to coercion and violence, ultimately establishing a framework for a conservative Christian proposal that combines the …

Quantifying Biodiversity In The Absence Of Taxonomic Data: A Study Of Thailand’S Economic Development Zones, Nikorn Mahawan, Wanpen Charoentrakulpeeti

Applied Environmental Research

The biodiversity status measures the ecological capacity of a given area. However, biodiversity assessments in developing countries are limited by the absence of taxonomic data on plants and animals. By developing methods to evaluate biodiversity via alternative data, it is now possible to quantify the ecological carrying capacity in areas where taxonomic data are lacking. The relationship between forest ecosystem health and biodiversity values can be used to estimate biodiversity values by considering the proportions of different land use types that are associated with forest ecosystem abundance. The biodiversity value of the area can be assessed by adding the abundance …

Using A Water Quality Index To Assess The Impacts Of Heavy Metals Contamination For Sustainable Water Management: A Case Study Of The Bang Pakong River, Thailand, Khin Yadana Soe, Pokchat Chutivisut, Wilailuk Niyommaneerat

Applied Environmental Research

Anthropogenic activities such as improper waste disposal, excessive fertilizer use, and industrial effluents cause heavy metal contamination in water, soil, and the atmosphere. Herein, the water quality index (WQI) was used to characterize heavy metal (i.e., cadmium (Cd), arsenic (As), and mercury (Hg)) contamination in the Bang Pakong River, Thailand. Specifically, water samples were collected during the dry season from four stations along the river from 2012–2022. The heavy metal concentrations in the samples were analyzed via atomic absorption spectrophotometry, and WQI values were calculated on the basis of standard water quality parameters. At the four sampling stations, high As …

Halotolerant Biodegradation And Detoxification Of Synthetic Dyes By Marine-Derived Penicillium Oxalicum M6a: Metabolite Profiling And Ecotoxicity Assessment, Ugochukwu Okechukwu Ozojiofor, Mohammed Sani Abdulsalami, Nkechi Eucharia Egbe, Ahmed Ali Haroun, Yakubu Magaji

Applied Environmental Research

The complex aromatic structures of synthetic dyes in contaminated water bodies make them difficult to degrade, posing a serious environmental challenge and representing a significant emerging pollutant that warrants urgent intervention. This study evaluated the biodegradation and detoxification potential of a halotolerant, marine-derived fungal strain, Penicillium oxalicum M6A, isolated from the Nigerian coastline, against Indigo carmine (IC) and Remazol Brilliant Blue R (RBBR). The effects of pH, temperature, salinity, and dye concentration on degradation efficiency, alongside enzymatic activity, were assessed. FTIR and GC‒MS analyses were employed to identify degradation products and predict metabolic pathways, whereas toxicity was evaluated in three …