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Development And Application Of Gpu Based Monte Carlo Simulation Techniques In Radiation Medicine, Satzhan Sitmukhambetov

Physics Dissertations - Archive

Cancer remains a significant public health challenge, with treatments like radiation therapy forming a cornerstone of modern care. To address this challenge, advanced computer simulations can improve radiotherapy in two primary ways. From one hand, mechanistic simulations help elucidate the fundamental radiobiological working principles, which could contribute to the clinical advancements from a bottom-up framework. On the other hand, modality simulations could help design better clinical systems with better detection and therapeutic capabilities. This research enhances these critical simulation tools by introducing two significant developments.

First, this work introduces a metaphase DNA model into a microscopic Monte Carlo simulation framework …

West From West Point: The U.S. Military Academy And The Romantic Frontier, Ryan Shaw

Yale Graduate School of Arts and Sciences Dissertations

This dissertation examines the influence of Romanticism on the culture and curriculum of the United States Military Academy in the early nineteenth century, and demonstrates how it shaped the behavior of U.S. Army officers on the far western frontier. While historians have long associated Romanticism with the frontier experience, it has traditionally been framed as an output, rather than an input. This study identifies West Point as an unexpected but significant source of Romantic ideals.

The history of the Academy is presented uniquely here as a contest between three competing visions: A republican ideal of a modest military …

Breaking Ground On Self-Efficacy: A Qualitative Exploration Of Intimate Partner Violence Survivors’ Experiences With Therapeutic Horticulture, Rachel Marie Reeves

Theses and Dissertations--Sociology

This dissertation explores how participation in a Therapeutic Horticulture program may support the self-efficacy of survivors of Intimate Partner Violence. Through a thematic analysis of interviews with 45 women living at a domestic violence shelter in Lexington, Kentucky, this study investigates whether and how gardening activities contributed to participants’ belief in their abilities to shape outcomes in their lives.

Findings are organized around Bandura’s four sources of self-efficacy: enactive mastery experiences, vicarious experience, verbal persuasion, and physiological/affective states. These insights contribute to feminist criminology and trauma-informed care literature by illuminating the transformative potential of nature-assisted healing programs.

Dna Methylation Variation In Eastern Diamondback Rattlesnakes (Crotalus Adamanteus) On A Georgia Barrier Island, Megan Hoog

College of Graduate Studies: Theses & Dissertations

The Eastern Diamondback Rattlesnake (Crotalus adamanteus, EDB) is the largest rattlesnake in the world and is thought to be declining in many portions of its range. Genetic venom studies in the Southeast United States have shown evidence of fine-scale differences within two main geographic groups on Jekyll Island. My objective is to expand on this finding to determine if epigenetic mechanisms, specifically DNA methylation, varies among different populations of EDB in similar environments, age classes, and sexes. I collected EDB blood samples through a partnership with the Jekyll Island Authority and screened 44 individuals for epigenetic variation from …

The Diseased Extracellular Matrix In Chronic Obstructive Pulmonary Disease Modeling, Leigh-Ann M. Antczak

Theses and Dissertations

Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world, with an increasing prevalence as the world’s population ages. In the distal regions of the lungs, COPD is characterized by progressive emphysema due to an imbalance of proteases that continuously degrade essential extracellular matrix (ECM) proteins within the alveolar walls, causing fatal tissue impairment. This dissertation examines the unique properties of this diseased lung ECM in two parts: (1) As a key constituent in inflammatory signaling that leads to increased inflammation and progression of COPD, and (2) as a tool in three-dimensional (3D) in …

Bs Clinical Laboratory Science, Biological Sciences

Program Revisions/Additions

No abstract provided.

Wiring Attachment, Alexander K. Bacon

Theses and Dissertations

This thesis began with a question: can diagrams create understanding, or only reflect it? Through paintings that layer automotive wiring schematics with family photographs, I explore how the human attachment system resists easy mapping. Using digital tools like Photoshop and scanning, alongside analog methods such as papier-collé and photo transfer, I examine how systems built for clarity—like wiring diagrams—contrast with the layered, often messy realities of human relationships. Drawing from attachment theory’s empirical foundation, rather than the metaphorical leanings of psychoanalysis, my work investigates how emotional bonds form, falter, and repair over time. Material loss and layering are not flaws, …

The Dance Of Human Affairs: Public Administration Leaders’ Perceptions Of Candor’S Impact On A Sense Of Belonging, Aaron Dimmock

Theses and Dissertations

This dissertation examines public administration leaders’ perceptions within the executive branch of the state government studied to determine if the components of radical candor, care personally and challenge directly, are associated with the sense of belonging in a public administration setting. Questions from surveys conducted by the state government studied were used to create the variables analyzed in this study. To the researcher’s knowledge, this is the first study to apply components from the Radical Candor® Framework to determine a relationship with sense of belonging in a public administration setting.

The significance of these components was tested through a quantitative, …

Identification Of Mechanisms Associated With Electronic Nicotine Delivery System Use For Weight Control In Young Adults, Gabrielle Maldonado

Theses and Dissertations

Electronic nicotine delivery system (ENDS) use continues to rise among young adults in the United States, raising public health concerns as the harmful effects of ENDS continue to rise while tailored cessation programs lag. Weight control motives may drive ENDS initiation and frequent use, particularly among sexual and gender minority (SGM) populations, who report higher ENDS use, body dissatisfaction, and disordered eating behaviors than those who identify as heterosexual and cisgender. Understanding these behaviors, their mechanisms, and at-risk populations is critical for improving public health. Seven hundred and eight young adults (ages 18–30; M = 26, SD = 3.3) reporting …

Ecological Interactions Of Large Mammals In Luangwa, Zambia, Jahzara Osborne, Amelia Villaseñor

2025 Research Poster Competition

"The connection between mammalian behavior in national parks and human-driven environmental change is tenuous. National parks are often considered the last vestiges of natural space, yet they are created and maintained by humans. South Luangwa National Park (SLNP) within the southern East African Rift is a microcosm of this global conundrum and is also a region where stable isotope data is sparce. Understanding the mammalian diets of mammals in the SLNP via carbon and oxygen stable isotopes in teeth will provide a means of understanding variation in one aspect of mammal behavior that may be affected by changing animal-human relationships. …

Unbridled Healing: Identifying The Barriers Of Equine-Assisted Therapy, Sally A. Hamm, Amanda Terrell

2025 Research Poster Competition

Despite the documented benefits of equine-assisted therapy (EAT) for mental health conditions, this complementary approach remains underutilized. This qualitative study investigated barriers preventing wider EAT implementation by examining challenges faced by clients, facilities, and volunteers. Data collected through open-ended surveys from 33 participants and the researcher's autoethnographic observations revealed eight common barriers: Accessibility (48 mentions), Money (43), Time (30), Awareness (23), Physical Factors (13), Relationships (13), Risk (13), and Weather (7). Clients identified financial constraints as their primary barrier, particularly insurance limitations. Facilitators struggled most with accessibility challenges, including lack of resources, trained staff, suitable horses, and appropriate facilities. Volunteers …

Effect Of Vibration Isolation During Transportation On Beef Sirloin Subprimal And Steak Quality, Kylie Nevada Krueger

Electronic Theses and Dissertations

The objective of this study was to determine the influence of vibration during transportation on beef sirloin water holding capacity, color, and tenderness. USDA Choice center-cut sirloin top butts (n = 45 cases) were collected at a commercial processing facility and randomly allocated to one of three treatments 1) regular pallet driven 241 km (Reg241), 2) regular pallet driven 644 km (Reg644), and 3) vibration isolation pallet driven 644 km (Iso644). All subprimals were transported at -2.2 °C (d0) and stored for 10 days to mimic industry practices for product aging. Following storage (d11), one subprimal per case was evaluated …

Adam As Imago Dei Statue In The Hebrew Bible, Andrei Orlov

Theology Faculty Research and Publications

In recent decades, there has been a significant shift in scholarly perspectives on ancient Near Eastern cultic images. This shift moves away from the traditional view that regarded cultic statues as merely idolatrous representations — an attitude often reflected in certain biblical narratives—toward a more nuanced understanding of these images as paradoxical channels for divine presence. Recent research on polemics against idolatry in the Hebrew Bible and other Jewish texts reveals efforts to recontextualize traditions of cultic statues within the lives of biblical patriarchs and prophets, portraying them as bearers of the sacred.

Polarimetric Capture And Differentiable Rendering, Katherine Anne Salesin

Dartmouth College Ph.D Dissertations

Many scientific fields rely on the capture and modeling of light to extract underlying information about the world. Often, more information can be extracted by capturing more about the nature of the light, such as its spectral shape or polarization state. While polarization is a relatively unexplored topic in computer graphics, when used in tandem with other recent advancements in the field it has enormous potential to improve both forward and inverse models in other scientific disciplines. We demonstrate this potential in two distinct settings in this thesis.

First, we apply the capture of polarized light to an inverse problem …

The Fearless Decision And The Future Of Race-Conscious Charities, Chenglin Liu

Faculty Articles

Historically, courts tended to differentiate between invidious discrimination against racial minorities and benign discrimination against whites in the context of affirmative action movements. With the social movements galvanized by the conservatives and the change of composition of the Supreme Courts and lower courts, the feasibility of race-conscious measures aimed at helping minorities is substantially reduced. The conservatives' win in Fearless, coupled with the Trump Administration's attacks on DEI, have produced a self-censoring effect on charitable organizations. Because of these threats, race-conscious charities will have to modify their practices to become more "inclusive" or face legal challenges from conservatives.

The Towering Inferno: Art, Policy, And Legacy, Charles R. Jennings

Publications and Research

The Christian Regenhard Center for Emergency Response Studies, leveraging the expertise of its faculty, staff, Advisory Board and colleagues, has consistently programmed activities focused on high-rise fire safety. The upcoming 50^th anniversary of the film The Towering Inferno was an inspiration.

We decided this would be more lighthearted and less purely technical than many of our events. We wanted to consider both the film, and use it to reflect on the state of fire safety in tall buildings in New York City.

Of course it does not escape us that the topic of fire safety is a serious one, …

Biodistribution And Method Validation Of Xylazine In A Mouse Model Using Liquid-Chromatography-Quadrupole-Time Of Flight Mass Spectrometry, Julia E. Perschbacher

Master of Science in Forensic Science Directed Research Projects

Xylazine is a nonopioid veterinary sedative and an α2 adrenergic receptor agonist. It emerged in the opioid epidemic as an adulterant of illicit fentanyl. As xylazine becomes more involved in fatal overdoses, it is relevant to elucidate its biodistribution post-exposure due to its exacerbation of adverse events, namely respiratory depression, as xylazine’s contributions to existing adverse effects of synthetic opioids is understudied. A bioanalytical method to quantify xylazine and select metabolites in tissue using LC-QToF was validated and applied to a preclinical mouse model in order to characterize xylazine’s biodistribution in whole blood and six tissues at a dose known …

Novel Time-Since-Deposition Signatures For Canine Blood; Implications For Animal Cruelty Investigations, Alysia M. Townsley

Master of Science in Forensic Science Directed Research Projects

Dogfighting is a felony in all 50 states and is often tied to other organized crime activities including gambling, narcotics, and weapons trafficking. Because of the clandestine nature of dogfighting crimes, it may be necessary to determine the age of blood samples from suspected events, not just the source. In this study, flow cytometry was used to identify cellular autofluorescence signatures for estimating TSD (time-since-deposition) in canine blood deposits up to 6 months old. To accomplish this, blood was taken from canines of various chronological ages and breeds, then deposited to create TSD samples ranging between 1 day and 180 …

Who Grows There? Rethinking Forest Types Beyond Biomass And Composition In Coastal Ecuador, Evelyn Kent

Geography Honors Projects

Tropical Dry Forests (TDFs) are among the world’s most threatened ecosystems. Many are biodiversity hotspots, and most are fragmented and vulnerable to deforestation, wildfires and climate change. TDFs also receive less conservation attention compared to other tropical forest types. To provide critical baseline information for their conservation, this research defines and quantifies the extent of different forest types and their respective aboveground biomass (AGB) in a fragmented TDF landscape in Manabí, Ecuador. Focusing on two forest reserves and their adjacent areas, we used tree plot inventories (N=16) and community composition analyses to define forest types based on tree community composition. …

Cultivating A Community-Based Food System In Western Montana, Elaina Lamphere

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Expanding The Performance And Functionality Of Air-Jet Dry Powder Inhalers Across Multiple Applications, Ghali H. Aladwani

Theses and Dissertations

This dissertation aims to expand the performance and functionality of air-jet dry powder inhaler (DPI) applications through the development of a next-generation, mesh-nebulizer-based, and scalable spray dryer for the production of pharmaceutical aerosols, along with new spray-dried formulation production methods, novel formulations, and new air-jet DPI components for aerosol delivery to both infants and adults. The first aim focused on the development of a custom small-particle spray drying system capable of integrating vibrating mesh nebulizer technologies in various configurations for the production of excipient enhanced growth (EEG) formulations. This flexible system enabled efficient production of both small- and large-particle powders …

Pla Polymer Binder In Core Production - Influence On Final Casting Dimensions, Artur Soroczyński, Krzysztof Rechowicz

Virginia Digital Maritime Center (VDMC) Faculty Publications

The foundry industry is seeking an ecological alternative to synthetic molding resins. This study evaluates the technological properties of core sands bonded with biodegradable polylactide (PLA). Cores prepared on a 2% quartz sand matrix were subjected to casting processes using two alloys with extremely different pouring temperatures: gray cast iron (approx. 1200 °C) and AK11 silumin (approx. 710 °C). The research methodology included macroscopic assessment, dimensional analysis using 3D scanning (GOM Inspect), and qualitative knock-out assessment supported by numerical temperature field simulation. The results showed that the high crystallization temperature of cast iron leads to complete thermal degradation of the …

Enhanced Diagnostics And Surveillance Of Enteroviruses Including Serotypes Associated With Acute Flaccid Myelitis, Denise Lynette Kramer

Browse all Theses and Dissertations

Prior to 2014, Enterovirus D68 infections typically caused symptoms resembling the common cold. From 2014-2018, D68 was associated with an increase in acute flaccid myelitis. However, since 2020, neurological complications have all but disappeared. We selected 1076 respiratory specimens previously determined to be positive for rhinovirus or enterovirus from Department of Defense members and their beneficiaries collected globally from October 2018 through January 2024 and underwent sequencing. Of these specimens, 93.7% were identified as rhinoviruses, while 6.3% were enteroviruses, including 30 enterovirus D68. We utilized the Nextstrain bioinformatic pipeline to reconstruct the phylogenetic relationship of these 30 D68 viruses. Twenty-two …

The Role Of Rad51 And Its Paralogs In Dna Damage Response In Quiescent Cells Exposed To Solar Simulating Uv Radiation, Angitha Radhakrishnan Nair

Browse all Theses and Dissertations

Rad51, and its five paralog proteins Rad51B, Rad51C, Rad51D, XRCC2, and XRCC3, are crucial in homologous recombination (HR) repair of DNA double-strand breaks. Prior studies have extensively shown the roles of Rad51 in the S/G2 phase, but its role in the G0/G1 phase is still unclear. Our lab focuses on studying the role of Rad51 and its paralogs in quiescent cells. RT-qPCR and western blots helped us understand the expression of Rad51 paralogs in proliferating and quiescent keratinocyte cells. Using a pharmacological inhibitor of Rad51, we found that Rad51 promotes quiescent cell survival after exposure to UV radiation. Like Rad51, …

Determinants Of Bat Activity And Habitat-Use At Runkle Woods And Huffman Metropark, Ohio, Heidi E. Orloff

Browse all Theses and Dissertations

North American bats are an excellent control of pests as most are insectivorous feeders. They face numerous threats including habitat loss, anthropogenic development, disease (White-nose Syndrome), and potentially artificial light at night (ALAN). It is important to track species populations and habitat-use to determine the magnitude of effects from these threats. Acoustic monitoring has proven a useful and non-invasive method for tracking bat populations. In my research, I conducted stationary acoustic surveys of bat activity at Wright State University’s Runkle Woods and nearby Huffman MetroPark during the summers of 2023 and 2024. I recorded bat calls in three different habitats …

Comparative Impact Of Canagliflozin Versus Pioglitazone On Biomarkers Of Diabetic Kidney Disease In Db/Db Mice, Siri Chandana Minikuri

Browse all Theses and Dissertations

Diabetes mellitus is a leading cause of chronic kidney disease (CKD), primarily through dysregulation of the renin-angiotensin system (RAS), characterized by elevated Ang II which promotes vasoconstriction, oxidative stress, and renal fibrosis, along with increased urinary shedding of angiotensin converting enzyme 2 (ACE2), which can exacerbate the imbalance of RAS and tubular injury. Previous studies demonstrated that rosiglitazone, a PPAR-γ agonist, attenuated hyperglycemia, glycosuria, albuminuria, and decreased urinary ACE2 shedding in db/db mice, suggesting a RAS-mediated renoprotective mechanism. Building on this evidence, the current study compared the renal effects of pioglitazone (a PPAR-γ agonist) and canagliflozin (an SGLT2 inhibitor) in …

Towards A Comprehensive Model Of Compassion Fatigue In The Animal Welfare Community, Elizabeth Ellis

Browse all Theses and Dissertations

The COVID-19 pandemic highlighted the stress endured by those in caring professions and emphasized the impact that compassion fatigue and burnout have on helping professionals’ well-being and retention (J. Huang et al., 2024; Volk et al., 2022). However, researchers often have failed to adequately distinguish between compassion fatigue and burnout (e.g. Boyle, 2011). Additionally, researchers have overlooked the animal welfare community (e.g., Figley & Roop, 2006) in favor of focusing on human healthcare workers. Thus, the purposes of my study were to 1) examine whether emotional exhaustion and compassion fatigue were related but distinct phenomena and 2) propose and examine …

Characterization Of Atr Kinase Function In Quiescent Keratinocytes Exposed To Solar Simulating Uv Radiation, Mohamed Sameer Cholakkathody

Browse all Theses and Dissertations

This study examines the role of Ataxia Telangiectasia and Rad3-related kinase in quiescent human keratinocytes exposed to solar-simulated UV radiation (SSL). The ATR inhibitor VE-822 did not significantly affect cell viability in the absence of UV exposure, showing that ATR kinase activity is not essential for quiescent cell survival in the absence of additional genotoxic stress. After SSL exposure, ATR inhibition did not impact acute cell viability but reduced the cells’ long-term ability to proliferate. Western blot analysis demonstrated that VE-822 potently suppressed phosphorylation of ATR target proteins KAP1 and CHK2 in a dose-dependent manner after SSL exposure, confirming strong …

Reducing Operator Training Time Through Virtual Reality: A Case Study On The Lpkf Protomat E44 Machine, Joshua C. Patel

Browse all Theses and Dissertations

This thesis presents the development of an immersive virtual reality (VR) simulation that replicates the operation of the LPKF ProtoMat E44 PCB milling machine. Aimed at reducing operator training time and improving procedural understanding, the simulation offers an interactive and realistic environment where users can safely engage with machine workflows and start-up sequences. The emphasis is on accurate representation, usability, and maintaining immersion to support intuitive learning. Although formal evaluation is outside the scope of this work, the system is designed to serve as a foundation for cost-effective, scalable training in technical and manufacturing contexts, offering a modern alternative to …

Vagus Nerve Stimulation Ameliorates Cognitive Impairment Caused By Hypoxia, Birendra Sharma

Browse all Theses and Dissertations

Hypoxia disrupts brain function due to the high demand for oxygen, leading to significant cognitive impairments. While vagus nerve stimulation (VNS) has been shown to enhance cognition, its ability to counteract hypoxia-induced deficits remains unclear. In this study, male Sprague–Dawley rats were assigned to sham, hypoxia, or VNS + hypoxia groups, with VNS delivered during hypoxia (8% oxygen) using biphasic pulses (100 μs, 30 Hz, 0.8 mA). Cognitive performance was evaluated using multiple behavioral paradigms, and hippocampal tissue was analyzed for neurotrophin expression through quantitative PCR and immunohistochemistry. Among the behavioral measures, hypoxia specifically impaired performance on the passive avoidance …